accession stringlengths 6 10 | name stringlengths 6 11 | Full Name stringlengths 1 147 ⌀ | taxon stringlengths 3 46 ⌀ | sequence stringlengths 16 2.75k | function stringlengths 6 5.51k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q6CP05 | FYV10_KLULA | Protein FYV10 | Kluyveromyces | MTSLNEPNVDFHLKLNQQQFNIPSELLKRNWDKFNNLYTSYSVELQGQFATLNTLLEDPNKDEQSIEKLNDIINTVNILQKRLSQLHDNELTILERIEKRVEYFKQFERFKYDSNTDKLLKWYRSYTDLLIADYLVRHGSNSIDHKNKIASNSGIEFIKTRGLEDLIDYEVLIEANQISMELIENKNLRPLLEWIENNSAHLTEKGSHLQFQALLQEYIELVRCSDYKAAIRCFQTHLAHFANIYPKELKLAAGILAFFKSCLNNGRDDEVTNEQKLFHAYFRKQMYRPHPLSSISSSNVVHNAELCRYGPLLDHERWES... | Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase. | Q6CP05 |
C4V7V1 | RSSA_NOSCE | 40S ribosomal protein S0 | Nosema | MAKVNIPIPNDFVKLILISQGHLGGIKTSKLMERYVFGTRKLENIKVIDIEKTWEKFILAARMFCSLKHPSDAVVVSTKTFGRKGVLKFCESTCATPVIGRFIPGTFCNNQVKRPLEPRVLIVSDPFADKQAVIEGSHVNLQTIAFCNTDNDVSFVDIVIPMNNRSPVSISAGLFILSRLIRFMKTGEPLDENMKEVELFIYRDPIELEKLVEEQKIIENANITIGEQELYEQEEFGNKAGWGIEPSLVSTEAVSEFSDNWKN | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. | C4V7V1 |
A8G0F9 | RSMC_SHESH | rRNA (guanine-N(2)-)-methyltransferase RsmC | Shewanella | MLTNPSQLILRNSDLFAGQNVLVLNYEGDLLPKQLLESAKKVTALSLDYHHHLIMSPYAEQNLALHFGHMLPDEEQFDTVIIYYPKAKALASYLLNLAGVHLKPNGQLLVVGENKGGIRSIVKQVPDYFDSPFKQDSARHCLLYVSQLVEKAPQINLSDWVRNYQLETPQGEITICNLVGVFSEKRLDEGTKLLLSHLPKMSGRVLDFGCGAGVITAALLKAQPELKVECVDINAMAIESCKLTLAANNFTADTYPSDGLTQTKGLFNGIISNPPFHDGLRSTTDIAKNFVKDSVQKLKKGGVWHIVANRHLPYSDSIST... | Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle. | A8G0F9 |
C5B7N9 | APAH_EDWI9 | Diadenosine tetraphosphatase | Edwardsiella | MSTLLIGDVHGCYHELRDLLSLADFDPARDTLWLTGDLVARGPDSLAVLRYVKSLGDSARLVLGNHDLHLLAIYAGISRNKPKDKLTPLLEAPDADSLINWLRRQPVLQVDNDLCLVMAHAGISPQWDLTTAQRCAREVEAMLASDSYPFFLNAMYGDMPNNWSESLSGLARLRFTTNALTRMRYCFPGGELDMICKDAPEDAPAPLRPWFDLDSPVREAGYSIAFGHWASLEGRSTPPQVYALDTGCCWGGTLTALRWEDRHSFSVPSRRASRHAKAE | Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP. | C5B7N9 |
Q39Z67 | DAPA_GEOMG | 4-hydroxy-tetrahydrodipicolinate synthase | Geobacter | MFKGSIVAIVTPFNNGQVDFEKLRELVEFQISNGTDAIVPCGTTGEASTLDYDEHMDVVKTVIEQVNKRVPVIAGTGSNSTAEAIELSQKAKEVGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIKEATGSLQQASEILALCGDKIDVLCGDDFITFPMMACGAKGVISVLANIMPKTVAELTDAFYAGDMEKARQLHLQTLKIGNAMFIESNPIPVKTALGLMGKCSDEVRLPLCPMGAANKEKLAAIMKEYELI | Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Q39Z67 |
Q1QEW1 | RLMF_PSYCK | rRNA adenine N-6-methyltransferase | Psychrobacter | MTSKPMNRRPTANNHRNRSPETAKKLGQLHPRNPHQGRYDFEVLTRALPELAKHTITNPKGESTINFSDSAAVRVLNQALLANYYGVKFWDIPEGYLCPPIPGRADYIHYIADLLAQTTHVNKDNTPPTGKEIHALDIGTGASAIYPIVGSQSYGWRFTASDIDPISVNTAALICETNPKLKSAVKVKLQTEPKFIFKNIIGRQDYFDVVVCNPPFHASLEEAMEANSRKQHNLQRHRGKNENEQISRSSTKPGNAAQNLNFGGQHKELWSEGGEIAFLTKMAKESQDFAEHVGWFTTLVSKSENVKPLQLLLKQLGVAQ... | Specifically methylates the adenine in position 1618 of 23S rRNA. | Q1QEW1 |
E3QFA7 | CLU5D_COLGM | Pathogenicity cluster 5 protein d | Colletotrichum graminicola species complex | MQIQNLIAALAGMAVVAEASVTFLDSPLSAALAKRQNKGGNNNNNNNNNNNNNNNNNKNNGGNNQLCLNPNNVQKGSQQAGTPKQGQANSAVDQANFINFCTGQQLTNGEQKTAGSCNGVVMGKIPSQNNMVSTIIKNPPPGGNLQANQQFNVQLKVNNLQAGSFTDAQSTYYSAPQDTNGAGNIIGHVHVTIQDMGNSLTPQNALDPKQFVFFKGIDDAGDGKGNLQATVTGGLPAGNYRVCTMSSASNHQPVLMPVAQRGAQDDCNKFTVGGNGGNGGNGGNGGNGGNGGNGGNGGNGGKNAAVNSGNADNGGNNDGG... | Secreted protein required for appressorial penetration of intact host epidermal cells and for pathogenicit, but not for subsequent biotrophic and necrotrophic colonization of leaves. | E3QFA7 |
B8CKC3 | LUXS_SHEPW | Autoinducer-2 production protein LuxS | Shewanella | MPLLDSFTVDHTRMNAPAVRVAKSMSTPKGDTITVFDLRFCVPNKQILSERGIHTLEHLFAGFMRDHLNGDNVEIIDISPMGCRTGFYMSLIGAPSESIVADAWLAAMQDVLAVVEQSEIPELNEYQCGTYEMHSLEQAKEIARSIISAGINVNRNDELTLSDEILNGL | Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhom... | B8CKC3 |
P53974 | ARK1_YEAST | Actin-regulating kinase 1 | Saccharomyces | MNQPQIGTYNVGTQLTVGSHQVEIIKYLTSGGFAQVYSALINPPDPHSNSSVACLKRVIVPDKPSLNTLRAEVDAMRLLKNNRYVVSYIDSHAAKAMLHNGSYEVFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVCGIIRPPRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGGDLAILSGKFEFPLYPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDIQVVQAPSSHLN... | Involved in regulation of actin cytoskeleton organization and endocytosis. | P53974 |
P45158 | RECD_HAEIN | Helicase/nuclease RecBCD subunit RecD | Haemophilus | MLSVLHKLKELRILSQGDYYFAKLIADKQCHTDYAEPVKNLAILLAALCSWRYTQGNTCSQLDRYLEHNLFGLAYRTTEEDYLAEIHEKIGYLPVEDWQNALCGHMAFTQDPVNQIAPMAFQFGALYFYRAWQDEYRIVQYIKNTLKKYRTLAFSYDEIHQKLEKYFPEKQEKTDWQKVAVATAIKSPFSIITGGPGTGKTTTVTRLLLVLQELFDCKLHIKLVAPTGKAASRLEESIKNALGFMQEKMNVSHSLFNAIPQKASTLHSLLGVNAFNDYTRYNSHNPLQLDVLVVDETSMIDLPMMAKLINALKPETRLIL... | A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucl... | P45158 |
Q8R806 | THIE_CALS4 | Thiamine-phosphate pyrophosphorylase | Caldanaerobacter | MKRIDFTLYAITDRSFIKGMDIAEAVEIAIKNGVTVVQLREKDISSREFYEIALKVKEVTRKYNVPLIINDRVDIALAVDAEGVHVGPDDLPVGVVRRILGPDKIVGGSAYSVEEALKAEKEGADYIGAGSVFAQPVKPEAEVIGIEGVRKIKEAVNIPVVAIGGVNKTNAYEVILHSGVDGISAIAGIFDGDIEANTKDMLREIRRAFKERGK | Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). | Q8R806 |
P74034 | TSAD_SYNY3 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaD | unclassified Synechocystis | MAIILAIETSCDETAVAIVNNRNVCSNVVSSQIQTHQIFGGVVPEVASRQHLLLINTCLDQALQASGLGWPEIEAIAVTVAPGLAGALMVGVTAAKTLAMVHQKPFLGVHHLEGHIYASYLSQPDLQPPFLCLLVSGGHTSLIHVKGCGDYRQLGTTRDDAAGEAFDKVARLLDLGYPGGPAIDRAAKQGDPGTFKLPEGKISLPQGGYHPYDSSFSGLKTAMLRLTQELKQSSAPLPVDDLAASFQDTVARSLTKKTIQCVLDHGLTTITVGGGVAANSRLRYHLQTAAQEHQLQVFFPPLKFCTDNAAMIACAAADHF... | Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct ca... | P74034 |
A9KIP3 | GREA_LACP7 | Transcript cleavage factor GreA | Lachnospiraceae | MAEKKNILTYEGLKQLEDELQDLKVNKRKEVSQKIKEAREQGDLSENAEYDAAKDEQRDIEARIEEIDKILKNAEVVVEDEVDVDTVNIGCLVRILDMEFNDELEYKIVGSTEANSLKGKISNESPVGKALIGARKDDVIEIEINGNSFKYKVLEIQKSN | Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factor... | A9KIP3 |
Q8THW2 | ACDA3_METAC | ACDS complex carbon monoxide dehydrogenase subunit alpha 3 | Methanosarcina | MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELGPMGPTAMAGLASYRSWNLLLLDRYEPVLTPMCDQCCYCTYGPCDLSGNKRGACGIDMAGQTGREFFLRVITGTACHAAHGRHLLDHVIEVFGEDLPLNLGESNVLTPNVTICTGLSPKTLGECRAPMEYVEEQLTQLLATIHAGQESAEIDYDSKALFSGSLDHVGMEVSDIAQVSAYDFPKADPEAPLIEIGMGSIDKSKPLIVAIGHNVAGVTYIMDYMEENNLTDKMEIAGLCCTAFDMTRYKEADRRAPYAKIVGSLAKELKVIRSGMPDVIVVDE... | Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. | Q8THW2 |
P00228 | FER_WHEAT | Ferredoxin, chloroplastic | Triticum | MAAALSLRAPFSLRAVAPPAPRVALAPAALSLAAAKQVRGARLRAQATYKVKLVTPEGEVELEVPDDVYILDQAEEEGIDLPYSCRAGSCSSCAGKLVSGEIDQSDQSFLDDDQMEAGWVLTCHAYPKSDIVIETHKEEELTA | Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | P00228 |
P58105 | RF2_CHLMU | Peptide chain release factor 2 | Chlamydia | MHENFDKRLELLLEGLSLTRRFLFDPEEKETELKNLEQLSIQDSFWDDVSRAGRISEKIARLKQQLLEYNELKNKINSIKFFLEDEESSKDLEIQKELEKEFIFCEKKIAEWETLRLLAGELDRNSCFLSINAGAGGTESCDWVEMLFRMYSRWANSHGWKVEVIDRLDGEVAGIKHITLKLIGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQSERSQIQNREACMNMLRARIYQKLLQERLEKQNTNRKEKKEISWGS... | Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. | P58105 |
Q58017 | T2M3_METJA | Type-2 restriction enzyme MjaIII | Methanocaldococcus | MNFEYIINSLLETIKTYNFFVDWEKIENNIKKIEKRLHILNYLIGKENFKEEFFELLKEYPEVITVFPILIAVRDNKITILNENMELETLEFKEKKYLTDEEIERYYKFFKETGLEDLLKNRKIKNLVDYVFGVEVGMDTNARKNRIGDLMENIVKKYIENLCKQNKNLDYIFQATKDKIKQKWGINLTLDKTNRKFDFAVFNKNTKKLYLIEVNFYSGGGSKLKATAGEYRSLNEFIKNNNNNVQFIWITDGKGWNTAKNPLKESFNSGVVILNLKMVKEGLLKEILTQ | A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GATC-3'; the cleavage site is unknown. | Q58017 |
A3Q5P5 | SUCC_MYCSJ | Succinyl-CoA synthetase subunit beta | unclassified Mycobacterium | MDLFEYQAKELFAKHNVPTTPGRVTDTAEDAKAIAEEIGKPVMVKAQVKVGGRGKAGGVKYAATADDAFTHAQNILGLDIKGHVVKKLLVAEASDIAEEYYISFLLDRANRTYLAMCSVEGGVEIEEVAATKPDRLARIPVDATKGVDEAFAREIAEKGHLPAEVLDAAAVTIAKLWEVFVGEDATLVEVNPLVRTPDDQILALDGKVTLDANADFRHPEHAEFEDRDATDPLELKAKENDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHNGVKPANFLDIGGGASAEVMANGLDVILNDSQVKSVFVNVFGGIT... | Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinat... | A3Q5P5 |
Q2N6Q7 | EX7L_ERYLH | Exodeoxyribonuclease VII large subunit | Erythrobacter | MSDLIAQSRAGDNAEPLSVSALSQMLKRTVEDRFGYVRLRGELSGVKRAASGHMYCSLKDEKAVIDGVMWKGTTARLAFQPEDGLEVIATGKLTTYPGRSKYQIVLESLEMAGEGALLALLEKTRQRLEAEGLFARDRKRPLPFLPRTIGVVTSPTGAVIRDILHRLADRFPSHVLVWPVLVQGQGAAEQVSAAIRGFGAIKAGGEVPRPDLLIVARGGGSIEDLWSFNEEMVVRAIADSPIPVISAVGHETDTTLADYAADRRAPTPTAAAEIAVPVKGELAATLNDYAARQQRGVLRPLSLGRERLEARVQRLPTIET... | Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. | Q2N6Q7 |
Q5E430 | METE_ALIF1 | Methionine synthase, vitamin-B12 independent isozyme | Aliivibrio | MTTESKTKTVTHILGYPRVGAQRELKFAQEKYWRGEIEQKELLAVGSELRQRHWKDQSASGLDFVTAGDFAWYDHVLTTSLLLGHVPARHNNGFPDLDTLFKVGRGQSQNSCGCGEAASDMTKWFNTNYHYIVPEFSKNDKFNVSWSQLFDEIAEAQKQGHNVKPVLLGPLSYLWLGKEVNDEEVEQGFDRLSLLPRLLTAYQAIFSKLSALGVEWVQIDEPILALELPKAWADSFKLAYQVIQSDVKLLLTTYFDGVEHHLDKITKLAVNGLHIDVSAAPDQLDAIVSALPKEWVLSVGAVNGRNVWRADLERLHERLQ... | Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. | Q5E430 |
Q96A44 | SPSB4_HUMAN | SPRY domain-containing SOCS box protein 4 | Homo | MGQKLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages... | Q96A44 |
Q2NUT9 | MIAB_SODGM | tRNA-i(6)A37 methylthiotransferase | Sodalis | MTKKLHIKTWGCQMNEYDSSKMADLLDSTHGYQLTDNPEEADVLLLNTCSIREKAQEKVFHQLGRWHMLKEARPELIIGVGGCVASQEGAHIRERANYVDIIFGPQTLHRLPEMINHVNGTRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCSFCVVPYTRGEEVSRPCDDILFEIAQLADQGVREVNLLGQNVNAYRGASYDGGICTFAELLRLVAAIDGIDRIRYITSHPIEFTDDIIDVYRDTPELVSFVHLPVQSGSDRILTMMKRAHTALEYKSIIRRLRKARPDIQISSDFIIGFPGETQQDFEQ... | Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | Q2NUT9 |
B5FA72 | RLME_ALIFM | rRNA (uridine-2'-O-)-methyltransferase | Aliivibrio | MSKNKVSASSGRWLKEHFDDKYVLEAQKRGYRSRAIFKIEEIQNKDKLLKSGMTVVDLGAAPGGWSQYAVEQVGDEGQVIACDILPMDSIAGVSFLQGDFREEAVLDALLERIQPDMVDVVMSDMAPNMSGNLAVDQPRAMYLVELALDMCRQVLAPNGSFTVKVFQGEGFDQYLQEVRNMFKVVKIRKPDSSRARSREVYIVATGYKG | Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | B5FA72 |
Q9X812 | COX4_STRCO | Cytochrome c oxidase polypeptide IV | Streptomyces albidoflavus group | MKIQGKMFIWLSVFILAVAVVYGYWSKEPAGTTALFLAFGLAIMIGFYLAFTARRVDAGAQDDMEADVADEAGEVGFFSPHSWQPLSLAVGGALAFLGIAVGWWVMYFSAPILMVGLFGWVFEYYRGENRTQ | Part of cytochrome c oxidase, its function is unknown. | Q9X812 |
O78426 | PSBC_GUITH | Protein CP-43 | Guillardia | MKTLYSLRRFYHVETPFNSNVGIAGRDIESTGFAWWSGNSRLINVSGKLLGAHVAHAGLMVFWCGAMTLFEVAHYIPEKPLYEQGLILLPHLATLGWGVGPGGEIIDVYPYFVVGVLHLISSAVLGFGGVYHSLIGPDTLEESFPAFGYDWRDKNKITTILGIHLVILGFGALLLVIKAIYVGGLYDTWAPGGGDVRIIDNPTLNPAVIFGYVLKSPWGGDGWIVSVNNMEDVVGGHIWIGFTCIAGGFWHILTKPFAWARRAYVWSGEAYLSYSLVAVSLMAFIASQYAWYNNTVYPSEFYGPTGPEASQSQAFTFLVR... | One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient sub... | O78426 |
C7Z3B7 | MEP_FUSV7 | Fungalysin MEP | Fusarium vanettenii | MRSVDSLLLLGLTGLASQANAHPAKRQPNDSPLSKRGVDLDAFRLPELAKYVPQDEVPDISNARIAPSSDYTKTAEEFVKSVVGKATFRLVSDHYVGTNGVAHVRFKQTVNDIDVDNADFNVNIGADGKVFSYGNSFYTGKIPGPLVKRDTSDPVTALKSTVEVLDLPVDASDAKAEPKGDEHYTFTDTSGTVKKPEAKLVYLIDGEQNLKLTWRVETDVLDNWLLTYVDADKTEKVVGVVDYVADLATYEVYPWGVNDPSKGSRSVVEDPWNIATSEFTWISDGSANYTTTRGNNAIAQVNPSGGTAYLNNYRPSSSSL... | Secreted metalloproteinase that allows assimilation of proteinaceous substrates. | C7Z3B7 |
Q82SY2 | LPXK_NITEU | Lipid A 4'-kinase | Nitrosomonas | MNWYELYWQRITPLHLFLWPVSQLLILFQSVRRFLYRRAILTSIHLPVPIIIIDSITTDSPVKTSLIIQIANILKAAGLRPGIISRGYPDNHRPPTRVTISSHPHLTGEKSLLLTYHLRETCPVWIGYDRIETAKALLNAHKECNVLICDDGLQDLRLQRDFEAVIVDTSVINSGNGLIMPAGPLRDSFARLKHTDAVILAGHQRRIPDITDEIRTIHTRPQKEHFFNLSWPELTADAAGLAGKRIHAIVCDPDTQNFLDNLEFLKLTVTPRVFPENHHFIATDFQSDEAEIILIPEEDAVKCLSLHDDRIWVLQQEYRV... | Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | Q82SY2 |
P53465 | ACT1_LYTPI | LPC1 | Lytechinus | MCDDDIAALVIDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGGQAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVFDSGDGVSYTVPIYEGYALPHAILRLDLAGRDITDYLMKILTERGYTFTTTAEREIVRDIKEKLCYVALDFEQEMQTAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETCYNSIMKCDVDIRKDLYANTVLSGGSTMFPGIADRMQKEITA... | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | P53465 |
P38984 | RSSA_HYDVD | p40 | Hydra | MSEGIDALSLKEEDVVKFLAAGVHLGSTNVGSSCQGYVFKRKSDGIHIINLRKTWEKLILAARIIASIENPADVCVISSRPYGTRAVLKFAQSTGAIPIAGRFTPGTFTNQIQKRFREPRLLISTDPQHDNQALTEASYVNIPVIALCNTDSPLRFVDCAIPCNNRGIQSIGTMWWILAREVLHLRGIISRKTPWNVMPDLFFYRDPEDIEKEEQAAAIASAKPDEPYQPDFSGNVDQSAAGADWGDQPVVTGADWTAEPSVSKDWAAEPAGWEADTTAVSGDWATPKTEDWA | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. | P38984 |
P0DMF6 | NDB4W_CHATC | Peptide Ctri9293 | Chaerilus | MKTQTVLFSFFLVLLLVATQTEGGILDALTGILGKRALRNQNFVDYAYDPSLSAADWRALETLLEDY | Antimicrobial peptide. | P0DMF6 |
Q72AX2 | DAPA_DESVH | 4-hydroxy-tetrahydrodipicolinate synthase | Desulfovibrio | MQFTGAFTAIVTPFRNGRVDEERFRELIEWQIEQGINGLVPCGTTGESATLSHDEHRDVIRICVEQVKGRIPVLAGAGSNNTREAIDLTRFAKEAGADGALLITPYYNKPTQEGLYLHFKAIASEVSMPFIVYNVPSRTGTNICPETLARLNRDIPEVVGVKEATGNLIQVSEILEYCGTDFQVLSGDDFTVLPLLSVGGCGVISVTSNVVPAKMSDMCRAFKAGDLATARRLHFELSPINRAMFLETNPIPVKTALALMGRIDLEMRLPLCPLQQVNQSRLRDILAAAGIL | Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Q72AX2 |
A8F7Q8 | GCH4_PSELT | GTP cyclohydrolase FolE2 | Pseudothermotoga | MKDVQNQPDNRNIYLQRVGIRNLQYPVTVMDRNNGYQDTVATINMYVDLPVNFRGTHMSRFVEVLNRYRLGIDPKIIKNMLEELRNNLNASVARVEIEFPYFILKKAPVSSIESFLKYTCRIEGQKTEKLYEFTMSVGVPIMTLCPCSKEISERGAHNQRAMAWIHIKSKKMIWFEELIDAAEQAASSPVFTILKRVDEKFVTEHAYDNPRFVEDVAREIAVRLNRDERISWYRVEVESFESIHDHSAYACVMKDKED | Converts GTP to 7,8-dihydroneopterin triphosphate. | A8F7Q8 |
Q5Z8T8 | XYXT1_ORYSJ | Xylan xylosyltransferase 1 | Oryza sativa | MKAAVRSKKSKGSFCHPPLLLLIVAIQFLVIYSPTLDQYMVMLTTGKPGFPSMLIDGRRSFKQVDEFIPEPHLRCDFRDNRSDVCEMEGAIRILGRTSEVFLVAPSLASISGGGGGVNATGVDANATRWKIQPYTRKGESRVMPGITEVTVRLVTADEAPPCDEWHDVPAIVYSNGGYCGNYYHDFNDNIIPLFITSRHLAGEVQLLVTQKQRWWFGKYREIVEGLTKYEPVDLDAEQRVRCYRRATVGLHSHKDLSIDPRRAPNNYSMVDFKRFLMWRYALPREHAIRMEEEDKSKKPRLLVINRRSRRRFVNLDEIVA... | Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms . Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone . Catalyzes the addition of 2-O-xylosyl side chains to t... | Q5Z8T8 |
O44185 | FLP13_CAEEL | ASSAPLIRF-amide | Caenorhabditis | MMTSLLTISMFVVAIQAFDSSEIRMLDEQYDTKNPFFQFLENSKRSDRPTRAMDSPLIRFGKRAADGAPLIRFGRAPEASPFIRFGKRAADGAPLIRFGRAPEASPFIRFGKRASPSAPLIRFGRSPSAVPLIRFGRSAAAPLIRFGRASSAPLIRFGRK | Acts as a ligand for isoform a of the dmsr-1 G-protein coupled receptor in vitro. | O44185 |
P42934 | PMT6_YEAST | Dolichyl-phosphate-mannose--protein mannosyltransferase 6 | Saccharomyces | MSKAKGTGFSSIDTEDENLRERYVNQPKANASDIQDEQLDCFEQLEEKHRTKKNEEYTALKILRDVIGPLLLTITSFYLRFQHIDQNNYVVWDEAHFGKFGSYYIKHEYYHDVHPPLGKMLIALSEWMAGFDGQFDFSSNNAYPENVNFKLMRQFNATFGALCTPVAFFTAKWMGFNYFTVYLIATMVTLEHSYIVLSKFILLDSMLLFFSMTTFACMIKLYTLRKQQMTKKWSLWMLLTGLSIGCVCSVKWVGLFITVVVGLYTCIELFLLYCDKELPRIKYYKHWLIRIINLIVIPFLIYLYCFKIHFVLLYKSGTGD... | Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. | P42934 |
Q1G7Z5 | MNMG_LACDA | Glucose-inhibited division protein A | Lactobacillus | MKTYVSNEYDVIVVGAGHAGCEAALASARMGEKTLLLTISLDMVAFMPCNPSVGGPAKGTVVREIDALGGEMGKNIDKTYIQMRMLNTGKGPAVRALRAQADKWDYHEEMKRTIENTPNLTLRQAVVDDLIVEDGECRGVVTNTGARYRAKSVVLTTGTAARGRIFIGELNYSSGPNNTIPAIKLSESLERLGFKLRRFKTGTPPRVNRHTIDYSKTEEEPGDKEPRHFSFTSRDEDYLTDQTSCWMTYTNPKTHEIINENLDRSPMFSGDIVGVGPRYCPSIETKVVRFADKDRHQIFLEPEGRKTEEIYVGDFSTSMP... | NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. | Q1G7Z5 |
A5IL80 | RIMO_THEP1 | Ribosome maturation factor RimO | Thermotoga | MRVGIKVLGCPKNEADCEVLAGVLREGGHEIVFDVKDADVVVLDTCAFIEDAKRESIDEIFSFVDAKDQYGYKLVVKGCLVQRYYEELKKEVPEVDQWIGVADPEEIANAIENGTDLVPDQPETVYRYRKRIDLEERPYAYVKISDGCDRGCTFCSIPSFKGSLRSRSIEDITREVEDLLKEGKKEIILVAQDTTSYGIDLYRKQALPDLLRRLNSLNGEFWIRVMYLHPDHLTEEIISAMLELDKVVKYFDVPVQHGSDKILKLMGRTKSSEELKKMLSSIRERFPDAVLRTSIIVGFPGETEEDFEELKQFVEEIQFD... | Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12. | A5IL80 |
Q7N8L2 | CYSG_PHOLL | Sirohydrochlorin ferrochelatase | Photorhabdus | MDYLPIFVELKGRLVLLVGGGEVAARKATLLLRAGALLQVVAPELCSELQQRYQAGELEWYQGEFQPEYLDGIFLVIAATDDRILNHQVFSEADKRSILVNVVDDQVHCSFIFPSIIDRSPVLVAISSAGKAPVLARLIREKLEALLPSSLGTMAKIAGKWRERVKQRLTSMRQRRSFWEQAFNGRFAMLVANGQIQQAEKQLEQQLEQSDLQGELALVGAGPGDPGLLTLKGLQVIQQADVVLYDHLVSSDVLDLIRRDADKICVGKRAGNHSVSQEETNRLIVKFARQGKKVVRLKGGDPFIFGRGGEELQVAASAGI... | Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yie... | Q7N8L2 |
Q21TG3 | LOLD_ALBFT | Lipoprotein-releasing system ATP-binding protein LolD | Rhodoferax | MGDIVLSARAITKRFTEGRLDVTVLQGVDLDVRAGETLAIVGASGSGKSTLLHLMGGLDAPTSGSVFLHGQDLAHQSAAAQGRLRNQYLGFVYQFHHLLPEFSALDNVAMPLWIRRLAPAESTHTATEMLAKVGLQERLAHRPSELSGGERQRVAIARALVTRPACVLADEPTGNLDRSTANGVFELMLELARVQGTAFVMVTHDESLAERCSRRIRLVQGRLLEAF | Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. | Q21TG3 |
Q8FJL0 | GSIA_ECOL6 | Glutathione import ATP-binding protein GsiA | Escherichia | MPHSDELDAGDVLAVENLNIAFMQEQQKIAAVRNLSFSLQRGETLAIVGESGSGKSVTALALMRLLEQAGGLVQCDKMLLQRRSREVIELSEQSAAQMRHVRGADMAMIFQEPMTSLNPVFAVGEQIAESIRLHQNASREEAMVEAKRMLDQVRIPEAQTILSRYPHQLSGGMRQRVMIAMALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQKEMSMGVIFITHDMGVVAEIADRVLVMYQGEAVETGSVEQIFHAPQHPYTRALLAAVPQLGAMKGLDYPRRFPLISLEHPAKQEPPIEQKTVVDGEPVLRVRNLV... | Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system. | Q8FJL0 |
Q7M456 | RNOY_CRAGI | Ribonuclease Oy | Crassostrea | KDWNYFTFAQQWPIAVCAEHKSCFIPDSVVGWGIHGLWPSSDTESKGPENCNGSWPFDINNVMPLVPELKKYWPNLYPDTKANSFWEHEWSKHGTCATSLPATSNELKYFGMGLKLHAKYNISRILVNQGILPSKTAGYMINETEAAVKRELGVDAVIECVYDKEKTKKQLLYEISICLTKEFELISCNKKEVSETTCPRKEPFFYPPVHDNN | Releases mononucleotides from RNA in the order of 3'-GMP, 3'-AMP and 3'-UMP. | Q7M456 |
Q9DCT2 | NDUS3_MOUSE | NADH-ubiquinone oxidoreductase 30 kDa subunit | Mus | MAAAAARVWCRGLLGAASVGRGAGRPSVLWQHVRRESAAADKRPTVRPRSDVTHKQLSAFGEYVAEILPKYVQQVQVSCLDELEICIHPDGVIPTLTFLRDHTNAQFKSLADLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYADELTPIDSIVSVHIAANWYEREVWDMFGVFFFNHPDLRRILTDYGFEGHPFRKDFPLTGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPESLKLEAGDKKPETK | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I . | Q9DCT2 |
P23944 | ADA1D_RAT | RA42 | Rattus | MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKG... | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. | P23944 |
B2JDN3 | RS15_PARP8 | 30S ribosomal protein S15 | Paraburkholderia | MSVAEIKKSDVVAQFARGANDTGSPEVQVALLTTRINELTVHFKAHTKDHHSRRGLLRMVSRRRKLLDYLKGKDADRYRALIEKLGLRK | Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | B2JDN3 |
Q823T8 | RNZ_CHLCV | tRNase Z | Chlamydia | MSCRELIILGCSSQQPTRMRNQGAYLFRWNNEGLLFDPGEGTQRQFIFANIAPTVVSRIFISHFHGDHCLGLGSMLMRLNLDKVTHPIHCYYPASGKKYFDRLRYGTIYHETIHVVEHPVDKEGIVEDFGNFRIEARKLDHLVDTLGWRITEPDTIKFIPEKIKAAGLRGPIMQDLLRDDHVTVNGNTIYLKDVSYVRKGDSIAVIADTLPCQSVVDLAKDARIMLCESTYLEEHLHLAKSHYHMTAKQAATQALAAGAQQLVLTHFSARYLNSKEFELEAGKIFPNVAAAEEFRSYPFPKNPSSK | Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. | Q823T8 |
A6MMF0 | PSBN_CHLSC | Protein PsbN | Chloranthus | METATLVAISISGSLVSFTGYALYTAFGQPSQQLRDPFEEHGD | May play a role in photosystem I and II biogenesis. | A6MMF0 |
Q3U6Q4 | PI3R6_MOUSE | p87 PI3K adapter protein | Mus | MESSDVELDFQRSVQAVLRELNTPNPALQSNQGMWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPEDLYHRAYTFCTRLLTLPAPYSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSASVCSALLLEIQAAQEQQTPEACMRHVVSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPSRLGHLEKMEEIYCSLLGPATTRRHCVGDLLQDRLPSIPLPSPYITFHLWTDQEQLWKELVLFLRPRSQLRLSADLDA... | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS b... | Q3U6Q4 |
Q00583 | HMDH3_HEVBR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3 | Hevea | MDEVRRRPPKHIVRKDHDGEVLNSFSHGHHLPPLKPSDYSLPLSLYLANALVFSLFFSVAYFLLHRWREKIRKSTPLHIVTFPEIAALICLVASVIYLLGFFGIGFVHSFSRASTDSWDVEEYDDDNIIIKEDTRPTGACAAPSLDCSLSLPTKIHAPIVSTTTTSTLSDDDEQIIKSVVSGSIPSYSLESKLGNCKRAALIRRETLQRMSGRSLEGLPLDGFDYESILGQCCEMAIGYVQIPVGIAGPLLLDGKEYTVPMATTEGCLVASANRGCKAIYASGGATSVLLRDGMTRAPVVRFPTAKRAADLKFFMEDPDN... | Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants. | Q00583 |
Q9KUX9 | DUSA_VIBCH | tRNA-dihydrouridine synthase A | Vibrio | MTHSCRLSVAPMLDWTDRHCRYFHRLLSAQTLLYTEMVTTGAIIHGRGDFLAYNQEEHPVALQFGGSNPKDLAHCAKLAQERGYDEINLNVGCPSDRVQNGRFGACLMGEPDLVAECVAAMRAVVDIPVTVKTRIGIDDQDSYEFLTQFIATVAEKGGCEQFTIHARKAWLSGLSPKENREIPPLDYPRAYQIKRDFPHLTIAVNGGVKSLEEAKLHLQHLDGVMIGREAYQNPYLLAEVDQQIFGLETPVKKRSQVIHEMMPYIERELSQGTHLGHMTRHMLGLFQNMPGARQWRRHISENAHKPGAGLEVVEQALAKI... | Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs. | Q9KUX9 |
Q5PL86 | GATY_SALPA | Tagatose-bisphosphate aldolase | Salmonella | MFIISSKNMLQKAQHAGYAVPAFNIHNLETLQVVVETAAEMRSPLIVAGTPGTFSYAGMGNIVAIAGDLAREYNLPLAIHLDHHESLADIESKVMAGIRSVMIDGSHFPFEENVALVKSVVDFCHRYDTSVEAELGRLGGIEDDLVVDSKDALYTNPQQAREFVARTGIDSLAVAIGTAHCMYAAEPKLDFERLAEIRALVDIPLVLHGASGLPESDIRQAISLGVCKVNVATELKIAFSDALKEYFLQNPKANDPRHYMQPAKQAMKEVVRKVIHVCGCEGQL | Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is inv... | Q5PL86 |
Q0I0B1 | RPOC_SHESR | Transcriptase subunit beta' | Shewanella | MKDLLKFLKQQSKTEEFNGIKIGLASPDLIRSWSFGEVKKPETINYRTFKPEREGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPVAHIWFLKSLPSRIGLMLDMTLRDIERVLYFESFVVIEPGMTSLERGQMLTEENYLDALEEYGDEFEAKMGAEAVLELLRAIDLEKEIEQMREELPSINSETRRKKVTKRLKLMEAFHTSGNKPEWMILKVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSN... | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Q0I0B1 |
Q5CZK6 | INSL4_PANTR | Early placenta insulin-like peptide A chain | Pan | MASLFWSYLPAIWLLLSQLLRESLAAELRGCGPRFGKHLLSYCPMPEKTFTTTPGGWLLESGRPTEMVSTSNNKDGQTLGTTSEFIPNLSPELKKPLSEGQPSLKKIILSRKKRSGRHRFDPFCCEVICDDGTSVKLCT | May play an important role in trophoblast development and in the regulation of bone formation. | Q5CZK6 |
Q0MQ87 | NDUAC_PANTR | NADH-ubiquinone oxidoreductase subunit B17.2 | Pan | MELVQVLKRGLQQITGHGGLRGYLRVFFRTNDAKVGTLVGEDKYGNKYYEDNKQFFGRHRWVVYTTEMNGKNTFWDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKFNVTGTPEQYVPYSTTRKKIQEWIPPSTPYK | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | Q0MQ87 |
P37472 | HGPRT_BACSU | Hypoxanthine-guanine phosphoribosyltransferase | Bacillus | MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKGALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDIIDSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDYAERYRNLPYIGVLKPAVYES | Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), wit... | P37472 |
P0C1H4 | H2B5_CHICK | H2B V | Gallus | MPEPAKSAPAPKKGSKKAVTKTQKKGDKKRRKSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated v... | P0C1H4 |
B7KU77 | RSMH_METC4 | rRNA (cytosine-N(4)-)-methyltransferase RsmH | Methylorubrum | MPMSRAPRTARAELPKGAQARHVPVLLAEVLAALSLDRPGLAVDGTFGAGGYTRALLEAGPEVRVIAIDRDPTAIRGGADLVNAFGGRLRLVQGRFGELDTLIADQNEAQADWVVLDIGVSSMQIDEAQRGFSFRQDGPLDMRMGGEGPSAADLVNGEEETTLADILYHFGEERRSRAVARAIVEARRRAPIVTTAQLADLVAGVVRPEPGSPIHPATRSFQGLRIAVNDELGELVRGLHAAERVLKPGGRLAVVTFHSLEDRIVKQFFSARSGRAAQASRHVPGVERPAPKSFKLVTKGPVLPSEAETDVNPRSRSAKL... | Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | B7KU77 |
A8YXI2 | ACPS_LACH4 | 4'-phosphopantetheinyl transferase AcpS | Lactobacillus | MIKGVGIDSIEVERVKKIVAKGDSFAEKVLTPKEFAQYQKMKGKRKVEYLGGRFSLKESFSKAMGTGLGKYVGFQDVETLWDDLGHPVMTSTKFDGNIFPSITHDNHEIITFVVLEEK | Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. | A8YXI2 |
A0RUE9 | OTC_CENSY | Ornithine carbamoyltransferase | Cenarchaeum | MKIRSKDLLTGAELDRKEILGIIESAIRLKKGGRSKAHPLDGRTLAMVFQKPSTRTRVSFAAGMFQLGGEAIYLPPGDMQLSRGETIPDTARALSGYVDVIVARVFGHETIEEIAASASVPVINGLSDTFHPCQILADLMTIKERKGRLKGLRAAWIGDGNNVCNSLLYGCAAVGIDISVATPAVFRPIPGVVDKCRESIDVKLTTDPAEAAAGADIVFTDTFASIHNMDKERERKFLPKYRVNAPLMKKAADDAIFMHCLPAKRGQEVDGEVIDGPQSAVWDEAENRLHSQKALLLALGI | Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. | A0RUE9 |
Q10YT3 | NU3C_TRIEI | NDH-1 subunit 3 | Trichodesmium | MFNRESYLLRKYRLIVFFLSGYEYFLGFLMISSLVPIIALTASKLLRPKTRGPERRTTYESGVEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFHQLGLLAFIEALIFIAILVVALVYAWRKGALEWS | NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus co... | Q10YT3 |
P53135 | SLD3_YEAST | DNA replication regulator SLD3 | Saccharomyces | METWEVIASVKEATKGLDLSLDHPLIIKSEDVPSNILQLLQQKNRRQLKHICMKSRKEYFLLEEYGPGFWVKWPYNYFNGYSLPERRTEVVTTVERERAKRETLKTWDELKFKELLHLWSEEPKGSCKLEKDKDLKLDMNPPDMKGESKINDYYSDPKEYIESKYYDALFSIHTPLAYFVKSNLVRLKNTCRTKYGSDSYKIAYQAMLQKFLLSIVQFKDRHDNRLLLEPFSSPIADEKRKNCLTKFVIQDENKNSSTIADLCVVLKSREIKLQILLLLEIIGLNDLDWNFRDFEKKYKLKLKKRSLNLTKKGLVRRRSK... | Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins. | P53135 |
Q3SSX9 | RPOC_NITWN | Transcriptase subunit beta' | Nitrobacter | MNQEVMNLFNPTTPAQVFDQIRISIASPEKILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYKGIICEKCSVEVTLSRVRRERMGHIELAAPVAHIWFLKSLPSRIGLLLDMTLKDLERILYFEYYVVLEPGLTALKDRQLLSEEEYLRAQDEYGQDSFTAMIGAEAIRELLKGLELERLEAELRAEMQATESDIKHKKLAKRLKIVEAFRFSGNKPEWMILTVVPVIPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLMELRAPDIIIRNEKRMLQEAVDALFDNGRRGRVITG... | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Q3SSX9 |
Q8ZVW1 | RS14Z_PYRAE | 30S ribosomal protein S14 type Z | Pyrobaculum | MPSTKPPKERPYGKSKIRCLRCGTREAVIRKYGLYLCRRCFREVAPQLGFKKYY | Binds 16S rRNA, required for the assembly of 30S particles. | Q8ZVW1 |
Q08826 | SNX3_YEAST | Golgi retention deficient protein 19 | Saccharomyces | MPREFKSFGSTEKSLLSKGHGEPSYSEIYAEPENFLEIEVHNPKTHIPNGMDSKGMFTDYEIICRTNLPSFHKRVSKVRRRYSDFEFFRKCLIKEISMLNHPKVMVPHLPGKILLSNRFSNEVIEERRQGLNTWMQSVAGHPLLQSGSKVLVRFIEAEKFVG | Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)). | Q08826 |
Q4ZSC0 | LCDH_PSEU2 | L-carnitine dehydrogenase | Pseudomonas syringae | MSFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRNRVAKCWGALEQQGLVPGASQNRLRFVATVEECVRDADFIQESAPERLELKLDLHSRISAAARSNVLIGSSTSGLLPSDVYESSAHPERCVVGHPFNPVYLLPLVEVVGGKNTAPAAIQAAIKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAGGEAGMRHFMTQFGPALQLPWTYLPAPELTDKLIDDVVDGTTDQLGKHSISGLERYRDDCLLAVLEAVKTTKARHGMA | Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine. | Q4ZSC0 |
Q0S319 | NTPP_RHOJR | Nucleotide pyrophosphatase | Rhodococcus | MTSFVLASASPARLAVLRSAGVEPIVRVSGVDEDAVIAALGADAAPEHVVTELARAKASDVLPVLARDGISDAVVVGCDSMLLIDGSLQGKPGTVDVARARWSAMAGRSATLLTGHSVLRIAEGAVVGDAHDHSATVVHFASPPDADLEAYLATGEPLQVAGAFTLDSLGGWFVDRIEGDPSSVIGIGLPLVRRLLAEVGVGVAELWASSGRVD | Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Q0S319 |
Q9TDM6 | CYB_PSECS | Ubiquinol-cytochrome-c reductase complex cytochrome b subunit | Pseudorca | MTNIRKTHPLMKIINNAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTSTAFSSVAHICRDVNYGWFIRYLHANGASMFFICLYAHIGRGLYYGSYMFQETWNIGVLLLLAVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFTLHFILPFIITALTATHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGALLLILTLLTLTLFTPDLLGDPDNYIPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILILIFIPMLQTSKQRSMMFRPF... | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is... | Q9TDM6 |
Q3SRS9 | AROQ_NITWN | Type II DHQase | Nitrobacter | MAKTIYVLNGPNLNMLGTREPDTYGHANLADVEQLCAETAKNFGLAADCRQSNREGELIDFIHEAHAKNAAGIVINAGGYSHTSIALHDALVAVKIPTVEVHISNIHAREDFRHHSFTAKAAFASLSGFGIDGYRLAINGLAAKIGAVDPSNKVKS | Catalyzes a trans-dehydration via an enolate intermediate. | Q3SRS9 |
B7ID85 | NRDR_THEAB | Transcriptional repressor NrdR | Thermosipho | MKCPYCGNDETRVLDSRVDSSGMTIRRRRECLKCKGRFTTYERYEFGPVFVIKKDGRREKFDRSKILSGIMKACEKTNVTLEEMEKLVDDVVNQIQKTGNLEISSLEIGKLVMEGLKKINEVAYVRFASVYKDFREIDQFLEVVKELKNEK | Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. | B7ID85 |
Q591Y8 | NU4LM_MICSM | NADH dehydrogenase subunit 4L | Microcebus | MPSISININLAFAVALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNLQFTMSFIMPILLLVFAACEAAIGLALLVMVSNNYGLDYIQNLNLLQC | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. | Q591Y8 |
A1SU19 | MURG_PSYIN | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase | Psychromonas | MRNKKTLVVMAGGTGGHVFPGLAVADALKEQGWAVSWLGTADRMEAQLVPKHGYEIDFIDIAGIRGNGLKRLLMAPIRIIKSIWQARSVLKKRRVDLVLGMGGFASGPGGIAAWSMGIPVILHEQNAVAGLTNRILSLFSKRVLMGFSGAFKSGKAILVGNPVRKQLVDLPVKKISSEDVALKVLVVGGSLGAKVLNDLLPAVFSSFDNENFNIMHQSGEGHYQAVQKGYEQRLVKANVQEFITDMASAYDWADLVICRAGALTVAELAVVGLPAIFVPLPHAVDDHQTKNAQYLVSQEAAVLIAQKELTAKKISDYLRL... | Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). | A1SU19 |
B8D8P7 | DAPE_BUCA5 | N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase | Buchnera | MTCSITELAKKLISIPSVSPKDLGCQDIIIKRLCAIGFDIKRVNVNDTKNFWAFRGTGKTLTFAGHTDVVPIGQDKDWQTDPFQPVIRSGYLFGRGSADMKGALAAMITAAERFVNKFPNHKGRLSFLITSDEESSAVDGTIKVVEYLMSKRDMIDYCIVGEPSSTNIVGDVIKNGRRGSITANITIHGIQGHIAYPDLADNPIHKGLPVILKILSIKLDSGNDFFLPSSINIANIHAGNGFNNVIPGSLFVQFNIRFSSEVSEKHIQSQIVNILNSNDINYSIEWLFSGKPFITKKGLLIDTVIQSIFYFNKKKPILST... | Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. | B8D8P7 |
P14770 | GPIX_HUMAN | Glycoprotein 9 | Homo | MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD | The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. | P14770 |
C0RH45 | PANC_BRUMB | Pantoate-activating enzyme | Brucella | MQIIHTIEELRQALAPARQQGKKIGFVPTMGYLHKGHLELVRRARVENDVTLVSIFVNPLQFGANEDLGRYPRDLERDAGLLHDAQVDYLFAPTVSDMYPRPMQTVVDVPPLGNQMEGEARPGHFAGVATVVSKLFNIVGPDAAYFGEKDFQQLVIIRRMVDDMAIPVRIVGVETVREDDGLACSSRNVYLTPEQRRAAIIVPQALDEADRLYRSGMDDPDALEAAIRTFIGRQPLAVPEVIAIRDPETLERLPALQGRPILVALFVRVGATRLLDNRVIGHAAPQITQERAA | Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. | C0RH45 |
Q9CA23 | UFM1_ARATH | Ubiquitin-fold modifier 1 | Arabidopsis | MATGGKVSFKVTLTSDPKLPFKVFSVPEGAPFTAVLKFAAEEFKVPPQTSAIITNDGIGINPQQSAGNVFLKHGSELRLIPRDRVGAVFVMDP | Ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins. | Q9CA23 |
Q503D6 | CCNQ_DANRE | Cyclin-related protein FAM58A | Danio | MSAHASTSAAANEARGRRSAEDVEYSKTHFRVCRFITETGVKLGMRSVPMATACVLYHRFFQSASLQIYEPYLVAMSAIHLAGKVEEQHLRTRDIINVCHRYFHPDSEPLELNGKFWELRDSIVQCELLILRQLNFQVTFEHPHKYLLHYLLSVRSLLNRHAWSRTPIAETALAVLKDSYHGSVCVRHRPQHLALTALYLALQTYGVQLPRGELEWWQVVCADITKAQIETIMSELLQLYDMEAKCT | May be an activating cyclin for the cyclin-associated kinase CDK10. | Q503D6 |
B1ICL9 | NADE_STRPI | NH(3)-dependent NAD(+) synthetase | Streptococcus | MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFVLGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQPDVSLVVNIKESVDAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQKLGAEPALYEKIPTADLEEDKPGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRRLPITVFDDFWE | Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | B1ICL9 |
Q3AVB7 | PANB_SYNS9 | Ketopantoate hydroxymethyltransferase | unclassified Synechococcus | MRPFDLIRFKQSGRPITMLTAWDCLSAALVEAAGADVVLVGDSLGMVALGHATTLPVTLDQMLHHTLAVARGFTASHDQQPLLVCDLPFLSYQCGPDLAVAAAGKLLKESSAAAVKLEGADPEIVAVVDRLVRMGIPVMGHLGLTPQAVHRLGYRRQALDPVSQDRLIEQALTLEKTGCFALVLEHVPSELAARARHELGIPVIGIGAGDDCDGQVRVTADLLGLTPHQPPFSPPQLNGRQLCIEALRGWIQEHQSSSPTTAPPQAEPDC | Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. | Q3AVB7 |
Q5P9I2 | RS20_ANAMM | 30S ribosomal protein S20 | Anaplasma | MPNHSSAKKMVRVIKERTFSNRVRKSRVRNSVKKFLAVLESKGHLEDAVTAFRAAESNIHKCVNKGVMHRNTAARKVKSLAAKLKAFDLSLQGTST | Binds directly to 16S ribosomal RNA. | Q5P9I2 |
B5QXI2 | GCST_SALEP | Glycine cleavage system T protein | Salmonella | MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGSRTREFLRYLLANDVAKLTKTGKALYSGMLNASGGVIDDLIIYYFTEDFFRLVVNSATREKDLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLFTDEQRHAVEGMKPFFGVQVGDLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEMDEGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRFTDAQGNQQEGIITSGTFSPT... | The glycine cleavage system catalyzes the degradation of glycine. | B5QXI2 |
Q3AW78 | RL18_SYNS9 | 50S ribosomal protein L18 | unclassified Synechococcus | MSKLSRKQQTQKRHRRLRRHITGTSNRPRLAVFRSNNHIYAQLIDDAAQSTLCSASTVDKELRSGLKNNAGSCDASVAVGALVAKRAIAKGIEQVVFDRGGNLYHGRIKALADAAREAGLQF | This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. | Q3AW78 |
Q87MB4 | DPO4_VIBPA | DNA polymerase IV | Vibrio | MSERIRKIIHVDMDCFYAAVEMRDNPNYRDIALAVGGHEKQRGVISTCNYEARKFGVRSAMPTARALQLCPHLLVVPGRMHIYKQVSLQIRAIFERYTSLIEPLSLDEAYLDVTDATACRGSATLIAESIRNDIRNELGLTASAGIAPIKFLAKVASDMNKPNGQFVIPPEKVQEVVDKLPLEKIPGVGKVSLEKLHQAGFYLCEDIKNSDYRELLRQFGRQGASLWKRSHGIDDREVVVERERKSVGVERTFSQNISTYDECWQVIEEKLYPELEKRLERASPDKSIIKQGIKVKFADFQLTTIEHIHPQLELEDFKLL... | Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in... | Q87MB4 |
B2HJN3 | EFTS_MYCMM | Elongation factor Ts | Mycobacterium | MANFTAADVKRLRELTGAGMLACKNALAESDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAKDGALIELNCETDFVAKNAEFQKLADDIVAAAVASKAADVDALKAASIGGQTVEEAIGALSAKIGEKLELRRVAIFGGTVETYLHRRAADLPPAVGVLVEYTGAGAEAAHAVALQIAALKARYLSREDVPEDLVASERRIAEETAKEEGKPEQALPKIVEGRLNGFFKDAVLLEQPSVSDSKKSVKALLDDAGVTVTQFVRFEVGQA | Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. | B2HJN3 |
O00321 | ETV2_HUMAN | Ets-related protein 71 | Homo | MDLWNWDEASPQEVPPGNKLAGLEGAKLGFCFPDLALQGDTPTATAETCWKGTSSSLASFPQLDWGSALLHPEVPWGAEPDSQALPWSGDWTDMACTAWDSWSGASQTLGPAPLGPGPIPAAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGPDGDTYWGSGLGGEPRTDCTISWGGPAGPDCTTSWNPGLHAGGTTSLKRYQSSALTVCSEPSPQSDRASLARCPKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRF... | Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. | O00321 |
Q4FM83 | NUOI_PELUB | NDH-1 subunit I | Candidatus Pelagibacter | MKISRIFKTIFLLDFLGGLNIAIKEIFKSKKTINYPFEKGKISPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIESSERADGSRKTTRYDIDMMKCIYCGLCEESCPVDAIVQGPNFEFSTETREELYYNKEKLLDNGDRWENVLAANIKADNSHR | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t... | Q4FM83 |
P20258 | PA2BA_PSEPO | Phosphatidylcholine 2-acylhydrolase | Pseudechis | NLYQFKNMIQCANKGSRSWLDYVNYGCYCGWGGSGTPVDELDRCCQTHDNCYDQAGKKGCFPKLTLYSWKCTGNVPTCNSKSGCKDFVCACDAEAAKCFAKAPYKKENFKIDTKTRC | PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. | P20258 |
Q1R1J7 | GPMI_CHRSD | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Chromohalobacter | MADTHTQRPRPVALLILDGYGQNDDTEYNAVYSARTPVMDALKQRYPSTLLHTDGKYVGLPDGQMGNSEVGHMNLGAGRIVYQDFTRITKAIEDNELASNPVLTAPIDAAVAAGRAVHLLGLLSPGGVHSHEDHILAVAALAAERGAKHVYLHAFLDGRDTAPKSARASLERANARLAELFGADNAYVASIVGRYYAMDRDNRWDRVEQAYRVIVEGEGSQVATSAEAGLDAAYERGETDEFVAATSIRPHGEPVRMADGDAALFLNFRADRARELTRAFVEDDFSGFTRQARPKLAHEGLVMLTEYAADIPAPVAFPPT... | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. | Q1R1J7 |
Q9ZUY3 | AROD3_ARATH | Prephenate dehydratase 1 | Arabidopsis | MRTLLPSHTPATVTTAARRRHVIHCAGKRSDSFSINSSSSDWQSSCAILSSKVNSQEQSESLSSNSNGSSSYHVSAVNGHNNGAGVSDLNLVPFNNNQSIQSKKPLSISDLSPAPMHGSNLRVAYQGVPGAYSEAAAGKAYPNCQAIPCDQFEVAFQAVELWIADRAVLPVENSLGGSIHRNYDLLLRHRLHIVGEVQLPVHHCLIALPGVRKEFLTRVISHPQGLAQCEHTLTKLGLNVAREAVDDTAGAAEFIAANNIRDTAAIASARAAEIYGLEILEDGIQDDASNVTRFVMLAREPIIPRTDRPFKTSIVFAHEK... | Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine . Together with GCR1 and GPA1, required for blue light-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings . | Q9ZUY3 |
B8DDS0 | PYRF_LISMH | OMP decarboxylase | Listeria | MNKPIIALDFQTYEEVEQFLAKFSGEALSVKVGMELFYSNGPIIVEKIKQQNHEIFLDLKLHDIPNTVKSAMVGLAKLGVDMVNVHAAGGKNMMEAALEGLEIGSGSGKRPKIIAVTQLTSTSEASMQSEQLIKTSLLESVLHYSALTNQAGLNGVVCSALEAEAIKQQNGADFLRVTPGIRLASDAADDQIRVVTPEKARLIGSTDIVVGRSITRANDPVAAYNQVLKEWNV | Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). | B8DDS0 |
Q97E05 | HTPG_CLOAB | High temperature protein G | Clostridium | MAVKQFKAESKRLLDLMINSIYTNKEIFLRELISNASDAIDKCYYRSLVDTNITFNKDDFYIRISADKENKTLTITDTGIGMTKDDLENNLGTIAKSGSFAFKSENEAKEGVDIIGQFGVGFYSAFMVADDVTVISRSVDSEEAYKWESKGVEGYTIEKCEKETPGTEIVLKIKENTDDEKYDEFLDEYKLRSLIKKYSDFIKYPIKMMTKKTRPKKDNDKETEEYLEDETLNSMVPIWRKNKNELKQEDYDNFYMDKHFGFEKPLKTIHSNVEGVVSYNTLLFIPASAPYDFYTKEFEKGLELYSNGVMIMQKCGDLLP... | Molecular chaperone. Has ATPase activity. | Q97E05 |
Q2KVJ9 | MNMC_BORA1 | FAD-dependent cmnm(5)s(2)U34 oxidoreductase | Bordetella | MSSAYQPLTPALTEVNEAGHLASRQYGDVYNSPADAYGQAVDVFLHGNDLPQRWRGRRHFTVCETGFGLGTNFLALWRAWREDPGRCGRLHMLSIEGHPLTREAYEAVLDTQVPEPLRAGARELLAQWPKLLPGLHRLEFEHGAVTLTLALGDIGQVAPRLSACVDAFFLDGFAPSKNPAMWDTYVLRRLLRLGAADATLATWTSAGFVRRGLQEAGFDIQRLTGARGKRHITVGRRSAWAGKHAPRRTDAPDAPVLVVGAGLAGAGMAQALALRGLSVRVIAESAQPHGGHLAAALTPLVARDDNARARLARAGSQRAW... | Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s... | Q2KVJ9 |
Q9LQC0 | HMOX4_ARATH | Heme oxygenase 4, chloroplastic | Arabidopsis | MATSRLNASCRFPASRRLDCESYVSLRAKTVTIRYVRTIAAPRRHLVRRANEDQTLVVNVVAAAGEKPERRYPREPNGFVEEMRFVVMKIHPRDQVKEGKSDSNDLVSTWNFTIEGYLKFLVDSKLVFETLERIINESAIQAYAGLKNTGLERAENLSRDLEWFKEQGYEIPESMVPGKAYSQYLKNIAEKDPPAFICHFYNINFAHSAGGRMIGTKVAEKILDNKELEFYKWDGQLSELLQNVSEELNKVAELWTREEKNHCLEETEKSFKFYWEIFRYLLS | Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Plays a minor role in phytochrome assembly and photomorphogenesis. | Q9LQC0 |
A9ITN7 | RLMH_BORPD | rRNA (pseudouridine-N3-)-methyltransferase RlmH | Bordetella | MKLIVIAVGNRMPAWVETAWDDYAKRLPPDCALELREIKPEPRTTGKTPAQMMAAEARRIEAAIPGGALRLALDERGRDLTTMALSQRLEQWRAGGRDVVFLVGGPDGLDDALKSACDGQIRLSSLTLPHPMVRVVLAEQLYRAWAILANHPYHRA | Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. | A9ITN7 |
A2C620 | SAHH_PROM3 | S-adenosyl-L-homocysteine hydrolase | Prochlorococcus | MVAVPTSMASLQAPPQYVVADIDLADFGRKELSIAETEMPGLMALRVKHGSEKPLKGARIAGSLHMTIQTGVLIETLVALGADVRWASCNIFSTQDHAAAAIAASGVPVFATKGETLDEYWAYTHRILEWGDGGTPNMILDDGGDATGLVMLGSKAESDSSVLDNPGNEEETALFASIRTKLAQDSSFYSRIKSNIQGVTEETTTGVARLYQMQKSGELPFPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAMEGYRVVRLDEVVQDVDIFVT... | May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | A2C620 |
Q59P44 | RU1C_CANAL | U1 small nuclear ribonucleoprotein C | Candida | MPKYYCDYCKSYLTHDTMSVRKSHLQGRNHIKFYCDYYEAKAKETNIWNPSSIPYEITLEKLNRYSDAKKSNGSSEDNMDIDKKENSSDHNKGNVVNHSDAGNDNDDDDDEMIFLPPPPNLSGLPLPPPAVYNNQKEYQKAILRQTLTKS | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seem... | Q59P44 |
Q9KIV0 | HGBC_HAEIF | Hemoglobin-binding protein C | Haemophilus | MANFRLNVLAYSVMLGLTAGVAYAAQPTNQPTNQPTNQNSNVSEQLEQINVSGSTENSDTKTPPKIAETVKTAKTLEREQANNIKDIVKYETGVTVVEAGRFGQSGFAIRGVDENRVAINIDGLRQAETLSSQGFKELFEGYGNFNNTRNGAEIETLKEVNITKGANSIKSGSGSLGGSVIYKTKDARDYLLNKDYYVSYKKGYATENNQSFNTLTLAGRYKKFDALVVTTRRNGHELENYDYKNADSLTQGKKREKADPYKIEQDSTLLKLSFNPTENHRFTLAADLYEHRSRGQDLSYTLKYQRSGNETPEVESRHTN... | Acts as a receptor for hemoglobin of the human host and is required for heme uptake. | Q9KIV0 |
B5F4U6 | LGT_SALA4 | Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase | Salmonella | MTSSYLHFPDFDPVIFSIGPVALHWYGLMYLVGFVFAMWLAVRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPLFLDNPLYLFRVWDGGMSFHGGLIGVILVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPDFRFAMLFPGSRAEDIALLPSHPQWQPIFDTYGVLPRHPSQLYELALEGVVLFIILNLFIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIIAGAIMMVWAYRRRPQQHVS | Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. | B5F4U6 |
Q07QX3 | NUOCD_RHOP5 | NDH-1 subunit C/D | Rhodopseudomonas | MSGAELISDLRARFGQAVLSEQSTNDAFPTLWIAPDAAPAVHRYLKHDVAKPFALLADLWAIDETARKHREGQPPSGITIASHLISLGRNADIVLKCPLDAKAPRATSIASVYPNADWYEREAFDLFGVHFDGRHDHRRILLPPLWEGHPLRKDQPARATEKPPFVMTAARFDAEEKALMIDPEALGLPTERDGVELMILNYGPHSMATHGVFRVVLALDGEEIVAARPDIGFHHRGAEKMGERQSWHQFIPYTDRIDYLGGVISEMPYLQAVERLCGITVPDRAKTIRIMLSEIYRIMNHLLLYGTMAQDCGAMSPVFY... | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t... | Q07QX3 |
Q2NHD6 | RLME_METST | rRNA (uridine-2'-O-)-methyltransferase | Methanosphaera | MSRWKAKHDKEHYYKLAKKQNYRSRASYKLKQLDKKYSLLKPDYNVVDLGAAPGGWSQVVAETIGEEGKGQIISVDLEYIKPIDHEAYTGVKGDFTTKETQDIIIELIDGKADVVLSDAAPKLTGIKDIDNFRAYDLSMAVIEIIDNILKNNGNLIMKAFQGEAYQEIIKNLKKKFRNVKTTKPNSSRKRSAEMYVIARGFRGSKK | Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | Q2NHD6 |
P11226 | MBL2_HUMAN | Mannose-binding lectin | Homo | MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI | Calcium-dependent lectin involved in innate immune defense . Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their upt... | P11226 |
Q1C4E6 | PROB_YERPA | Gamma-glutamyl kinase | Yersinia | MSGSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQQHAKGHRIVIVTFGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHIGQMLLTRADLEDRERFLNARDTMNALLDNRIVPVINENDAVATAEIKVGDNDNLSALAAILASADKLLLLTDQAGLYTADPRNNPEAELIREVHGIDDVLRGMAGDSVSGLGTGGMATKLQAADVACRAGIDVVIAAGSQVGVIADVIDGTPVGTRFHSLETPLENRKRWIFGAPPAGEITVDDGAVFAIMERGSSLLPKGIRSVKGDFSRGEVIRIRNLNG... | Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | Q1C4E6 |
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