Datasets:
johnseenun
/
thesis-data

Dataset card Data Studio Files
xet
 Community
text
stringlengths
0
5.79k
| DCIS-like
| DCIS architecture (solid, <br>cribriform, papillary, micropapillary)
|-
| '''Nuclei'''
| variable, no nucleolus
| hyperchromatic<br>& uniform, usu. no nucleolus
| evenly spaced +/-nucleolus
|-
|}
Treatment - implications:
*[[FEHUT]] - nothing; FEHUT is benign.
*[[ADH]] - simple excision, i.e. lumpectomy.
*[[DCIS]] - excision (lumpectomy) + radiation.
*Invasive ductal carcinoma - excision with sentinel lymph node biopsy (for staging)<ref>Sentinel Lymph Node Biopsy: What Breast Cancer Patients Need to Know. cancernews.com. URL: [http://www.cancernews.com/data/Article/202.asp http://www.cancernews.com/data/Article/202.asp]. Accessed on: 9 October 2009.</ref> and radia...
*Positive sentinel node - systemic chemotherapy. (???)
====IHC====
Usual ductal hyperplasia (AKA FEHUT) vs. [[ADH]]/[[DCIS]]:<ref>{{Cite journal | last1 = Rabban | first1 = JT. | last2 = Koerner | first2 = FC. | last3 = Lerwill | first3 = MF. | title = Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: a potentially difficult distinction resolved ...
*FEHUT: ER-low/CK5-high profile.
*ADH/DCIS: ER-high/CK5-low.
Where:
*ER-high = diffuse strong staining in >90% of cells.
*CK5-high = mosaic pattern of staining in >20% of cells
*CK5-low = absent or staining in <20% of cells.
==Atypical ductal hyperplasia==
*Abbreviated ''ADH''.
{{Main|Atypical ductal hyperplasia}}
==Ductal carcinoma in situ==
*Abbreviated ''DCIS''.
{{Main|Ductal carcinoma in situ}}
=Lobular neoplasia=
==Overview==
Includes:
#Atypical lobular hyperplasia (ALH).
#Lobular carcinoma in situ (LCIS).
*These entities (ALH, LCIS) are near identical from a histomorphologic perspective.
*The difference is extent of involvement:
**ALH <50% of terminal duct lobular unit (TDLU) is involved.
**LCIS >=50% of TDLU is involved.
==Atypical lobular hyperplasia==
*Abbreviated ''ALH''.
{{Main|Atypical lobular hyperplasia}}
==Lobular carcinoma in situ==
*Abbreviated ''LCIS''.
===General===
*Management is currently some matter of debate.
**''Association of Breast Surgery'' (UK) guidelines recommend excision of LCIS on biopsy,<ref name=pmid26492902/> as does a smaller (US) study.<ref name=pmid20637429>{{Cite journal | last1 = O'Neil | first1 = M. | last2 = Madan | first2 = R. | last3 = Tawfik | first3 = OW. | last4 = Thomas | first4 = PA. | last5 = Fan...
**In the UK, most surgeons (~60%) excise LCIS seen on biopsy; however, a significant minority considers followup appropriate.<ref name=pmid26492902>{{Cite journal | last1 = Chester | first1 = R. | last2 = Bokinni | first2 = O. | last3 = Ahmed | first3 = I. | last4 = Kasem | first4 = A. | title = UK national survey of ...
*Not detected radiologically - it is an incidental pathologic finding.
*The precursor to [[invasive ductal carcinoma of the breast]].
===Microscopic===
Features<ref name=Ref_TPoSP188>{{Ref TPoSP|188}}</ref><ref name=Ref_BP170>{{Ref BP|170}}</ref> - memory device ''ABCDEF'':
*'''A'''typia minimal - usually.
**Relatively small ~1-2x size lymphocyte.
*'''B'''orders of cells distinct/visible - ''dyscohesive''.
*'''C'''lear cytoplasm (focal).
**May have a signet ring cell-like appearance.
*'''D'''istend duct.
*'''E'''ccentric nucleus, usu. round.
*'''F'''illed ducts.
**'''No''' luminal spaces - '''key feature'''.
***Partially filled ducts are ''not'' LCIS.
DDx:
*[[Invasive ductal carcinoma of the breast|Invasive ductal carcinoma]].
*[[Atypical ductal hyperplasia]].
Images:
*[http://www.webpathology.com/image.asp?n=3&Case=291 LCIS (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=5&Case=291 LCIS (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=6&Case=291 LCIS - high mag. (webpathology.com)].
====Subclassification<ref name=Ref_BP170>{{Ref BP|170}}</ref>====
*Non-PLCIS.
**Type A.
***Nucleus 1-1.5x lymphocyte.
***No nucleolus.
**Type B.
***Nucleus ~2x lymphocyte.
***Nucleolus present.
*PLCIS (pleomorphic lobular carcinoma in situ).
DDx:
*Low-grade DCIS.
*High-grade DCIS for ''pleomorphic lobular carcinoma in situ''.
*[[Atypical lobular hyperplasia]].
===IHC===
*[[E-cadherin]] -ve ''or'' incomplete membrane staining.
*p120 catenin +ve cytoplasmic.<ref name="Sarrió-2004">{{Cite journal | last1 = Sarrió | first1 = D. | last2 = Pérez-Mies | first2 = B. | last3 = Hardisson | first3 = D. | last4 = Moreno-Bueno | first4 = G. | last5 = Suárez | first5 = A. | last6 = Cano | first6 = A. | last7 = Martín-Pérez | first7 = J. | last8 = Gamall...
**Membranous staining in DCIS.