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TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Infection | 0 | {"evidence_spans": [{"end": 2133, "start": 2005, "text": " 0.027). There were no significant differences between the two groups with respect to the incidence of arterial hypotension or i"}], "id": "410", "pmcid": "2575601", "prompt_id": "410", "split_group_id": "2575601", "votes": {"0": 1}} |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: FEV1% | 0 | {"evidence_spans": [{"end": 1507, "start": 1372, "text": "<0.001). No statistically significant change in FEV1% or oxygen saturation was observed after either HFCWO or usual ACTs compared with "}], "id": "244", "pmcid": "2922723", "prompt_id": "244", "split_group_id": "2922723", "votes": {"0": 2}} |
TITLE: Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated children with Guillain Barré syndrome: a randomized study
ABSTRACT.INTRODUCTION:
Respiratory failure is a life threatening complication of Guillain Barré syndrome (GBS). There is no consensus on the specif... | Intervention: plasma exchange (PE)
Comparator: intravenous immunoglobulin (IVIG)
Outcome: side effects | 0 | {"evidence_spans": [{"end": 13827, "start": 13711, "text": "ange) 1 Pearson test. There was no significant side effect attributable to any of the treatment modalities in any "}], "id": "468", "pmcid": "3387601", "prompt_id": "468", "split_group_id": "3387601", "votes": {"0": 2}} |
TITLE: A heart failure self-management program for patients of all literacy levels: A randomized, controlled trial [ISRCTN11535170]
ABSTRACT.BACKGROUND:
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patie... | Intervention: Follow-up and thorough education on self-care
Comparator: Standard information about self-care
Outcome: Hospitalization or death | 0 | {"evidence_spans": [{"end": 18242, "start": 18067, "text": "the outcome (IRR = 0.53; 95% CI 0.32, 0.89). 61% of patients in the control group had at least one hospitalization or died, and 42% of patients in the intervention group had a"}], "id": "214", "pmcid": "1475568", "prompt_id": "214", "split_group_id": "1475568"... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Sputum score improvement | 1 | {"evidence_spans": [{"end": 24053, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: A heart failure self-management program for patients of all literacy levels: A randomized, controlled trial [ISRCTN11535170]
ABSTRACT.BACKGROUND:
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patie... | Intervention: Follow-up and thorough education on self-care
Comparator: Standard information about self-care
Outcome: Daily weight monitoring at the end of treatment | 1 | {"evidence_spans": [{"end": 1700, "start": 1586, "text": "ificant. At 12 months, more patients in the intervention group reported monitoring weights daily (79% vs. 29%, p <"}, {"end": 19656, "start": 19504, "text": ".0026).\r\n\r\nBODY.RESULTS.OTHER OUTCOMES.SELF-CARE BEHAVIOR:\r\nSignificantly more patients in the int... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Incidence of pneumonia | 0 | {"evidence_spans": [{"end": 26371, "start": 26109, "text": "p to study medication] reported by \u22653% of patients The total incidence of pneumonia-related AEs (pneumonia, bronchopneumonia, lobar pneumonia and pneumonia staphylococcal) was similar for budesonide/formoterol 320/9 \u03bcg and 160/9 \u03bcg (4.0% and 3.... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: 1-hour post-dose FEV1 improvements | 1 | {"evidence_spans": [{"end": 18064, "start": 17777, "text": "placebo (p < 0.001) [figure 3a]. Although improvements in 1-hour post-dose FEV1 were significantly greater for both budesonide/formoterol dosages compared with placebo (primary comparison; p < 0.001), budesonide/formoterol 320/9 \u03bcg also resulted in signif... |
TITLE: Effects of high volume saline enemas vs no enema during labour – The N-Ma Randomised Controlled Trial [ISRCTN43153145]
ABSTRACT.BACKGROUND:
Enemas are used during labour in obstetric settings with the belief that they reduce puerperal and neonatal infections, shorten labour duration, and make delivery clea... | Intervention: 1 litre saline enema
Comparator: no enema
Outcome: Episiorraphy dehiscence rates | 0 | {"evidence_spans": [{"end": 2281, "start": 2151, "text": "= 0.24). Enemas didn't significantly change episiorraphy dehiscence rates (21/182 [12%] with enema v 32/190 [17%] without enema; P"}], "id": "445", "pmcid": "1468428", "prompt_id": "445", "split_group_id": "1468428", "votes": {"0": 2}} |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: Visual analogue scale scores for comfort | 0 | {"evidence_spans": [{"end": 16687, "start": 16574, "text": "sual ACT compared with HFCWO are shown in table 4. No significant differences were observed in VAS scores for com"}, {"end": 16688, "start": 16574, "text": "sual ACT compared with HFCWO are shown in table 4. No significant differences were observed in VAS scor... |
TITLE: Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial
ABSTRACT.BACKGROUND:
Laparoscopic surgery has become popular during the last decade, mainly because it is associated with fewer postoperative complications than the conventional open approach. It rem... | Intervention: Laparoscopic surgery
Comparator: Conventional open approach
Outcome: Surgery duration | 1 | {"evidence_spans": [{"end": 1096, "start": 985, "text": "ESULTS:\r\nOperating time in the laparoscopy group was significantly longer than in the open group (75 min versus"}], "id": "263", "pmcid": "2691927", "prompt_id": "263", "split_group_id": "2691927", "votes": {"1": 2}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Mean FEV1 at 12 hours on the day of randomization | 1 | {"evidence_spans": [{"end": 20044, "start": 19826, "text": " in the budesonide/formoterol groups. Mean FEV1 at 12 hours and baseline-adjusted average 12-hour FEV1 were significantly improved with both budesonide/formoterol dosages compared with placebo on the day of randomizati"}, {"end": 20045, "start": 19826, "text":... |
TITLE: Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial
ABSTRACT.BACKGROUND:
Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there a... | Intervention: progesterone
Comparator: placebo
Outcome: Instances of complications and adverse events | 0 | {"evidence_spans": [{"end": 2439, "start": 2254, "text": "oup, but there was no statistical significance between the two groups (P > 0.05). Instances of complications and adverse events associated with the administration of progesterone were n"}, {"end": 2439, "start": 2327, "text": "> 0.05). Instances of complications... |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Hypotension | 0 | {"evidence_spans": [{"end": 2133, "start": 2005, "text": " 0.027). There were no significant differences between the two groups with respect to the incidence of arterial hypotension or i"}], "id": "411", "pmcid": "2575601", "prompt_id": "411", "split_group_id": "2575601", "votes": {"0": 1}} |
TITLE: Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial
ABSTRACT.BACKGROUND:
Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there a... | Intervention: progesterone
Comparator: placebo
Outcome: The mortality rate | -1 | {"evidence_spans": [{"end": 2114, "start": 1982, "text": "< 0.01). The mortality rate of the progesterone group was significantly lower than that of the placebo group at 6-month follow-up (P"}, {"end": 2114, "start": 1983, "text": " 0.01). The mortality rate of the progesterone group was significantly lower than that o... |
TITLE: Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]
ABSTRACT.BACKGROUND:
Topical NSAIDs have been proven to relieve the symptoms of osteoarthritis (OA) in short-term studies (2 weeks). To justify its chronic use, efficacy of a t... | Intervention: topical diclofenac solution (Pennsaid®)
Comparator: vehicle control solution (carrier with no diclofenac)
Outcome: 50% reduction in pain | 1 | {"evidence_spans": [{"end": 18311, "start": 18106, "text": "2) for pain on walking (-1.2 vs. -0.8; p = 0.014). The response rate for at least a 50% reduction in pain (Table 3) was significantly greater following topical diclofenac treatment compared to vehicle cont"}], "id": "437", "pmcid": "1201146", "prompt_id": "437... |
TITLE: Clinical and radiological evaluation of Trabecular Metal and the Smith–Robinson technique in anterior cervical fusion for degenerative disease: a prospective, randomized, controlled study with 2-year follow-up
ABSTRACT:
A prospective, randomized, controlled study was carried out to compare the radiological... | Intervention: raditional Smith–Robinson (SR) procedure with autograft
Comparator: anterior cervical decompression and fusion (ACDF) with Trabecular MetalTM (TM)
Outcome: Radiological fusion | 1 | {"evidence_spans": [{"end": 3028, "start": 2874, "text": "y, Trabecular Metal showed a lower fusion rate than the Smith\u2013Robinson technique with autograft after single-level anterior cervical fusion without platin"}], "id": "483", "pmcid": "2899760", "prompt_id": "483", "split_group_id": "2899760", "votes": {"1": 2... |
TITLE: The role of somatostatin in 67 consecutive pancreatectomies: a randomized clinical trial
ABSTRACT.BACKGROUND::
Somatostatin has been found to be effective in the prevention of postoperative complications in pancreatic surgery. It can inhibit the pancreatic secretions that, quite often, are responsible for ... | Intervention: somatostatin
Comparator: No medication was given to the control group
Outcome: Postoperative complications | -1 | {"evidence_spans": [{"end": 868, "start": 735, "text": "SULTS::\r\nAdministration of somatostatin reduced the exocrine granule number, and the patients suffered from fewer postoperative compl"}, {"end": 9060, "start": 8895, "text": "came to the following conclusions. Initially, 6 of 35 (17%) in the treated group who r... |
TITLE: Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial [ISRCTN20244858]
ABSTRACT.BACKGROUND:
Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and defi... | Intervention: Exercise
Comparator: No exercise
Outcome: Knee injury and Osteoarthritis Outcome Score | 0 | {"evidence_spans": [{"end": 1393, "start": 1199, "text": "n = 31). No significant differences in the KOOS subscales assessing pain, other symptoms, or function in daily life or in sport and recreation were seen at any time point between exercisers and "}], "id": "421", "pmcid": "1187893", "prompt_id": "421", "split_gro... |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Skin-to-skin time | 0 | {"evidence_spans": [{"end": 10993, "start": 10881, "text": "\nBODY.RESULTS.DURATION OF SURGERY:\r\nNo significant difference was noted in the skin-to-skin time (in min) for th"}, {"end": 11106, "start": 10881, "text": "\nBODY.RESULTS.DURATION OF SURGERY:\r\nNo significant difference was noted in the skin-to-skin time (... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Photo-refractive keratectomy (PRK)
Comparator: Pre-surgery baseline
Outcome: Contrast sensitivity at 1 month seen at 12 cpd | -1 | {"evidence_spans": [{"end": 11348, "start": 11202, "text": "peratively (P > 0.131), while patients in the PRK group had a slight decrease in contrast sensitivity at 1 month seen at 3 and 12 cpd (P = 0.004) "}], "id": "239", "pmcid": "3090298", "prompt_id": "239", "split_group_id": "3090298", "votes": {"-1": 1}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Incidence of pneumonia | 0 | {"evidence_spans": [{"end": 26371, "start": 26109, "text": "p to study medication] reported by \u22653% of patients The total incidence of pneumonia-related AEs (pneumonia, bronchopneumonia, lobar pneumonia and pneumonia staphylococcal) was similar for budesonide/formoterol 320/9 \u03bcg and 160/9 \u03bcg (4.0% and 3.... |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: Sputum expectoration between treatments in a 24-hour period | 0 | {"evidence_spans": [{"end": 15613, "start": 15457, "text": "WO, high frequency chest wall oscillation. No statistically significant difference was observed in the amount of sputum expectorated when using HFCWO or u"}], "id": "247", "pmcid": "2922723", "prompt_id": "247", "split_group_id": "2922723", "votes": {"0": 1}... |
TITLE: Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: A Cluster-Randomised Trial in Eastern Zimbabwe
ABSTRACT.BACKGROUND:
HIV-1 control in sub-Saharan Africa requires cost-effective and sustainable programmes that promote behaviour change and reduce cofactor sexually transmi... | Intervention: Communities that received additional education and preventive measures
Comparator: Communities that received standard Government services
Outcome: HIV-1 incidence | 0 | {"evidence_spans": [{"end": 1094, "start": 891, "text": "mate. Despite greater programme activity and knowledge in the intervention communities, the incidence rate ratio of HIV-1 was 1.27 (95% confidence interval [CI] 0.92\u20131.75) compared to the control communi"}, {"end": 1835, "start": 1617, "text": "USIONS:\r\nIn... |
TITLE: Repair of Giant Midline Abdominal Wall Hernias: “Components Separation Technique” versus Prosthetic Repair
ABSTRACT.BACKGROUND:
Reconstruction of giant midline abdominal wall hernias is difficult, and no data are available to decide which technique should be used. It was the aim of this study to compare th... | Intervention: components separation technique (CST)
Comparator: prosthetic repair with e-PTFE patch (PR)
Outcome: Postoperative Mortality | 0 | {"evidence_spans": [{"end": 1091, "start": 1057, "text": " defect. There was no in-hospital "}, {"end": 14318, "start": 14288, "text": "ULTS.POSTOPERATIVE MORTALITY A"}], "id": "458", "pmcid": "1913177", "prompt_id": "458", "split_group_id": "1913177", "votes": {"0": 2}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Pre-dose inspiratory capacity | 0 | {"evidence_spans": [{"end": 20858, "start": 20776, "text": "I = pressurized metered-dose inhaler. No significant differences in pre-dose IC w"}], "id": "336", "pmcid": "3580134", "prompt_id": "336", "split_group_id": "3580134", "votes": {"0": 2}} |
TITLE: Cervical ripening with prostaglandin gel and hygroscopic dilators.
ABSTRACT:
OBJECTIVE: To study the effectiveness and morbidity of adding hygroscopic cervical dilators to prostaglandin gel for cervical ripening and labor induction. STUDY DESIGN: Patients of at least 34 weeks' gestation with a medical indi... | Intervention: Prostaglandin gel plus hygroscopic cervical dilators
Comparator: Prostaglandin gel
Outcome: Changes in Bishop score after 6 hours | 1 | {"evidence_spans": [{"end": 1163, "start": 1049, "text": "s. After six hours of ripening, the combined group achieved a greater change in Bishop score (3.6 vs. 2.1, P = 0.0"}], "id": "417", "pmcid": "1784771", "prompt_id": "417", "split_group_id": "1784771", "votes": {"1": 2}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Incidence of pneumonia | 0 | {"evidence_spans": [{"end": 26371, "start": 26109, "text": "p to study medication] reported by \u22653% of patients The total incidence of pneumonia-related AEs (pneumonia, bronchopneumonia, lobar pneumonia and pneumonia staphylococcal) was similar for budesonide/formoterol 320/9 \u03bcg and 160/9 \u03bcg (4.0% and 3.... |
TITLE: Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: A placebo-controlled double-blind trial
ABSTRACT.BACKGROUND:
The clinical effects of mucolytics in patients with chronic obstructive pulmonary disease (COPD) are discussed controversially. Cineole is the main constituent of eucal... | Intervention: cineole
Comparator: placebo
Outcome: Dyspnea during exercise | 0 | {"evidence_spans": [], "id": "454", "pmcid": "2720945", "prompt_id": "454", "split_group_id": "2720945", "votes": {"0": 1}} |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Intracranial pressure recurrence after treatment withdrawal | 0 | {"evidence_spans": [{"end": 20711, "start": 20573, "text": "pental and 108 \u00b1 100 hours for pentobarbital (P = 0.06). Seven (31.8%) patients presented an ICP rebound with thiopental and six (27.3%) w"}], "id": "414", "pmcid": "2575601", "prompt_id": "414", "split_group_id": "2575601", "votes": {"0": 1}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Breathlessness Cough and Sputum Scale improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Cervical ripening with prostaglandin gel and hygroscopic dilators.
ABSTRACT:
OBJECTIVE: To study the effectiveness and morbidity of adding hygroscopic cervical dilators to prostaglandin gel for cervical ripening and labor induction. STUDY DESIGN: Patients of at least 34 weeks' gestation with a medical indi... | Intervention: Prostaglandin gel plus hygroscopic cervical dilators
Comparator: Prostaglandin gel
Outcome: Induction time | 0 | {"evidence_spans": [{"end": 1241, "start": 1049, "text": "s. After six hours of ripening, the combined group achieved a greater change in Bishop score (3.6 vs. 2.1, P = 0.007) and tended to have a shorter induction time (21.7 vs. 26.4 hours, P = 0.08"}, {"end": 1241, "start": 1078, "text": "g, the combined group achiev... |
TITLE: Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]
ABSTRACT.BACKGROUND:
Topical NSAIDs have been proven to relieve the symptoms of osteoarthritis (OA) in short-term studies (2 weeks). To justify its chronic use, efficacy of a t... | Intervention: topical diclofenac solution (Pennsaid®)
Comparator: vehicle control solution (carrier with no diclofenac)
Outcome: Dry skin at the application site | 1 | {"evidence_spans": [{"end": 19488, "start": 19290, "text": "\u2265 10% of the scale. \r\n\r\nBODY.RESULTS.ADVERSE EVENTS:\r\nThe major adverse effect reported was dry skin at the application site, occurring in 42/107 (39.3%) and 23/109 (21.1%; p = 0.004) of topical dic"}], "id": "439", "pmcid": "1201146", "prompt_id": ... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Amount of exacerbations per patient-treatment year | -1 | {"evidence_spans": [{"end": 22305, "start": 22046, "text": "terol (p = 0.026) [figure 6]. In addition, significant reductions in the overall number of exacerbations per patient-treatment year were observed with budesonide/formoterol 320/9 \u03bcg and 160/9 \u03bcg versus placebo (37% and 41%, respectively; p < 0.001) a... |
TITLE: Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial
ABSTRACT.BACKGROUND:
Laparoscopic surgery has become popular during the last decade, mainly because it is associated with fewer postoperative complications than the conventional open approach. It rem... | Intervention: Laparoscopic surgery
Comparator: Conventional open approach
Outcome: Better scar appearance score as measured by visual analog scale | 1 | {"evidence_spans": [{"end": 13213, "start": 13006, "text": " 0.90.007\r\n\r\nBODY.RESULTS.VAS APPEARANCE OF SCAR:\r\nThe VAS score for appearance of the scar left by the respective procedures (subjectively recorded in the same way as pain) differed by 2.3 points, favoring "}], "id": "274", "pmcid": "2691927", "prompt_i... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Pre-dose inspiratory capacity | 0 | {"evidence_spans": [{"end": 20858, "start": 20776, "text": "I = pressurized metered-dose inhaler. No significant differences in pre-dose IC w"}], "id": "339", "pmcid": "3580134", "prompt_id": "339", "split_group_id": "3580134", "votes": {"0": 2}} |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Scar length | -1 | {"evidence_spans": [{"end": 1661, "start": 1579, "text": "P = 0.017). Transverse incisions were found to be significantly shorter than midli"}, {"end": 14687, "start": 14496, "text": "bserved difference is significant (P < 0.0001). The length of the incisions was 140 \u00b1 24 mm and 164 \u00b1 28 mm for the transverse... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: 1-hour post-dose inspiratory capacity mean improvements from baseline to the average over the randomized treatment period | 1 | {"evidence_spans": [{"end": 18320, "start": 18078, "text": "moterol (p = 0.023) [figure 3b]. Improvements from baseline were apparent at the first assessment (pre-dose FEV1 at end of month 1; 1-hour post-dose FEV1 at day of randomization) and overall maintained over the 12-month treatment period for b"}, {"end": 21101,... |
TITLE: Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: A placebo-controlled double-blind trial
ABSTRACT.BACKGROUND:
The clinical effects of mucolytics in patients with chronic obstructive pulmonary disease (COPD) are discussed controversially. Cineole is the main constituent of eucal... | Intervention: cineole
Comparator: placebo
Outcome: change of FVC and VC | 0 | {"evidence_spans": [{"end": 15052, "start": 14947, "text": "treatment with placebo was determined. The difference concerning change of FVC and VC between both treatm"}], "id": "449", "pmcid": "2720945", "prompt_id": "449", "split_group_id": "2720945", "votes": {"0": 2}} |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: O2 saturation | 0 | {"evidence_spans": [{"end": 1506, "start": 1372, "text": "<0.001). No statistically significant change in FEV1% or oxygen saturation was observed after either HFCWO or usual ACTs compared with"}, {"end": 1507, "start": 1372, "text": "<0.001). No statistically significant change in FEV1% or oxygen saturation was observe... |
TITLE: Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial [ISRCTN20244858]
ABSTRACT.BACKGROUND:
Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and defi... | Intervention: Exercise
Comparator: No exercise
Outcome: Baseline characteristics | 0 | {"evidence_spans": [{"end": 12832, "start": 12736, "text": "increased knee symptoms (Figure 1). There were no clinically significant differences in baseline"}], "id": "424", "pmcid": "1187893", "prompt_id": "424", "split_group_id": "1187893", "votes": {"0": 1}} |
TITLE: A heart failure self-management program for patients of all literacy levels: A randomized, controlled trial [ISRCTN11535170]
ABSTRACT.BACKGROUND:
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patie... | Intervention: Follow-up and thorough education on self-care
Comparator: Standard information about self-care
Outcome: Cardiac-related hospitalization | 0 | {"evidence_spans": [{"end": 18428, "start": 18282, "text": ".13).\r\n\r\nBODY.RESULTS.CARDIAC HOSPITALIZATION:\r\n39% of patients in the control group and 34% of patients in the intervention group had at least on"}, {"end": 18555, "start": 18282, "text": ".13).\r\n\r\nBODY.RESULTS.CARDIAC HOSPITALIZATION:\r\n39% of pat... |
TITLE: Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated children with Guillain Barré syndrome: a randomized study
ABSTRACT.INTRODUCTION:
Respiratory failure is a life threatening complication of Guillain Barré syndrome (GBS). There is no consensus on the specif... | Intervention: plasma exchange (PE)
Comparator: intravenous immunoglobulin (IVIG)
Outcome: Period of mechanical ventilation | -1 | {"evidence_spans": [{"end": 1453, "start": 1293, "text": "0.606). Children in the PE group had a shorter period of MV (median 11 days, IQR 11.0 to 13.0) compared to IVIG group (median 13 days, IQR 11.3 to 14.5) with p"}, {"end": 12779, "start": 12663, "text": "t 2 Chi square test. Children receiving PE had a signif... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Dyspnoea score improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial [ISRCTN20244858]
ABSTRACT.BACKGROUND:
Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and defi... | Intervention: Exercise
Comparator: No exercise
Outcome: SF-36 Mental Component Summary scale at 6 months | 0 | {"evidence_spans": [{"end": 15937, "start": 15685, "text": "TWEEN-GROUP DIFFERENCES.SECONDARY OUTCOMES:\r\nA significant improvement was found in the exercise group compared to the control group at six weeks with regard to the SF-36 Mental Component Summary scale (MCS) (2.1 vs -1.6, p = 0.04). At six months follo"}], "... |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Surgery duration | 0 | {"evidence_spans": [{"end": 11284, "start": 11107, "text": " 26.8 min, respectively (P = 0.35). The total duration of the procedures until extubation (in min) did not differ between the midline and transverse incisions (71.0 \u00b1 30.5 and 6"}], "id": "398", "pmcid": "2690844", "prompt_id": "398", "split_group_id": "2... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Photo-refractive keratectomy (PRK)
Comparator: Pre-surgery baseline
Outcome: Contrast sensitivity at 6 months seen at 3 cpd | -1 | {"evidence_spans": [{"end": 11468, "start": 11349, "text": "nd (P = 0.025), respectively. At 6 months contrast sensitivity in the PRK group was still significantly decreased from "}, {"end": 11558, "start": 11349, "text": "nd (P = 0.025), respectively. At 6 months contrast sensitivity in the PRK group was still signifi... |
TITLE: Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial
ABSTRACT.BACKGROUND:
Laparoscopic surgery has become popular during the last decade, mainly because it is associated with fewer postoperative complications than the conventional open approach. It rem... | Intervention: Laparoscopic surgery
Comparator: Conventional open approach
Outcome: Ulcer location | 0 | {"evidence_spans": [{"end": 9538, "start": 9466, "text": "ot differ between groups (Table 2). Location of the perforated ulcers wa"}, {"end": 9539, "start": 9466, "text": "ot differ between groups (Table 2). Location of the perforated ulcers was"}], "id": "271", "pmcid": "2691927", "prompt_id": "271", "split_group_id":... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Photo-refractive keratectomy (PRK)
Comparator: Thin-flap laser in situ keratomileusis (LASIK)
Outcome: Uncorrected distance visual acuity at 6 months | 0 | {"evidence_spans": [{"end": 10186, "start": 9924, "text": "months postoperatively. Statistically significant differences were found between PRK and thin-flap LASIK in UDVA at 1 month postoperatively, with thin-flap LASIK eyes showing more improvement in UDVA. Visual acuities were not statistically different between the... |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: Adverse events | 0 | {"evidence_spans": [{"end": 18388, "start": 18300, "text": "dent of order, time or day and position of treatment. Neither HFCWO nor any of the usual"}, {"end": 18389, "start": 18300, "text": "dent of order, time or day and position of treatment. Neither HFCWO nor any of the usual "}], "id": "251", "pmcid": "2922723", "... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: 1-hour post-dose inspiratory capacity mean improvements from baseline to the average over the randomized treatment period | 1 | {"evidence_spans": [{"end": 21101, "start": 20872, "text": "mong the treatment groups (figure 5a). Improvements from baseline to the average over the randomized treatment period in 1-hour post-dose IC were significantly greater with both budesonide/formoterol dosages compared with placebo"}], "id": "342", "pmcid": "358... |
TITLE: Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: A Cluster-Randomised Trial in Eastern Zimbabwe
ABSTRACT.BACKGROUND:
HIV-1 control in sub-Saharan Africa requires cost-effective and sustainable programmes that promote behaviour change and reduce cofactor sexually transmi... | Intervention: Baseline communities that received additional education and preventive measures
Comparator: Baseline communities that received standard Government services
Outcome: HIV/AIDS meeting attendance | 1 | {"evidence_spans": [{"end": 24014, "start": 23829, "text": "ramme meeting, respectively (Table 5). More respondents in the intervention communities than in the control communities attended an HIV/AIDS meeting (41% versus 28%, prevalence rate rat"}, {"end": 24089, "start": 23829, "text": "ramme meeting, respectively (Ta... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Baseline-adjusted average 12-hour FEV1 at end of treatment | 1 | {"evidence_spans": [{"end": 20391, "start": 20057, "text": " of treatment (p \u2264 0.002) [table II]. Although both budesonide/formoterol dosages demonstrated significant improvements in mean FEV1 at 12 hours and in baseline-adjusted average 12-hour FEV1 compared with formoterol on the day of randomization (p \u2264 0... |
TITLE: Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]
ABSTRACT.BACKGROUND:
Topical NSAIDs have been proven to relieve the symptoms of osteoarthritis (OA) in short-term studies (2 weeks). To justify its chronic use, efficacy of a t... | Intervention: topical diclofenac solution (Pennsaid®)
Comparator: vehicle control solution (carrier with no diclofenac)
Outcome: good or very good PGA response and OMERACT-OARSI responder | 1 | {"evidence_spans": [{"end": 18556, "start": 18312, "text": "ol (46/105 [43.8%] vs. 27/107 [25.2%]; p = 0.004). The topical diclofenac group had a significantly greater number of participants with good or very good PGA response (43.8% vs. 16.8%; p <0.0001) compared to the vehicle control group and of OME"}], "id": "438"... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Sleep score improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Sleep score improvement | 1 | {"evidence_spans": [{"end": 24264, "start": 24055, "text": "otal daily rescue medication use) [p \u2264 0.003]. Compared with formoterol, mean improvements were significantly greater with budesonide/formoterol 320/9 \u03bcg (p \u2264 0.038) for all COPD symptom variables except sputu"}], "id": "371", "pmcid": "3580134"... |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Intracranial pressure control | 1 | {"evidence_spans": [{"end": 2004, "start": 1842, "text": "rbital \u2013 thiopental was more effective than pentobarbital in terms of controlling intracranial pressure (odds ratio = 5.1, 95% confidence interval 1.2 to 21.9; P "}], "id": "409", "pmcid": "2575601", "prompt_id": "409", "split_group_id": "2575601", "votes":... |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Mean barbiturate coma length | 0 | {"evidence_spans": [{"end": 20572, "start": 20442, "text": "16.5 (3.0 to 21.5) in the pentobarbital group (P = 0.9). The mean \u00b1 SD duration of the barbiturate coma was 156 \u00b1 60 hours for thi"}], "id": "413", "pmcid": "2575601", "prompt_id": "413", "split_group_id": "2575601", "votes": {"0": 1}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Cough score improvement | 1 | {"evidence_spans": [{"end": 24387, "start": 24055, "text": "otal daily rescue medication use) [p \u2264 0.003]. Compared with formoterol, mean improvements were significantly greater with budesonide/formoterol 320/9 \u03bcg (p \u2264 0.038) for all COPD symptom variables except sputum score and percentage of awakening-... |
TITLE: An Open Label, Randomised Trial of Artesunate+Amodiaquine, Artesunate+Chlorproguanil-Dapsone and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria
ABSTRACT.BACKGROUND:
Artesunate+amodiaquine (AS+AQ) and artemether-lumefantrine (AL) are now the most frequently recommended first line treatme... | Intervention: Artesunate+amodiaquine (AS+AQ)
Comparator: artemether-lumefantrine (AL)
Outcome: parasitological or clinical failure rates by day 14 or day 28 in G6PD deficient children | 0 | {"evidence_spans": [{"end": 20938, "start": 20787, "text": "l-dapsone * \r\n exact P values \r\n \r\n\r\nBODY.RESULTS.G6PD DEFICIENT CHILDREN:\r\nThere was no statistically significant differences in the parasitological o"}], "id": "471", "pmcid": "2430614", "prompt_id": "471", "split_group_id": "2430614", "votes": {"0... |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Sepsis related Organ-Failure Assessment (SOFA) maximum score during treatment | 0 | {"evidence_spans": [{"end": 23856, "start": 23608, "text": " presented with at least one MAP measurement below 80 mmHg. There were no differences between groups with respect to the incidence of infections, Sepsis related Organ-Failure Assessment (SOFA) scores before initiation of treatment, or the maximum S"}], "id": "... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Pre-dose FEV1 improvement | 1 | {"evidence_spans": [{"end": 17687, "start": 17538, "text": "UNCTION.CO-PRIMARY ASSESSMENTS:\r\nImprovements in pre-dose FEV1 were significantly greater for budesonide/formoterol 320/9 \u03bcg compared with formoterol"}, {"end": 17776, "start": 17538, "text": "UNCTION.CO-PRIMARY ASSESSMENTS:\r\nImprovements in pre-dose ... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Improvements in St. George's Respiratory Questionnaire overall score | 1 | {"evidence_spans": [{"end": 23588, "start": 23378, "text": " EVALUATIONS.HEALTH STATUS AND COPD SYMPTOMS:\r\nImprovements in SGRQ total score were significantly greater for both budesonide/formoterol dosages compared with placebo (p \u2264 0.006) and for budesonide/formoterol "}, {"end": 23598, "start": 23378, "text": ... |
TITLE: Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated children with Guillain Barré syndrome: a randomized study
ABSTRACT.INTRODUCTION:
Respiratory failure is a life threatening complication of Guillain Barré syndrome (GBS). There is no consensus on the specif... | Intervention: plasma exchange (PE)
Comparator: intravenous immunoglobulin (IVIG)
Outcome: could walk unaided within four weeks after PICU discharge | 0 | {"evidence_spans": [{"end": 1721, "start": 1562, "text": "0.094). A total of 20/21 (95.2%) and 18/20 (90%) children in the PE and IVIG groups respectively could walk unaided within four weeks after PICU discharge (p "}], "id": "466", "pmcid": "3387601", "prompt_id": "466", "split_group_id": "3387601", "votes": {"0": 2... |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Pain on day two after surgery | -1 | {"evidence_spans": [{"end": 1855, "start": 1708, "text": "appearance. More patients having undergone a midline incision, reported pain on day one, two and three postoperatively than patients from the trans"}, {"end": 11988, "start": 11844, "text": "\r\n\r\nBODY.RESULTS.PAIN AND ANALGESICS:\r\nSignificantly more patient... |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Administration of hyperosmolar treatments | 0 | {"evidence_spans": [{"end": 20441, "start": 20196, "text": "p and in two of the patients in the pentobarbital group. The number of hyperosmolar treatments administered (manitol and/or hypertonic saline) during the barbiturate coma was similar in both groups: 16.5 (8.0 to 24.2) in the thiopental group and"}], "id": "412... |
TITLE: Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
ABSTRACT.BACKGROUND/AIMS:
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 1... | Intervention: Rosuvastatin
Comparator: Atorvastatin
Outcome: Apolipoprotein-B levels after 6 weeks of treatment | -1 | {"evidence_spans": [{"end": 1201, "start": 783, "text": "ESULTS:\r\nAfter 6 weeks of treatment, greater reductions in total cholesterol (- 35.94 \u00b1 11.38 vs. - 30.07 \u00b1 10.46%, p < 0.001), LDL-C (48.04 \u00b1 14.45 vs. 39.52 \u00b1 14.42%, p < 0.001), non-high-density lipoprotein cholesterol (- 42.93 \u00b1 13.... |
TITLE: Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
ABSTRACT.BACKGROUND/AIMS:
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 1... | Intervention: Rosuvastatin
Comparator: Atorvastatin
Outcome: Patients attaining the NCEP ATP III goal | 1 | {"evidence_spans": [{"end": 1358, "start": 1203, "text": "n group. Overall, the percentage of patients attaining the NCEP ATP III goal was higher with rosuvastatin as compared to atorvastatin (87.64 vs. 69.88%, p "}, {"end": 13978, "start": 13842, "text": "lyzed after 6 weeks in each group. The percentage of patients ... |
TITLE: A randomized trial of artemether-lumefantrine
ABSTRACT.BACKGROUND:
The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum. The fixed combination of oral artemether-lumefantrine, an artemisinin combination therapy (ACT) is ... | Intervention: Artemether-lumefantrine
Comparator: Mefloquine-artesunate
Outcome: Adverse events | 0 | {"evidence_spans": [{"end": 1645, "start": 1531, "text": "loquine. Both regimens were very well tolerated with no serious adverse events observed attributable to either com"}, {"end": 16640, "start": 16511, "text": "s at admission during follow-up in both groups. Overall, there were less adverse events in ALN group com... |
TITLE: Q-TWiST analysis to estimate overall benefit for patients with metastatic renal cell carcinoma treated in a phase III trial of sunitinib
ABSTRACT.BACKGROUND::
In a randomised phase III trial of treatment-naive patients with metastatic renal cell carcinoma, sunitinib showed significant improvement in progr... | Intervention: Sunitinib
Comparator: Interferon (IFN)-α
Outcome: Quality-adjusted survival times | 1 | {"evidence_spans": [{"end": 12731, "start": 12541, "text": "ib Q-TWiST\u2013IFN-\u03b1 Q-TWiST). The difference in scores ranged from 177 to 56 days. Interpreted another way, sunitinib had higher quality-adjusted survival times than IFN-\u03b1 across the entire ran"}, {"end": 12717, "start": 12619, "text": ". Interpret... |
TITLE: A Randomized Controlled Trial Investigating the Effects of a Low–Glycemic Index Diet on Pregnancy Outcomes in Gestational Diabetes Mellitus
ABSTRACT.OBJECTIVE:
The prevalence of gestational diabetes mellitus (GDM) is rising. There is little evidence to demonstrate the effectiveness of one dietary therapy o... | Intervention: low–glycemic index diet (target glycemic index [GI] ~50)
Comparator: high-fiber moderate-GI diet (HF) (target glycemic index GI ~60)
Outcome: birth weight, birth weight centile, prevalence of macrosomia, insulin treatment, adverse pregnancy outcomes | 0 | {"evidence_spans": [{"end": 1376, "start": 1054, "text": " 0.001). At birth, there was no significant difference in birth weight (LGI 3.3 \u00b1 0.1 kg vs. HF 3.3 \u00b1 0.1 kg; P = 0.619), birth weight centile (LGI 52.5 \u00b1 4.3 vs. HF 52.2 \u00b1 4.0; P = 0.969), prevalence of macrosomia (LGI 2.1% vs. HF 6.7%; P = ... |
TITLE: Antibiotic Prophylaxis Using Third Generation Cephalosporins Can Reduce the Risk of Early Rebleeding in the First Acute Gastroesophageal Variceal Hemorrhage: A Prospective Randomized Study
ABSTRACT:
Bacterial infection may be a critical trigger for variceal bleeding. Antibiotic prophylaxis can prevent rebl... | Intervention: received antibiotics treatment after randomization with intravenous cefotaxime 2 gram q 8 hr for 7 days
Comparator: received antibiotics only when infection was suspected or established
Outcome: Total mortality and 30-day mortality | 0 | {"evidence_spans": [{"end": 16360, "start": 16271, "text": "d on-demand group, respectively. Total mortality and 30-day mortality were not different "}, {"end": 16434, "start": 16272, "text": " on-demand group, respectively. Total mortality and 30-day mortality were not different between the two groups (Table 7). The o... |
TITLE: Fibrin Glue Reduces the Duration of Lymphatic Drainage after Lumpectomy and Level II or III Axillary Lymph Node Dissection for Breast Cancer: A Prospective Randomized Trial
ABSTRACT:
This randomized prospective study investigated the effect of fibrin glue use on drainage duration and overall drain output a... | Intervention: fibrin glue group (glue sprayed onto the axillary dissection site)
Comparator: control group
Outcome: drainage duration | 0 | {"evidence_spans": [{"end": 804, "start": 670, "text": "a. Overall, the fibrin glue and control groups were similar in terms of drainage duration, overall drain output, and incidence of sero"}], "id": "541", "pmcid": "2650992", "prompt_id": "541", "split_group_id": "2650992", "votes": {"0": 1}} |
TITLE: Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial [ISRCTN20244858]
ABSTRACT.BACKGROUND:
Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and defi... | Intervention: Exercise
Comparator: No exercise
Outcome: Knee injury and Osteoarthritis Outcome Score quality of life subscale at 6 weeks | 0 | {"evidence_spans": [{"end": 1556, "start": 1394, "text": "ontrols. In the exercise group, an improvement was seen at 6 weeks in the KOOS subscale quality of life compared to the control group (mean change 4.0 vs. -0.7, p"}], "id": "422", "pmcid": "1187893", "prompt_id": "422", "split_group_id": "1187893", "votes": {"0"... |
TITLE: Lay support for pregnant women with social risk: a randomised controlled trial
ABSTRACT.OBJECTIVES:
We sought evidence of effectiveness of lay support to improve maternal and child outcomes in disadvantaged families.
ABSTRACT.DESIGN:
Prospective, pragmatic, individually randomised controlled trial.
... | Intervention: additional lay support (in this instance Pregnancy Outreach Workers, POWs)
Comparator: standard maternity care
Outcome: Antenatal attendances | 0 | {"evidence_spans": [{"end": 1811, "start": 1607, "text": "\n\r\nABSTRACT.RESULTS:\r\nAntenatal attendances were high in the standard care control and did not increase further with addition of the POW intervention (10.1 vs 10.1 (mean difference; MD) \u22120.00, 95% CI (95%"}, {"end": 1810, "start": 1608, "text": "\r\nAB... |
TITLE: Lay support for pregnant women with social risk: a randomised controlled trial
ABSTRACT.OBJECTIVES:
We sought evidence of effectiveness of lay support to improve maternal and child outcomes in disadvantaged families.
ABSTRACT.DESIGN:
Prospective, pragmatic, individually randomised controlled trial.
... | Intervention: additional lay support (in this instance Pregnancy Outreach Workers, POWs)
Comparator: standard maternity care
Outcome: Mother-to-infant bonding | 1 | {"evidence_spans": [{"end": 2187, "start": 2055, "text": "% CI \u22121.24 to 0.06). Mother-to-infant bonding was significantly better in the intervention group for all women (MD \u22120.30 (95% CI \u22120."}, {"end": 2246, "start": 2055, "text": "% CI \u22121.24 to 0.06). Mother-to-infant bonding was significantly bett... |
TITLE: Effects of 3-Dimensional Lumbar Stabilization Training for Balance in Chronic Hemiplegic Stroke Patients: A Randomized Controlled Trial
ABSTRACT.OBJECTIVE:
To investigate the effects of the newly developed Spine Balance 3D system on the balance and gait abilities of hemiplegic stroke patients.
ABSTRACT.... | Intervention: Spine Balance 3D (CyberMedic)
Comparator: Biodex Balance System (Biodex Medical Systems, Shirley, NY, USA)
Outcome: The 10mWT (10-m walking test ) | 1 | {"evidence_spans": [{"end": 12368, "start": 12172, "text": "ents in the same tests. However, the results for the 10mWT showed only significant improvements in the experimental group (11.38\u00b13.0 to 10.12\u00b12.47 seconds; p=0.01); whereas the control group did n"}], "id": "568", "pmcid": "5256321", "prompt_id": "56... |
TITLE: Effects of 3-Dimensional Lumbar Stabilization Training for Balance in Chronic Hemiplegic Stroke Patients: A Randomized Controlled Trial
ABSTRACT.OBJECTIVE:
To investigate the effects of the newly developed Spine Balance 3D system on the balance and gait abilities of hemiplegic stroke patients.
ABSTRACT.... | Intervention: Spine Balance 3D (CyberMedic)
Comparator: Biodex Balance System (Biodex Medical Systems, Shirley, NY, USA)
Outcome: trunk strength (BPR score) | 1 | {"evidence_spans": [{"end": 12625, "start": 12370, "text": " show significant improvements. The improvement levels of the trunk strength (BPR score) for the experimental group using Spine Balance 3D system's evaluation program showed significant improvements at the 15\u00b0 open mode; whereas the control group did not ... |
TITLE: Implementing a structured education program for children with diabetes: lessons learnt from an integrated process evaluation
ABSTRACT.BACKGROUND:
There is recognition of an urgent need for clinic-based interventions for young people with type 1 diabetes mellitus that improve glycemic control and quality of... | Intervention: The Child and Adolescent Structured Competencies Approach to Diabetes Education (CASCADE) is a structured educational group program, using psychological techniques, delivered primarily by diabetes nurses.
Comparator: control
Outcome: HbA1c at 12 or 24 months. | 0 | {"evidence_spans": [{"end": 10018, "start": 9722, "text": " assessed by the trial.11 Given that the trial found no evidence of benefits on venous HbA1c at 12 and 24 months and little evidence of benefits on secondary outcomes, the focus of this paper is to use the findings of the process evaluation to suggest how futur... |
TITLE: The effect of uphill stride manipulation on race walking gait
ABSTRACT:
Stride length analysis represents an easy method for assessing race walking kinematics. However, the stride parameters emerging from such an analysis have never been used to design a training protocol aimed at increasing stride length.... | Intervention: stride frequency manipulation
Comparator: free stride frequency
Outcome: contact time | 1 | {"evidence_spans": [{"end": 1137, "start": 647, "text": "s. Kinematic parameters measured before and after the 3-week training in RWM showed increased stride length (4.54%; p<0.0001) and contact time (4.58%; p<0.001); inversely, a decreased stride frequency (4.44%; p<0.0001) and internal work (7.09%; p<0.05) were found... |
TITLE: The effect of uphill stride manipulation on race walking gait
ABSTRACT:
Stride length analysis represents an easy method for assessing race walking kinematics. However, the stride parameters emerging from such an analysis have never been used to design a training protocol aimed at increasing stride length.... | Intervention: stride frequency manipulation
Comparator: free stride frequency
Outcome: stride frequency | -1 | {"evidence_spans": [{"end": 1137, "start": 647, "text": "s. Kinematic parameters measured before and after the 3-week training in RWM showed increased stride length (4.54%; p<0.0001) and contact time (4.58%; p<0.001); inversely, a decreased stride frequency (4.44%; p<0.0001) and internal work (7.09%; p<0.05) were found... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Lifting heavy objects without discomfort | 1 | {"evidence_spans": [], "id": "584", "pmcid": "4819709", "prompt_id": "584", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Walking long distances (> 20 min) | 1 | {"evidence_spans": [], "id": "588", "pmcid": "4819709", "prompt_id": "588", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Partial return to normal work/employment | 1 | {"evidence_spans": [], "id": "594", "pmcid": "4819709", "prompt_id": "594", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Going out socially | 1 | {"evidence_spans": [], "id": "596", "pmcid": "4819709", "prompt_id": "596", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Sporting activity or exercise | 1 | {"evidence_spans": [], "id": "597", "pmcid": "4819709", "prompt_id": "597", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Endovenous laser ablation
Comparator: surgery
Outcome: Bending the legs without discomfort, Lifting heavy objects without discomfort, Moving from standing to sitting without discomfort, Standing still for a long time (> 15 min) without discomfort, Walking short distances (< 20 min) without discomfort, Wal... | 1 | {"evidence_spans": [], "id": "600", "pmcid": "4819709", "prompt_id": "600", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Premedication with midazolam prior to cesarean delivery in preeclamptic parturients: A randomized controlled trial
ABSTRACT.BACKGROUND::
Anxiety is a concern in obstetrics, especially in preeclamptic mothers. Sedation is not commonly used in parturients for fear of adverse neonatal effect. We investigated ... | Intervention: intravenous dose of 0.035 mg/kg of midazolam
Comparator: equal volume of normal saline, 30 min before spinal anesthesia
Outcome: preoperative anxiety | -1 | {"evidence_spans": [{"end": 1183, "start": 1029, "text": "SULTS::\r\nMothers premedicated with midazolam showed a lower level of preoperative anxiety and a higher degree of postoperative satisfaction than the contr"}, {"end": 13503, "start": 13493, "text": "e in both "}, {"end": 13735, "start": 13505, "text": "oups.\r\... |
TITLE: Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial
ABSTRACT.BACKGROUND:
To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules.
ABSTRACT.METHO... | Intervention: receive a dose of 0.25 mg (1:1:1 ratio) and then allocated to active treatment (CCH)
Comparator: dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated placebo (4:1 ratio)
Outcome: global assessment of improvement | 0 | {"evidence_spans": [{"end": 1734, "start": 1556, "text": "stigator global assessment of improvement was significantly greater with CCH 0.40 mg and 0.60 mg (P \u2264 0.0014) but not statistically significant with CCH 0.25 mg versus placebo (P"}], "id": "612", "pmcid": "5577662", "prompt_id": "612", "split_group_id": "55... |
TITLE: Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial
ABSTRACT.BACKGROUND:
To compare the effects of resistance training versus passive physical therapy on bone turnover markers (BTM) in the metastatic bone during radiation... | Intervention: resistance training dyrung radiation therapy
Comparator: passive physical therapy
Outcome: pyridinoline | -1 | {"evidence_spans": [{"end": 1360, "start": 1099, "text": "RESULTS:\r\nMean change values of PYD and CTX-I were significantly lower at 3 months after RT (p = 0.035 and p = 0.043) in Arm A. Importantly, all markers decreased in both arms, except of PYD and CTX-I in arm B, although significance was not reached for some bi... |
TITLE: Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial
ABSTRACT.SUMMARY.BACKGROUND:
Identification of new ways to increase access to antiretroviral therapy in Africa is an urgent priority. We... | Intervention: Home-based HIV-care strategy
Comparator: Facility-based HIV-care strategy
Outcome: Mortality rates | 0 | {"evidence_spans": [{"end": 22492, "start": 22411, "text": "rate ratio [RR] 0\u00b788, 95% CI 0\u00b770\u20131\u00b710). Mortality rates were much the same in t"}, {"end": 22736, "start": 22411, "text": "rate ratio [RR] 0\u00b788, 95% CI 0\u00b770\u20131\u00b710). Mortality rates were much the same in the two groups ... |
TITLE: Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial
ABSTRACT.SUMMARY.BACKGROUND:
Identification of new ways to increase access to antiretroviral therapy in Africa is an urgent priority. We... | Intervention: Home-based HIV-care strategy
Comparator: Facility-based HIV-care strategy
Outcome: Admission diagnoses | 0 | {"evidence_spans": [{"end": 22972, "start": 22914, "text": "and had undetectable plasma viral loads. Admission diagno"}, {"end": 23432, "start": 22914, "text": "and had undetectable plasma viral loads. Admission diagnoses were similar in both groups (table 3). 20 (13%) patients who were admitted died (15 on home and ... |
TITLE: Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial
ABSTRACT.SUMMARY.BACKGROUND:
Identification of new ways to increase access to antiretroviral therapy in Africa is an urgent priority. We... | Intervention: Home-based HIV-care strategy
Comparator: Facility-based HIV-care strategy
Outcome: Increase in CD4-cell counts | 0 | {"evidence_spans": [{"end": 23494, "start": 23434, "text": "f were infectious and parasitic disease. CD4-cell counts in"}, {"end": 23988, "start": 23434, "text": "f were infectious and parasitic disease. CD4-cell counts increased rapidly in both groups (figure 3). 748 (87%) participants in home care and 521 (88%) in ... |
TITLE: The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome: A randomized placebo-controlled trial
ABSTRACT.BACKGROUND::
Evidence has shown beneficial effects of probiotics in the treatment of irritable bowel syndrome (IBS); however, there is sti... | Intervention: receive a probiotic compound containing seven bacteria species including Lactobacillus strains, Bifidobacterium strains and Streptococcus thermophiles
Comparator: similar placebo, twice daily after a meal for 14 consecutive days
Outcome: decrease in abdominal pain and distension severity | 0 | {"evidence_spans": [{"end": 1284, "start": 1077, "text": "SULTS::\r\nAfter treatment, there was a decrease in abdominal pain and distension severity in both probiotic and the placebo groups (P<0.001), but there was no difference between the two groups in this regard "}, {"end": 1284, "start": 1095, "text": "atment, the... |
TITLE: Interferon-gamma in the first-line therapy of ovarian cancer: a randomized phase III trial
ABSTRACT:
Intraperitoneal treatment with interferon-γ (IFN-γ) has been shown to achieve surgically documented responses in the second-line therapy of ovarian cancer. To assess its efficacy in the first-line therapy, ... | Intervention: Cisplatin and Cyclophosphamide, plus subcutaneous IFN-γ
Comparator: Cisplatin and Cyclophosphamide
Outcome: Progression-free survival after 3 years | 1 | {"evidence_spans": [{"end": 915, "start": 671, "text": "e. Progression-free survival at 3 years was improved from 38% in controls to 51% in the treatment group corresponding to median times to progression of 17 and 48 months (P = 0.031, relative risk of progression 0.48, confidence interval 0.28\u20130.8"}, {"end": 916... |
TITLE: Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial
ABSTRACT:
BODY:
Radiotherapy in head and neck cancer patients can induce oral mucositis, which is an acute inflammation of the oral mucosa. Until now... | Intervention: PTA lozenge
Comparator: Placebo lozenge
Outcome: Need of feeding tube | 0 | {"evidence_spans": [{"end": 12922, "start": 12759, "text": "of radiation.\r\n\r\nBODY.RESULTS.FEEDING:\r\nSix patients (19%) in the placebo group (n=32) and two patients (6%) in the PTA group (n=33) needed nasogastric tube feedin"}], "id": "504", "pmcid": "2376383", "prompt_id": "504", "split_group_id": "2376383", "vot... |
TITLE: Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial
ABSTRACT:
BODY:
Radiotherapy in head and neck cancer patients can induce oral mucositis, which is an acute inflammation of the oral mucosa. Until now... | Intervention: PTA lozenge
Comparator: Placebo lozenge
Outcome: Candida sp. colonisation during the study | -1 | {"evidence_spans": [{"end": 13698, "start": 13303, "text": "e and colonisation was found in both groups. The colonisation and carriage of Candida species at baseline was equal in both groups (P>0.8). During the first two radiation weeks the colonisation for Candida species showed an increase in the placebo group and a... |
TITLE: Improvements in survival of the uncemented Nottingham Total Shoulder prosthesis: a prospective comparative study
ABSTRACT.BACKGROUND:
The uncemented Nottingham Total Shoulder Replacement prosthesis system (Nottingham TSR) was developed from the previous BioModular® shoulder prosthesis taking into considera... | Intervention: Initial Nottingham TSR design prosthesis
Comparator: BioModular® shoulder prosthesis
Outcome: 8-year survivorship | 1 | {"evidence_spans": [{"end": 17046, "start": 16877, "text": "s.\r\n\r\nBODY.RESULTS:\r\nThe eight year survivorship of the initial Nottingham TSR design (Group 2) was higher (p < 0.001) than observed in Group 1 patients with implanted B"}], "id": "508", "pmcid": "1964758", "prompt_id": "508", "split_group_id": "1964758"... |
TITLE: Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
ABSTRACT.BACKGROUND/AIMS:
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 1... | Intervention: Rosuvastatin
Comparator: Atorvastatin
Outcome: Levels of non-high-density lipoprotein cholesterol after 6 weeks of treatment | -1 | {"evidence_spans": [{"end": 1202, "start": 783, "text": "ESULTS:\r\nAfter 6 weeks of treatment, greater reductions in total cholesterol (- 35.94 \u00b1 11.38 vs. - 30.07 \u00b1 10.46%, p < 0.001), LDL-C (48.04 \u00b1 14.45 vs. 39.52 \u00b1 14.42%, p < 0.001), non-high-density lipoprotein cholesterol (- 42.93 \u00b1 13.... |
TITLE: Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
ABSTRACT.BACKGROUND/AIMS:
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 1... | Intervention: Rosuvastatin
Comparator: Atorvastatin
Outcome: Changes in glucose and insulin levels | 0 | {"evidence_spans": [{"end": 1515, "start": 1357, "text": " < 0.001). Changes in glucose and insulin levels, and homeostasis model assessment of insulin resistance index were not significantly different between the tw"}, {"end": 14837, "start": 14744, "text": " at 6 weeks are summarized in Table 3. Changes in glucose an... |
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