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*Beta-catenin +ve<ref name=pmid11813884>{{Cite journal | last1 = Hasegawa | first1 = M. | last2 = Muramatsu | first2 = N. | last3 = Tohma | first3 = Y. | last4 = Fukaya | first4 = K. | last5 = Fujisawa | first5 = H. | last6 = Hayashi | first6 = Y. | last7 = Tachibana | first7 = O. | last8 = Kida | first8 = S. | last9 ... |
==Molecular== |
Overview: <ref>{{Cite journal | last1 = Agnihotri | first1 = S. | last2 = Jalali | first2 = S. | last3 = Wilson | first3 = MR. | last4 = Danesh | first4 = A. | last5 = Li | first5 = M. | last6 = Klironomos | first6 = G. | last7 = Krieger | first7 = JR. | last8 = Mansouri | first8 = A. | last9 = Khan | first9 = O. | ti... |
* Most common: NF2 (in Vestibular Schwannoma up to84%). |
* less common: ARID1A, ARID1B, DDR, TSC1, TSC2, CDC27 and USP8. |
* SH3PXD2A-HTRA1 fusions (10%). |
*INI1 mosaic pattern in familiar schwannomatosis.<ref>{{Cite journal | last1 = Caltabiano | first1 = R. | last2 = Magro | first2 = G. | last3 = Polizzi | first3 = A. | last4 = Praticò | first4 = AD. | last5 = Ortensi | first5 = A. | last6 = D'Orazi | first6 = V. | last7 = Panunzi | first7 = A. | last8 = Milone | first... |
* LZTR1-associated vestibular schwannomas.<ref>{{Cite journal | last1 = Evans | first1 = DG. | last2 = Bowers | first2 = NL. | last3 = Tobi | first3 = S. | last4 = Hartley | first4 = C. | last5 = Wallace | first5 = AJ. | last6 = King | first6 = AT. | last7 = Lloyd | first7 = SKW. | last8 = Rutherford | first8 = SA. | ... |
Molecular subgroups:<ref>{{Cite journal | last1 = Agnihotri | first1 = S. | last2 = Jalali | first2 = S. | last3 = Wilson | first3 = MR. | last4 = Danesh | first4 = A. | last5 = Li | first5 = M. | last6 = Klironomos | first6 = G. | last7 = Krieger | first7 = JR. | last8 = Mansouri | first8 = A. | last9 = Khan | first9... |
*Group 1: vestibular (has significant higher rate of 22q loss). |
*Group 2: spinal. |
==Sign out== |
<pre> |
Lesion, Right Ulnar Nerve, Excision: |
- Schwannoma. |
</pre> |
===Block letters=== |
<pre> |
LESION, LEFT ANTERIOR TIBIA, EXCISION: |
- SCHWANNOMA. |
- NEGATIVE FOR MALIGNANCY. |
</pre> |
===Micro=== |
The sections show a soft tissue spindle cell lesion, with cellular fibrillary areas (Antoni A) and pauci-cellular microcystic areas (Antoni B). There are also pauci-nuclear areas surrounded by clusters of nuclei (Verocay bodies). Thick hyaline blood vessels are present within the lesion. There is no apparent nuclear a... |
==See also== |
*[[Peripheral nerve sheath tumours]]. |
==References== |
{{Reflist|2}} |
[[Category:Peripheral nerve sheath tumours]] |
[[Category:Diagnosis]] |
[[Category:Neuropathology tumours]] |
bea8827edee63c1724d0f94c545c61ac8fd7d602fb7fd8b32785abfdee321b2e librepath-schwannoma.txt |
{{ Infobox diagnosis |
| Name = {{PAGENAME}} |
| Image = Sclerosing_adenosis_--_high_mag.jpg |
| Width = |
| Caption = Sclerosing_adenosis. [[H&E stain]]. |
| Synonyms = |
| Micro = increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini |
| Subtypes = |
| LMDDx = low-grade [[invasive ductal carcinoma of the breast|ductal carcinoma]], [[tubular adenoma of the breast]], [[adenomyoepithelioma]], breast adenosis |
| Stains = |
| IHC = |
| EM = |
| Molecular = |
| IF = |
| Gross = |
| Grossing = |
| Staging = |
| Site = [[breast]] |
| Assdx = |
| Syndromes = |
| Clinicalhx = |
| Signs = |
| Symptoms = |
| Prevalence = common |
| Bloodwork = |
| Rads = |
| Endoscopy = |
| Prognosis = benign, increased risk of breast cancer |
| Other = |
| ClinDDx = |
| Tx = |
}} |
'''Sclerosing adenosis of the breast''', also '''[[sclerosing adenosis]]''', a benign pathology of the breast associated with an increased risk of malignancy. |
==General== |
*Can look like [[Invasive ductal carcinoma of the breast|ductal carcinoma]]. |
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular proliferation). |
**Think ''scaring'' + ''many glands packed together''. |
Management: |
*Follow-up - no further treatment.<ref>URL: [http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions]. Accessed on: 30 April 2012.</... |
==Microscopic== |
Features: |
*Acini are smaller than usual and there are more of them. |
**Acini often slit-like. |
*Fibrosis (scleroses) - pink on H&E surrounds the acini. |
**Can mimic a [[desmoplastic reaction]]. |
Notes: |
*The acini should: |
**Be in lobular arrangements, i.e. in groups (benign appearance at low power) - '''key feature'''. |
**Have two cell layers like well-behaved breast glands do. |
DDx: |
*Low-grade [[Invasive ductal carcinoma of the breast|ductal carcinoma]]. |
*[[Tubular adenoma of the breast]]. |
*[[Adenomyoepithelioma]].<ref name=chu>Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: [http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf]. Accessed on: 28 April 2012.</ref> |
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