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TITLE: A randomized trial of artemether-lumefantrine
ABSTRACT.BACKGROUND:
The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum. The fixed combination of oral artemether-lumefantrine, an artemisinin combination therapy (ACT) is ... | Intervention: Artemether-lumefantrine
Comparator: Mefloquine-artesunate
Outcome: Fever clearance times | 0 | {"evidence_spans": [{"end": 12671, "start": 12590, "text": "rature on day 3 (2 in ALN and 1 in MAS3). There was no difference in fever cleara"}], "id": "518", "pmcid": "1261533", "prompt_id": "518", "split_group_id": "1261533", "votes": {"0": 2}} |
TITLE: A randomized trial of artemether-lumefantrine
ABSTRACT.BACKGROUND:
The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum. The fixed combination of oral artemether-lumefantrine, an artemisinin combination therapy (ACT) is ... | Intervention: Artemether-lumefantrine
Comparator: Mefloquine-artesunate
Outcome: New P. falciparum infections during the 42-day follow-up | 0 | {"evidence_spans": [{"end": 13762, "start": 13599, "text": "e slide for asexual P. falciparum forms. During the 42-day follow-up period, 27 new P. falciparum infections occurred among artemether-lumefantrine and 24 among a"}], "id": "520", "pmcid": "1261533", "prompt_id": "520", "split_group_id": "1261533", "votes": {... |
TITLE: A randomized trial of artemether-lumefantrine
ABSTRACT.BACKGROUND:
The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum. The fixed combination of oral artemether-lumefantrine, an artemisinin combination therapy (ACT) is ... | Intervention: Artemether-lumefantrine
Comparator: Mefloquine-artesunate
Outcome: PCR-adjusted cure rates after 42 days | 0 | {"evidence_spans": [{"end": 1530, "start": 1353, "text": "sponses. In both groups, the PCR adjusted cure rates by day 42 were high: 98.8% (95% CI 96.4, 99.6%) for artemether-lumefantrine and 96.3% (95% CI 93.1, 98.0%) for artesunate-me"}, {"end": 13929, "start": 13774, "text": "floquine recipients (P > 0.05) (Table 2).... |
TITLE: Q-TWiST analysis to estimate overall benefit for patients with metastatic renal cell carcinoma treated in a phase III trial of sunitinib
ABSTRACT.BACKGROUND::
In a randomised phase III trial of treatment-naive patients with metastatic renal cell carcinoma, sunitinib showed significant improvement in progr... | Intervention: Sunitinib
Comparator: Interferon (IFN)-α
Outcome: Adverse events | 1 | {"evidence_spans": [{"end": 8539, "start": 8415, "text": "0.25.\r\n\r\nBODY.RESULTS:\r\nThere were more reported occurrences of most general adverse events of all grades in the sunitinib a"}, {"end": 8540, "start": 8415, "text": "0.25.\r\n\r\nBODY.RESULTS:\r\nThere were more reported occurrences of most general adverse... |
TITLE: Q-TWiST analysis to estimate overall benefit for patients with metastatic renal cell carcinoma treated in a phase III trial of sunitinib
ABSTRACT.BACKGROUND::
In a randomised phase III trial of treatment-naive patients with metastatic renal cell carcinoma, sunitinib showed significant improvement in progr... | Intervention: Sunitinib
Comparator: Interferon (IFN)-α
Outcome: Overall survival | 0 | {"evidence_spans": [{"end": 10462, "start": 10335, "text": "er duration of median PFS; overall survival was also longer with sunitinib than with IFN-\u03b1, although the difference did not rea"}, {"end": 10463, "start": 10335, "text": "er duration of median PFS; overall survival was also longer with sunitinib than with... |
TITLE: Q-TWiST analysis to estimate overall benefit for patients with metastatic renal cell carcinoma treated in a phase III trial of sunitinib
ABSTRACT.BACKGROUND::
In a randomised phase III trial of treatment-naive patients with metastatic renal cell carcinoma, sunitinib showed significant improvement in progr... | Intervention: Sunitinib
Comparator: Interferon (IFN)-α
Outcome: Quality-of-life scores | 1 | {"evidence_spans": [{"end": 9319, "start": 9143, "text": "% CI: 18, 37; Table 1). However, the mean time spent without symptoms of disease progression or toxicity of treatment (i.e., TWiST) was 151 days higher in the sunitinib than in"}, {"end": 11327, "start": 11134, "text": "sunitinib than with IFN-\u03b1. Quality-of... |
TITLE: Q-TWiST analysis to estimate overall benefit for patients with metastatic renal cell carcinoma treated in a phase III trial of sunitinib
ABSTRACT.BACKGROUND::
In a randomised phase III trial of treatment-naive patients with metastatic renal cell carcinoma, sunitinib showed significant improvement in progr... | Intervention: Sunitinib
Comparator: Interferon (IFN)-α
Outcome: Duration of median PFS | 1 | {"evidence_spans": [{"end": 378, "start": 268, "text": "a, sunitinib showed significant improvement in progression-free survival (PFS) compared with interferon (IFN)-"}, {"end": 10333, "start": 10192, "text": "SCUSSION AND CONCLUSIONS:\r\nResults from this phase III trial of sunitinib vs IFN-\u03b1 showed that sunitini... |
TITLE: A Theory-Based Video Messaging Mobile Phone Intervention for Smoking Cessation: Randomized Controlled Trial
ABSTRACT.BACKGROUND:
Advances in technology allowed the development of a novel smoking cessation program delivered by video messages sent to mobile phones. This social cognitive theory-based interve... | Intervention: an automated package of video and text messages over 6 months that was tailored to self-selected quit date, role model, and timing of messages. Extra messages were available on demand to beat cravings and address lapses.
Comparator: set a quit date and received a general health video message sent to their... | 0 | {"evidence_spans": [{"end": 1856, "start": 1729, "text": " addiction. Continuous abstinence at 6 months was 26.4% (29/110) in the intervention group and 27.6% (32/116) in the control gr"}, {"end": 1857, "start": 1729, "text": " addiction. Continuous abstinence at 6 months was 26.4% (29/110) in the intervention group an... |
TITLE: Antibiotic Prophylaxis Using Third Generation Cephalosporins Can Reduce the Risk of Early Rebleeding in the First Acute Gastroesophageal Variceal Hemorrhage: A Prospective Randomized Study
ABSTRACT:
Bacterial infection may be a critical trigger for variceal bleeding. Antibiotic prophylaxis can prevent rebl... | Intervention: received antibiotics treatment after randomization with intravenous cefotaxime 2 gram q 8 hr for 7 days
Comparator: received antibiotics only when infection was suspected or established
Outcome: The incidence of bacterial infection | -1 | {"evidence_spans": [{"end": 1025, "start": 956, "text": "s. Antibiotic prophylaxis decreased infection (3.2% vs. 15.5%, p=0.02"}, {"end": 13874, "start": 13731, "text": "gy is outlined in Table 2. The incidence of bacterial infection was significantly lower in patient receiving antibiotic prophylaxis (2/62, 3.2%"}], "i... |
TITLE: Antibiotic Prophylaxis Using Third Generation Cephalosporins Can Reduce the Risk of Early Rebleeding in the First Acute Gastroesophageal Variceal Hemorrhage: A Prospective Randomized Study
ABSTRACT:
Bacterial infection may be a critical trigger for variceal bleeding. Antibiotic prophylaxis can prevent rebl... | Intervention: received antibiotics treatment after randomization with intravenous cefotaxime 2 gram q 8 hr for 7 days
Comparator: received antibiotics only when infection was suspected or established
Outcome: Enteric bacteria | -1 | {"evidence_spans": [{"end": 14094, "start": 13967, "text": "mmon sources of infection. Enteric bacteria were more frequently identified in patients without antibiotic prophylaxis (0/62, 0"}], "id": "538", "pmcid": "2722000", "prompt_id": "538", "split_group_id": "2722000", "votes": {"-1": 1}} |
TITLE: Fibrin Glue Reduces the Duration of Lymphatic Drainage after Lumpectomy and Level II or III Axillary Lymph Node Dissection for Breast Cancer: A Prospective Randomized Trial
ABSTRACT:
This randomized prospective study investigated the effect of fibrin glue use on drainage duration and overall drain output a... | Intervention: fibrin glue group (glue sprayed onto the axillary dissection site)
Comparator: control group
Outcome: overall drain output | 0 | {"evidence_spans": [{"end": 804, "start": 670, "text": "a. Overall, the fibrin glue and control groups were similar in terms of drainage duration, overall drain output, and incidence of sero"}], "id": "542", "pmcid": "2650992", "prompt_id": "542", "split_group_id": "2650992", "votes": {"0": 1}} |
TITLE: Physiological-dose steroid therapy in sepsis [ISRCTN36253388]
ABSTRACT.INTRODUCTION:
The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortality in patie... | Intervention: received standard therapy for sepsis and physiological-dose steroid therapy for 10 days;
Comparator: received only standard therapy for sepsis
Outcome: Sequential Organ Failure Assessment (SOFA) score | 0 | {"evidence_spans": [{"end": 18876, "start": 18658, "text": "dard therapy groups, respectively (Table 4). No statistically significant difference was found between the changes in the percentage of SOFA scores of the steroid therapy group (43.1 \u00b1 26.5%) and the standard therapy g"}], "id": "549", "pmcid": "125315", ... |
TITLE: Physiological-dose steroid therapy in sepsis [ISRCTN36253388]
ABSTRACT.INTRODUCTION:
The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortality in patie... | Intervention: received standard therapy for sepsis and physiological-dose steroid therapy for 10 days;
Comparator: received only standard therapy for sepsis
Outcome: The 28-day mortality | 0 | {"evidence_spans": [{"end": 15228, "start": 15107, "text": "\n\r\nBODY.RESULTS.THE 28-DAY MORTALITY:\r\nThere were eight deaths (40%) in the steroid therapy group and 12 (60%) deaths in "}], "id": "550", "pmcid": "125315", "prompt_id": "550", "split_group_id": "125315", "votes": {"0": 1}} |
TITLE: Effects of lifestyle physical activity on perceived symptoms and physical function in adults with fibromyalgia: results of a randomized trial
ABSTRACT.INTRODUCTION:
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated... | Intervention: lifestyle physical activity (LPA) - 30 minutes of self-selected moderate-intensity LPA, five to seven days per week
Comparator: fibromyalgia (FM) education control (FME) group - received information and support
Outcome: perceived functional deficits | -1 | {"evidence_spans": [{"end": 1119, "start": 1020, "text": " by 54%. Compared to FME, the LPA group reported significantly less perceived functional deficits ("}], "id": "559", "pmcid": "2888205", "prompt_id": "559", "split_group_id": "2888205", "votes": {"-1": 1}} |
TITLE: Effects of lifestyle physical activity on perceived symptoms and physical function in adults with fibromyalgia: results of a randomized trial
ABSTRACT.INTRODUCTION:
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated... | Intervention: lifestyle physical activity (LPA) - 30 minutes of self-selected moderate-intensity LPA, five to seven days per week
Comparator: fibromyalgia (FM) education control (FME) group - received information and support
Outcome: Fatigue severity scale | 0 | {"evidence_spans": [{"end": 22063, "start": 21906, "text": "ion 73 46.3 \u00b1 24.2 62.4 \u00b1 24.5 16.1 (4.6 to 27.5) 0.006 .67 Fatigue severity scale \u2003Baseline 84 51.9 \u00b1 9.3 52.3 \u00b1 9.1 .4 (-3.6 to 4.4) 0.843 .04 \u2003Post interv"}], "id": "562", "pmcid": "2888205", "prompt_id": "562", "split_group_id... |
TITLE: Effects of lifestyle physical activity on perceived symptoms and physical function in adults with fibromyalgia: results of a randomized trial
ABSTRACT.INTRODUCTION:
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated... | Intervention: lifestyle physical activity (LPA) - 30 minutes of self-selected moderate-intensity LPA, five to seven days per week
Comparator: fibromyalgia (FM) education control (FME) group - received information and support
Outcome: Body mass index (BMI) | 0 | {"evidence_spans": [{"end": 22517, "start": 22360, "text": "vention 72 16.0 \u00b1 2.3 16.8 \u00b1 2.0 .8 (-.35 to 1.9) 0.172 .37 Body mass index (BMI) \u2003Baseline 82 31.4 \u00b1 8.4 29.8 \u00b1 6.2 1.6 (-4.7 to 1.7) 0.360 .22 \u2003Post interv"}], "id": "564", "pmcid": "2888205", "prompt_id": "564", "split_group_id... |
TITLE: Effects of lifestyle physical activity on perceived symptoms and physical function in adults with fibromyalgia: results of a randomized trial
ABSTRACT.INTRODUCTION:
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated... | Intervention: lifestyle physical activity (LPA) - 30 minutes of self-selected moderate-intensity LPA, five to seven days per week
Comparator: fibromyalgia (FM) education control (FME) group - received information and support
Outcome: Center for Epidemiologic Studies Depression Scale (CES-D) | 0 | {"evidence_spans": [{"end": 22203, "start": 22063, "text": "ention 73 50.6 \u00b1 9.9 51.4 \u00b1 10.1 .8 (-3.9 to 5.5) 0.727 .07 CES-D* \u2003Baseline 84 23.4 \u00b1 8.6 24.0 \u00b1 10 .6 (-3.8 to 4.5) 0.798 .06 \u2003Post interv"}], "id": "565", "pmcid": "2888205", "prompt_id": "565", "split_group_id": "2888205", "vo... |
TITLE: Effects of 3-Dimensional Lumbar Stabilization Training for Balance in Chronic Hemiplegic Stroke Patients: A Randomized Controlled Trial
ABSTRACT.OBJECTIVE:
To investigate the effects of the newly developed Spine Balance 3D system on the balance and gait abilities of hemiplegic stroke patients.
ABSTRACT.... | Intervention: Spine Balance 3D (CyberMedic)
Comparator: Biodex Balance System (Biodex Medical Systems, Shirley, NY, USA)
Outcome: he Berg Balance Scale (BBS), Timed Up and Go Test (TUG), Functional Reach Test (FRT), the Korean version of the Fall Efficacy Scale-International (KFES-I) | 1 | {"evidence_spans": [], "id": "570", "pmcid": "5256321", "prompt_id": "570", "split_group_id": "5256321", "votes": {"1": 1}} |
TITLE: The effect of uphill stride manipulation on race walking gait
ABSTRACT:
Stride length analysis represents an easy method for assessing race walking kinematics. However, the stride parameters emerging from such an analysis have never been used to design a training protocol aimed at increasing stride length.... | Intervention: stride frequency manipulation
Comparator: free stride frequency
Outcome: stride length | 1 | {"evidence_spans": [{"end": 769, "start": 647, "text": "s. Kinematic parameters measured before and after the 3-week training in RWM showed increased stride length (4.54%; p<0.00"}], "id": "575", "pmcid": "4577567", "prompt_id": "575", "split_group_id": "4577567", "votes": {"1": 2}} |
TITLE: Are CT Scans a Satisfactory Substitute for the Follow-Up of RSA Migration Studies of Uncemented Cups? A Comparison of RSA Double Examinations and CT Datasets of 46 Total Hip Arthroplasties
ABSTRACT:
As part of the 14-year follow-up of a prospectively randomized radiostereometry (RSA) study on uncemented cu... | Intervention: CT scan
Comparator: 2–4 stereo radiograph pair examinations
Outcome: datasets of 3D coordinates | 0 | {"evidence_spans": [{"end": 1187, "start": 706, "text": ". The precision of RSA corresponding to the 99% confidence interval was 1.36\u00b0, 1.36\u00b0, and 0.60\u00b0 for X-, Y-, and Z-rotation and 0.40, 0.17, and 0.37 mm for X-, Y-, and Z-translation. The limit of agreement between CT and RSA was 1.51\u00b0, 2.17\u00... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Moving from standing to sitting without discomfort | 1 | {"evidence_spans": [], "id": "585", "pmcid": "4819709", "prompt_id": "585", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Driving a car | 1 | {"evidence_spans": [], "id": "590", "pmcid": "4819709", "prompt_id": "590", "split_group_id": "4819709", "votes": {"1": 2}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Looking after children | 1 | {"evidence_spans": [], "id": "592", "pmcid": "4819709", "prompt_id": "592", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Endovenous laser ablation
Comparator: Ultrasound‐guided foam sclerotherapy
Outcome: Bending the legs without discomfort, lifting heavy objects without discomfort, Moving from standing to sitting without discomfort, Standing still for a long time (> 15 min) without discomfort, Driving a car, Doing housewor... | 0 | {"evidence_spans": [], "id": "598", "pmcid": "4819709", "prompt_id": "598", "split_group_id": "4819709", "votes": {"0": 1}} |
TITLE: Premedication with midazolam prior to cesarean delivery in preeclamptic parturients: A randomized controlled trial
ABSTRACT.BACKGROUND::
Anxiety is a concern in obstetrics, especially in preeclamptic mothers. Sedation is not commonly used in parturients for fear of adverse neonatal effect. We investigated ... | Intervention: intravenous dose of 0.035 mg/kg of midazolam
Comparator: equal volume of normal saline, 30 min before spinal anesthesia
Outcome: postoperative satisfaction | 1 | {"evidence_spans": [{"end": 1183, "start": 1029, "text": "SULTS::\r\nMothers premedicated with midazolam showed a lower level of preoperative anxiety and a higher degree of postoperative satisfaction than the contr"}], "id": "605", "pmcid": "5062194", "prompt_id": "605", "split_group_id": "5062194", "votes": {"1": 2}} |
TITLE: Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial
ABSTRACT.BACKGROUND:
To compare the effects of resistance training versus passive physical therapy on bone turnover markers (BTM) in the metastatic bone during radiation... | Intervention: resistance training dyrung radiation therapy
Comparator: passive physical therapy
Outcome: beta-isomer of carboxy-terminal telopeptide of type I collagen | -1 | {"evidence_spans": [{"end": 1207, "start": 1100, "text": "ESULTS:\r\nMean change values of PYD and CTX-I were significantly lower at 3 months after RT (p = 0.035 and p"}, {"end": 1900, "start": 1853, "text": "luence BTM. PYD and CTX-I decreased significant"}], "id": "614", "pmcid": "4794897", "prompt_id": "614", "split... |
TITLE: Routine resite of peripheral intravenous devices every 3 days did not reduce complications compared with clinically indicated resite: a randomised controlled trial
ABSTRACT.BACKGROUND:
Peripheral intravenous device (IVD) complications were traditionally thought to be reduced by limiting dwell time. Current... | Intervention: clinically indicated
Comparator: routine replacement
Outcome: hospital costs per patient for the course of IV therapy | -1 | {"evidence_spans": [{"end": 1899, "start": 1747, "text": " patient in the routine replacement (mean, 1.8) than the clinical indication group (mean, 1.5), with significantly higher hospital costs per patient (P "}, {"end": 25682, "start": 25451, "text": "t resited, or infusion failure had already occurred.) Mean hospita... |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: Sputum expectoration over a 24-hour period | -1 | {"evidence_spans": [{"end": 1371, "start": 1181, "text": "e study. Significantly more sputum was expectorated during a single treatment session and over a 24 h period (mean difference 4.4 g and 6.9 g, respectively) with usual ACTs than with HFCWO ("}, {"end": 1372, "start": 1181, "text": "e study. Significantly more sp... |
TITLE: Randomised phase II evaluation of irinotecan plus high-dose 5-fluorouracil and leucovorin (ILF)
ABSTRACT:
An open-label randomised comparison of efficacy and tolerability of irinotecan plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) (ILF) with etoposide plus 5-FU/LV (ELF) in patients with untreat... | Intervention: Irinotecan with high-dose 5-fluorouracil plus leucovorin (ILF)
Comparator: Etoposide with 5-fluorouracil plus leucovorin (ELF)
Outcome: Progression-free survival | 0 | {"evidence_spans": [{"end": 15717, "start": 15410, "text": "from a cardiovascular event. Compared with ELF, the ILF regimen extended median progression-free survival, median time to treatment failure and median overall survival (Table 4). However, when the treatment groups were compared by log-rank test, there was no ... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Moving from standing to sitting without discomfort | 1 | {"evidence_spans": [], "id": "826", "pmcid": "4819709", "prompt_id": "826", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Doing housework | 1 | {"evidence_spans": [], "id": "832", "pmcid": "4819709", "prompt_id": "832", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Wearing clothes that show the legs | 0 | {"evidence_spans": [], "id": "834", "pmcid": "4819709", "prompt_id": "834", "split_group_id": "4819709", "votes": {"0": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Endovenous laser ablation
Comparator: Ultrasound?guided foam sclerotherapy
Outcome: Bending the legs without discomfort, lifting heavy objects without discomfort, Moving from standing to sitting without discomfort, Standing still for a long time (>?15 min) without discomfort, Driving a car, Doing housewor... | 0 | {"evidence_spans": [], "id": "839", "pmcid": "4819709", "prompt_id": "839", "split_group_id": "4819709", "votes": {"0": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Endovenous laser ablation
Comparator: Ultrasound?guided foam sclerotherapy
Outcome: walking short distances without discomfort, walking long distances, looking after children, full return to normal work/employment | -1 | {"evidence_spans": [{"end": 17579, "start": 17375, "text": "mized to EVLA and those randomized to UGFS (Table \r\n4). Return to 'walking short distances without discomfort', 'walking long distances', 'looking after children' and 'full return to normal work/employme"}], "id": "840", "pmcid": "4819709", "prompt_id": "84... |
TITLE: Statin efficacy in the treatment of hepatitis C genotype I
ABSTRACT.BACKGROUND::
Lipid metabolism is one of the hepatitis C virus (HCV) life cycle steps. Statins can reduce cholesterol level and finally can decrease HCV replication. Thus, we assessed the effect of Statins in combination with standard antiv... | Intervention: 20 mg atorvastatin nightly for 3 months
Comparator: placebo
Outcome: mean of HCV-RNA numbers at the end of treatment | 0 | {"evidence_spans": [{"end": 1354, "start": 1155, "text": "SULTS::\r\nWe didn't find any significant differences in the mean of HCV-RNA numbers between statin and placebo groups in 12th week of treatment, in the end of treatment and 6 months after treatment (P"}, {"end": 8177, "start": 7996, "text": "n and placebo, also... |
TITLE: Short-term effects of physiotherapy combining repetitive facilitation
exercises and orthotic treatment in chronic post-stroke patients
ABSTRACT:
[Purpose] This study investigated the short-term effects of a combination therapy
consisting of repetitive facilitative exercises and orthotic treatment. [Subje... | Intervention: after 4 weeks of repetitive facilitative exercises and orthotic treatment.
Comparator: before repetitive facilitative exercises and orthotic treatment.
Outcome: comfortable gait speed and fast gait speed | 1 | {"evidence_spans": [{"end": 8184, "start": 7978, "text": "tion, TUG decreased\r\nsignificantly from 17.35 \u00b1 5.57 seconds to 14.02 \u00b1 4.46 seconds (p<0.01), comfortable\r\ngait speed increased significantly from 0.68 \u00b1 0.22 (m/sec) to 0.81 \u00b1 0.24 (m/sec)\r\n(p<0.01), and "}], "id": "870", "pmcid": "53... |
TITLE: Expanding access to parasite-based malaria diagnosis through retail drug shops in Tanzania: evidence from a randomized trial and implications for treatment
ABSTRACT.BACKGROUND:
Tanzania has seen a reduction in the fraction of fevers caused by malaria, likely due in part to scale-up of control measures. Whi... | Intervention: After trainings covered signs and symptoms of uncomplicated and severe malaria, stocking, use, and disposal of RDTs, and appropriate case management based on RDT results.
Comparator: Before trainings covered signs and symptoms of uncomplicated and severe malaria, stocking, use, and disposal of RDTs, and a... | 1 | {"evidence_spans": [{"end": 20577, "start": 20339, "text": "in the intervention and control groups during the study (Fig. 2b). The proportion of patients present at the ADDO who received a diagnostic test increased from 19% pre-intervention to 74% post-intervention in the intervention districts an"}], "id": "872", "pmc... |
TITLE: Potential benefit of bosentan therapy in borderline or less severe pulmonary hypertension secondary to idiopathic pulmonary fibrosis—an interim analysis of results from a prospective, single-center, randomized, parallel-group study
ABSTRACT.BACKGROUND:
No drugs have been approved for the treatment of patie... | Intervention: bosentan
Comparator: no treatment
Outcome: overall survival of patients with pulmonary hypertension (PH) secondary to idiopathic pulmonary fibrosis (IPF) | 1 | {"evidence_spans": [], "id": "874", "pmcid": "5729252", "prompt_id": "874", "split_group_id": "5729252", "votes": {"1": 2}} |
TITLE: How to avoid discontinuation of antihypertensive treatment. The experience in São Paulo, Brazil
ABSTRACT.OBJECTIVES::
To evaluate the importance of providing guidelines to patients via active telephone calls for blood pressure control and for preventing the discontinuation of treatment among hypertensive p... | Intervention: phone calls" group
Comparator: "no phone calls" group
Outcome: discontinued treatment | -1 | {"evidence_spans": [{"end": 1345, "start": 1197, "text": ".RESULTS::\r\nSignificantly fewer patients in the \"phone calls\" group discontinued treatment compared to those in the \"no phone calls\" group (4 vs. 30"}], "id": "876", "pmcid": "2974815", "prompt_id": "876", "split_group_id": "2974815", "votes": {"-1": 2}} |
TITLE: How quick is soon? Early response to continuous positive airway pressure: a randomized controlled trial
ABSTRACT:
BODY.INTRODUCTION:
Numerous studies have confirmed that using non-invasive continuous positive airway pressure (nCPAP) for chronic obstructive pulmonary disease and congestive heart failur... | Intervention: CPAP + standard of care (nCPAP group)
Comparator: standard group
Outcome: rate of intubations | -1 | {"evidence_spans": [{"end": 2399, "start": 2286, "text": "pectively). Finally, the rate of intubations was higher in the standard group (n = 8, n = 3) than the nCPAP group"}], "id": "878", "pmcid": "4088715", "prompt_id": "878", "split_group_id": "4088715", "votes": {"-1": 2}} |
TITLE: The Effects of Vitamin D Supplementation on Signaling Pathway of Inflammation and Oxidative Stress in Diabetic Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial
ABSTRACT:
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inf... | Intervention: vitamin D supplements at a dosage of 50,000 IU (n = 30) every 2 weeks for 12 weeks
Comparator: placebo (n = 30) every 2 weeks for 12 weeks
Outcome: gene expression of transforming growth factor beta (TGF-?), protein kinase C (PKC), mitogen-activated protein kinases 1 (MAPK1) | -1 | {"evidence_spans": [{"end": 1414, "start": 900, "text": "at after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1\u03b2 (P = 0.02), tumor necrosis factor alpha (TNF-\u03b1) (P = 0.02) and interferon gamma (IFN-\u03b3) (P = 0.03) in PBMCs o... |
TITLE: The Effects of Vitamin D Supplementation on Signaling Pathway of Inflammation and Oxidative Stress in Diabetic Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial
ABSTRACT:
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inf... | Intervention: vitamin D supplements at a dosage of 50,000 IU (n = 30) every 2 weeks for 12 weeks
Comparator: placebo (n = 30) every 2 weeks for 12 weeks
Outcome: nuclear factor kappa B (NF-kB), interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF) | 0 | {"evidence_spans": [{"end": 1862, "start": 1449, "text": "s. Although not significant, vitamin D supplementation let to a reduction of nuclear factor kappa B (NF-kB) (p = 0.75) expression in PBMCs isolated from diabetic patients compared to the placebo group. There was no statistically significant change following supp... |
TITLE: Belatacept-Based Immunosuppression in
ABSTRACT:
This exploratory phase II study evaluated the safety and efficacy of belatacept in de novo adult liver transplant recipients. Patients were randomized (N = 260) to one of the following immunosuppressive regimens: (i) basiliximab + belatacept high dose [HD] +... | Intervention: belatacept groups
Comparator: tacrolimus groups
Outcome: By month 12, the proportion surviving with a functioning graft | -1 | {"evidence_spans": [{"end": 1051, "start": 822, "text": "p. By month 12, the proportion surviving with a functioning graft was higher with tacrolimus + MMF (93%) and lower with belatacept LD (67%) versus other groups (90%: basiliximab + belatacept HD; 83%: belatacept HD; 88%: tacrolimu"}], "id": "895", "pmcid": "414054... |
TITLE: Evaluation of the functional efficacy of an antioxidative probiotic in healthy volunteers
ABSTRACT.BACKGROUND:
In persons without clinical symptom it is difficult to assess an impact of probiotics regarding its effect on health. We evaluated the functional efficacy of the probiotic Lactobacillus fermentum ... | Intervention: Capsule trial, ME-3
Comparator: Placebo
Outcome: glutathione red-ox ratio | 0 | {"evidence_spans": [{"end": 20439, "start": 20319, "text": "14 \u00b1 0.03 to 0.11 \u00b1 0.02 \u03bcg/ml, p < 0.01) in the goat milk trial. When the probiotic was consumed in capsulated form, no"}], "id": "898", "pmcid": "1198254", "prompt_id": "898", "split_group_id": "1198254", "votes": {"0": 1}} |
TITLE: Efficacy and Safety of a Lidocaine Gel in Patients from 6 Months up to 8 Years with Acute Painful Sites in the Oral Cavity: A Randomized, Placebo-Controlled, Double-Blind, Comparative Study
ABSTRACT:
Lidocaine is a well-accepted topical anaesthetic, also used in minors to treat painful conditions on mucosa... | Intervention: lidocaine gel (2%)
Comparator: placebo
Outcome: On average (median) pain in the paediatric population | -1 | {"evidence_spans": [{"end": 11540, "start": 11302, "text": ". RESULTS.3.3. EFFICACY RESULTS:\r\nOn average (median) pain has been reduced by 2.0/5 (verum) versus 1.2/5 (placebo) (Table 3). Nonparametric analysis (Mann-Whitney U test) of treatment related difference in pain assessment yielded a stat"}, {"end": 11706, "... |
TITLE: A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β
ABSTRACT.BACKGROUND:
Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA i... | Intervention: Abediterol
Comparator: placebo
Outcome: peak FEV1 | 1 | {"evidence_spans": [{"end": 1583, "start": 1352, "text": "ESULTS:\r\nAbediterol produced dose-dependent improvements in peak FEV1 from baseline compared with placebo, from 0.274 (95% CI 0.221, 0.327) to 0.405 L (95% CI 0.353, 0.458) for abediterol 0.313 to 2.5 \u03bcg, respectively (p < 0.0001 a"}], "id": "903", "pmcid... |
TITLE: A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β
ABSTRACT.BACKGROUND:
Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA i... | Intervention: Abediterol
Comparator: placebo
Outcome: Dose-dependent changes from baseline in trough FEV1 | 1 | {"evidence_spans": [{"end": 1869, "start": 1677, "text": "butamol. Dose-dependent changes from baseline in trough FEV1 versus placebo were 0.219 (95% CI 0.136, 0.302) to 0.400 L (95% CI 0.317, 0.483) for abediterol 0.313 to 2.5 \u03bcg, respectively (p < "}], "id": "905", "pmcid": "4320624", "prompt_id": "905", "split_... |
TITLE: Assessing Calcium Intake in Postmenopausal Women
ABSTRACT.INTRODUCTION:
Because foods fortified with calcium are increasingly available, the calcium content of calcium-fortified foods may not be adequately captured in traditional assessments of dietary intake, such as dietary records analyzed with commerci... | Intervention: calcium-focused food frequency questionnaire (CFFFQ)
Comparator: 24-hour recall
Outcome: Estimation of underreported calcium as daily calcium intake increased | -1 | {"evidence_spans": [{"end": 1282, "start": 1148, "text": "< .001). As daily calcium intake increased, the 24-hour recall increasingly underreported calcium (r = 0.41, P < .001) compared with t"}], "id": "910", "pmcid": "2774638", "prompt_id": "910", "split_group_id": "2774638", "votes": {"-1": 2}} |
TITLE: Cluster Randomized Trial of Text Message Reminders to Retail Staff in Tanzanian Drug Shops Dispensing Artemether-Lumefantrine: Effect on Dispenser Knowledge and Patient Adherence
ABSTRACT:
Artemisinin combination therapies are available in private outlets, but patient adherence might be compromised by poor... | Intervention: receive text message reminders about what advice to provide when dispensing artemether-lumefantrine (AL).
Comparator: no text message
Outcome: completion of each dose at the correct time | 0 | {"evidence_spans": [{"end": 1163, "start": 915, "text": "e, there was no difference between arms in adherence measured as completion of all doses (intervention 68.3%, control 69.8%, p [adjusted] = 0.6), or as completion of each dose at the correct time (intervention 33.1%, control 32.6%, p [adjusted] = 0"}, {"end": 124... |
TITLE: Effects of transcranial direct current stimulation on temperature and pain perception
ABSTRACT:
Transcranial direct current stimulation modifies cortical excitability and in consequence some cerebral functions. In the present study we aimed to elucidate whether tDCS could affect temperature and pain percep... | Intervention: 2?mA anodal tDCS, when applied for 15?min over the motor cortex
Comparator: baseline
Outcome: cold perception thresholds | 1 | {"evidence_spans": [{"end": 19311, "start": 19131, "text": "OVA for cold perception: F(2,18) = 3,68; p = 0.046)). In details, 15 minutes 2 mA anodal tDCS induced a significant increase in cold perception thresholds immediately after the end"}], "id": "932", "pmcid": "5462761", "prompt_id": "932", "split_group_id": "546... |
TITLE: Custodiol - N versus Custodiol: a prospective randomized double blind multicenter phase III Trial
ABSTRACT:
BODY.BACKGROUND/INTRODUCTION:
HTK-Solution (Custodiol) is a well-established cardioplegic and organ preservation solution. We currently developed a novel HTK based solution Custodiol-N which inc... | Intervention: Custodiol-N
Comparator: Custodiol
Outcome: Cardiac index, catecholamines ICU-stay and mortality (1 death in the control group) | 0 | {"evidence_spans": [{"end": 1761, "start": 1650, "text": "odiol-N group. Cardiac index, catecholamines ICU-stay and mortality (1 death in the control group) was similar "}], "id": "946", "pmcid": "4693888", "prompt_id": "946", "split_group_id": "4693888", "votes": {"0": 2}} |
TITLE: Custodiol - N versus Custodiol: a prospective randomized double blind multicenter phase III Trial
ABSTRACT:
BODY.BACKGROUND/INTRODUCTION:
HTK-Solution (Custodiol) is a well-established cardioplegic and organ preservation solution. We currently developed a novel HTK based solution Custodiol-N which inc... | Intervention: Custodiol-N
Comparator: Custodiol
Outcome: peak CKMB | -1 | {"evidence_spans": [{"end": 1649, "start": 1488, "text": "n both groups. Although the trial was designed for non-inferiority, peak CKMB (52 \u00b1 40 vs. 41 \u00b1 30 U/l, superiority p < 0.002) was significantly lower in the Cus"}, {"end": 1648, "start": 1541, "text": "n-inferiority, peak CKMB (52 \u00b1 40 vs. 41 \u0... |
TITLE: Continued stabilization of trabecular metal tibial monoblock total knee arthroplasty components at 5 years—measured with radiostereometric analysis
ABSTRACT.BACKGROUND AND PURPOSE:
The trabecular metal tibial monoblock component (TM) is a relatively new option available for total knee arthroplasty. We hav... | Intervention: The trabecular metal tibial monoblock component (TM)
Comparator: cemented component.
Outcome: maximum total point motion (MTPM) | 0 | {"evidence_spans": [{"end": 1228, "start": 1177, "text": "d group. MTPM values were similar in the 2 groups ("}, {"end": 13223, "start": 13099, "text": "cular metal group (p = 0.2). At the 5-year follow-up, there was no difference in MTPM between the cemented group and the tr"}], "id": "949", "pmcid": "3278655", "prom... |
TITLE: Clinical evaluation of the AutoPulse automated chest compression device for out-of-hospital cardiac arrest in the northern district of Shanghai, China
ABSTRACT.INTRODUCTION:
Whether the AutoPulse automated chest compression device is worthy of clinical use for out-of-hospital cardiac arrest (OHCA) remains ... | Intervention: AutoPulse automated chest compression device
Comparator: manual chest compression for cardiopulmonary resuscitation (CPR) of out-of-hospital cardiac arrest (OHCA)
Outcome: The hospital discharge rate of the patients with OHCA | 1 | {"evidence_spans": [{"end": 1627, "start": 1465, "text": "= 0.03). The hospital discharge rate of the patients with OHCA was significantly higher in the AutoPulse CPR group than in the Manual CPR group (18.8% vs. 6.3%; p"}], "id": "964", "pmcid": "4889691", "prompt_id": "964", "split_group_id": "4889691", "votes": {"1"... |
TITLE: Interferon-gamma in the first-line therapy of ovarian cancer: a randomized phase III trial
ABSTRACT:
Intraperitoneal treatment with interferon-γ (IFN-γ) has been shown to achieve surgically documented responses in the second-line therapy of ovarian cancer. To assess its efficacy in the first-line therapy, ... | Intervention: Cisplatin and Cyclophosphamide, plus subcutaneous IFN-γ
Comparator: Cisplatin and Cyclophosphamide
Outcome: Full clinical responses | 0 | {"evidence_spans": [{"end": 1093, "start": 1004, "text": "). Complete clinical responses were observed in 68% with IFN-\u03b3 versus 56% in controls (n."}, {"end": 1094, "start": 1004, "text": "). Complete clinical responses were observed in 68% with IFN-\u03b3 versus 56% in controls (n.s"}], "id": "492", "pmcid": "236... |
TITLE: Interferon-gamma in the first-line therapy of ovarian cancer: a randomized phase III trial
ABSTRACT:
Intraperitoneal treatment with interferon-γ (IFN-γ) has been shown to achieve surgically documented responses in the second-line therapy of ovarian cancer. To assess its efficacy in the first-line therapy, ... | Intervention: Cisplatin and Cyclophosphamide, plus subcutaneous IFN-γ
Comparator: Cisplatin and Cyclophosphamide
Outcome: Toxicity | 0 | {"evidence_spans": [{"end": 1230, "start": 1095, "text": "). Toxicity was comparable in both groups except for a mild flu-like syndrome, experienced by most patients after administration of IFN"}, {"end": 1231, "start": 1095, "text": "). Toxicity was comparable in both groups except for a mild flu-like syndrome, experi... |
TITLE: Double-Blind Placebo-Controlled Treatment Trial of
ABSTRACT:
Objective: The purpose of this study was to determine if treatment of pregnant women with Chlamydia trachomatis infection would lower the incidence of preterm delivery and/or low birth weight.
Methods: Pregnant women between the 2... | Intervention: Erythromycin
Comparator: Placebo
Outcome: Low birth weight | 0 | {"evidence_spans": [{"end": 691, "start": 549, "text": "esults: When the results were examined without regard to study site, erythromycin had little impact on reducing low birth weight (8% vs. 11%, "}, {"end": 691, "start": 610, "text": "y site, erythromycin had little impact on reducing low birth weight (8% vs. 11%, "... |
TITLE: Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial
ABSTRACT:
BODY:
Radiotherapy in head and neck cancer patients can induce oral mucositis, which is an acute inflammation of the oral mucosa. Until now... | Intervention: PTA lozenge
Comparator: Placebo lozenge
Outcome: Weight loss | 0 | {"evidence_spans": [{"end": 13098, "start": 12950, "text": "od (P=0.08).\r\n\r\nBODY.RESULTS.BODY WEIGHT:\r\nThe mean weight loss after 5 weeks of radiation was less in the PTA group by 1.3 kg (s.d. 3.0) than in th"}], "id": "505", "pmcid": "2376383", "prompt_id": "505", "split_group_id": "2376383", "votes": {"0": 1}} |
TITLE: Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial
ABSTRACT:
BODY:
Radiotherapy in head and neck cancer patients can induce oral mucositis, which is an acute inflammation of the oral mucosa. Until now... | Intervention: PTA lozenge
Comparator: Placebo lozenge
Outcome: Aerobic Gram-negative bacilli colonisation at 3-5 weeks | 0 | {"evidence_spans": [{"end": 14223, "start": 14045, "text": "at baseline was equal in both groups (P=0.9). During the radiation period the colonisation in the PTA group was less than in the placebo group, but the difference was only signif"}, {"end": 14532, "start": 14369, "text": "up (lines) and the placebo group (soli... |
TITLE: Improvements in survival of the uncemented Nottingham Total Shoulder prosthesis: a prospective comparative study
ABSTRACT.BACKGROUND:
The uncemented Nottingham Total Shoulder Replacement prosthesis system (Nottingham TSR) was developed from the previous BioModular® shoulder prosthesis taking into considera... | Intervention: Redesigned Nottingham TSR prosthesis
Comparator: BioModular® shoulder prosthesis
Outcome: 4-year survivorship | 1 | {"evidence_spans": [{"end": 21470, "start": 21073, "text": "fidence intervals). The observed four-year survivorship of the patients in Group 3 was also significantly higher than the survivorship rates of the BioModular\u00ae prosthesis observed after the first four years after implantation (p = 0.02), with a 93.1% cum... |
TITLE: Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
ABSTRACT.BACKGROUND/AIMS:
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 1... | Intervention: Rosuvastatin
Comparator: Atorvastatin
Outcome: Total cholesterol after 6 weeks of treatment | -1 | {"evidence_spans": [{"end": 1202, "start": 783, "text": "ESULTS:\r\nAfter 6 weeks of treatment, greater reductions in total cholesterol (- 35.94 \u00b1 11.38 vs. - 30.07 \u00b1 10.46%, p < 0.001), LDL-C (48.04 \u00b1 14.45 vs. 39.52 \u00b1 14.42%, p < 0.001), non-high-density lipoprotein cholesterol (- 42.93 \u00b1 13.... |
TITLE: Evaluation of the functional efficacy of an antioxidative probiotic in healthy volunteers
ABSTRACT.BACKGROUND:
In persons without clinical symptom it is difficult to assess an impact of probiotics regarding its effect on health. We evaluated the functional efficacy of the probiotic Lactobacillus fermentum ... | Intervention: L. fermentum ME-3 fermented goat milk
Comparator: goat milk
Outcome: total fecal counts of lactobacilli | 1 | {"evidence_spans": [{"end": 1370, "start": 1229, "text": "ESULTS:\r\nME-3 was well tolerated and a significant increase in total faecal lactobacilli yet no predominance of ME-3 was detected in all stud"}, {"end": 17408, "start": 17104, "text": "nd no changes were found in capsule placebo group. Figure 1Increase of tot... |
TITLE: A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated
ABSTRACT.BACKGROUND:
Many countries have implemented artemisinin-based combination therapy (ACT) for the first-l... | Intervention: arthemeter-lumefantrine (AL)
Comparator: dihydroartemisinin-piperaquine (AP)
Outcome: Gametocyte dynamics | 0 | {"evidence_spans": [{"end": 18437, "start": 18316, "text": "the cases gametocytes were observed by microscopy. There was no difference between children older than 60 months and youn"}], "id": "650", "pmcid": "2600646", "prompt_id": "650", "split_group_id": "2600646", "votes": {"0": 1}} |
TITLE: A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β
ABSTRACT.BACKGROUND:
Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA i... | Intervention: Abediterol
Comparator: placebo
Outcome: Change from baseline in normalized FEV1 AUC0–6, FEV1 AUC0–12, and FEV1 AUC0–2 | 1 | {"evidence_spans": [{"end": 22132, "start": 21919, "text": " (analysis of covariance). FEV1, forced expiratory volume in 1 s. Change from baseline in normalized FEV1 AUC0\u20136, FEV1 AUC0\u201312, and FEV1 AUC0\u201324 was significantly higher for all doses of abediterol versus placebo"}, {"end": 22133, "start": 2191... |
TITLE: Assessing Calcium Intake in Postmenopausal Women
ABSTRACT.INTRODUCTION:
Because foods fortified with calcium are increasingly available, the calcium content of calcium-fortified foods may not be adequately captured in traditional assessments of dietary intake, such as dietary records analyzed with commerci... | Intervention: calcium-focused food frequency questionnaire (CFFFQ)
Comparator: 24-hour recall
Outcome: Estimation of total daily calcium intake | 1 | {"evidence_spans": [{"end": 1147, "start": 1006, "text": "< .001). The CFFFQ estimated greater total daily calcium intake than did the 24-hour recall (mean [SD], 1,021 [624] mg/d vs 800 [433] mg/d, P"}], "id": "909", "pmcid": "2774638", "prompt_id": "909", "split_group_id": "2774638", "votes": {"1": 2}} |
TITLE: Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population
ABSTRACT:
Haptoglobin's (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular d... | Intervention: daily doses of 400 IU of vitamin E and 1000 mg of vitamin C from 9-16 weeks gestation until delivery.
Comparator: placebo from 9-16 weeks gestation until delivery.
Outcome: preeclampsia risk in Hispanic Hp 2-2 women. | 1 | {"evidence_spans": [{"end": 23502, "start": 23220, "text": "tion in Hp 2-2 women was only seen in Hispanics. Hispanic 2-2 women who were not taking prenatal vitamins at randomization had a smaller increase in preeclampsia risk with supplementation than Hispanic 2-2 women who were taking prenatal vitamins at randomizati... |
TITLE: Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population
ABSTRACT:
Haptoglobin's (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular d... | Intervention: Haptoglobin's (Hp) 1-1, 2-1,
Comparator: Haptoglobin's (Hp) 2-2 phenotypes
Outcome: preeclampsia risk | 0 | {"evidence_spans": [{"end": 2069, "start": 1911, "text": "n. Hp phenotype does not influence preeclampsia risk, or identify a subset of women who may benefit from vitamin C and E supplementation to prevent preeclamps"}, {"end": 19173, "start": 18976, "text": "TS.PRIMARY OUTCOME AND PREECLAMPSIA RISK:\r\nHp phenotype wa... |
TITLE: The Effect of Yellow Tinted Intraocular Lenses on the Result of Frequency Doubling Perimetry after Cataract Surgery
ABSTRACT.PURPOSE:
To investigate the effect of yellow tinted intraocular lenses (IOLs), implanted in the bag after phacoemulsification, on the result of frequency doubling technique (FDT) per... | Intervention: IOLs were selected randomly among two types of yellow IOLs (Acrysof SN60WF IOL, Hoya YA60BBR IOL)
Comparator: clear IOL was used as a control.
Outcome: the result of frequency doubling technique (FDT) perimetry. | 0 | {"evidence_spans": [{"end": 5854, "start": 5495, "text": "ve phase (Table 2). The results of FDT perimetry testing are shown in Figs. 1, 2, and 3. There were no statistically significant differences for MD and PSD between the clear IOL and Hoya YA60BBR IOL groups (MD: clear IOL, -5.09 \u00b1 4.72 Db; Hoya YA60BBR IOL,... |
TITLE: Antibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana
ABSTRACT.BACKGROUND:
Babies are increasingly being exposed to antibiotics intrapartum in the bid to reduce neonatal and maternal deaths. Intrapartum antibiotic exposure, ... | Intervention: antibiotics
Comparator: no antibiotics
Outcome: birthweight, incidence of congenital birth defect and mean Apgar scores | 0 | {"evidence_spans": [{"end": 1601, "start": 1464, "text": " mother. Intrapartum antibiotic exposure did not significantly affect the birthweight, incidence of congenital birth defect and mean Apga"}], "id": "942", "pmcid": "5551012", "prompt_id": "942", "split_group_id": "5551012", "votes": {"0": 2}} |
TITLE: Antibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana
ABSTRACT.BACKGROUND:
Babies are increasingly being exposed to antibiotics intrapartum in the bid to reduce neonatal and maternal deaths. Intrapartum antibiotic exposure, ... | Intervention: antibiotics in less than 24 h to parturition
Comparator: no antibiotics
Outcome: mean Apgar | -1 | {"evidence_spans": [{"end": 2192, "start": 2090, "text": "gar scores. However, antibiotic use less than 24 h to delivery was associated with a decrease in mean "}, {"end": 15895, "start": 15607, "text": "an Apgar scores (i.e. 8.242 \u00b1 1.3 vs 8.32 \u00b1 1.62 (p = 0.414, F = 1.59)). However when mothers were treated... |
TITLE: Custodiol - N versus Custodiol: a prospective randomized double blind multicenter phase III Trial
ABSTRACT:
BODY.BACKGROUND/INTRODUCTION:
HTK-Solution (Custodiol) is a well-established cardioplegic and organ preservation solution. We currently developed a novel HTK based solution Custodiol-N which inc... | Intervention: Custodiol-N
Comparator: Custodiol
Outcome: CKMB AUC and Troponin-T AUC | 0 | {"evidence_spans": [{"end": 1487, "start": 1306, "text": "en the groups. CKMB AUC (878 \u00b1 549 vs. 778 \u00b1 439 h*U/l, non-inferiority p < 0.001) and Troponin-T AUC (12990 \u00b1 8347 vs. 13498 \u00b1 6513 h*pg/ml, non-inferiority p < 0.001) was similar "}], "id": "948", "pmcid": "4693888", "prompt_id": "948", "sp... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Bending the legs without discomfort | 1 | {"evidence_spans": [{"end": 13146, "start": 12797, "text": "ULTRASOUND\u2010GUIDED FOAM SCLEROTHERAPY :\r\nParticipants randomized to UGFS recalled being able to carry out 13 of the 15 behaviours significantly more quickly than those randomized to surgery (Table \r\n2\r\n). The two behaviours for which there was no ev... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Lifting heavy objects without discomfort | 1 | {"evidence_spans": [{"end": 13146, "start": 12797, "text": "ULTRASOUND\u2010GUIDED FOAM SCLEROTHERAPY :\r\nParticipants randomized to UGFS recalled being able to carry out 13 of the 15 behaviours significantly more quickly than those randomized to surgery (Table \r\n2\r\n). The two behaviours for which there was no ev... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Walking long distances (>?20 min) | 1 | {"evidence_spans": [{"end": 12958, "start": 12797, "text": "ULTRASOUND\u2010GUIDED FOAM SCLEROTHERAPY :\r\nParticipants randomized to UGFS recalled being able to carry out 13 of the 15 behaviours significantly more quickly than "}, {"end": 13144, "start": 12960, "text": "ose randomized to surgery (Table \r\n2\r\n). Th... |
TITLE: A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change
ABSTRACT.BACKGROUND:
To examine the effects of a 6 month lifestyle intervention on quality of life, depression, self-efficacy and eating behavior changes in overwe... | Intervention: lifestyle intervention (LI) consisting of exercise and nutritional counseling with cognitive-behavior modification
Comparator: usual care
Outcome: self-efficacy related to social pressure and restraint in overweight and obese endometrial cancer survivors. | 1 | {"evidence_spans": [{"end": 919, "start": 788, "text": "comfort. There was a significant improvement for self-efficacy related to social pressure (p = .03) and restraint (p = .02) in the "}], "id": "959", "pmcid": "2656477", "prompt_id": "959", "split_group_id": "2656477", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Looking after children | 1 | {"evidence_spans": [], "id": "833", "pmcid": "4819709", "prompt_id": "833", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability
ABSTRACT:
The beneficial health effects of cranberries have been attributed to their (poly)phenol content. Recent studies have investigated the absorption, metabol... | Intervention: cranberry juices
Comparator: nothing
Outcome: 14 (poly)phenol metabolites | 1 | {"evidence_spans": [{"end": 10722, "start": 10356, "text": "catechol-O-sulfate. The time to reach Cmax (Tmax) varied depending on the metabolite and depending on the amount of (poly)phenols in the juice (Supplementary Figure S1). The level of TP in cranberry juice seemed to impact the Tmax of individual metabolites, f... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Endovenous laser ablation
Comparator: surgery
Outcome: Bending the legs without discomfort, Lifting heavy objects without discomfort, Moving from standing to sitting without discomfort, Standing still for a long time (>?15 min) without discomfort, Walking short distances (<?20 min) without discomfort, Wal... | 1 | {"evidence_spans": [], "id": "841", "pmcid": "4819709", "prompt_id": "841", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Premedication with midazolam prior to cesarean delivery in preeclamptic parturients: A randomized controlled trial
ABSTRACT.BACKGROUND::
Anxiety is a concern in obstetrics, especially in preeclamptic mothers. Sedation is not commonly used in parturients for fear of adverse neonatal effect. We investigated ... | Intervention: intravenous dose of 0.035 mg/kg of midazolam
Comparator: equal volume of normal saline, 30 min before spinal anesthesia
Outcome: neonatal outcome | 0 | {"evidence_spans": [{"end": 1255, "start": 1184, "text": "l group. There were no between-group differences regarding the neonatal"}], "id": "604", "pmcid": "5062194", "prompt_id": "604", "split_group_id": "5062194", "votes": {"0": 2}} |
TITLE: Statin efficacy in the treatment of hepatitis C genotype I
ABSTRACT.BACKGROUND::
Lipid metabolism is one of the hepatitis C virus (HCV) life cycle steps. Statins can reduce cholesterol level and finally can decrease HCV replication. Thus, we assessed the effect of Statins in combination with standard antiv... | Intervention: 20 mg atorvastatin nightly for 3 months
Comparator: placebo
Outcome: mean of HCV-RNA numbers 6 months after treatment | 0 | {"evidence_spans": [{"end": 1354, "start": 1155, "text": "SULTS::\r\nWe didn't find any significant differences in the mean of HCV-RNA numbers between statin and placebo groups in 12th week of treatment, in the end of treatment and 6 months after treatment (P"}, {"end": 8217, "start": 7996, "text": "n and placebo, also... |
TITLE: Short-term effects of physiotherapy combining repetitive facilitation
exercises and orthotic treatment in chronic post-stroke patients
ABSTRACT:
[Purpose] This study investigated the short-term effects of a combination therapy
consisting of repetitive facilitative exercises and orthotic treatment. [Subje... | Intervention: after 4 weeks of repetitive facilitative exercises and orthotic treatment.
Comparator: before repetitive facilitative exercises and orthotic treatment.
Outcome: FMA-LE: the Fugl-Meyer Assessment of the lower extremity; SIAS: Stroke Impairment Assessment Set; | 1 | {"evidence_spans": [{"end": 1146, "start": 983, "text": "n. [Results] The findings of the Fugl-Meyer\r\nassessment, Stroke Impairment Assessment Set, Timed Up & Go test, and 10-m walk test\r\nsignificantly improved after the"}, {"end": 7565, "start": 7310, "text": "(m/sec)0.68 \u00b1 0.220.81 \u00b1 0.240.12 \u00b1 0.0... |
TITLE: Short-term effects of physiotherapy combining repetitive facilitation
exercises and orthotic treatment in chronic post-stroke patients
ABSTRACT:
[Purpose] This study investigated the short-term effects of a combination therapy
consisting of repetitive facilitative exercises and orthotic treatment. [Subje... | Intervention: after 4 weeks of repetitive facilitative exercises and orthotic treatment.
Comparator: before repetitive facilitative exercises and orthotic treatment.
Outcome: TUG: Timed "Up & Go" test; | -1 | {"evidence_spans": [{"end": 7978, "start": 7890, "text": "significantly from 46.59 \u00b1\r\n8.34 to 53.63 \u00b1 7.63 (p<0.01). In terms of functional ambula"}], "id": "869", "pmcid": "5332972", "prompt_id": "869", "split_group_id": "5332972", "votes": {"-1": 1}} |
TITLE: Expanding access to parasite-based malaria diagnosis through retail drug shops in Tanzania: evidence from a randomized trial and implications for treatment
ABSTRACT.BACKGROUND:
Tanzania has seen a reduction in the fraction of fevers caused by malaria, likely due in part to scale-up of control measures. Whi... | Intervention: After trainings covered signs and symptoms of uncomplicated and severe malaria, stocking, use, and disposal of RDTs, and appropriate case management based on RDT results.
Comparator: Before trainings covered signs and symptoms of uncomplicated and severe malaria, stocking, use, and disposal of RDTs, and a... | 1 | {"evidence_spans": [{"end": 1951, "start": 1760, "text": "n ADDOs. Pre-treatment testing performed within the ADDO increased from 0 to 65% of suspected malaria patients who visited a shop (95% CI 60.8\u201369.6%) with no difference between intervention d"}], "id": "871", "pmcid": "5209819", "prompt_id": "871", "split_g... |
TITLE: Potential benefit of bosentan therapy in borderline or less severe pulmonary hypertension secondary to idiopathic pulmonary fibrosis—an interim analysis of results from a prospective, single-center, randomized, parallel-group study
ABSTRACT.BACKGROUND:
No drugs have been approved for the treatment of patie... | Intervention: bosentan
Comparator: no treatment
Outcome: hospital-free survival of patients with pulmonary hypertension (PH) secondary to idiopathic pulmonary fibrosis (IPF) | 1 | {"evidence_spans": [{"end": 32465, "start": 32050, "text": "ere PH, 2 were confirmed to have been hospitalized based on the data obtained on the cutoff date. At the time of survival time analysis, hospital-free survival was 358.87 \u00b1 68.65 days (mean \u00b1 SE) (median, 331 days) in the untreated group, which was ... |
TITLE: How to avoid discontinuation of antihypertensive treatment. The experience in São Paulo, Brazil
ABSTRACT.OBJECTIVES::
To evaluate the importance of providing guidelines to patients via active telephone calls for blood pressure control and for preventing the discontinuation of treatment among hypertensive p... | Intervention: phone calls" group
Comparator: "no phone calls" group
Outcome: The percentage of patients with controlled blood pressure (<140/90 mmHg) | 0 | {"evidence_spans": [{"end": 1531, "start": 1346, "text": " p<0.0094). There was no difference in the percentage of patients with controlled blood pressure in the \"phone calls\" group and \"no phone calls\" group or in the \"traditional\" and \"curre"}], "id": "877", "pmcid": "2974815", "prompt_id": "877", "split_group... |
TITLE: Adjuvant radiation for salivary gland malignancies is associated with improved survival: A National Cancer Database analysis
ABSTRACT.OBJECTIVE:
There are no randomized data to support the use of postoperative radiation for salivary gland malignancies. This study uses the National Cancer Database (NCDB) to... | Intervention: major salivary gland cancer in high risk group plus adjuvant radiation therapy
Comparator: major salivary gland cancer in high risk group without adjuvant radiation therapy
Outcome: survival | 1 | {"evidence_spans": [{"end": 1605, "start": 1431, "text": "8 years. Patients in the high-risk group had greater survival (hazard ratio [HR], 0.76; P = .002; 95% confidence interval [CI], 0.64-0.91) if they received adjuvant radiation"}], "id": "884", "pmcid": "5514258", "prompt_id": "884", "split_group_id": "5514258", "... |
TITLE: Adjuvant radiation for salivary gland malignancies is associated with improved survival: A National Cancer Database analysis
ABSTRACT.OBJECTIVE:
There are no randomized data to support the use of postoperative radiation for salivary gland malignancies. This study uses the National Cancer Database (NCDB) to... | Intervention: major salivary gland cancer in low/intermediate risk group plus adjuvant radiation therapy
Comparator: major salivary gland cancer in low/intermediate risk group without adjuvant radiation therapy
Outcome: survival | 0 | {"evidence_spans": [{"end": 1819, "start": 1606, "text": "therapy. In contrast, patients in the intermediate- (HR, 1.01; P = .904; 95% CI, 0.85-1.20) and low-risk groups (HR, 0.85; P = .427; 95% CI, 0.57-1.26) did not experience a survival benefit with adjuvant radiation"}, {"end": 1819, "start": 1619, "text": "ontrast... |
TITLE: The Effects of Vitamin D Supplementation on Signaling Pathway of Inflammation and Oxidative Stress in Diabetic Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial
ABSTRACT:
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inf... | Intervention: vitamin D supplements at a dosage of 50,000 IU (n = 30) every 2 weeks for 12 weeks
Comparator: placebo (n = 30) every 2 weeks for 12 weeks
Outcome: gene expression of interleukin (IL), tumor necrosis factor alpha (TNF-?), interferon gamma (IFN-?) | -1 | {"evidence_spans": [{"end": 1168, "start": 867, "text": "s: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1\u03b2 (P = 0.02), tumor necrosis factor alpha (TNF-\u03b1) (P = 0.02) and interferon gamma (... |
TITLE: Randomized Trial Comparing Esomeprazole and Rabeprazole in First-line Eradication Therapy for
ABSTRACT.OBJECTIVE :
CYP2C19 metabolic activity influences the efficacy of Helicobacter pylori eradication therapies comprising PPIs. Rabeprazole (RPZ) and esomeprazole (EPZ) are PPIs not extensively metabolized ... | Intervention: amoxicillin (750 mg), clarithromycin (200 mg), and either esomeprazole (20 mg) (EAC group), twice a day for one week.
Comparator: amoxicillin (750 mg), clarithromycin (200 mg), and rabeprazole (10 mg) (RAC group), twice a day for one week.
Outcome: H. pylori eradication | 0 | {"evidence_spans": [{"end": 1280, "start": 923, "text": "SULTS :\r\nThe eradication rates of the EAC and RAC regimens were 79.8% (95% confidential interval: 71.7-89.0%) and 74.7% (66.0-83.4%), respectively, in a per protocol (PP) analysis (p=0.488). The eradication rates of the EAC and RAC regimens were not significant... |
TITLE: A randomised controlled trial to prevent smoking relapse among recently quit smokers enrolled in employer and health plan sponsored quitlines
ABSTRACT.OBJECTIVE:
To test adding an interactive voice response (IVR)-supported protocol to standard quitline treatment to prevent relapse among recently quit smoke... | Intervention: Technology Enhanced Quitline-10
Comparator: Technology Enhanced Quitline-20
Outcome: Number of positive screens | -1 | {"evidence_spans": [{"end": 26455, "start": 26208, "text": "counselling calls between the TEQ-10 and TEQ-20 groups (p=0.28). There was a statistical difference in the number of positive screens between the two intervention groups, with TEQ-20 having slightly more positive screens than TEQ-10 (on average, 1"}], "id": "1... |
TITLE: Tranexamic acid for patients with traumatic brain injury: a randomized, double-blinded, placebo-controlled trial
ABSTRACT.BACKGROUND:
Traumatic brain injury (TBI) is commonly accompanied by intracranial bleeding which can worsen after hospital admission. Tranexamic acid (TXA) has been shown to reduce bleed... | Intervention: Tranexamic acid
Comparator: Placebo
Outcome: Intracranial haemorrhage | 0 | {"evidence_spans": [{"end": 1689, "start": 1458, "text": "ESULTS:\r\nProgressive intracranial haemorrhage was present in 21 (18%) of 120 patients allocated to TXA and in 32 (27%) of 118 patients allocated to placebo. The difference was not statistically significant [RR = 0.65 (95% CI 0.40 t"}, {"end": 13249, "start": 1... |
TITLE: Pioglitazone Decreases Hepatitis C Viral Load in Overweight, Treatment Naïve, Genotype 4 Infected-Patients: A Pilot Study
ABSTRACT.BACKGROUND:
Insulin resistance (IR) is induced by chronic hepatitis C virus (HCV) genotypes 1 and 4 infections. It is not known whether drugs that affect IR such as Pioglitazon... | Intervention: Pioglitazone (30 mg/day for 14 days)
Comparator: baseline
Outcome: serum IL-8 levels at day-14 | 1 | {"evidence_spans": [{"end": 22507, "start": 22353, "text": "described in Methods . It has been suggested that serum IL-8 values are elevated in HCV infection and that these values may reflect the effects of the "}, {"end": 22508, "start": 22354, "text": "escribed in Methods . It has been suggested that serum IL-8... |
TITLE: Pioglitazone Decreases Hepatitis C Viral Load in Overweight, Treatment Naïve, Genotype 4 Infected-Patients: A Pilot Study
ABSTRACT.BACKGROUND:
Insulin resistance (IR) is induced by chronic hepatitis C virus (HCV) genotypes 1 and 4 infections. It is not known whether drugs that affect IR such as Pioglitazon... | Intervention: Pioglitazone (30 mg/day for 14 days)
Comparator: baseline
Outcome: day-14 in serum IL-28B, TNF-?, IL-1?, IL-1?, IL-6, IL-8, IL-10, IFN-?, MCP-1 and HGF | 0 | {"evidence_spans": [{"end": 23914, "start": 23762, "text": "\u22125.9, 2.6 \r\n MCP-1 (pg/ml) 338.4(151.4) 330.6(157.9) 0.915 155, 170 \r\n HGF (pg/ml) 1008 (736) 975 (603) 0.914 \u2212665, 732 Values are mean (+/\u2212 SD). Seru"}, {"end": 23927, "start": 23762, "text": "\u22125.9, 2.6 \r\n MCP-1 (pg/ml) 338.4(151.... |
TITLE: How do patients with severe mental diagnosis cope in everyday life - a qualitative study comparing patients’ experiences of self-referral inpatient treatment with treatment as usual?
ABSTRACT.BACKGROUND:
Several hospitals in Norway provide short self-referral inpatient treatment to patients with severe men... | Intervention: Self-referral treatment
Comparator: Inpatient treatment
Outcome: Self-confidence in applying methods to deal with mental illness | 1 | {"evidence_spans": [{"end": 1390, "start": 1273, "text": "wed that patients with a contract for self-referral appeared to have more confidence in strategies to cope with menta"}, {"end": 40052, "start": 39870, "text": "re proactive strategies are used by persons who have come farthest in the recovery process. One of th... |
TITLE: How do patients with severe mental diagnosis cope in everyday life - a qualitative study comparing patients’ experiences of self-referral inpatient treatment with treatment as usual?
ABSTRACT.BACKGROUND:
Several hospitals in Norway provide short self-referral inpatient treatment to patients with severe men... | Intervention: Self-referral treatment
Comparator: Inpatient treatment
Outcome: Patients striving for recovery | 1 | {"evidence_spans": [{"end": 44652, "start": 44426, "text": "e argue that recovery has to be pursued actively by the patient, and that not everybody does this\r\n[3]. The findings in the present study indicate that patients who have had the opportunity to decide whether and when they need"}], "id": "1035", "pmcid": "413... |
TITLE: Pioglitazone Decreases Hepatitis C Viral Load in Overweight, Treatment Naïve, Genotype 4 Infected-Patients: A Pilot Study
ABSTRACT.BACKGROUND:
Insulin resistance (IR) is induced by chronic hepatitis C virus (HCV) genotypes 1 and 4 infections. It is not known whether drugs that affect IR such as Pioglitazon... | Intervention: Prednisone (40 mg/day for 4 days)
Comparator: baseline
Outcome: serum ALT, AST, IL-8 or other inflammatory mediators | 0 | {"evidence_spans": [{"end": 26710, "start": 26578, "text": "ponectin (\u00b5g/ml) 5.9 (8.2) 2.6 (2.1) 0.306 \u22124.5 \r\n Resistin (ng/ml) 3.4 (2.5) 2.7 (2.2) 0.591 \u22122.4 Values are mean (+/\u2212 SD). Tests"}], "id": "1163", "pmcid": "3296686", "prompt_id": "1163", "split_group_id": "3296686", "votes": {"0": 1}... |
TITLE: Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes
ABSTRACT.BACKGROUND:
This randomized, partially single-blinded, 6-period crossover clinical study of adult smokers compared the nicotine pharmacokinetics, impacts on smoki... | Intervention: E-cigarettes
Comparator: Conventional tobacco cigarette
Outcome: Nicotine concentration after ad lib use | -1 | {"evidence_spans": [{"end": 27903, "start": 27747, "text": "ly glycerin, which provided a 33 % lower overall exposure. However, the nicotine concentration at the end of the ad lib use period was significantly higher "}, {"end": 37710, "start": 37540, "text": "tine concentration and continued reduction in smoking urge t... |
TITLE: Efficacy of Web-Based Weight Loss Maintenance Programs: A Randomized Controlled Trial Comparing Standard Features Versus the Addition of Enhanced Personalized Feedback over 12 Months
ABSTRACT:
Few randomized controlled trials (RCT) have evaluated the efficacy of web-based programs targeting maintenance of ... | Intervention: Enhanced weight loss maintenance program
Comparator: Basic weight loss maintenance program
Outcome: Attrition after 12 months | 0 | {"evidence_spans": [{"end": 10984, "start": 10863, "text": "lian-born (Table 1). There was no significant between-group difference in attrition after 12 months, basic 18.4% and enha"}], "id": "1043", "pmcid": "5746685", "prompt_id": "1043", "split_group_id": "5746685", "votes": {"0": 1}} |
TITLE: Randomised controlled trial to evaluate the efficacy and usability of a computerised phone-based lifestyle coaching system for primary and secondary prevention of stroke
ABSTRACT.BACKGROUND:
One of the most effective current approaches to preventing stroke events is the reduction of lifestyle risk factors,... | Intervention: CAPSYS system
Comparator: Standard care
Outcome: Systolic blood pressure | -1 | {"evidence_spans": [{"end": 1857, "start": 1397, "text": "ESULTS:\r\nThe statistical evaluation of primary measures revealed significant decreases of systolic blood pressure (mean of the differences = \u20139 mmHg; p = 0.03; 95 % CI = [\u201317.29, \u20130.71]), LDL (pseudo-median of the differences = \u20137.9 mg/dl; ... |
TITLE: Randomised controlled trial to evaluate the efficacy and usability of a computerised phone-based lifestyle coaching system for primary and secondary prevention of stroke
ABSTRACT.BACKGROUND:
One of the most effective current approaches to preventing stroke events is the reduction of lifestyle risk factors,... | Intervention: CAPSYS system
Comparator: Standard care
Outcome: LDL values | -1 | {"evidence_spans": [{"end": 1662, "start": 1397, "text": "ESULTS:\r\nThe statistical evaluation of primary measures revealed significant decreases of systolic blood pressure (mean of the differences = \u20139 mmHg; p = 0.03; 95 % CI = [\u201317.29, \u20130.71]), LDL (pseudo-median of the differences = \u20137.9 mg/dl; ... |
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