| { |
| "allow_unverified_wt_in_exploratory_analysis": true, |
| "alpha": 0.05, |
| "batch_A_genes": 24, |
| "conditional_estimand": "E[CRISPR X | A=1,B=1] - E[CRISPR X | A=1,B=0]", |
| "download_optional_omics": true, |
| "drug_estimand": "E[PRISM AUC | A=1,B=1] - E[PRISM AUC | A=1,B=0]", |
| "expected_crispr_sigma": 0.45, |
| "figshare_article_id": 27993248, |
| "figshare_version": 1, |
| "genotypes_require_both_matrices": true, |
| "gsea_max_size": 300, |
| "gsea_min_size": 10, |
| "holdout_fraction": 0.2, |
| "interaction_auxiliary": "A*B non-additive association, not necessary for conditional estimand", |
| "max_condition_number": 1000000000.0, |
| "min_enrichment_genes": 5, |
| "min_gene_observations": 12, |
| "min_overlap_per_lineage_arm": 2, |
| "min_per_arm_estimable": 5, |
| "min_per_arm_for_four_group": 5, |
| "min_reporting_effect_gene": 1, |
| "min_residual_df": 8, |
| "multiplicity": "Original Simes pair BH / within BH / global gene-context BH, BY dependence sensitivity", |
| "mutation_call": "OR(damaging,hotspot); zero is no reported qualifying mutation, NOT verified WT", |
| "n_gsea_permutations": 250, |
| "pathway_for_discoveries_only": true, |
| "pinned_release": "DepMap 24Q4 Public v1 (machine-accessible verified release)", |
| "report_top_n": 20, |
| "researcher_review": "PENDING", |
| "root": "/kaggle/working/final_comutation_fresh_20261104_192636_UTC", |
| "run_four_group_interactions": true, |
| "run_live": true, |
| "run_pan_cancer": true, |
| "run_within_lineage": true, |
| "save_pair_chunk_rows": 500000, |
| "seed": 20261026, |
| "source_policy": "Only raw provider releases fetched in this run; never read previous result repositories", |
| "target_ci_halfwidth": 0.25, |
| "use_mutation_burden_covariate": true |
| } |
