| { |
| "_meta": { |
| "purpose": "Hand-written retrieval sanity set. Each question lists passage ids that correctly answer it; a hit means one of them is in the top 3. Written from the passage content, then frozen, so it checks retrieval and does not tune it.", |
| "recorded": "2026-10-01" |
| }, |
| "tcga-nsclc": [ |
| { |
| "q": "which features separate squamous from adenocarcinoma of the lung", |
| "expect": [ |
| "lung-luad-vs-lusc", |
| "lung-lusc-cytomorphology" |
| ] |
| }, |
| { |
| "q": "keratin pearls intercellular bridges", |
| "expect": [ |
| "lung-lusc-cytomorphology", |
| "lung-lusc-definition", |
| "lung-luad-vs-lusc" |
| ] |
| }, |
| { |
| "q": "glandular acinar pattern mucin production", |
| "expect": [ |
| "lung-luad-definition", |
| "lung-luad-cytomorphology", |
| "lung-luad-grading" |
| ] |
| }, |
| { |
| "q": "how is lung adenocarcinoma graded by pattern", |
| "expect": [ |
| "lung-luad-grading" |
| ] |
| }, |
| { |
| "q": "TTF-1 Napsin A p40 p63 staining", |
| "expect": [ |
| "lung-luad-ihc", |
| "lung-lusc-ihc" |
| ] |
| }, |
| { |
| "q": "squamous carcinoma subtypes basaloid keratinizing", |
| "expect": [ |
| "lung-lusc-subtypes" |
| ] |
| }, |
| { |
| "q": "lepidic micropapillary predominant pattern subtypes of adenocarcinoma in situ", |
| "expect": [ |
| "lung-luad-subtypes", |
| "lung-luad-grading" |
| ] |
| }, |
| { |
| "q": "poorly differentiated solid tumour ambiguous morphology what resolves it", |
| "expect": [ |
| "lung-luad-vs-lusc" |
| ] |
| }, |
| { |
| "q": "What growth patterns are recognised in lung adenocarcinoma and how do lepidic, acinar, papillary, micropapillary and solid look?", |
| "expect": [ |
| "lung-luad-libre-growth-patterns", |
| "lung-luad-patterns-who-2021-wikipedia" |
| ] |
| }, |
| { |
| "q": "What distinguishes lepidic growth from invasive adenocarcinoma in the lung?", |
| "expect": [ |
| "lung-luad-lepidic-definition", |
| "lung-luad-libre-extent-classification" |
| ] |
| }, |
| { |
| "q": "How is lung adenocarcinoma graded by its dominant growth pattern and what is the 20 percent high-grade rule?", |
| "expect": [ |
| "lung-luad-grading-who-vs-iaslc", |
| "lung-luad-grading-iaslc-biopsy-cohort", |
| "lung-luad-grading-cap-libre" |
| ] |
| }, |
| { |
| "q": "Do pathologists agree on the predominant pattern of lung adenocarcinoma?", |
| "expect": [ |
| "lung-luad-pattern-interobserver-variability", |
| "lung-luad-pattern-ai-agreement" |
| ] |
| }, |
| { |
| "q": "Which nuclear and cytoplasmic features suggest adenocarcinoma of the lung on H&E?", |
| "expect": [ |
| "lung-luad-libre-microscopy", |
| "lung-luad-cohort-morphology" |
| ] |
| }, |
| { |
| "q": "How common is an acinar component in lung adenocarcinoma and what is its prognosis?", |
| "expect": [ |
| "lung-luad-acinar-definition" |
| ] |
| }, |
| { |
| "q": "What are keratin pearls and intercellular bridges and why do they point to squamous carcinoma of the lung?", |
| "expect": [ |
| "lung-lusc-keratin-pearls-bridges-review", |
| "lung-lusc-libre-microscopy", |
| "lung-lusc-cohort-morphology" |
| ] |
| }, |
| { |
| "q": "What is the difference between keratinizing, non-keratinizing and basaloid squamous carcinoma?", |
| "expect": [ |
| "lung-lusc-subtypes-wikipedia" |
| ] |
| }, |
| { |
| "q": "How is squamous cell carcinoma of the lung graded by keratinization?", |
| "expect": [ |
| "lung-lusc-libre-microscopy", |
| "lung-lusc-keratinization-grading-cohort" |
| ] |
| }, |
| { |
| "q": "Can squamous carcinoma grow under alveolar pneumocytes and look like a lepidic tumour?", |
| "expect": [ |
| "lung-lusc-subepithelial-growth-mimic" |
| ] |
| }, |
| { |
| "q": "What patterns does peripheral squamous carcinoma show and which carries a good prognosis?", |
| "expect": [ |
| "lung-lusc-definition-pattern-series", |
| "lung-lusc-subepithelial-growth-mimic" |
| ] |
| }, |
| { |
| "q": "How can I tell lung adenocarcinoma from squamous carcinoma on H&E when glands are not obvious?", |
| "expect": [ |
| "lung-luad-vs-lusc-libre-bridges-mucin", |
| "lung-luad-vs-lusc-solid-variant-nos" |
| ] |
| }, |
| { |
| "q": "When does H&E morphology misclassify lung adenocarcinoma versus squamous carcinoma on a small biopsy?", |
| "expect": [ |
| "lung-luad-vs-lusc-ihc-reclassification", |
| "lung-luad-vs-lusc-adenosquamous" |
| ] |
| }, |
| { |
| "q": "How do I prove that a solid tumour without glands is adenocarcinoma rather than non-keratinizing squamous carcinoma?", |
| "expect": [ |
| "lung-luad-solid-mucin-lineage", |
| "lung-luad-vs-lusc-solid-variant-nos", |
| "lung-luad-libre-special-stains" |
| ] |
| }, |
| { |
| "q": "Is tumour location central or peripheral useful for separating lung adenocarcinoma from squamous carcinoma?", |
| "expect": [ |
| "lung-luad-vs-lusc-location-clinical", |
| "lung-lusc-keratin-pearls-bridges-review" |
| ] |
| }, |
| { |
| "q": "What are the differential diagnoses listed for lung adenocarcinoma?", |
| "expect": [ |
| "lung-luad-libre-differential" |
| ] |
| } |
| ], |
| "bracs-fine": [ |
| { |
| "q": "difference between atypical ductal hyperplasia and ductal carcinoma in situ", |
| "expect": [ |
| "breast-adh-vs-dcis", |
| "breast-hard-boundaries" |
| ] |
| }, |
| { |
| "q": "usual ductal hyperplasia no atypia", |
| "expect": [ |
| "breast-udh" |
| ] |
| }, |
| { |
| "q": "flat epithelial atypia apical snouts calcifications", |
| "expect": [ |
| "breast-fea" |
| ] |
| }, |
| { |
| "q": "loss of myoepithelial layer stromal invasion", |
| "expect": [ |
| "breast-ic" |
| ] |
| }, |
| { |
| "q": "what is in the pathological benign category", |
| "expect": [ |
| "breast-pb" |
| ] |
| }, |
| { |
| "q": "comedonecrosis pleomorphic nuclei high grade", |
| "expect": [ |
| "breast-dcis-grades" |
| ] |
| }, |
| { |
| "q": "cribriform micropapillary monomorphic cells partial involvement of ducts", |
| "expect": [ |
| "breast-adh-khoury", |
| "breast-adh-bracs" |
| ] |
| }, |
| { |
| "q": "normal breast tissue luminal and myoepithelial cells epithelium to stroma ratio", |
| "expect": [ |
| "breast-normal" |
| ] |
| }, |
| { |
| "q": "how is the whole slide label defined in BRACS", |
| "expect": [ |
| "breast-wsi-label-rule" |
| ] |
| }, |
| { |
| "q": "why are atypical lesions clinically important", |
| "expect": [ |
| "breast-atypical-significance" |
| ] |
| }, |
| { |
| "q": "What does normal breast tissue look like at gland level?", |
| "expect": [ |
| "breast-n-libre-resting-breast", |
| "breast-n-bracs-paper-tissue" |
| ] |
| }, |
| { |
| "q": "Which cell layers line a normal breast duct and how are they shown by stain?", |
| "expect": [ |
| "breast-n-myoepithelium-key", |
| "breast-n-libre-resting-breast" |
| ] |
| }, |
| { |
| "q": "How does stroma in normal breast differ from benign pathology?", |
| "expect": [ |
| "breast-n-vs-pb-ratio-and-glands", |
| "breast-n-libre-resting-breast" |
| ] |
| }, |
| { |
| "q": "What is the ratio of epithelium to stroma in normal versus benign lesion tissue in BRACS?", |
| "expect": [ |
| "breast-n-bracs-paper-tissue", |
| "breast-n-vs-pb-ratio-and-glands" |
| ] |
| }, |
| { |
| "q": "Which benign lesions are grouped into the pathological benign class of BRACS?", |
| "expect": [ |
| "breast-pb-bracs-composition" |
| ] |
| }, |
| { |
| "q": "What are the H&E features of fibrocystic change?", |
| "expect": [ |
| "breast-pb-fibrocystic-libre" |
| ] |
| }, |
| { |
| "q": "How does sclerosing adenosis mimic carcinoma on H&E?", |
| "expect": [ |
| "breast-pb-sclerosing-adenosis-libre" |
| ] |
| }, |
| { |
| "q": "What distinguishes an intraductal papilloma from papillary DCIS?", |
| "expect": [ |
| "breast-pb-papilloma-libre", |
| "breast-dcis-subtypes-architecture" |
| ] |
| }, |
| { |
| "q": "What stromal features define a fibroadenoma?", |
| "expect": [ |
| "breast-pb-fibroadenoma-libre-wikipedia" |
| ] |
| }, |
| { |
| "q": "Is fibrocystic change benign or does it imply cancer risk?", |
| "expect": [ |
| "breast-pb-fibrocystic-libre", |
| "breast-n-vs-pb-ratio-and-glands" |
| ] |
| }, |
| { |
| "q": "How many cell layers does usual ductal hyperplasia have and what do its lumina look like?", |
| "expect": [ |
| "breast-udh-libre-florid-hyperplasia", |
| "breast-udh-wikipedia-histology" |
| ] |
| }, |
| { |
| "q": "Why is usual ductal hyperplasia not atypical?", |
| "expect": [ |
| "breast-udh-bracs-and-terminology", |
| "breast-udh-libre-florid-hyperplasia" |
| ] |
| }, |
| { |
| "q": "Which immunostain pattern separates usual hyperplasia from atypical hyperplasia?", |
| "expect": [ |
| "breast-udh-ck56-er-pattern" |
| ] |
| }, |
| { |
| "q": "What risk does usual ductal hyperplasia carry compared with atypical hyperplasia?", |
| "expect": [ |
| "breast-udh-risk-and-molecular", |
| "breast-udh-libre-florid-hyperplasia" |
| ] |
| }, |
| { |
| "q": "What do columnar cell lesions with atypia look like and how many cell layers are involved?", |
| "expect": [ |
| "breast-fea-who-definition-ccl-spectrum", |
| "breast-fea-libre-features" |
| ] |
| }, |
| { |
| "q": "How reproducible is the diagnosis of flat epithelial atypia between pathologists?", |
| "expect": [ |
| "breast-fea-interobserver-variability", |
| "breast-fea-vs-adh-expert-disagreement" |
| ] |
| }, |
| { |
| "q": "What is the difference between columnar cell change and flat epithelial atypia?", |
| "expect": [ |
| "breast-fea-who-definition-ccl-spectrum", |
| "breast-fea-libre-features" |
| ] |
| }, |
| { |
| "q": "What cytologic features define flat epithelial atypia in the BRACS description?", |
| "expect": [ |
| "breast-fea-bracs-and-expert-definition" |
| ] |
| }, |
| { |
| "q": "What is known about proliferation and upgrade risk of flat epithelial atypia?", |
| "expect": [ |
| "breast-fea-proliferation-and-risk" |
| ] |
| }, |
| { |
| "q": "How do I tell usual ductal hyperplasia from flat epithelial atypia?", |
| "expect": [ |
| "breast-udh-vs-fea-indirect" |
| ] |
| }, |
| { |
| "q": "Is there a direct comparison between usual hyperplasia and flat epithelial atypia in the sources?", |
| "expect": [ |
| "breast-udh-vs-fea-indirect" |
| ] |
| }, |
| { |
| "q": "Which lesion shows streaming multilayered epithelium and which shows monomorphic columnar cells with snouts?", |
| "expect": [ |
| "breast-udh-vs-fea-indirect", |
| "breast-udh-libre-florid-hyperplasia", |
| "breast-fea-libre-features" |
| ] |
| }, |
| { |
| "q": "Do usual hyperplasia and flat epithelial atypia differ molecularly or by basal cytokeratin staining?", |
| "expect": [ |
| "breast-udh-vs-fea-indirect", |
| "breast-udh-risk-and-molecular", |
| "breast-udh-vs-fea-ihc-molecular" |
| ] |
| }, |
| { |
| "q": "What size limit defines atypical ductal hyperplasia?", |
| "expect": [ |
| "breast-adh-libre-features-size", |
| "breast-adh-wikipedia-size-criteria", |
| "breast-adh-review-morphology" |
| ] |
| }, |
| { |
| "q": "What architecture and cells are seen in atypical ductal hyperplasia?", |
| "expect": [ |
| "breast-adh-libre-features-size", |
| "breast-adh-review-morphology", |
| "breast-adh-bracs-definition" |
| ] |
| }, |
| { |
| "q": "How often do pathologists disagree on atypical ductal hyperplasia?", |
| "expect": [ |
| "breast-adh-interobserver-variability" |
| ] |
| }, |
| { |
| "q": "What share of atypical hyperplasia on core biopsy is upgraded at excision?", |
| "expect": [ |
| "breast-adh-risk-upgrade", |
| "breast-adh-wikipedia-size-criteria" |
| ] |
| }, |
| { |
| "q": "Which architectural feature turns a columnar cell lesion from flat epithelial atypia into atypical ductal hyperplasia?", |
| "expect": [ |
| "breast-fea-vs-adh-architecture" |
| ] |
| }, |
| { |
| "q": "Do breast pathology experts agree when flat atypia has focal architectural atypia?", |
| "expect": [ |
| "breast-fea-vs-adh-expert-disagreement", |
| "breast-fea-interobserver-variability" |
| ] |
| }, |
| { |
| "q": "How many ducts are involved in ADH compared with FEA?", |
| "expect": [ |
| "breast-fea-vs-adh-architecture", |
| "breast-adh-review-morphology" |
| ] |
| }, |
| { |
| "q": "Is flat epithelial atypia always flat?", |
| "expect": [ |
| "breast-fea-vs-adh-architecture", |
| "breast-fea-bracs-and-expert-definition" |
| ] |
| }, |
| { |
| "q": "What separates atypical ductal hyperplasia from low-grade DCIS?", |
| "expect": [ |
| "breast-adh-vs-dcis-libre-table", |
| "breast-adh-vs-dcis-size-rules-disagree", |
| "breast-adh-vs-dcis-same-biology" |
| ] |
| }, |
| { |
| "q": "Do different sources agree on the 2 mm rule and the two-duct rule for ADH versus DCIS?", |
| "expect": [ |
| "breast-adh-vs-dcis-size-rules-disagree" |
| ] |
| }, |
| { |
| "q": "Are ADH and low-grade DCIS biologically different?", |
| "expect": [ |
| "breast-adh-vs-dcis-same-biology", |
| "breast-dcis-low-grade-vs-high-grade-pathway" |
| ] |
| }, |
| { |
| "q": "What do lumina and cell spacing look like in ADH versus DCIS?", |
| "expect": [ |
| "breast-adh-vs-dcis-libre-table" |
| ] |
| }, |
| { |
| "q": "How is nuclear grade of DCIS judged against red blood cells?", |
| "expect": [ |
| "breast-dcis-libre-features-grading" |
| ] |
| }, |
| { |
| "q": "What are the architectural subtypes of DCIS?", |
| "expect": [ |
| "breast-dcis-subtypes-architecture", |
| "breast-dcis-bracs-definition" |
| ] |
| }, |
| { |
| "q": "Is DCIS grading reproducible between pathologists?", |
| "expect": [ |
| "breast-dcis-grading-variability" |
| ] |
| }, |
| { |
| "q": "Do low-grade and high-grade DCIS share a pathway?", |
| "expect": [ |
| "breast-dcis-low-grade-vs-high-grade-pathway" |
| ] |
| }, |
| { |
| "q": "What H&E evidence establishes invasion in breast carcinoma?", |
| "expect": [ |
| "breast-ic-libre-invasion-criteria", |
| "breast-ic-bracs-definition" |
| ] |
| }, |
| { |
| "q": "What is invasive carcinoma of no special type?", |
| "expect": [ |
| "breast-ic-wikipedia-nst", |
| "breast-ic-libre-invasion-criteria" |
| ] |
| }, |
| { |
| "q": "How is invasive breast carcinoma graded?", |
| "expect": [ |
| "breast-ic-libre-invasion-criteria" |
| ] |
| }, |
| { |
| "q": "What does loss of the myoepithelial layer indicate?", |
| "expect": [ |
| "breast-ic-bracs-definition", |
| "breast-dcis-vs-ic-myoepithelium" |
| ] |
| }, |
| { |
| "q": "How do I tell DCIS from invasive carcinoma?", |
| "expect": [ |
| "breast-dcis-vs-ic-myoepithelium", |
| "breast-dcis-vs-ic-he-stroma", |
| "breast-dcis-vs-ic-confined-to-basement-membrane" |
| ] |
| }, |
| { |
| "q": "Which stains show myoepithelial cells around a duct and what do they show in invasive cancer?", |
| "expect": [ |
| "breast-dcis-vs-ic-myoepithelium", |
| "breast-n-myoepithelium-key" |
| ] |
| }, |
| { |
| "q": "Is DCIS confined by the basement membrane?", |
| "expect": [ |
| "breast-dcis-vs-ic-confined-to-basement-membrane", |
| "breast-dcis-bracs-definition" |
| ] |
| }, |
| { |
| "q": "What stromal pattern signals invasion beyond in situ disease?", |
| "expect": [ |
| "breast-dcis-vs-ic-he-stroma", |
| "breast-ic-libre-invasion-criteria" |
| ] |
| }, |
| { |
| "q": "How do I distinguish pathological benign breast tissue from normal breast tissue?", |
| "expect": [ |
| "breast-n-vs-pb-ratio-and-glands", |
| "breast-n-bracs-paper-tissue" |
| ] |
| }, |
| { |
| "q": "Do dilated glands with two cell layers imply pathological benign rather than normal?", |
| "expect": [ |
| "breast-n-vs-pb-ratio-and-glands", |
| "breast-pb-fibrocystic-libre" |
| ] |
| }, |
| { |
| "q": "Which BRACS class is the catch-all for benign changes that are neither UDH nor FEA nor ADH?", |
| "expect": [ |
| "breast-pb-bracs-composition" |
| ] |
| }, |
| { |
| "q": "Is fibrocystic change normal or pathological?", |
| "expect": [ |
| "breast-n-vs-pb-ratio-and-glands", |
| "breast-pb-fibrocystic-libre" |
| ] |
| }, |
| { |
| "q": "Which fine classes belong to the benign, atypical and malignant coarse groups of BRACS?", |
| "expect": [ |
| "breast-coarse-groups-bracs" |
| ] |
| } |
| ], |
| "ebr-coarse30": [ |
| { |
| "q": "fried egg cells chicken wire capillaries", |
| "expect": [ |
| "cns-oligodendroglioma-histology" |
| ] |
| }, |
| { |
| "q": "necrosis microvascular proliferation glioblastoma", |
| "expect": [ |
| "cns-gbm-histology", |
| "cns-astrocytoma-idh-grading" |
| ] |
| }, |
| { |
| "q": "EGFR amplification TERT promoter chromosome 7 gain 10 loss", |
| "expect": [ |
| "cns-gbm-definition" |
| ] |
| }, |
| { |
| "q": "what happened to the names anaplastic astrocytoma and glioblastoma IDH-mutant", |
| "expect": [ |
| "cns-legacy-names", |
| "cns-who5-overview" |
| ] |
| }, |
| { |
| "q": "meningioma subtype grades atypical anaplastic chordoid", |
| "expect": [ |
| "cns-meningioma-grading" |
| ] |
| }, |
| { |
| "q": "ATRX loss p53 overexpression IDH1 R132H", |
| "expect": [ |
| "cns-astrocytoma-idh-ihc" |
| ] |
| }, |
| { |
| "q": "circumscribed glioma grade 1 KIAA1549 BRAF", |
| "expect": [ |
| "cns-pilocytic" |
| ] |
| }, |
| { |
| "q": "ependymoma classification by location ZFTA PFA", |
| "expect": [ |
| "cns-ependymoma" |
| ] |
| }, |
| { |
| "q": "medulloblastoma WNT SHH molecular groups", |
| "expect": [ |
| "cns-medulloblastoma" |
| ] |
| }, |
| { |
| "q": "1p/19q codeletion oligodendroglioma grade 3", |
| "expect": [ |
| "cns-oligodendroglioma-molecular-grading", |
| "cns-oligodendroglioma-histology" |
| ] |
| }, |
| { |
| "q": "Cerebellar tumour of vacuolated stromal cells in a rich capillary network with reticulin", |
| "expect": [ |
| "cns-haemangioblastoma-histology-case", |
| "cns-haemangioblastoma-clear-cell-vascular", |
| "cns-haemangioblastoma-libre-profile" |
| ] |
| }, |
| { |
| "q": "How to tell haemangioblastoma from metastatic clear cell renal carcinoma", |
| "expect": [ |
| "cns-haemangioblastoma-vs-metastatic-rcc-lineage", |
| "cns-haemangioblastoma-libre-profile" |
| ] |
| }, |
| { |
| "q": "Which stain is positive in haemangioblastoma but not in renal cell carcinoma metastasis", |
| "expect": [ |
| "cns-haemangioblastoma-vs-metastatic-rcc-lineage", |
| "cns-haemangioblastoma-libre-profile" |
| ] |
| }, |
| { |
| "q": "Vascular channels lined by benign endothelium with red blood cells in the brain", |
| "expect": [ |
| "cns-haemangioma-libre-histology", |
| "cns-haemangioma-cavernous-venous-malformation" |
| ] |
| }, |
| { |
| "q": "Cavernous haemangioma is a venous malformation with back to back dilated channels", |
| "expect": [ |
| "cns-haemangioma-cavernous-venous-malformation" |
| ] |
| }, |
| { |
| "q": "Vessel rich lesion versus angiomatous meningioma: what separates a vascular malformation", |
| "expect": [ |
| "cns-haemangioma-vs-angiomatous-meningioma", |
| "cns-angiomatous-libre-histology" |
| ] |
| }, |
| { |
| "q": "Why is haemangiopericytoma now called solitary fibrous tumour and what fusion defines it", |
| "expect": [ |
| "cns-haemangiopericytoma-naming-grading" |
| ] |
| }, |
| { |
| "q": "Staghorn vessels and patternless spindle cell growth with hyalinised collagen", |
| "expect": [ |
| "cns-haemangiopericytoma-histology", |
| "cns-haemangiopericytoma-libre-sft" |
| ] |
| }, |
| { |
| "q": "Dural spindle cell tumour: solitary fibrous tumour versus fibrous meningioma on stains and pseudoinclusions", |
| "expect": [ |
| "cns-haemangiopericytoma-vs-meningioma" |
| ] |
| }, |
| { |
| "q": "Intracranial mass made of mature fat cells without atypia", |
| "expect": [ |
| "cns-lipoma-histology", |
| "cns-lipoma-vs-normal-fat" |
| ] |
| }, |
| { |
| "q": "Lipoma versus liposarcoma and normal fat", |
| "expect": [ |
| "cns-lipoma-vs-normal-fat" |
| ] |
| }, |
| { |
| "q": "Cerebellopontine angle lipoma mistaken for hamartoma", |
| "expect": [ |
| "cns-lipoma-histology" |
| ] |
| }, |
| { |
| "q": "Wet keratin stellate reticulum and palisading basal cells in a sellar cystic tumour", |
| "expect": [ |
| "cns-acp-histology", |
| "cns-acp-libre-profile" |
| ] |
| }, |
| { |
| "q": "Adamantinomatous versus papillary craniopharyngioma histology", |
| "expect": [ |
| "cns-acp-vs-papillary" |
| ] |
| }, |
| { |
| "q": "Craniopharyngioma with CTNNB1 mutation and calcifications", |
| "expect": [ |
| "cns-acp-libre-profile" |
| ] |
| }, |
| { |
| "q": "Reticulin stain to tell pituitary adenoma from normal anterior pituitary", |
| "expect": [ |
| "cns-pituitary-adenoma-vs-normal-and-metastasis", |
| "cns-pituitary-adenoma-libre-profile" |
| ] |
| }, |
| { |
| "q": "Pituitary adenoma versus metastasis mitoses and pleomorphism", |
| "expect": [ |
| "cns-pituitary-adenoma-vs-normal-and-metastasis" |
| ] |
| }, |
| { |
| "q": "Why pituitary adenoma is now called PitNET and how it is typed", |
| "expect": [ |
| "cns-pituitary-adenoma-libre-profile" |
| ] |
| }, |
| { |
| "q": "Antoni A and Antoni B areas with Verocay bodies", |
| "expect": [ |
| "cns-schwannoma-libre-histology", |
| "cns-schwannoma-case-histology" |
| ] |
| }, |
| { |
| "q": "Schwannoma versus meningioma thick walled hyalinised vessels", |
| "expect": [ |
| "cns-schwannoma-libre-histology" |
| ] |
| }, |
| { |
| "q": "Spindle cell tumour S100 and SOX10 positive with EMA negative", |
| "expect": [ |
| "cns-schwannoma-case-histology" |
| ] |
| }, |
| { |
| "q": "Well demarcated brain lesion without cytoplasmic processes and with malignant nuclear atypia", |
| "expect": [ |
| "cns-metastasis-libre-histology", |
| "cns-metastasis-vs-primary-tumour" |
| ] |
| }, |
| { |
| "q": "How to separate a glial tumour from a metastatic carcinoma at high power", |
| "expect": [ |
| "cns-metastasis-vs-primary-tumour", |
| "cns-metastasis-libre-histology" |
| ] |
| }, |
| { |
| "q": "TTF-1 CK7 CDX2 PAX8 lineage stains for brain metastasis", |
| "expect": [ |
| "cns-metastasis-lineage-stains" |
| ] |
| }, |
| { |
| "q": "Periventricular large B cell lymphoma with perivascular clustering and CD20", |
| "expect": [ |
| "cns-cnsdlbcl-libre-histology", |
| "cns-cnsdlbcl-vs-glioblastoma" |
| ] |
| }, |
| { |
| "q": "Primary CNS lymphoma versus glioblastoma angiotropism versus necrosis and microvascular proliferation", |
| "expect": [ |
| "cns-cnsdlbcl-vs-glioblastoma" |
| ] |
| }, |
| { |
| "q": "Lymphoma versus tumefactive demyelination foamy macrophages and Creutzfeldt-Peters cells", |
| "expect": [ |
| "cns-cnsdlbcl-vs-demyelination" |
| ] |
| }, |
| { |
| "q": "Reniform nuclei with grooves foamy cytoplasm and eosinophils", |
| "expect": [ |
| "cns-lch-libre-histology", |
| "cns-lch-hypothalamic-cytology" |
| ] |
| }, |
| { |
| "q": "CD1a and langerin positive histiocytes in the suprasellar region", |
| "expect": [ |
| "cns-lch-hypothalamic-cytology" |
| ] |
| }, |
| { |
| "q": "Differential diagnosis of pituitary stalk and hypothalamic lesions histiocytosis", |
| "expect": [ |
| "cns-lch-sellar-differential" |
| ] |
| }, |
| { |
| "q": "Syncytial meningioma with nuclear pseudoinclusions and AKT1 mutation", |
| "expect": [ |
| "cns-meningothelial-libre-histology", |
| "cns-meningioma-classic-histology" |
| ] |
| }, |
| { |
| "q": "Meningothelial meningioma lobules separated by thin collagenous septa", |
| "expect": [ |
| "cns-meningothelial-case-histology" |
| ] |
| }, |
| { |
| "q": "Whorls psammoma bodies and nuclear pseudoinclusions in meningioma", |
| "expect": [ |
| "cns-meningioma-classic-histology" |
| ] |
| }, |
| { |
| "q": "Meningioma of parallel spindle cell bundles lacking whorls", |
| "expect": [ |
| "cns-fibrous-libre-histology", |
| "cns-fibrous-vs-transitional-histology" |
| ] |
| }, |
| { |
| "q": "Fibrous versus transitional meningioma collagenous stroma and psammoma bodies", |
| "expect": [ |
| "cns-fibrous-vs-transitional-histology" |
| ] |
| }, |
| { |
| "q": "Fibrous meningioma versus solitary fibrous tumour by EMA and STAT6", |
| "expect": [ |
| "cns-haemangiopericytoma-vs-meningioma" |
| ] |
| }, |
| { |
| "q": "Mixed meningothelial and fibrous meningioma with whorls and psammoma bodies", |
| "expect": [ |
| "cns-transitional-libre-histology", |
| "cns-fibrous-vs-transitional-histology" |
| ] |
| }, |
| { |
| "q": "Lobular and fascicular growth together in one meningioma", |
| "expect": [ |
| "cns-transitional-libre-histology" |
| ] |
| }, |
| { |
| "q": "Transitional component of a dumbbell meningioma histology", |
| "expect": [ |
| "cns-fibrous-vs-transitional-histology" |
| ] |
| }, |
| { |
| "q": "Meningioma in which vessels exceed half of the tumour volume", |
| "expect": [ |
| "cns-angiomatous-histology", |
| "cns-angiomatous-libre-histology" |
| ] |
| }, |
| { |
| "q": "Angiomatous meningioma bleeding risk and low Ki-67", |
| "expect": [ |
| "cns-angiomatous-histology" |
| ] |
| }, |
| { |
| "q": "Cystic angiomatous meningioma mimicking haemangioblastoma", |
| "expect": [ |
| "cns-angiomatous-cystic-mimics-haemangioblastoma", |
| "cns-angiomatous-libre-histology" |
| ] |
| }, |
| { |
| "q": "Pseudopsammoma bodies PAS positive hyaline inclusions in meningioma", |
| "expect": [ |
| "cns-secretory-histology", |
| "cns-secretory-libre-differential" |
| ] |
| }, |
| { |
| "q": "Secretory meningioma KLF4 and TRAF7 mutations with CEA positive inclusions", |
| "expect": [ |
| "cns-secretory-libre-differential" |
| ] |
| }, |
| { |
| "q": "Secretory meningioma versus metastatic mucinous adenocarcinoma", |
| "expect": [ |
| "cns-secretory-libre-differential" |
| ] |
| }, |
| { |
| "q": "Criteria for atypical meningioma mitoses brain invasion sheeting", |
| "expect": [ |
| "cns-atypical-vs-classic-criteria", |
| "cns-atypical-sellar-histology" |
| ] |
| }, |
| { |
| "q": "Atypical meningioma small cell change and loss of lobular architecture", |
| "expect": [ |
| "cns-atypical-sellar-histology" |
| ] |
| }, |
| { |
| "q": "What separates grade 2 from grade 1 meningioma", |
| "expect": [ |
| "cns-atypical-vs-classic-criteria" |
| ] |
| }, |
| { |
| "q": "Anaplastic meningioma 20 mitoses per 10 high power fields carcinoma-like", |
| "expect": [ |
| "cns-anaplastic-vs-atypical-criteria", |
| "cns-anaplastic-meningioma-case-criteria" |
| ] |
| }, |
| { |
| "q": "Anaplastic versus atypical meningioma mitotic threshold", |
| "expect": [ |
| "cns-anaplastic-vs-atypical-criteria" |
| ] |
| }, |
| { |
| "q": "TERT promoter mutation or CDKN2A deletion grade 3 meningioma in a child", |
| "expect": [ |
| "cns-anaplastic-meningioma-case-criteria" |
| ] |
| }, |
| { |
| "q": "Perivascular pseudorosettes and true ependymal rosettes in a sharply demarcated tumour", |
| "expect": [ |
| "cns-ependymoma-histology" |
| ] |
| }, |
| { |
| "q": "Ependymoma versus glioblastoma border circumscribed or invasive", |
| "expect": [ |
| "cns-ependymoma-libre-differential" |
| ] |
| }, |
| { |
| "q": "Clear cell ependymoma mimicking oligodendroglioma ZFTA", |
| "expect": [ |
| "cns-ependymoma-clear-cell-vs-oligodendroglioma" |
| ] |
| }, |
| { |
| "q": "Grade 3 ependymoma criteria mitoses microvascular proliferation", |
| "expect": [ |
| "cns-anaplastic-ependymoma-grading", |
| "cns-anaplastic-ependymoma-histology" |
| ] |
| }, |
| { |
| "q": "Anaplastic ependymoma legacy name and grade", |
| "expect": [ |
| "cns-anaplastic-ependymoma-grading" |
| ] |
| }, |
| { |
| "q": "Spinal ependymoma with nuclear pleomorphism and MYCN expression", |
| "expect": [ |
| "cns-anaplastic-ependymoma-histology" |
| ] |
| }, |
| { |
| "q": "Biphasic tumour with Rosenthal fibres and eosinophilic granular bodies", |
| "expect": [ |
| "cns-pilocytic-histology-review", |
| "cns-pilocytic-libre-histology" |
| ] |
| }, |
| { |
| "q": "Piloid gliosis around craniopharyngioma mimicking pilocytic astrocytoma", |
| "expect": [ |
| "cns-pilocytic-differential-piloid-gliosis" |
| ] |
| }, |
| { |
| "q": "Pilocytic astrocytoma versus oligodendroglioma circumscribed and BRAF", |
| "expect": [ |
| "cns-pilocytic-vs-oligodendroglioma" |
| ] |
| }, |
| { |
| "q": "Dysplastic neurons together with neoplastic glia in a temporal lobe epilepsy tumour", |
| "expect": [ |
| "cns-ganglioglioma-histology-review", |
| "cns-ganglioglioma-libre-histology" |
| ] |
| }, |
| { |
| "q": "Ganglioglioma versus DNET and pilocytic astrocytoma", |
| "expect": [ |
| "cns-ganglioglioma-vs-dnet-and-pilocytic" |
| ] |
| }, |
| { |
| "q": "Ganglioglioma lymphocytic cuffing and perimembranous Nissl", |
| "expect": [ |
| "cns-ganglioglioma-libre-histology" |
| ] |
| }, |
| { |
| "q": "Biphasic glioblastoma with reticulin rich GFAP negative sarcomatous areas", |
| "expect": [ |
| "cns-gliosarcoma-biphasic-histology", |
| "cns-gliosarcoma-vs-glioblastoma" |
| ] |
| }, |
| { |
| "q": "Sarcomatous components in gliosarcoma cartilage bone muscle", |
| "expect": [ |
| "cns-gliosarcoma-sarcomatous-types" |
| ] |
| }, |
| { |
| "q": "Gliosarcoma versus glioblastoma distinction", |
| "expect": [ |
| "cns-gliosarcoma-vs-glioblastoma" |
| ] |
| }, |
| { |
| "q": "Anaplastic astrocytoma with pleomorphism mitoses but no necrosis or vascular proliferation", |
| "expect": [ |
| "cns-anaplastic-astrocytoma-wt-histology", |
| "cns-anaplastic-astrocytoma-wt-vs-gbm" |
| ] |
| }, |
| { |
| "q": "Anaplastic astrocytoma versus glioblastoma histological line", |
| "expect": [ |
| "cns-anaplastic-astrocytoma-wt-vs-gbm" |
| ] |
| }, |
| { |
| "q": "IDH-wildtype astrocytoma underdiagnosed glioblastoma", |
| "expect": [ |
| "cns-anaplastic-astrocytoma-wt-histology" |
| ] |
| }, |
| { |
| "q": "Small round cell cerebellar tumour with Homer-Wright rosettes", |
| "expect": [ |
| "cns-medulloblastoma-histology" |
| ] |
| }, |
| { |
| "q": "Group 3 and group 4 medulloblastoma histology and MYC", |
| "expect": [ |
| "cns-medulloblastoma-groups-and-histology" |
| ] |
| }, |
| { |
| "q": "Medulloblastoma versus ATRT ETMR and other small round cell tumours", |
| "expect": [ |
| "cns-medulloblastoma-small-round-cell-differential" |
| ] |
| }, |
| { |
| "q": "Why can a tumour that looks like grade 2 astrocytoma on H&E be grade 4", |
| "expect": [ |
| "cns-astrocytoma-idh-mutant-grading-review", |
| "cns-gbm-histological-vs-molecular" |
| ] |
| }, |
| { |
| "q": "Molecular glioblastoma without necrosis or microvascular proliferation TERT EGFR", |
| "expect": [ |
| "cns-gbm-histological-vs-molecular", |
| "cns-aa-idh-wt-histologic-grade-outcome" |
| ] |
| }, |
| { |
| "q": "IDH wildtype grade 2 or 3 astrocytoma outcome compared with glioblastoma", |
| "expect": [ |
| "cns-aa-idh-wt-histologic-grade-outcome" |
| ] |
| }, |
| { |
| "q": "Does medulloblastoma histology determine the molecular group", |
| "expect": [ |
| "cns-medulloblastoma-histology-vs-molecular-group" |
| ] |
| }, |
| { |
| "q": "Langerhans cell nuclear grooves eosinophils and overlapping histiocytic lesions", |
| "expect": [ |
| "cns-lch-he-limitation" |
| ] |
| }, |
| { |
| "q": "Can a metastasis infiltrate brain beyond a well-demarcated border", |
| "expect": [ |
| "cns-metastasis-infiltration-caveat" |
| ] |
| }, |
| { |
| "q": "Perinuclear halo and chicken wire vessels in a tumour that is not oligodendroglioma", |
| "expect": [ |
| "cns-oligodendroglioma-like-pitfall" |
| ] |
| } |
| ], |
| "bracs-coarse": [ |
| { |
| "q": "Which fine classes belong to the benign, atypical and malignant coarse groups of BRACS?", |
| "expect": [ |
| "breast-coarse-groups-bracs" |
| ] |
| }, |
| { |
| "q": "How many slides are in each BRACS coarse group?", |
| "expect": [ |
| "breast-coarse-groups-bracs" |
| ] |
| }, |
| { |
| "q": "Why are atypical lesions hard to classify on needle biopsy?", |
| "expect": [ |
| "breast-coarse-groups-bracs", |
| "breast-fea-vs-adh-expert-disagreement" |
| ] |
| }, |
| { |
| "q": "What separates atypical from malignant lesions in the ductal spectrum?", |
| "expect": [ |
| "breast-adh-vs-dcis-libre-table", |
| "breast-adh-vs-dcis-same-biology" |
| ] |
| } |
| ] |
| } |
|
|
