accession stringlengths 6 10 | name stringlengths 6 11 | Full Name stringlengths 1 147 ⌀ | taxon stringlengths 3 46 ⌀ | sequence stringlengths 16 2.75k | function stringlengths 6 5.51k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q6A998 | HRCA_CUTAK | Heat-inducible transcription repressor HrcA | Cutibacterium | MLDDRKLDVLKAIVTDYVSSKEPVGSKALVERHGLRVSPATVRNDMAVLEEEGYITHPHTSAGRIPTDKGYRLFVDRIATLKPLSAPERRAIQAFMTGAVDLDDIVRRTVRLLAQITHQVAIMQYPVATTGTIRHLELVSLSTDRILIVLIMSSGSVEQQIVELPGHDEQSLAALRTRLNETLVGLTVAEAADSLNRFLDDLGPAEGPRAASVIATVLEILAVDPSARVVVAGVPNLTAFGAQWETAVRPVLEALEEQVVLMRLLGEATAGEAGEVTVRIGAENTDVPFQSTSLVASTYGPEDALSSLGVVGPIRMDYPS... | Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Q6A998 |
A8G1H1 | SELU_SHESH | tRNA 2-selenouridine synthase | Shewanella | MSQNIVPKSAYREIMLSGHPMMDVRAPIEFNKGAFPSSTNLPLMQDSERQKVGTCYKNKGQDAAIALGHSLVNGQIKQQRVEAWLEFISLHPNAYLYCFRGGLRSQLTQQWIKEAGIEIPYVEGGYKAMRQYLIEVIDEAPKQSPIHILSGITGSGKTDFLLQRSEAIDLEGLAHHRGSSFGRYHEPQPSQINFENNLAVSLLKHQERAEKCLLVEDESFLIGRSAIPKQFYSGMQAADMLVLEEPEGARLNRLLNEYVHKMHSGYVERLGEEAGFDAFAEYLSQSITGIKKRLGGQLHDEFQSIIANALNIQRQRGDTQ... | Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS... | A8G1H1 |
G7CBF6 | IRTB_MYCT3 | Mycobactin import ATP-binding/permease protein IrtB | Mycolicibacterium | MIRTLLRLVPAEKRGAVAGYAVLTLLSVLLRAVGAVLLIPLLAALFSDTPSDAWLWLGWLTAVTLAGWVTDTNTARLGFDLGFAVLSRTQHDMADRLPNVAMSWFTPDNTATARQAIAATGPELAGLVVNLLTPLIGAALLPAAIGVALLFVSVPLGLAALAGVAVLFGALALSGRLSRAADKVAGETNSAFTERIIEFARTQQALRAARRVEPARSQVGSALAAQHGAGLRLLTMQIPGQVLFSLAGQVALIGFAGMAVWLTVRGQLGVPEAIALIVVLVRYLEPFAAIADLAPALETTRATLNRIQAVLDAPTLPAGR... | Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) . Has a preference for Fe-MBT over Fe-cMBT . Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation . | G7CBF6 |
B4U858 | HIS1_HYDS0 | ATP phosphoribosyltransferase | unclassified Hydrogenobaculum | MLKIAIPKGRLLEEVSELFLSKSLIPSKIEESRKLIVDIDYFRFLIVKPSDVATYVEQGAADIGVVGLDVLKEEPKEIYEILDLKNIGKCSMVVAGKPEKLGDYKILHFTKVATKYVNIARSFFEGKDVSINIIKLNGSVEIAPIIGLSDYIVDITQTGKTLKENGLIVMEKIFDSHAKIICNKVAFRIKKYDIFKILDKLSDI | Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | B4U858 |
B8DPP9 | BIOB_DESVM | Biotin synthase | Desulfovibrio | MNPLLERLCARLSDTIPPGTETPYASPSHARTEEAPWSGITGEEALAVARLPASDILDILAVAQAVRSARKGPLATTCGIVNAKSGRCGEDCAFCAQSSHHDTGAPVHALLGPDALLRHAEELARAGVRRFGIVTSGNALSEREFDAVCHAARLLRDRVDIGLCASLGQLATGSAESGNRGERARRLKDAGISSYHHNLETARSFFPQVCTTHPYDDDIATVREAARAGLRTCCGGILGLGETWEHRVELALTLRELDVDSIPLNFLHPVPGTRLGHRSPLPPMEALRAIAVFRLLHPQRDILVCGGRETTLGQWQSWVF... | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. | B8DPP9 |
Q15RN4 | RUVC_PSEA6 | Holliday junction resolvase RuvC | Pseudoalteromonas | MAIILGIDPGSRITGYGVIQRAGRQQQYLGSGCIRMQGDALAPRLQQIFDGVSQLILQYKPDMFAIEQVFMAKNPDSALKLGQARGAAIVAASNQGLDVAEYSARQIKQSVVGNGNAQKSQVQHMVTFILKLPGTPQADAADALAVALCHSHTNENLIKMSGQVKKTVRGRLR | Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | Q15RN4 |
O24149 | CAMT2_TOBAC | Trans-caffeoyl-CoA 3-O-methyltransferase 2 | Nicotiana | MATNGENGRHQEVGHKSLLQSDALYQYILETSVYPREPEPMKELREITAKHPWNLMTTSADEGQFLSMLLKLINAKNTMEIGVFTGYSLLATAMALPDDGKILAMDINRENYEIGLPIIEKAGLAHKIVFREGPALPVLDQMIEDGKYHGSYDFIFVDADKDNYLNYHKRLIDLVKVGGLIGYDNTLWNGSVVAPPDAPLRKYVRYYRDFVLELNKALAADSRIEICQLPVGDGITLCRRIS | Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic ... | O24149 |
B2VBL4 | MIAB_ERWT9 | tRNA-i(6)A37 methylthiotransferase | Erwinia | MTKKLHIKTWGCQMNEYDSSKMADLLNSTHGYTLTEQAEDADVLLLNTCSIREKAQEKVFALLGRWKKLKESNPDMIIGVGGCVASQEGAQIRQRASCVDIVFGPQTLHRLPEMINSVRGTRSPVVDVSFPEIEKFDRMPEPRADGPTAFVSIMEGCNKYCTFCVVPYTRGEEVSRPSDDILFEVAQLAAQGVREVNLLGQNVNAYRGETFDGGICSFAELLRLVAAIDGIDRIRFTTSHPIEFNDDIIDVYRDTPELVSFLHLPVQSGADRILTLMKRAHTALEYKAIIRKLLAARPNIQISSDFIIGFPGETQADFEQ... | Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | B2VBL4 |
Q5R6Y0 | HBS1L_PONAB | HBS1-like protein | Pongo | MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMREILGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEGTVSTGKIAKGKPVDSQTSRSESEIVPKVAKMTVSGKKQTMGFEVPGVSSEENGHSFHTPQKGPPIEDAIASSDVLETASKSANPPHTIQASEEQSSTPAPVKKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDETGEER... | Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of e... | Q5R6Y0 |
D2TPS5 | PDUW_CITRI | Propionate kinase | Citrobacter | MSHKIMAINAGSSSLKFQLLDMPQGKLLCQGLIERIGMANAGITLKAQEQKWQQTAPVADHREAVTLLLDMLTGHGIIRSIAEIEGVGHRVAHGGETFKDSARVTDETLAEIERLAELAPLHNPVNLLGINVFRQLLPDVPAVAVFDTAFHQTLNEAAYIYPLPWRYYEEFGIRRYGFHGTSHKYVSATLAEKLGVPLSALRVVSCHLGNGSSLCAIKGGKSVNTSMGFTPQSGVMMGTRSGDIDPSILPWLAQREGKTPQQLNQLLNNESGLLGVSGVSHDYRDVEQAADAGNPRAALALTLFAERIRATIGSYIMQMG... | Works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of 1,2-propanediol (1,2-PD). | D2TPS5 |
P40210 | SIP5_YEAST | SNF1-interacting protein 5 | Saccharomyces | MGNVPGKIDQEDSFNDVRPDSSYNTTSSNSVIKQYDEEASSRVRTRRTTSLVNNILNGNNARTKTGSHLSSTSRRKTSREKELAKEAHAKQLVVRCSETVDGGFLAPFGCYSFEKLDYDATVVKNLIIKRKLAPFYTPLQDFDESWTRDELIKIVDGLPLHDTFDENLEEFEDVPIGNLRKSTFNELIDKSLSKKEQRRMHAKIFRARLYKKRILWQENENETFLERKLEMKRIGSKSSNVEDNTSSQPRKNYHLPSDDLKYTLYKNGSECPICFLYFPGPFNYSKCCQQPICTECFVQIKRADPHFPHDEVDPTEPQTN... | May negatively regulate the SNF1 kinase by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. Deletion of SIP5 promotes resistance to artimisin, which is probably an indirect effect of an action on the electron transport chain. | P40210 |
A4SHF6 | RL31_AERS4 | 50S ribosomal protein L31 | Aeromonas | MKAGIHPEYVAITAKCSCGNVINTFSTMGKDLNLDVCSACHPFYTGKQKEVSSGGRVDKFNKRFGGLTAKK | Binds the 23S rRNA. | A4SHF6 |
B7LRL5 | AAEB_ESCF3 | p-hydroxybenzoic acid efflux pump subunit AaeB | Escherichia | MGIFSIANQHIRFAVKLASAIVLTLFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYAGAIRYRGMLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRVENSYAWGLAGYTALIIVITIQPEPLLTPQFALERCSEIVVGIVCAIVADLIFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGEAEEVDKAWGNLVRRTTALEGMRSNLNMESSRWARANRRLKALNTLSLTLITQSCETYLIQNTRPELITETFREFFSTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWAGAATRYLLI... | Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. | B7LRL5 |
P34706 | SDC3_CAEEL | Zinc finger protein sdc-3 | Caenorhabditis | MSDEPPIVLPTEEDGPFSNCVSIAFVNDKSIPVELRIRKAIRGKVTFTQELVVAARRLYLDGELERPDLNYHVAADFYDPFMIPVPDHRNWEYNPLYPREWPRLIDRDLVQKIKMSNTYKKNQARRKRRRLLRIFHRKRGGEFLNYLWHSKENDVHYKRYMAAYQFPLPFEKCIRDVVREELKDPETSFSKPPSVVHHSKIRPATPDLLKLAKYLGKDRFCFIVTPFKFRSQFRLRYYKKSPFKRSNILEKWLKFKKVRDQGVFNIRDAAREVKKLLQRKNVYHMTDPQCEQEFWDVYRLQMQWLEEDNIEENITMLREN... | Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals . Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its ... | P34706 |
Q7WHI8 | ECTB_BORBR | L-2,4-diaminobutyric acid transaminase | Bordetella | MDLKIFDRMESEVRGYIRSFPVIFSQARGSLLIDEEGNEYIDFFSGAGTLNYGHNNPVFKERLLEYLHSDGVVHGLDMATSAKKRFLETVDRVLLKPRNWQYTLQFTGPTGTNAVEAALKLARQVKGRSNIISFTHGFHGVSGGSLAATANAKFRDAAGVSLGNTTFMPYDGYFGPDVDTIAYIERMLDDPSSGLDKPAAVIVETVQGEGGVNVATLRWLKDLQKLCRRHDMLMIVDDIQVGCGRTGSFFSFEAAGIQPDIITLSKSLSGFGLPMSLVLMKPELDVWKPGAHSGTFRGNNLAFVTATQALETYWSSDAFS... | Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. | Q7WHI8 |
A3N6Z8 | CAPP_BURP6 | Phosphoenolpyruvate carboxylase | pseudomallei group | MKSSGSARATRRNAVSSSSAPAHAEPPARRAAKSARKLDGAAARPLAPTNAASAKPQGRTREDKDRPLFEDIRYLGRLLGDVVREQEGDAVFDVVETIRQTAVKFRREDDKAAAQTLEKMLRKLTPEQTVSVVRAFSYFSHLANIAEDRHHNRRRRIHALAGSAAQAGTVAYALDKLKQAGDASSKTIKQFFEGALIVPVLTAHPTEVQRKSILDAQHDIARLLAERDQPLTARELAHNEALLRARVTTLWQTRMLRDARLTVADEIENALSYYRATFLDELPALYADIEEALAEHGLRARVPAFFQMGSWIGGDRDGNP... | Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. | A3N6Z8 |
Q9CLQ2 | YIDC_PASMU | Membrane protein YidC | Pasteurella | MDSRRSLLVIALLFISFLVYQQWQLDYHTPKPVATEQVKVSSDVPASSASSSSDIATTAQAQGRIITLENDVFRLEVDTLGGDVVHSELLKYDAELNSNTPFTLLTNKANHVYIAQSGLVGKDGIDTKAGRANYQVDGDTFKLADGQNELAVPFVFEKDGVTFRKIFVLKRGAYDIAVNFEIDNQSDKTIEVEPYGQLRHTLVEDTGNVAMPTYTGGAYSSSETNYKKYSFADMEKANLSISTKAGWVAVLQHYFVSAWIPNQDADNQLYSLTDKANNLASIGYRGPVTAIPAGAKETIRSSLWTGPKLQDQMATVANHL... | Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning memb... | Q9CLQ2 |
B8FY51 | ISPE_DESHD | 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase | Desulfitobacterium | MIKNQVEMFAYAKINLALAITGRRPDGYHELESVMQSIGIYDRIRVTLAEGGIQCSCGEWSGPENLAYRAAEAFLSGLGSSQGIHIDIEKNIPVQAGLGGGSADAAAALQALNKLFKEPYTEEELKSFAAQLGADVAFCLKGGTQWATGVGEELKGLPHAPKINLVLIKPDQGVNTAEAYRAFDQEGKFSHLDYAGWQEALASGRAESLIPLLYNDLEPASMKLLPEIAWVKEELMKQNGCLGALMSGSGSAVFGIVQTEEQAEKIAAIWRERNYHVWVTHTMERGNIYG | Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | B8FY51 |
A8GMN4 | RPPH_RICAH | (Di)nucleoside polyphosphate hydrolase | spotted fever group | MRNSSKKHLDLPYRLGVGMMILNADNHIFVGKRIDTKLSAWQMPQGGIVPGETPSIAAMREMLEEIGSDKGYIIAESKCWYSYDVPSLLIPKLWNGNFRGQKQRWFLIRFTGNNEDININTSNPEFDQWRWASLDELLSIIIPFKRKLYQAVVKEFKSLIQ | Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. | A8GMN4 |
Q9XXV8 | MYOK_DICDI | Myosin-K heavy chain | Dictyostelium | MFRLFSSGVDDLVLVSNPSNGEVTSQIGARFDRELIYTNIGEVLIAVNPYKALPITGPEFIKLYQNASGSDASPHIYALAERAYRRMVDENESQCVIISGESGAGKTVSAKLILQYVTSVSPNNSSGGGIGGSGGGNGGIPQYDGGSDDRPSPPMGRGMGMPGMVGRGGLPTRGGGPPSRGGGPPPTRGRGGPPPPIPQNRGAPPPVSNGGAPPPVARGPVAPPPTRGAPPTRGGGPANRGGRGGGPPPVSTSRGGGGYGGSSKTVDVEHIKKVILDSNPLMEAIGNAKTVRNDNSSRFGKYLEIQFDDNNAPVGGLIST... | Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex. | Q9XXV8 |
Q1J1C0 | PANB_DEIGD | Ketopantoate hydroxymethyltransferase | Deinococcus | MKRSVPDLMNASEPLVMVTAYDYPGARHAEAAGVDLILVGDSLGNVVLGYDSTAPVTLDDMIHHARAVRRGAPNTFLVVDLPFGTYHTGVTDAMRNAVRVIQQTGADAVKLEGATPEVLDVVGVLARNGIPVMGHVGLMPQTATAQGGLKVQGRDEASARRTLEGALALEAAGAFSVVLEAIPARLARLITERLHVPTIGIGAGVHCRGQVLVYHDLLGLYEGDEKKLAKRYAELGKEAREAIAAYAREVRAREFPTKDQSFVMKDDVLGKLY | Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. | Q1J1C0 |
C4WUT0 | ENOPH_ACYPI | 2,3-diketo-5-methylthio-1-phosphopentane phosphatase | Acyrthosiphon | MPVNENVILLDIEGTITSISFVKDTLFPYVTKVLEDYIEKYWDDESFQQDLELLRAQAVIDSNVEGFVPISTGDNAKTSVINNVLWQMTNDKKTTALKQLQGHIWKDGYESGLLRGHLYEDVLPVLNKLTDFGKKIYTYSSGSTKAQEYLFQYSMYGDVSGIFLKYFDTKMGPKGSETSYINIANEINVNCSDILFLTDVVVEAEAAVKAGCNSIFLVRPGNAPLDPEKSSKFRIIKTLDELLETE | Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). | C4WUT0 |
A9BNG6 | DNAJ_DELAS | Chaperone protein DnaJ | Delftia | MSKRDFYEVLGVAKNASDDDIKKAYRKLAMKYHPDRNQGDAAREAEEKFKEAKEAYEMLSDSNKRAAYDQYGHAGVDPNRGMGGGAEGFGGFAEAFGDIFGDMFNQGGGRRGGAGGGRQVYRGNDLSYAMEITLEEAAHGKDAQIRIPSWDGCDTCHGSGAKPGTSAKTCTTCNGMGSVQMRQGFFSVQQTCPHCRGTGKIIPEPCTSCGGQGKVKRQKTLEVKIPAGIDDGMRIRSSGNGEPGTNGGPAGDLYIEIRIKDHDIFERDGDDLHCNVPVSFITAALGGEIEVPTLSGKAAIDIPEGTQAGKQFRLRGKGIK... | Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bou... | A9BNG6 |
Q97S28 | PNP_STRPN | Polynucleotide phosphorylase | Streptococcus | MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAVMSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQIIINPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQEEIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQVVKDQVTAVYEEKYADHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPD... | Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. | Q97S28 |
Q9YEV9 | Y021_AERPE | Putative antitoxin APE_0472b.1 | Aeropyrum | MSEIEGIVKSGVIIPLKPLTELEGKKIKIKIVDAESVDAEKLYSYLRLLREGEDARDFFKI | Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. | Q9YEV9 |
B8ZUE2 | GUAA_MYCLB | Glutamine amidotransferase | Mycobacterium | MADSAGLDQPEPSPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTTSIEEITARDPLAIVLSGGPASVYTEGAPQLDPALFDLGLPVFGICYGFQAMAQVLGGTVARTKTSEYGRTELKVLGGDLHSGLPGVQPVWMSHGDAVTAAPDGFDVAASSSGAPVAAFENRDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLDADWTAANIAGVLVEQVRAQIGNGHAICGLSGGVDSAVAAALVQRAIGDRLTCIFVDHGLLRDGERGQVQRDFVAATGAKLVTVDAAETFLQALSGVTNPEGKRKIIGRQFIRAFEGA... | Catalyzes the synthesis of GMP from XMP. | B8ZUE2 |
Q60FX9 | CCNB2_ANGJA | G2/mitotic-specific cyclin-B2 | Anguilla | MSLAVRGINRNAENAAPMGKAITDGTRRPVLGEISNFANKAVQVKKNTTLKAQAVKTAKPASQQQTLPTAALHKRAPVLPVIADPPQVVSVSTDVAIKEEELCQAFSDALLAVEDIDEGDADMPQLCSEYVKDIYVYLRNLEVQQCIRPRYMQGYEINERMRALLVDWLIQVHSRFQLLQETLYMTVAILDRFLQVQPVSRRKLQLVGVTAMLVASKYEEMYAPEVGDFVYITDNAFTKAQIREMEMLILRDLNFQLGRPLPLHFLRRASKAGSADAEKHTLAKYLMELTLMDYDMLHYHPSEIAAAALCLSQLVLDGQK... | Essential for the control of the cell cycle at the G2/M (mitosis) transition. | Q60FX9 |
Q6MPK2 | METK_BDEBA | Methionine adenosyltransferase | Bdellovibrio | MKNYLFTSESVSEGHPDKMADQISDGILDAILAQDPKGRVACETLLTTGLVVVAGEITTSAKVNFSEVARDVVKRIGYDHSDKGFDYKTCGVMIAVGQQSPDIAVGVKETLSDNQGAGDQGLMFGYAVNETPELMPLSIAMSHKLVKDLAALRKANKVDWLRPDAKSQVTVQYENGIAKRIDAVVISTQHADSVSNSTIQEFITEELIKKSIPGNWIDSKTKFFINPTGRFVTGGPMGDAGLTGRKIIVDTYGGHGAHGGGAFSGKDPSKVDRSAAYASRHIAKNIVGAGLAERCLVQVAYAIGVAEPVSITVNDYGTSK... | Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Q6MPK2 |
Q5HTM5 | PDXJ_CAMJR | Pyridoxine 5'-phosphate synthase | Campylobacter | MLLGVNIDHIAVLRQARMVNDPDLLEAAFIVARHGDQITLHVREDRRHAQDFDLENIIKFCKSPVNLECALNDEILNLALKLKPHRVTLVPEKREELTTEGGLCLNHAKLKQSIEKLHNANIEVSLFINPSLEDIEKSKILKAQFIELHTGHYANLHNALFSNISHTAFALKELNQDKKTLQAQFEKELQNLELCAKKGLELGLKVAAGHGLNYKNVKPVVKIKEICELNIGQSIVARSVFTGLQNAILEMKELIKR | Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | Q5HTM5 |
Q9PN86 | RNY_CAMJE | Ribonuclease Y | Campylobacter | MIESLIALIAAIVGLGIGYLVAKKINDAKYEIFVEQAKAKAKAIEYEAELILKDAKNSILNAELEVKKKYEEKTHKFQKDFNQKFDDLSKKEQKLQQEEEKLKEDKEYLCKSQKHIQNLQSDVDKLKNKYQEKLDDVLKILEHSTGLTQNEAKEIILKKVEENSREQIAHIVRKYEEEAKNEAKRKANFIIAQATSRFAGEFAAERLINVINIKNDELKGRIIGKEGRNVKTLEMVLGVDIIIDDTPGAIIVSCFNLYRRAIATKVIELLVEDGRIQPARIEEIHEKVCKEFDSAILEEGETIVMDLGLNKIHPEIVKLI... | Endoribonuclease that initiates mRNA decay. | Q9PN86 |
C5B8B9 | MNMA_EDWI9 | tRNA-specific 2-thiouridylase MnmA | Edwardsiella | MSDNSQKKVIVGMSGGVDSSVSAYLLQQQGYQVAGLFMKNWEEDDSDEYCSAATDLADAQAVCDRLGIELHTVNFAAEYWDNVFELFLQEYRAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRRDINGTTQLLRGVDANKDQSYFLYTLSHQQVAQSLFPVGELEKPEVRRIAAQLDLATAKKKDSTGICFIGERKFREFLGRYLPAQPGKIVTVDGETIGEHQGLMYHTLGQRKGLGIGGTKEGSEEPWYVVDKDLDNNVLVVAQGHDHPRLFSNGLIAQQLHWVDRLPLGAPLRCTVKTRYRQADIPC... | Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs. | C5B8B9 |
Q75WM6 | H1FNT_HUMAN | Histone H1t2 | Homo | MEQALTGEAQSRWPRRGGSGAMAEAPGPSGESRGHSATQLPAEKTVGGPSRGCSSSVLRVSQLVLQAISTHKGLTLAALKKELRNAGYEVRRKSGRHEAPRGQAKATLLRVSGSDAAGYFRVWKVPKPRRKPGRARQEEGTRAPWRTPAAPRSSRRRRQPLRKAARKAREVWRRNARAKAKANARARRTRRARPRAKEPPCARAKEEAGATAADEGRGQAVKEDTTPRSGKDKRRSSKPREEKQEPKKPAQRTIQ | Essential for normal spermatogenesis and male fertility . Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-st... | Q75WM6 |
B2SB62 | GATA_BRUA1 | Glutamyl-tRNA(Gln) amidotransferase subunit A | Brucella | MSELTALTIAEARDKLKAKAITATELTDAYLSAIDAANDAINAYVAVTHDQARSMAKASDERIAKGEAGALEGIPLGVKDLFATKGVHTQACSHILDGFKPEYESTVTANLWADGAVMLGKLNMDEVAMGSSNETSYYGPVKNPWRAKGSNADLVPGGSSGGSAAAVAAHLCAGATATDTGGSIRQPAAFTGTVGIKPTYGRVSRWGTVAFASSLDQAGPIARDVRDAAILMKSMASLDLKDTTSVDLPVPDYEAALGRSVKGMKIGIPREYRVDGMPGEIEELWQKGIQYLKDAGAEIVDISLPHTKYALPAYYIVAPA... | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). | B2SB62 |
B2JCN4 | COAD_PARP8 | Pantetheine-phosphate adenylyltransferase | Paraburkholderia | MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRNKRPFFNLEERLEIANEVLGHYPNVQVMSFKGLLKDFVRVNNARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKRLQDKVAALEQARAANP | Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. | B2JCN4 |
Q9VA37 | DJ1B_DROME | Protein dj-1beta | Sophophora | MSKSALVILAPGAEEMEFIIAADVLRRAGIKVTVAGLNGGEAVKCSRDVQILPDTSLAQVASDKFDVVVLPGGLGGSNAMGESSLVGDLLRSQESGGGLIAAICAAPTVLAKHGVASGKSLTSYPSMKPQLVNNYSYVDDKTVVKDGNLITSRGPGTAYEFALKIAEELAGKEKVQEVAKGLLVAYN | Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor . Does not play a role in methylglyoxal detoxification . Plays a role in mitochondrial function together with Pink1 . In motor neurons regulates structural synaptic plasticity of locomotor behavior ... | Q9VA37 |
A7A1V6 | DIF1_YEAS7 | Damage-regulated import facilitator 1 | Saccharomyces | MDAQLEWASSLVPKRQLQQQQQQEQQQQQQDFHKDQLMTVGMRIRQRVDQGYASRTPSTSDASLQPGVIRDYSSVIVPQFTRSPLPTANSLPPMLINQRTMSTEASSLEKWDVAEPAAEHETMVNGSKRRL | Mediates the nuclear localization of RNR2 and RNR4, 2 subunits of the ribonucleotide reductase. | A7A1V6 |
A8KBE0 | OXR1_XENTR | Oxidation resistance protein 1 | Silurana | MFSTRRLKKKSQSVDIAASGYNPLSDASAPQASRVPPPIVKAISEEEHHNTTNAQKRHLRRGDLKRGYTIDTGQKKTLEKKDGRRMSFQRPKGTMEYTVETRDSLNSIALKFDTTPNELVQLNKLFSRAVVPGQLLYVPDPDYISSVESSPSLSPISPLSPTSSEAEFEKSTDTERMPYKEITSSPAYSAIRPSRVVSSTSEEEEAFTEKFLKINCKYITDGKGTVNGVLLVTPNNIMFDPHKNDLLVQEKGCEEYGIMCPMEEVTSAAMYKEIVNSKLKDSVSVDVGQLSCMREFCHLKKISPGNLHDIDSQMWDAGND... | May be involved in protection from oxidative damage. | A8KBE0 |
B7VJT3 | PEPB_VIBA3 | Aminopeptidase B | Vibrio | MSTQMSVFLSQEAAQPQWGARAILSFSEAGATIHIGEGHDLGAVQRAGRTLDGQGIALVALSGKGWDLESVWAFYQGYRGPKKKNALEWDALAEADQVELEARIRATDWTRDIINKTAEEVAPRQLATMAAEYIKSVAPAGTVKAKIVKDKDLLTEGWEGIYAVGRGSERTSAMLQLDFNPTGDENAPVFACLVGKGITFDSGGYSIKPGQFMTAMKADMGGAATITGGLGLAIERGLNKRIKLILCCAENMISGRALKLGDIITYKNGKTVEIMNTDAEGRLVLADGLMFASAQNPELIIDCATLTGAAKNALGNDYHA... | Probably plays an important role in intracellular peptide degradation. | B7VJT3 |
A4QJ96 | PSBA_AETCO | Photosystem II Q(B) protein | Aethionema | MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSSSLHFFLTAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADI... | Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photoni... | A4QJ96 |
Q6I628 | PSS2_ORYSJ | Phosphatidylserine synthase 2 | Oryza sativa | MEAKQRTRHRDGEERRLVAAADGGAEEYDPWTAWLYKPHTISVLLVGACLLIWASGALDPEGASYHSSATSIKRGVWAMIAVFLAYCTLQAPSTILIRPHPAVWRLVHGLAVVYLVALAFLLFQNRDDARQFMKHLYPDLGVELPERSYGADCRLYVPENPKNKFINIYETLFDEFVVAHILGWWGKAVMIRNQLLLWVLSIGFELMELTFRHMLPNFNECWWDSIILDILICNWFGIWAGMHTVRYFDGKTYEWVGLSRQPSIMGKVKRSLSQFTPAQWDKDQWYPFMGPLRFVQVLFLCVVFMTVELNTFFLKFCLWI... | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. | Q6I628 |
Q6G564 | HRCA_BARHE | Heat-inducible transcription repressor HrcA | Bartonella | MKHKLIDDELKYLDERSRDIFRHIVEAYLNDGGPVGSRNLSRLLRQTLSPATIRNVMSDLEHLGLIYAPHVSAGRMPTQSGLRFFVDAFMEAGDLPNEERENIEAQVKEAGHAQSVEHFLVQASQVLSDLSRGAGLVLATKHEGTLKHIEFVRLDGEHALAVLVTQQGGVENRIVHLPEGVTHAQLTEATNFLNAHIQGLTLSEAKEEIARLCSETRAALDHLSHHLVETGLALWGGEGADHKIRLIVRGRSNLLEDVKAEEDLKRLRHLFDDLETRESMAQLLDLTDEGSGVRIFIGSENKLFSLSGSSLVVAPYRDSQ... | Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Q6G564 |
P07665 | SRYB_DROME | Serendipity locus protein beta | Sophophora | MSSTRPFCFVCGKEKSVGVFQLIEGCIVPGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEYLFNYDRLVRNLSQVQRQIADALLGCRQVEGKAETKQQAAKRARVQVPAFKIVQATALKEPERQPGEEDECEEFMKEEMLDEEFQFSEPDDSMPSSEEEFFTETTEIPCHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDC... | Binds to the consensus DNA sequence 5'-YCAGAGATGCGCA-3'. | P07665 |
Q5RCE3 | PELO_PONAB | Protein pelota homolog | Pongo | MKLVRKNIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHIHFDVVKCILVASPGFVREQFCDYMFQQAVKTDNKLLLENRSKFLQVHASSGHKYSLKEVLCDPTVASRLSDTKAAGEVKALDDFYKMLQHGPDRAFYGLKQVEKANEAMAIDTLLISDELFRH... | Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of... | Q5RCE3 |
A1TB00 | TRPD_MYCVP | Anthranilate phosphoribosyltransferase | Mycolicibacterium | MTTPPPQLASAQNPSGDTPTWAMILGRLTTGQGLAPGQTAWAMDQIMTGTATPAQIAAFAVSMKMKRPTSAEVTELADIMLKHARRVPTDVIGTATVDIVGTGGDGANTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGLRIDLGPDEVARCVAEVGIGFAFAPQFHPSYRHAGAVRREIGVPTVFNLLGPLTNPASPRAGLIGCAWADLAEVMAGVFATRGSSVLVVHGDDGLDELTTTTTSTIWRVQAGTVERLTFDPAAFGFARAHVSELTGGDAESNAASARAVLGGAKGPVRDAVVLNAAGALVA... | Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA). | A1TB00 |
Q74DU7 | YACG_GEOSL | DNA gyrase inhibitor YacG | Geobacter | MITTLTCPRCRAETVWEGNPHRPFCSARCKTVDLAAWADEEYRIAGPEAPSDNDENDRE | Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | Q74DU7 |
A4ILT6 | DAPEL_GEOTN | N-acetyldiaminopimelate deacetylase | Geobacillus | METISPFVAIRRDLHKIPELGFQEFKTQQYLLNYIQSLPQERLDVRTWKTGIFVKVSGTAPRKTIGYRADIDGLPISEETGLPYRSEHAGQMHACGHDVHMSIALGVLTHFAHNPIRDDLLFIFQPAEEGPGGAKPMLESDIMREWKPDMIVALHIAPEYPVGTIATKEGLLFANTSELFIDLKGKGGHAAFPHLANDMVVAACALVTQLQSIVARNVDPLDSAVITIGKITSGTVQNVIAEHARLEGTIRTLSIDAMQAVKRRIEALVRGVEVAYECEAVIDYGAMYHEVYNNPALTTEFIQFAETHTDMNVIRCKEAM... | Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. | A4ILT6 |
A1L259 | URAD_DANRE | null | Danio | MDINVVNALAYEDFVKLFGNVVEKCPLISAAIWSYRPFKDLADIEARISEFIHSLPDSGKEGILRCHPDLAGRDLQSGTLTPESQEEQSQAGMTTLDSAEIVHMYRLNSEYKERFGFPFVICARLNNKADIVRQLSERLKNRRTAELECAIEEVKKICSLRLHSIVLSDIQTKL | Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. | A1L259 |
B7GW14 | RL5_ACIB3 | 50S ribosomal protein L5 | Acinetobacter calcoaceticus/baumannii complex | MARLKARYNDELKAKLQEELSIKNVMEIPRITKITLNMGVGAAATDKKLLDGAVADMQLIAGQKPVVTLARKSIAGFKIRDGWPIGCKVTLRGDQMYEFLDRLISIAIPRIRDFRGFSAKSFDGRGNYSMGLKEQIVFPEIDFDKIDRIRGMDITITTTARTDDEGRALMRAFGFPFK | This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement... | B7GW14 |
C5DXI0 | ENOPH_ZYGRC | 2,3-diketo-5-methylthio-1-phosphopentane phosphatase | Zygosaccharomyces | MSVSVYLLDIEGTVCPISFVKETLFPYFSAKLPSLVKSDDVSIKSVLAQFPQHGDSQALQTHIQSLVSNDVKDPTLKQLQGTVWSQGYTSGEIKAPVYKDAIEFMKRKENVYIYSSGSVQAQKLLFGHVANPDNSGSNESSLDLNPLIKGYFDINTSGKKLESSSYEKIVTQIGVAAEQVLFISDNVKELEAAHAAGVKTLLAIRPGNPPVQENHGFRTVEKFDSL | Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). | C5DXI0 |
C0QY54 | Y0430_BRAHW | P-H7 | Brachyspira | MRKTVKIITSLVLIACLFLLASCANKGSSSSGDATTLKVAVMPFLNSVPIEYMINNKLDEKYGFKIETVYFPSGGPMNEALGAGLWEVGTLSAASVYSLANYNAHVVADIGHSEGGIEVLVNPDSDILTVKGVNKDFPEVYGDAATLKGKTIAVPTGTISHLNVIHWLRAINVDPNTVNIVHMEFPQAYQALKAKKIDAAALNPPTSFSAEADGMKIVSSLTTLNIPQYDSIIVSDEAFNNKKDTIVLYIKAFLEACDALQADPNMAAQELLNWYTKNGSTSTLEACQSEVQTRPFVTTEEIKNIKTGDSVRITADFFAS... | Probably part of an ABC transporter complex. | C0QY54 |
Q2W4A1 | SURE_MAGSA | Nucleoside 5'-monophosphate phosphohydrolase | Magnetospirillum | MTFPPVADPSSLRILISNDDGINAPGIKVLERIARTLSKDVWVVAPETEQSAAGHSLTIRRPLRVRKVSARRYAVDGTPTDSVLLGVNHVLKGKKPDLVLSGINRGANLGEDVTYSGTVAAAMEGTILGIPAIALSQTLEHPHPVKWGTVEHWAPDVIRRLLAKGWSRNVLINVNFPDVIAASVTGIEITRQGKRKIGDEIMERHDPRGEAYVWIGAQRAEDRSKPGTDIEAVFRGAISVTPLCFDLTHRDDMKALETAF | Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. | Q2W4A1 |
Q924X1 | EPGN_MOUSE | Epithelial mitogen | Mus | MALGVLIAVCLLFKAMKAALSEEAEVIPPSTAQQSNWTFNNTEADYIEEPVALKFSHPCLEDHNSYCINGACAFHHELKQAICRCFTGYTGQRCEHLTLTSYAVDSYEKYIAIGIGVGLLISAFLAVFYCYIRKRCINLKSPYIICSGGSPL | Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. | Q924X1 |
Q6A8H6 | KGUA_CUTAK | GMP kinase | Cutibacterium | MSSVPVIPQARGLRHTGPVTVAVVSGPTAVGKGTVVGALLRSHPEIVVSRSVTTRPPRPTERDGIDYDFITPEQFDKLVDGEGLLEWATVHNSHRYGTPRGPVERAVADNRTVVLEIDLQGARQVRETYPQATQIFLAPPSWEELVHRLIGRGTETPEQQKQRLETAKVELANADEFDAVVVNDTVDHAVAHLVELLSL | Essential for recycling GMP and indirectly, cGMP. | Q6A8H6 |
A1WAT8 | TRPA_ACISJ | Tryptophan synthase alpha chain | unclassified Acidovorax | MSRIADTFAELQSKGRKALIPYVTAGFPFVDITPALMHGMVEAGADVIELGVPFSDPMADGPVIQKAGEKALALGVGLAQVLEMVRRFRLRNSTTPVVLMGYANPVERYEQRHGKGAFARDAGEAGVDGVLIVDYPPEECEQFAADLRGHGIDLIFLLAPTSTPERMQQVARVASGYVYYVSLKGVTGSGALDTAAVEAMLPRIREHVKVPVGVGFGIRDAATAQAIGRVADAVVIGSRIIQLIEDQPHEKVVGITVDFLRGVRKALDA | The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. | A1WAT8 |
B0BQ37 | AMPA_ACTPJ | Leucyl aminopeptidase | Actinobacillus | MEFSVKNGSVEKQRTACLVVGVYEPRRLSAAAEQLDKLSEGYISTLLRRGDLEGKAGQTLLLHNVPNVPADRVLLVGCGKERELTERQYKQIIQKMVQAVSETGSMEVVCFLTELHVKGRTSYWNVRFAIEAIQESLYSYNDFKSIKPEVRREFRRVIFNVANRKDLADAERALEQGKAISTGVAFAKNVANCPPNVCNPAYLAELAKGLAAEYDNIRTTVIDEAEMAALGMNAYLAVSRGSQNPAYLSVIEYKNHPNPDAKPIVLVGKGLTFDSGGISIKPSDSMDEMKYDMGGAASVYGTMKALAEMKLPLNVIGVLA... | Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. | B0BQ37 |
Q9VT20 | OR67B_DROME | Odorant receptor 67b | Sophophora | MQDQLDHELERIDKLPKLGLLWVEYSAYALGVNIAPRKRSSKYCRLTRILVLIVNLSIIYSLVAFIMENYMISFETYVEAVLLTFQLSVGVVKMFHFQNKVESCSQLVFSTETGEVLKSLGLFQLDLPRKKELLSSVSLILLNNWMIIDRQVMFFFKIVCMPVLYYCVRPYFQYIFDCYIKDKDTCEMTLTYPAIVPYLQLGNYEFPSYVIRFFLLQSGPLWCFFAVFGFNSLFVVLTRYESGLIKVLRFLVQNSTSDILVPKDQRVKYLQCCVRLFARISSHHNQIENLFKYIILVQCSVSSILICMLLYKISTVLEVG... | Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged o... | Q9VT20 |
P07924 | RT13_WHEAT | Ribosomal protein S13, mitochondrial | Triticum | MSYISGARSLPDEQVRIASTKMDGIGPKKAIQLRYRLGISGNIKMNELTKYQIDQIEQMIAQDHVVHWELKRGERADIERLISISRYRGIRHQDGSPLRGQRTHTNARTARKQIRK | Located at the top of the head of the small subunit, it contacts several helices of the 18S rRNA. | P07924 |
Q9KNM9 | NHAP2_VIBCH | Potassium/proton antiporter NhaP2 | Vibrio | MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPVAYLVSNLALAIILLDGGMRTRVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLLQGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGTNDPMAVFLTVTLIAVLGSAETNLSAGFLLLSFIQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSNALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIALPGLALAVGMILFARPIAVW... | K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels. | Q9KNM9 |
A5I1U0 | DIVIB_CLOBH | Cell division protein DivIB | Clostridium | MSKDLISTDEYIKIKKKRKRIKKIVVLFIFLISILVTLCLKIPYFNIESIEIKGNVNIPKEVIKDSSTIKTGNNIFYTNKKDAIENISLNPYIEEVKITKKLPNKLQIYVKEREALFYNKVDNDFFIISKNGCVLEKRKEIKNMKLINLQGFEFNESKIGSALKAKDERAVKILNDFGVLLKNNTSDVIFTQLDLRNLLDIKIYYNGICVKIGTSDQIEKKLNTAINILKRDELKKAKKGYVDVSYEGNPVFYIEK | Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex. | A5I1U0 |
Q0I8T6 | DNAA_SYNS3 | Chromosomal replication initiator protein DnaA | unclassified Synechococcus | MELTGSELWDKVQHALQSNLSKPTFETWIRPARCSSFQDRMLTLQAPNSFASNWLRKNYASTIAEVAQEIIGHPIEVIVLAQDDEDAESGSTPLSRVSTSNQPLASTAAEAAAAVSAPPSTAPRRLPGLNMRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPLFICGGVGLGKTHLMQAIGHYRLEIDPEARVFYVSTETFTNDLITAIRKDGMQAFRDRYRAADLILVDDIQFIEGKEYTQEEFFHTFNALHDAGRQIVIASDRPPSQIPRLQERLISRFSMGLIADIQAPDLETRMAILQKKAEQERVALPRDLIQ... | Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Q0I8T6 |
B7L0R2 | RL4_METC4 | 50S ribosomal protein L4 | Methylorubrum | MKLDITTLDGGSAGSVELNEAIYGLEPRADILQRMVRYQLAKRRAGTHAVKNRSDVDRTSKKLYKQKGTGNARHGAASAPQFRGGGRAFGPVVRDHSHDLPKKVRALALKHALSAKAKASTLIVVDDIKVDNHKTKAMIERFEKLGLSSALIIGGSEVDENFGRAARAIPKIDVLPVQGINVYDILRRDTLVLTRAAVDALEERFK | Forms part of the polypeptide exit tunnel. | B7L0R2 |
B7MSY3 | MUTL_ECO81 | DNA mismatch repair protein MutL | Escherichia | MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD... | This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part ... | B7MSY3 |
B5E230 | HRCA_STRP4 | Heat-inducible transcription repressor HrcA | Streptococcus | MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVHLLNFANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQVNV... | Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. | B5E230 |
Q81W03 | SYM1_BACAN | Methionyl-tRNA synthetase 1 | Bacillus cereus group | MTEENKSFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKCMQGYNVHYLTGTDEHGQKIQKKAEELNVTPQAYVDNIVAGIKELWEKMDISYDDFIRTTEDRHKDVVEKIFKQLVDQGDIYLDEYEGWYSVQDETFYTEHQLVDPIMEGDKVVGGKSPDSGHDVELVREESYFFRMGKYVDRLLKFYEDNPHFIQPESRKNEMINNFIKPGLEDLAVSRTSFDWGVRVPGNPKHVIYVWVDALSNYITALGYGTENEEMYKKFWPADVHLVGKEIVRFHTIYWPIILMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVD... | Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Q81W03 |
A3KGW5 | GT253_MOUSE | Cerebral endothelial cell adhesion molecule | Mus | MHVARLLPLLLLLGQQLRAASVTEPTLPTVVLAILARNAEHSLPHYLGALERLDYPRARLALWCATDHNMDNTTGMLREWLAAVGRDYATVVWKPEEEARSYPDEQGPKHWTKERHQFLMELRQEALAFARDWGADYILFADTDNILTNNQTLKLLIDRQLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRQGCFRVPMVHSTFLLSLQTEETARLAFYPPHPNYSWPFDDIIVFAYACQAAGVSMHVCNDHRYGYMNVVVKPHQSLEEEKTNFIHLILEALVDGPPMLASAHVSRPPKKLSKMGFDEVF... | Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro. | A3KGW5 |
P0A4N1 | MALC_STRPN | Maltodextrin transport system permease protein MalC | Streptococcus | MKGVNMEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFLALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRINNGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLPPNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQPFIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALIPWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPND... | Part of the binding-protein-dependent transport system for maltodextrin; probably responsible for the translocation of the substrate across the membrane. | P0A4N1 |
Q9HI27 | GVPL1_HALSA | Protein GvpL 1 | Halobacterium | MTDHRPSPEEEQTTANEERTVSNGRYLYCVVDTTSSESATLSTTGVDDNPVYVVEADGVGAVVHDCETVYETEDLEQVKRWLVTHQQVVDAASDAFGTPLPMRFDTVLEGGDASIERWLEDHYEGFRDELASFAGVWEYRINLLWDSAPFEETIADRDDRLRELRQRQQQSGAGKKFLLEKQSDQRLQELKRERRTELADQLKEAITPVVNDLTEQDTNTPLQDEHSSIEKEQIVRFAVLADEDDETALGDRLDTIVEHEGVEIRFTGPWPPYTFAPDIGK | May play a structural or regulatory role in gas vesicle synthesis. | Q9HI27 |
Q608M7 | RNC_METCA | Ribonuclease III | Methylococcus | MIRSHEHLARKLGIPFRDPGLLRNALTHRSAEGVNNERLEFLGDSVLGFVVTEYLYQRFPSADEGVLSRLRATLVNETSLARIARELELGEYLILGSGELKSGGYRRDSILSDALEAILGAVLRDQGIDACRALILTLFERPLSALSLDDWKKDPKTRLQELMQGRGLPLPVYTLIDQSGLPHDQHFRVRCEVPLAVEPCVGEGSSRKKAEQQAAENMLSRLSDQSRFRV | Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Q608M7 |
Q1IFU7 | RL15_PSEE4 | 50S ribosomal protein L15 | Pseudomonas | MKLNDLSPAPGSRREKHRPGRGIGSGLGKTGGRGHKGQTSRSGGSIAPGFEGGQQPLHRRLPKFGFVSLKAMDRAEVRLSELAKVEGDLITVQSLKDANVIGQHVQRVKIMLSGEVTRAVTLKGIAVTKGARAAIEAAGGKFEE | Binds to the 23S rRNA. | Q1IFU7 |
Q5PRA2 | DHTK1_DANRE | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial | Danio | MLIHLPRLLHRSFGARRSFLASLYHTQRGVYGFRPRDGPERRAELTQISALNRDHGLARLVEAYRAHGHKVAKINPLLPQSPVLESVPEISLLNGAVRGVLNTTGLRHFGKAEATAEEVVAYLESTYCGGISVETSQLQTLEEREWFADRFEELKKEAFSPEERRMLAKLMLESQEFDHFLATKFATVKRYGGEGAESMMGFFYELFRSSVYSGVTDVVMGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPEHSPSIGDVLSHLTSTVELDFGAGHPLHVTMLPNPSHLEAINPVTQGKTRGRQQVKQDGDYSTDPHS... | 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate vi... | Q5PRA2 |
A0QNH5 | SAEB_MYCS2 | Putative ESX-1 scaffolding and assembly protein SaeB | Mycolicibacterium | MTSRFGQLTYTSFDAVGTVGGWQVKETSDALTPEETQLMLAGVRTVFRTVEPMPDYPTPEQLEAAPRRLAYSRVGETYAALWHTVPAGADSTGRPGNVFAHVLLDRTPDVAPRHRAIQWWRSPHWLCPYGATAVSRAALAEPGAEPGRVVTKDSVVAFALDTTTWRLATLFGLLDAVAAALDGGPPVVLGVESPDNAAQWIGLLSFLMSPGTAAQLSFSTFDRADQLNPHSGQMLSAVPLEDLSAVPAGMVAISEAETLSLGELGGEPHRTAGGYAIDVTPWSAMAQVVVLDPGSARRLLDDIDAVAEQVRDSGLHPAWP... | May be involved in assembly of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB . Involved in DNA conjugation in recipient (MDK8) but not donor (mc(2)155) strain . | A0QNH5 |
B9JEX1 | EFTS_AGRRK | Elongation factor Ts | Agrobacterium tumefaciens complex | MTEITAALVKELREKSGAGMMDCKKALIETNGDIEAAIDWLRAKGISKADKKSGRTAAEGLVAIAGAGHKAVVVELNSETDFVARNDAFQELVRGIAEVALSTDGTVEAISAATYPASGKPVADTIKDAIATIGENMTLRRAAKLEVEHGVVATYIHNAAGDGIGKLGVLVALKSVGDKAVLTSIGRQVAMHIAATNPLAIRAEEVDAAVAERERNVFIEQSRESGKPEAIIEKMVEGRMRKFFEEVALLSQAFVINPDLTVGAAIKEAEKTAGAAIEVVGMARLLLGEGVEKEEADFAAEVAAVAKG | Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. | B9JEX1 |
C0QS00 | PROA_PERMH | Glutamyl-gamma-semialdehyde dehydrogenase | Persephonella | MDIKFYTEKLAREARESQKFLRRVTTDIKNRVLLRTAELLIEKKEIIKEANDKDLEFAQKKGYSKALLDRLTLNEKRINGMVQVLKDVASLPDPVGEIISMWTRPNGLRVGQMRVPLGTVMIIYEARPNVTVEAASLCIKSSNAVILKGGSETINSNRVLVEILRQAARESGFPERAIQFVDTTDREAVNHLLTLDQYIDVVIPRGGEGLIRAVAEKATMPVIKHYKGVCNLYIDDEADMEKALNIAYNAKVERPSVCNAIENLIVHKDIAEKFLPEIAYYYGKAGVEMRCDERALEILRDHPKANDTEIVPAKEDDYYE... | Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. | C0QS00 |
B0RZW0 | DNLJ_FINM2 | Polydeoxyribonucleotide synthase [NAD(+)] | Finegoldia | MEKQDRIKYLVDILNKYAYHYYTLDDPLIADSEYDVLYDELVNLEKETGIVLPNSPTNRIGGEVLSGFEKHEHLNTLYSLGKAQSKEEVRNWVDKTIEFVQNYNENHVNKLPKVEFYVEFKFDGLTVNLTYDGGYLVMATTRGNGTIGEVITSQVKTINSIPLKIKDTRLMEIQGEGVMPLSSLENYNKTHEPKLKNARNAAAGALRNLDPAVTRERNLDAYFYNVNYLQDNELETQEEMIKFLGDNYFKLYPYEKHATSFEEVSKFIDEIFELRNEIDVLTDGVVIKVNDFKTREKLGYTNKFPRWAIAYKFEPERFTT... | DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | B0RZW0 |
A9MJF2 | HUTG_SALAR | Formiminoglutamate hydrolase | Salmonella | MTQWYPVSPTLWQGRDDSAEAADARRLFQTVIRSEDFAPQDWPKQIALMGFACDEGVKRNAGRPGAAGAPDALRKALANMASHNGHERLVDLGNWVAQAPDLEGAQQTLRDAVRRCLCAGMRTLVLGGGHETAFGHGAGVLDAFAQESVGIINLDAHLDLRQTERATSGTPFRQLAQLCDAQRRVFHYACFGVSRAANTRALWREATRRNVTVVEDLDCYNALAQMTQFIARVDKIYLTIDLDVLPVWEMPAVSAPAALGVPLIQILRLIEPVCRSGKLQAADLVEFNPRFDKDGAAARVAARLGWQIAHWWR | Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide. | A9MJF2 |
Q4ZVE8 | TUSA_PSEU2 | Sulfur carrier protein TusA | Pseudomonas syringae | MSEPIENLTVDAELDAVGLFCPEPVMMLHQKVRDLPAGGLLKVIATDPSTRRDIPKFCVFLGHELVAEQAEEGTFLYWIRKKSD | Sulfur carrier protein which probably makes part of a sulfur-relay system. | Q4ZVE8 |
Q5F3F5 | LMBD2_CHICK | G-protein coupled receptor-associated protein LMBRD2 | Gallus | MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIIATLLAWYLCFLIVFILPLDVSTTIYNRCKLAVNSSPAESNSSFVTLAPSKQQCFKPWSYIPNGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPKFNLQWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSHWNGAKRGYLLMKTYFKAAKLMTEKADAEENLEDIMEEVRKVSESIKYNHPLRKCVDTILKKCPTEYQERMGRNMDDYEDFDERQNSYPSEKSLVKLHKQVIYSVQRHRRTQVQ... | May associate with G-protein coupled receptors and regulate downstream signaling pathways. | Q5F3F5 |
A3LNR6 | HAS1_PICST | ATP-dependent RNA helicase HAS1 | Scheffersomyces | MAKNVNSKANGKKSGSVKRALKEKKQPEPEFSDSEDDEVDQEKLVEELDEDFDEVANMLGADVTDPEEKKQSKLERKRKRDEEATAEYTKPEVVDNEDDAQNDKFEDAGLSEPTMRAISDMGFKTMTKVQAKTIPPLLAGKDVLGAAKTGSGKTLAFLIPAIELLYSLKFKPRNGTGVIVVSPTRELALQIFGVARELMAHHTQTFGIVIGGANRRQEAEKLAKGVNLLIATPGRLLDHLQNTQGFVFKNLKALVIDEADRILEIGFEEEMKQIIKILPKEERQSMLFSATQTTKVEDLARISLRPGPLYINVVPETAAS... | ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. | A3LNR6 |
Q9UTN3 | CID14_SCHPO | Polynucleotide adenylyltransferase cid14 | Schizosaccharomyces | MGKKSVSFNRNNYKKRKNERTEPLPRRIFKNDKPSKFKSKRKEKDKNSDAYDEMLLNNNFTLLDQEEPMVEIGSKKSRNDNDSEGIRDKGGVEISNKNDPYIQFGKADPLEPLEKPDLPEEAIKRGEPTILLGIPKREGRKTNPVHDKAVENNSDFIKFDWNSDEDEDSVSNDKSKNNESLKKSSKNEIPGFMRQRGRFFHEANEKSDSNRKRKRQAYELDSQSCPWHRQYKVEREVSRIFHQDILHFIDYITPTPEEHAVRKTLVSRINQAVLQKWPDVSLYVFGSFETKLYLPTSDLDLVIISPEHHYRGTKKDMFVL... | Required for 3' polyadenylation of the 5.8S and 25S rRNAs as a prelude to their degradation in the exosome. Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis. | Q9UTN3 |
P58414 | CADA_LISMO | Cadmium-efflux ATPase | Listeria | MSKASKQTTYRVDGMSCTNCAGKFEKNVKNLEGVTDAKVNFGAGKISVYGETSISQIEKAGAFENLRVTDEKDYSSKPAKKESFLKKNWHLVVSIIFIILAFISQNISGEDSTTTIILYVIAIVVGGFNLFKEGFANLIKLDFTMESLMTIAIIGASIIGEWAEGSIVVILFAFSEVLERYSMDKARQSIRSLMDIAPKEALIRRDDVEQMIAVSDIQIGDIMIIKPGQKIAMDGVVIKGYSAINQSAITGESIPVEKKVDDEVFAGTLNEEGLLEVKVTKHVEDTTISKIIHLVEEAQGERAPAQAFVDKFAKYYTPTI... | Couples the hydrolysis of ATP with the export of cadmium. | P58414 |
Q5MCS0 | VSPHA_HYDHA | Snake venom serine protease | Hydrophis | MPLIRVLASLLILQLSYGKSLDNGAKAITSLDRIIGGFECNPSEHRSLVYLYNSAGFFCSGTLLNHEWVLTAAHCNREDIQIRLGVHNVHVHYEDEQIRVPKEKLCCLSTNNCTQFSQDIMLIRLNSPVNYSEHIAPLSLPSNPPSMGSVCCVMGWGTITSPEVTYPEVPHCVDINILHIPVCQAAYPTMSGKNILCAGILEGGKDSCKGDSGGPLICNGQIQGIVSWGRFPCAQFLEPGIYTKVFDYKDWIEGIIAGNSNVICP | Serine protein with fibrinolytic and fibrinogenolytic activities. Degrades Bbeta-chain (FGB) of fibrinogen first and then the Aalpha-chain (FGA). Gamma-chain (FGG) are also digested on prolonged incubation. In vitro, it cleaves high molecular weight (HMW) kininogen (KNG) releasing bradykinin that promotes vasodilation.... | Q5MCS0 |
A4VYQ4 | RL24_STRS2 | 50S ribosomal protein L24 | Streptococcus | MFVKKGDKVRVIAGKDKGVEAVVVTALPKVNKVIVEGVNIVKKHQKSNSENPQGAIVEKEAPIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD | One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. | A4VYQ4 |
Q6C4H1 | EIF3F_YARLI | Eukaryotic translation initiation factor 3 subunit F | Yarrowia | MSETLQISRVAGTNGAPTHVTVTAQALFQILDHALRREEEQSKVIGTLVGIRSEDGSEVEVRNAYAVPHSESEQEMTIDLEYNPTMLALHRKAFPKEVIVGWYATSSELNTFSGLIHDYYTQLDGTPAIHLTVEAANLADTLLPRTYVASAVGIDPSKNSGNCVFVPISNEVKFNDSADRAALEAISSARESPERSINLTSDLANLENSLTQVLDMLERVQTYVARVISGEESSEKAQQVGKQLLSTLTLTPSLDAQNLEALFNSHLQDVLMVVYLANTVKTQLQLSAKLTTLV | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates t... | Q6C4H1 |
Q8KM02 | SLYA_PHOLL | Transcriptional regulator SlyA | Photorhabdus | MESTLGSDLARLVRIWRALIDYRLKPLELTQTHWVTLYNISRLPQEQSQIQLAKAIGIEQPSLVRTLDQLEEKKLITRHTCANDRRAKRIKLTEDSASVIRELDGVIESTRNEILGGISREELAFLSTLVQKLEQNIIQLQSR | Transcription regulator that can specifically activate or repress expression of target genes. Regulates the cpm operon, which contains cpmA, cpmB, cpmC, cpmD, cpmE, cpmF, cpmG and cpmH, involved in carbapenem-like antibiotic production. | Q8KM02 |
B1JR11 | YIHI_YERPY | Der GTPase-activating protein YihI | Yersinia | MKQPNKAPRANIAAPKGTATPKRRRKTRDELDAEARDRKRQKKHSGNRSGARTNVEGSNKKGHSQTQEKDPRVGSKVPVPLVIESQVKAKSMPKPVENNVVKPRLTPEEELAKLENDERLDALLDRLDNDEVLNKEDQAYVDLTLDRIDALMEQLGIELGDDEDDVEREEKQEDILQLLKRGNPKDTF | A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. | B1JR11 |
Q5L3Z9 | EFTU_GEOKA | Elongation factor Tu | Geobacillus thermoleovorans group | MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITTVLAKQGKAEAKAYDQIDAAPEERERGITISTAHVEYETDARHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLSEYDFPGDEVPVIKGSALKALEGDPQWEEKIIELMNAVDEYIPTPQREVDKPFMMPIEDVFSITGRGTVATGRVERGTLKVGDPVEIIGLSDEPKTTTVTGVEMFRKLLDQAEAGDNIGALLRGVSRDEVERGQVLAKPGSITPHTKFKAQVYVLTKEEGGR... | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. | Q5L3Z9 |
Q82WC5 | CCME_NITEU | Heme chaperone CcmE | Nitrosomonas | MKPRHKKMAVIALSVSALTVAVVLVLNAFQSNLVFFFSPSQVAAKEAPIGKSFRIGGLVEEGSLKREGDGTTLNFAITDTAEVIRVVYTGILPDLFKEGKGVVAQGKMADDGIFYADEVLAKHDENYMPPEAASALEQAAKAQKTSLAQ | Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. | Q82WC5 |
B9MKG1 | KAD_CALBD | Adenylate monophosphate kinase | Caldicellulosiruptor | MRLILLGAPGAGKGTQAEYLSKRFSIPHISTGDILRENVKNETELGKKAKEYMDKGLLVPDEIVIEIVKDRLSKEDCKNGFLLDGFPRTIAQAEALDKVLEELGQKIDKVLNIEVPDEKILERMSGRRICKNCGASFHVIYRPPQKEGVCDVCGGELYQREDDKEETVKKRLEVYHAQTQPLIDYYKAKGLLVVAYGQEEIADTTKEVLKALGIE | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. | B9MKG1 |
Q98QV3 | FOLD_MYCPU | Methenyltetrahydrofolate cyclohydrolase | Mycoplasmopsis | MMKKLLSNELVQIKRAELKEKFSKLDQKVKFAIVLIGDNASSKIYVKKKIEFAQDIGVEAKLFHFEENVDFNLLKDAFKKIDKEYDGIILQLPVLHFDVNELLLMIDKNKDLDGLNPENEKAFYENRECIIPATARAIWTFLKFHKISVENKKVFVVGQSRLVGKPISQFLKNNNAIVRVFDKSTGLKGTEEADILIVATGVAQLIKAENIKENSILIDVGFSKINNKIYGDLDIESIKEKALKYTPPIGAIGPVTVLSLFENLYEIILKKK | Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Q98QV3 |
B8ISA2 | RS5_METNO | 30S ribosomal protein S5 | Methylobacterium | MAREREGRRRDDREERDSEFVDRLVHINRVAKVVKGGRRFGFAALVVVGDQKGRVGFGHGKAREVPEAIRKATEAAKRGLVRVALREGRTLHHDVAGRHGAGKVILRAAPQGTGIIAGGPMRAVFESLGMQDVVAKSLGSSNPYNLIRATFDALKREDSPRAVAARRGLKVSTLQARRRDAEPGADAADAA | Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. | B8ISA2 |
B2UYH3 | GLMM_CLOBA | Phosphoglucosamine mutase | Clostridium | MDRMFGTDGVRGIANTELTAQMAYNLGRAGAYVLTEGAHKPKILVAKDTRISGDMLESALVAGILSVGAEAVILGVVPTPAVAYLTREYNADAGVMISASHNPVEYNGIKFFNNKGYKLSDELEDGIQKVIESDFEGVPSPIGIDLGRERIEVAALEDYTEFAKQTIPYNLKGMKIALDCANGASYKSAVKAFRDLGADVFVINDNPDGTNINKNCGSTHPEELMDYVVKKGCDLGFAFDGDADRCLAVDENGKLINGDFILMLCANYLKEIGKLKDDTLVVTVMSNLGLDIACRGLGIKLEKTKVGDRYVLEEMTKDNY... | Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. | B2UYH3 |
Q39UF9 | GLMM_GEOMG | Phosphoglucosamine mutase | Geobacter | MKKLFGTDGVRGVANVYPMTTEMAMQIGRAAAYLFKNGNRRHRIVIGKDTRLSGYMLENALVAGICSMGVDVLVVGPLPTPGIANITSSMRADAGVVISASHNAFQDNGIKFFSRDGFKLPDEMELKIEELIFSKKIDSLRPIATEVGKAYRIDDAVGRYVVFLKNTFPKELDLTGMKIVLDCANGAAYKVAPAVLEELGAEVIPYGIKPNGTNINAGFGSLHPEVISEAVKEHRADLGIALDGDADRVIFVDEFGNEVDGDHIMAICATDMLKHKKLRKNTLVATVMSNMGLDIAVKKAGGKVIKTAVGDRYVVEEMLK... | Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. | Q39UF9 |
Q5P7X8 | RL20_AROAE | 50S ribosomal protein L20 | Aromatoleum | MSRVKRGVTARARHKKVLDQAKGYRGRRKNVYRIAKQAVMKAGQYAYRDRRQRKRQFRALWIARINAAAREVGLTYSTFMNGLKKAAIEVDRKVLADLAVFDKPAFAALADQARAKLAA | Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | Q5P7X8 |
Q21W25 | RLMN_ALBFT | tRNA m2A37 methyltransferase | Rhodoferax | MTANLLDFDLDGLAVFCERLGEKRYRAVQLFRWIHQKGASNFDDMSDLAKSLREKLKVSAQVKAPDLISQHISSDGTIKWLFDVGGGDAVEAVFIPEEDRGTLCISSQAGCAMGCRFCSTGHQGFSRNLKTGEIIAQLWFAEHFLRKHLQRDERVISNVVMMGMGEPLQNYAELVPALRAMLDDHGYGLSRRRVTVSTSGVVPMMDRLARDCPVALAVSLHAPNDLLRDDLVPLNKKYSLAELLNACNRYLAYAPRDFITFEYCMLEDVNDQPEHAQQLVRLVQHYSSGGVWCKFNLIPFNPFPASGLTRSTPERIQAFA... | Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. | Q21W25 |
Q3A6N3 | RS8_SYNC1 | 30S ribosomal protein S8 | Syntrophotalea | MAMTDPIADMLTRIRNAGLAKHQKCDMPASNVKLAIVNVLKELGYIKNFKQISDDKQGILRIYLKFDNENKHIIHAIDRVSTPGCRVYVGKDEIPVVKNGLGNAILSTSKGVMHDAAAREAQLGGEVLCSVW | One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. | Q3A6N3 |
Q46633 | AMSC_ERWAM | Amylovoran biosynthesis protein AmsC | Erwinia | MAIYWIVSYSILVFCFFELAMINQASEAKTKILINYFFLIGVFALILFAGIRGPDSGMDDSQYVGFFHDFSRQTGMTGYQAVANIYRYENFFMVLAWVASCFTHESYFFLLFISFIAVSTNAWVYKKYSPLILCSLCLYSAHLFINKDMNQIRFGLCSAFAIAFICSLVARNYLLALLFIVLSTQSHSTGYTIVMIIPFFFIRERKYLPLVLVIASIPLGIIGGKKLFLDSLGIVPVLGERAASYSGTNFDTTSPVFGLANLKNIAFIGAFTLYYFRKGIMKEDRFVYILLIAYSIGAAVRITFSDFSIFGGRVGNLFLH... | Involved in the biosynthesis of amylovoran which functions as a virulence factor. | Q46633 |
A6VCK5 | TPIS_PSEA7 | Triose-phosphate isomerase | Pseudomonas | MRRPLVAGNWKMHGTHSSVADLIKGLRQLALPSGVDVAVMPPCLFISQVVQGLAGKAIGVGAQNSAVEPMQGALTGEIAPSQLADAGCGMVLVGHSERRLILGESDEVVSRKFAAAQSCGLVPVLCVGETRAEREAGKTLEVVARQLGSVIDELGVGAFARAVVAYEPVWAIGTGLTASPAQAQEVHAAIRAQLAAENAEVAKGVRLLYGGSVKAASAAELFGMPDIDGGLVGGASLNADEFGAICRAAGS | Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). | A6VCK5 |
A8FAR9 | GATC_BACP2 | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C | Bacillus | MSRISIEEVKHVAHLARLAITEEEAEMFTEQLDSIISFAEQLNEVDTENVEPTTHVLKMKNVMREDVPNKGLSIEAVIKNAPDHKDGYIRVPSILD | Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated ... | A8FAR9 |
O22897 | DUF6_ARATH | DUF724 domain-containing protein 6 | Arabidopsis | MEETIRKGSEVEVSSTEEGFADAWFRGILQENPTKSGRKKLRVRYLTLLNDDALSPLIENIEPRFIRPVPPENEYNGIVLEEGTVVDADHKDGWWTGVIIKKLENGKFWVYYDSPPDIIEFERNQLRPHLRWSGWKWLRPDIQELDKSMFSSGTMAEVSTIVDKAEVAWFPAMIIKEIEVDGEKKFIVKDCNKHLSFSGDEARTNSTIDSSRVRPTPPPFPVEKYELMDRVEVFRGSVWRQGLVRGVLDHNCYMVCLVVTKEEPVVKHSDLRPCKVWEDGVWQDGPKQTPVIETPSNVMKTKPMRSCSGAKSMTPKRTTK... | May be involved in the polar growth of plant cells via transportation of RNAs. | O22897 |
B1X0B0 | DER_CROS5 | GTP-binding protein EngA | Crocosphaera subtropica | MALPIVAIIGRPNVGKSTLVNRLAKDRQAIVHDQPGITRDRTYRPAFWCDRDFQVVDTGGLVFDDDTEFLPLIREQAMAALTEASAAIFVVDGQLGPTAGDREISDWLRRQKVPVLLAVNKCESPEMGLIQAAEFWELGLGEPYPISGIHGSGTGELLDQLITYLPSPDELPDREEINVSIIGRPNVGKSSLLNAFLGEQRAIVSPISGTTRDAIDTVVERGDNTYRLIDTAGIRRKKNVNYGAEFFSINRAFKAIRRADVVLLVIDAIDGVTDQDIKLADRIIDEGRAAIIVVNKWDAVEKDSYTIYDYKQKVMDRLYF... | GTPase that plays an essential role in the late steps of ribosome biogenesis. | B1X0B0 |
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