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|-
| CK14
| 77% +ve
| 32% +ve
|-
| Uroplakin III
| 0% +ve
| 14% +ve
|}
==Sign out==
<pre>
Lung, Right Upper Lobe, Core Biopsy:
- SQUAMOUS CELL CARCINOMA.
COMMENT:
The tumour stains as follows:
POSITIVE: p40, CK5/6.
NEGATIVE: TTF-1, napsin.
</pre>
===Block letters===
<pre>
LUNG, RIGHT UPPER LOBE, BIOPSY:
- INVASIVE SQUAMOUS CELL CARCINOMA.
COMMENT:
The tumour stains as follows:
POSITIVE: p40, CK5/6.
NEGATIVE: TTF-1, napsin.
</pre>
===Resection===
<pre>
LUNG, RIGHT UPPER LOBE, LOBECTOMY:
- SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, pT2b, pN0.
-- MARGINS NEGATIVE.
-- PLEASE SEE TUMOUR SUMMARY.
</pre>
==See also==
*[[Squamous cell carcinoma]].
*[[Lung tumours]].
*[[Lung cytopathology]].
==References==
{{Reflist|2}}
[[Category:Diagnosis]]
[[Category:Lung tumours]]
c5e019286a80a9d8719d23edc7f34d6238dee3a382a533a9f4e401488d4346f4 librepath-lung-scc.txt
{{ Infobox diagnosis
| Name = {{PAGENAME}}
| Image = Medulloblastoma with rosettes.jpg
| Width =
| Caption = Classic medulloblastoma [[H&E stain]].
| Synonyms =
| Micro =
| Subtypes =
| LMDDx = small cell round blue tumous.
| Stains = Reticulin +ve (in desmoplastic MB)
| IHC = MAP2+ve
| EM =
| Molecular =
| IF =
| Gross = cerebellar.
| Grossing =
| Site = brain - usu. [[cerebellum]]
| Assdx =
| Syndromes =
| Clinicalhx =
| Signs =
| Symptoms =
| Prevalence = common - esp. in children
| Bloodwork =
| Rads =
| Endoscopy =
| Prognosis = subtype-dependent (WHO Grade IV)
| Other =
| ClinDDx =
| Tx =
}}
'''Medulloblastoma''' is a [[malignant]] [[small round cell tumour]] that is found in the [[cerebellum]] or dorsal brainstem. It is the most common malignant CNS tumour in children.
==General==
*Mostly paediatric population (mean age: 9 years).
*Tumors consists of histologically and molecular distinct subgroups.
*All subgroups correspond to WHO grade IV.
*May be seen as a component of [[nevoid basal cell carcinoma syndrome]] (NBCCS) AKA Gorlin syndrome, [[Li-Fraumeni syndrome]], Turcot syndrome, Rubinstain-Taybi syndrome and Nijmegen breakage syndrome.
**Show molecularly spatially homogeneous transcriptomes, allowing for accurate subgrouping of tumors from a single biopsy.<ref>{{Cite journal | last1 = Morrissy | first1 = AS. | last2 = Cavalli | first2 = FMG. | last3 = Remke | first3 = M. | last4 = Ramaswamy | first4 = V. | last5 = Shih | first5 = DJH. | last6 = Holg...
*Commonly spread via cerebrospinal fluid (CSF).<ref>{{Ref APBR|424 Q34}}</ref>
**May be detected in [[CSF cytopathology]] specimens.
==Gross==
*Location: cerebellum - '''key feature''' or dorsal brainstem (lower rhombic lip).
**For morphologically identical supratentorial tumours see possible DDx.