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File:Histology RGNT HE.jpg | RGNT, HE stain (WC/jensflorian). |
File:RGNT HE 2.jpg | RGNT, higher magnification (WC/jensflorian). |
</gallery> |
===Polymorphous low-grade tumor of the young (PLNTY)=== |
* [[Pediatric-type diffuse low-grade glioma#Diffuse low-grade glioma, MAPK pathway-altered|Polymorphous low-grade tumor of the young (PLNTY)]] |
==Pineal tumours== |
{{Main|Pineal gland}} |
* [[Pineocytoma]] |
* [[Pineal parenchymal tumour of intermediate differentiation]] |
* [[Pineoblastoma]] |
* [[Papillary tumour of the pineal region]] |
==Embryonal tumours== |
* [[Atypical teratoid/rhabdoid tumour]] (AT/RT) or (AT-RT) |
* [[Medulloblastoma]] |
* [[Primitive neuroectodermal tumour]] (PNET) |
* [[Embryonal tumour with abundant neuropil and true rosettes]] (ETANTR) |
DDx: |
* [[Ewing sarcoma]] |
* [[Sarcoma with CIC-rearrangement]] |
==Peripheral nerve sheath tumours== |
{{Main|Peripheral nerve sheath tumours}} |
A classification:<ref name=pmid17893219>{{cite journal |author=Wippold FJ, Lubner M, Perrin RJ, Lämmle M, Perry A |title=Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns |journal=AJNR Am J Neuroradiol |volume=28 |issue=9 |pages=1633–8 |year=2007 |month=October |pmid=17893219 |doi=10.3174/a... |
'''Benign:''' |
*[[Schwannoma]]. |
*[[Neurofibroma]]. |
*[[Perineurioma]]. |
*Ganglioneuroma. |
**[[Traumatic neuroma]]. |
'''Malignant:''' |
*[[Malignant peripheral nerve sheath tumour]] (MPNST). |
===Ganglioneuroma=== |
:'''Not''' to be confused with ''[[ganglioglioma]]''. |
*[[AKA]] ganglioma.<ref>URL: [http://medical-dictionary.thefreedictionary.com/ganglioma http://medical-dictionary.thefreedictionary.com/ganglioma]. Accessed on: 8 November 2010.</ref> |
{{Main|Ganglioneuroma}} |
==Meningioma== |
{{Main|Meningioma}} |
==Chordoma== |
{{Main|Chordoma}} |
==Hemangioblastoma== |
{{Main|Hemangioblastoma}} |
==CNS lymphoma== |
Classification: |
*Primary CNS lymphoma. |
*Non-primary CNS lymphoma - see ''[[lymphoma]]'' article. |
===General - primary CNS=== |
*Classically periventicular distribution. |
*Usually large B cell; can be considered a type of [[diffuse large B cell lymphoma]] (DLBCL). |
**Prognosis of CNS (DLBCL) lymphomas worse than nodal (non-CNS) DLBCL.<ref name=pmid19925562>{{cite journal |author=Raoux D, Duband S, Forest F, ''et al.'' |title=Primary central nervous system lymphoma: Immunohistochemical profile and prognostic significance |journal=Neuropathology |volume=30 |issue=3 |pages=232–40 |y... |
===Microscopic=== |
Features: |
*Large cell lymphoma. |
**Size = 2x diameter normal lymphocyte. |
**Nucleolus - common. |
*Perivascular clustering. |
====Images==== |
www: |
*[http://frontalcortex.com/?page=image&topic=1&qid=1237 CNS lymphoma (frontalcortex.com)]. |
*[http://path.upmc.edu/cases/case403.html Primary CNS lymphoma - several images (upmc.edu)]. |
<gallery> |
Image:Primary CNS lymphoma - low mag.jpg | CNS lymphoma - low mag. (WC) |
Image:Primary CNS lymphoma - intermed mag.jpg | CNS lymphoma - intermed. mag. (WC) |
Image:Primary CNS lymphoma - high mag.jpg | CNS lymphoma - high mag. (WC) |
Image:Primary CNS lymphoma - very high mag.jpg | CNS lymphoma - very high mag. (WC) |
</gallery> |
<gallery> |
Image: CNS lymphoma (1) B-cell type.jpg | CNS lymphoma. (WC/KGH) |
Image: CNS lymphoma (2) B-cell type.jpg | CNS lymphoma. (WC/KGH) |
</gallery> |
===IHC=== |
Can be subclassified in ''GCB (germinal centre B-cell-like)'' and ''non-GCB'' by CD10, Bcl-6, MUM1/IRF-4, and Bcl-2.<ref name=pmid19925562/> |
Common pattern: |
*[[CD20]] +ve - key stain. |
*CD3 -ve. |
*Ki-67 ~40%. |
*Bcl-6 +ve. |
*Bcl-1 -ve. |
==Ganglioneuroblastoma== |
{{Main|Neuroblastoma}} |
===General=== |
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