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*Breast adenosis - should have visble lumens.
===Images===
<gallery>
Image: Sclerosing adenosis -- low mag.jpg | SA - low mag. (WC)
Image: Sclerosing adenosis -- intermed mag.jpg | SA - intermed. mag. (WC)
Image: Sclerosing adenosis -- high mag.jpg | SA - high mag. (WC)
Image: Sclerosing adenosis -- very high mag.jpg | SA - very high mag. (WC)
</gallery>
==See also==
*[[Breast pathology]].
*[[Sclerosing adenosis]].
==References==
{{Reflist|1}}
[[Category:Diagnosis]]
[[Category:Breast pathology]]
1e227fa7af17ea44bd05da63767ea72770edef569a9b1371a8b9a2bc8442c098 librepath-sclerosing-adenosis-breast.txt
{{ Infobox diagnosis
| Name = {{PAGENAME}}
| Image = Solitary_fibrous_tumour_high_mag.jpg
| Width =
| Caption = Solitary fibrous tumour. [[H&E stain]].
| Micro = spindle cells in a patternless pattern, hemangiopericytoma-like areas ([[staghorn vessels]]), keloid-like collagen bundles, +/-well-circumscribed (common)
| Subtypes = benign (common), malignant (uncommon)
| LMDDx =
| Stains =
| IHC = CD34 ~90% +ve, CD99 ~70% +ve, BCL2 ~50% +ve
| EM =
| Molecular =
| IF =
| Gross =
| Grossing =
| Site = [[soft tissue lesions|soft tissue]] - [[fibroblastic/myofibroblastic tumours]], pleura
| Assdx =
| Syndromes = Doege-Potter syndrome
| Clinicalhx =
| Signs =
| Symptoms =
| Prevalence =
| Bloodwork =
| Rads =
| Endoscopy =
| Prognosis = usu. good
| Other =
| ClinDDx =
}}
'''Solitary fibrous tumour''', abbreviated '''SFT''', is a type of [[soft tissue lesion|soft tissue tumour]] that fits in the [[fibroblastic/myofibroblastic tumours]]. It is usually benign.
SFT of the pleura is dealt with in a separate article ''[[solitary fibrous tumour of the pleura]]''.
==General==
*Grouped with ''hemangiopericytoma'' in the WHO classification - as it is thought to be the same tumour because both share the same molecular alteration.<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref><ref>{{Cite journal | last1 = Schweizer | first1 = L. | last2 = Koelsche | first2 = C. | last3 = Sahm | first3 = F. | last...
*May be benign ''or'' malignant; more commonly benign.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9]. Accessed on: 25 June 2010.</ref><ref>URL: [http://wjso.com/content/6/1/86 http://wjso.com/content...
*May be associated with hypoglycemia.
**Known as ''Doege-Potter syndrome''.<ref name=pmid1474302>{{Cite journal | last1 = Roy | first1 = TM. | last2 = Burns | first2 = MV. | last3 = Overly | first3 = DJ. | last4 = Curd | first4 = BT. | title = Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome. | journal = J Ky Med Assoc | v...
*Leptomeningeal SFTs/hemangiopericytomas are classified as follows:
** WHO grade I: classical SFT
** WHO grade II: classical [[hemangiopericytoma]]
** WHO grade III: anaplastic hemangiopericytoma / malignant SFT
==Gross==
*Soft tissue mass.
==Microscopic==
Features - benign:
*Spindle cells in a patternless pattern.
**Occasionally epithelioid cells - rare.<ref name=pmid17577399>{{Cite journal | last1 = Martorell | first1 = M. | last2 = Pérez-Vallés | first2 = A. | last3 = Gozalbo | first3 = F. | last4 = Garcia-Garcia | first4 = JA. | last5 = Gutierrez | first5 = J. | last6 = Gaona | first6 = J. | title = Solitary fibrous tumor of...
*Hemangiopericytoma-like area ([[staghorn vessels]]).
*Keloid-like collagen bundles - '''key feature'''.
*+/-Well-circumscribed (common).
Criteria for malignancy:<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref>
*Necrosis.
*Mitoses >4/10 HPF -- definition suffers from [[HPFitis]].
*Increased cellularity.
*Marked nuclear atypia.
*Infiltrative margin.
===Images===
<gallery>
Image:Solitary_fibrous_tumour_low_mag.jpg | Benign SFT - low mag. (WC)
Image:Solitary_fibrous_tumour_intermed_mag.jpg | Benign SFT - intermed. mag. (WC)
Image:Solitary_fibrous_tumour_high_mag.jpg | Benign SFT - high mag. (WC)
File:Neuropathology_case_VI_01.jpg | Nuclear STAT6 immunoreactivity in malignant SFT (WC/jensflorian)
</gallery>
www:
*[http://path.upmc.edu/cases/case272.html SFT of the brain - several images (upmc.edu)].
Malignant solitary fibrous tumor (low to intermediate grade tumor). 15 cm mass in upper arm of 50 year old man.<ref>Am J Surg Pathol 2014;38:552-559</ref>
<gallery>
File:3 18039322534203 sl 1.png|malignant solitary fibrous tumor | Hypocellular (green arrow) and hypercellular (cyan arrow) areas alternate.
File:3 18039322534203 sl 2.png|malignant solitary fibrous tumor | Vascular spaces suggest antlers (staghorn). Note subcapsular hemorrhage.
File:3 18039322534203 sl 3.png|malignant solitary fibrous tumor | Stromal hyalinization
File:3 18039322534203 sl 4.png|malignant solitary fibrous tumor | Nuclei, lacking organization, show varied size and shape, with some cells being round to ovoid. The arrow points to myxoid focus in stroma. When a majority of the following are present, a low to intermediate grade malignant solitary fibrous tumor is pres...
</gallery>
==IHC==