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TITLE: Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes
ABSTRACT.BACKGROUND:
Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent pati... | Intervention: neurally adjusted ventilatory assist (NAVA)
Comparator: pressure support ventilation (PSV)
Outcome: fragmentation index | -1 | {"evidence_spans": [{"end": 1833, "start": 1552, "text": "f sleep. Proportions of REM sleep duration were different in the two ventilatory modes (4.5% (range, 3-11%) in PSV and 16.5% (range, 13-29%) during NAVA (p = 0.001)), as well as the fragmentation index, with 40 \u00b1 20 arousals and awakenings per hour in PSV a... |
TITLE: Randomised controlled trial to evaluate the efficacy and usability of a computerised phone-based lifestyle coaching system for primary and secondary prevention of stroke
ABSTRACT.BACKGROUND:
One of the most effective current approaches to preventing stroke events is the reduction of lifestyle risk factors,... | Intervention: CAPSYS system
Comparator: Standard care
Outcome: Self-reported consumption of fruits and vegetables | 1 | {"evidence_spans": [{"end": 2033, "start": 1885, "text": "tected a statistically significant increase in self-reported fruit and vegetable consumption (pseudo-median of the differences = 5.4 servings/week; "}, {"end": 20327, "start": 20001, "text": " 0.61) or cholesterol-lowering medication (SC: 39 [85 %]; IC: 44 [92 %... |
TITLE: Randomised controlled trial to evaluate the efficacy and usability of a computerised phone-based lifestyle coaching system for primary and secondary prevention of stroke
ABSTRACT.BACKGROUND:
One of the most effective current approaches to preventing stroke events is the reduction of lifestyle risk factors,... | Intervention: CAPSYS system
Comparator: Standard care
Outcome: Self-reported consumption of sweets | -1 | {"evidence_spans": [{"end": 2210, "start": 1858, "text": "l group. Furthermore, we detected a statistically significant increase in self-reported fruit and vegetable consumption (pseudo-median of the differences = 5.4 servings/week; p = 0.04; 95 % CI = [0.5, 10.5]) and a decrease in sweets consumption (pseudo-median of... |
TITLE: Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes
ABSTRACT.BACKGROUND:
Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent pati... | Intervention: neurally adjusted ventilatory assist (NAVA)
Comparator: pressure support ventilation (PSV)
Outcome: episodes of central apnea and ineffective efforts | -1 | {"evidence_spans": [{"end": 2008, "start": 1835, "text": " 0.001). There were large differences in ineffective efforts (24 \u00b1 23 per hour of sleep in PSV, and 0 during NAVA) and episodes of central apnea (10.5 \u00b1 11 in PSV vs. 0 duri"}, {"end": 15960, "start": 15683, "text": "a, and 11 exhibited ineffective eff... |
TITLE: Efficacy and Safety of Subcutaneous Golimumab in Methotrexate‐Naive Patients With Rheumatoid Arthritis: Five‐Year Results of a Randomized Clinical Trial
ABSTRACT.OBJECTIVE:
To evaluate the safety and efficacy of golimumab through 5 years in adults with active rheumatoid arthritis (RA) who had not previousl... | Intervention: Golimumab plus?MTX
Comparator: Placebo?plus MTX or Golimumab
Outcome: ACR20/50/70 response | 0 | {"evidence_spans": [{"end": 15571, "start": 15450, "text": "zed patients are shown in Table 2. At week 256, 72.8% of all patients had an ACR20 response, 54.6% had an ACR50 response,"}, {"end": 15700, "start": 15572, "text": "and 38.0% had an ACR70 response. After the placebo crossover at week 52, ACR20 and ACR50 respon... |
TITLE: Evaluation of different sodium bicarbonate regimens for the prevention of contrast medium-induced nephropathy
ABSTRACT.INTRODUCTION:
The rapid decline in renal function caused by radiographic contrast agents usually is transient, but it can result in chronic kidney disease. The pathophysiology of contrast-... | Intervention: sodium bicarbonate solution using the short regimen (intravenous bolus 3 mL/kg/h of 166 mEq/L sodium bicarbonate for 1 hour immediately before radiocontrast)
Comparator: sodium bicarbonate solution using the long regimen (initial intravenous bolus of 3 mL/kg/h of 166 mEq/L sodium bicarbonate for 6 hr).
Ou... | -1 | {"evidence_spans": [{"end": 11462, "start": 10924, "text": "ar contrast agents. We observed a significant increase in S. Cr. and significant decrease in eGFR calculated by MDRD formula in (group 1) when we compare their levels prior to contrast administration with their levels 48 hr after the intervention (S. Cr: 2.32... |
TITLE: Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy
ABSTRACT.OBJECTIVE:
Identification of pretreatment patient characteristics predictive of psychotherapy outcome could help to guide treatment choices. This study evaluates patients' initial level of imma... | Intervention: Short-term psychotherapy
Comparator: Long-term psychotherapy
Outcome: Decrease in symptoms among patients with high immature defense style after 3 years | -1 | {"evidence_spans": [{"end": 22573, "start": 22282, "text": "se style according to all six outcome measures. At the end of the 3-year follow-up, on the other hand, a statistically larger symptom reduction in the long-term therapy group than in the short-term therapy group (26\u201364% vs. 21\u201345%, respectively) was ... |
TITLE: Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies
ABSTRACT.INTRODUCTION:
To examine pooled efficacy data from three, large phase III studies comparing mirabegron (50... | Intervention: mirabegron (50 and 100 mg)
Comparator: placebo
Outcome: the mean number of incontinence episodes/24 h and the mean number of micturitions/24 h | -1 | {"evidence_spans": [{"end": 20543, "start": 19804, "text": "\n\r\nBODY.RESULTS.EFFICACY OUTCOMES:\r\nMirabegron at doses of 50 and 100 mg once daily demonstrated statistically significant improvement from baseline to Final Visit compared with placebo in reducing the mean number of incontinence episodes/24 h and the mea... |
TITLE: Randomized comparison of etoposide pharmacokinetics after oral etoposide phosphate and oral etoposide.
ABSTRACT:
Etoposide phosphate is a water-soluble prodrug of etoposide. The plasma pharmacokinetics of etoposide following oral administration of etoposide phosphate or oral etoposide were compared. Sevent... | Intervention: Oral etoposide phosphate
Comparator: Oral etoposide
Outcome: Toxicity | 0 | {"evidence_spans": [{"end": 1399, "start": 1311, "text": "n. Toxicities of oral etoposide phosphate were not different from those known for etopos"}], "id": "1055", "pmcid": "2223531", "prompt_id": "1055", "split_group_id": "2223531", "votes": {"0": 2}} |
TITLE: Effectiveness of a serious game for medical education on insulin therapy for diabetes: randomized controlled trial
ABSTRACT:
BODY.BACKGROUND:
Most patients with diabetes mellitus (DM) are followed by primary care physicians, who often lack knowledge about DM care, especially on insulin. Traditional co... | Intervention: serious game called InsuOnLine©
Comparator: traditional on-site learning activity
Outcome: Absolute increase in performance of insulin therapy for DM. | 1 | {"evidence_spans": [{"end": 2278, "start": 2178, "text": "han at baseline. Absolute increase in performance was higher in the game group (40%) than in control"}, {"end": 2278, "start": 2180, "text": "n at baseline. Absolute increase in performance was higher in the game group (40%) than in control"}], "id": "1184", "pm... |
TITLE: Effects of Neuromuscular Electrical Stimulation Combined with Exercises versus an Exercise Program on the Pain and the Function in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
ABSTRACT:
Objectives. To investigate the effect of 8 weeks of NMES + Ex (neuromuscular electrical stimulation... | Intervention: NMES plus exercise
Comparator: Exercise alone
Outcome: Timed Up and Go test | 0 | {"evidence_spans": [{"end": 1310, "start": 1057, "text": "ed. For the comparison between the groups, no statistically significant difference was found between the NMES + Ex and the Ex groups in NRS (P = 0.52), TUG test (P = 0.12), and aspects of WOMAC: pain (P = 0.26), function (P = 0.23), and stiffness (P = 0"}, {"end... |
TITLE: Effects of Neuromuscular Electrical Stimulation Combined with Exercises versus an Exercise Program on the Pain and the Function in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
ABSTRACT:
Objectives. To investigate the effect of 8 weeks of NMES + Ex (neuromuscular electrical stimulation... | Intervention: NMES plus exercise
Comparator: Exercise alone
Outcome: Western Ontario and McMaster Universities Osteoarthritis Index for pain | 0 | {"evidence_spans": [{"end": 1247, "start": 1096, "text": "ps, no statistically significant difference was found between the NMES + Ex and the Ex groups in NRS (P = 0.52), TUG test (P = 0.12), and aspects of WO"}, {"end": 13773, "start": 13629, "text": "ODY.3. RESULTS.3.2. SECONDARY OUTCOMES:\r\nNo significant differenc... |
TITLE: The Effect of Breathing Exercises on the Nocturnal Enuresis in the Children with the Sleep-Disordered Breathing
ABSTRACT.BACKGROUND:
The nocturnal enuresis is one of the most common complaints of childhood. Upper airway obstruction and nocturnal snoring affect the nocturnal enuresis in children.
ABSTRAC... | Intervention: breathing exercises were performed for 45 minutes, and were pursued for four weeks in the morning following and prior to sleeping
Comparator: no breathing exercises
Outcome: O2sat, PaO2 | 1 | {"evidence_spans": [{"end": 1384, "start": 1296, "text": " < 0.0001). Likewise, O2sat, PaO2 in the case group were higher than the control group ("}, {"end": 1384, "start": 1306, "text": ". Likewise, O2sat, PaO2 in the case group were higher than the control group ("}], "id": "1185", "pmcid": "3971783", "prompt_id": "1... |
TITLE: The Effect of Breathing Exercises on the Nocturnal Enuresis in the Children with the Sleep-Disordered Breathing
ABSTRACT.BACKGROUND:
The nocturnal enuresis is one of the most common complaints of childhood. Upper airway obstruction and nocturnal snoring affect the nocturnal enuresis in children.
ABSTRAC... | Intervention: breathing exercises were performed for 45 minutes, and were pursued for four weeks in the morning following and prior to sleeping
Comparator: no breathing exercises
Outcome: PaCO2 and Respiratory rates | -1 | {"evidence_spans": [{"end": 1295, "start": 1170, "text": "T.RESULTS:\r\nAfter intervention the means of PaCO2 and RR in the control group were significantly higher than the case group ("}], "id": "1187", "pmcid": "3971783", "prompt_id": "1187", "split_group_id": "3971783", "votes": {"-1": 1}} |
TITLE: The evaluation of effects two different doses of hydrocortisone on the intensity of perioperative shivering in elective surgery under spinal anesthesia: A double-blind randomized controlled trial study
ABSTRACT.BACKGROUND::
Post- and intra-operative shivering is one of the most complications of spinal anes... | Intervention: received 1 mg/kg and 2 mg/kg hydrocortisone
Comparator: received normal saline
Outcome: incidence and intensity of shivering | -1 | {"evidence_spans": [{"end": 1430, "start": 1013, "text": "SULTS::\r\nThe investigation of the incidence of inter- and post-operative shivering in patients in the three groups revealed that within the study period, 31 patients suffered from shivering among which 9, 5, and 17 cases were in 1 mg/kg hydrocortisone group, 2... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: mean daily number of moderate to severe hot flushes at week 4 | -1 | {"evidence_spans": [{"end": 10472, "start": 10253, "text": "apy).17,18 In SMART-2, at week 4, BZA 20 mg/CE 0.45 mg and BZA 20 mg/CE 0.625 mg were associated with a significant decrease (P < 0.001) in the adjusted mean daily number of moderate to severe hot flushes as compared w"}, {"end": 10472, "start": 10265, "text"... |
TITLE: The efficacy of duloxetine: A comprehensive summary of results from MMRM and LOCF_ANCOVA in eight clinical trials
ABSTRACT.BACKGROUND:
A mixed-effects model repeated measures approach (MMRM) was specified as the primary analysis in the Phase III clinical trials of duloxetine for the treatment of major depr... | Intervention: A mixed-effects model repeated measures approach (MMRM)
Comparator: analysis of covariance (ANOVA or ANCOVA) with missing data imputed by the last observation carried forward approach (LOCF_ANCOVA)
Outcome: HAMD17 total score, | 1 | {"evidence_spans": [{"end": 22202, "start": 22019, "text": "1.40 2.18 134 -5.22 1.94 In the case of the HAMD17 total score, advantages for duloxetine over placebo at endpoint (Week 9) from MMRM in Studies 1 and 2 were 4.86 (p < .001) and 2.1"}], "id": "1066", "pmcid": "520750", "prompt_id": "1066", "split_group_id": ... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: increase from baseline in the mean proportion of intermediate cells | 1 | {"evidence_spans": [{"end": 14678, "start": 14398, "text": "o (P < 0.001). Both BZA/CE groups also showed a significantly greater reduction from baseline in the mean proportion of parabasal cells (P < 0.001) and a significantly greater increase from baseline in the mean proportion of intermediate cells (P < 0.05) compa... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: improvement in the women's most bothersome vulvovaginal atrophy symptoms | 1 | {"evidence_spans": [{"end": 14934, "start": 14693, "text": " Additionally, treatment with BZA 20 mg/CE 0.625 mg resulted in a significantly greater decrease from baseline in vaginal pH (P < 0.001) and a greater improvement in the women's most bothersome vulvovaginal atrophy symptoms (P < 0.05) compar"}, {"end": 14948, ... |
TITLE: Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study
ABSTRACT:
The aim of this study was to investigate the safety of injection of bone marrow aspirate concentrate during core decompression and to study its clinical (visual an... | Intervention: core decompression with the application of bone marrow aspirate concentrate
Comparator: core decompression only
Outcome: femoral head necrosis (FHN) | 0 | {"evidence_spans": [{"end": 1126, "start": 1036, "text": "t, we could not perceive any significant change in the volume of FHN in both treatment gro"}, {"end": 10860, "start": 10593, "text": "steonecrosis in both groups. In contrast to the clinical outcome, we could not perceive any significant change in the volume of ... |
TITLE: Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study
ABSTRACT:
The aim of this study was to investigate the safety of injection of bone marrow aspirate concentrate during core decompression and to study its clinical (visual an... | Intervention: core decompression with the application of bone marrow aspirate concentrate
Comparator: core decompression only
Outcome: the head survival rate | 0 | {"evidence_spans": [{"end": 1014, "start": 898, "text": "s. Over the period of two years there was no significant difference between the head survival rate between both grou"}, {"end": 11369, "start": 11059, "text": "hin two years in both groups. Over the period of two years there was no significant difference between ... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: reduction in the incidence of dyspareunia | 1 | {"evidence_spans": [{"end": 15650, "start": 15332, "text": "o (P < 0.001). This maturation of the vaginal epithelium was associated with a statistically significant reduction in the incidence of dyspareunia relative to placebo during weeks 9\u201312 of therapy (P < 0.001) and in ease of lubrication score from baseline ... |
TITLE: The effect of hip abduction on the EMG activity of vastus medialis obliquus, vastus lateralis longus and vastus lateralis obliquus in healthy subjects
ABSTRACT.STUDY DESIGN:
Controlled laboratory study.
ABSTRACT.OBJECTIVES:
The purposes of this paper were to investigate (d) whether vastus medialis obli... | Intervention: knee extension at 90° of flexion
Comparator: hip abduction at 0° and 30°
Outcome: vastus lateralis obliquus (VLO) EMG activity | 1 | {"evidence_spans": [{"end": 13457, "start": 13153, "text": "mong the three exercises tested. C) Significantly higher VLO activity for male subjects was observed in MVIC knee extension at 90\u00b0 of flexion compared with MVIC hip abduction at 0\u00b0 and 30\u00b0 of abduction and for female subjects performing MVIC kne... |
TITLE: Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet
ABSTRACT:
Oxidative stress has previously been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications. In the present study, the effects ... | Intervention: high-fat diet enriched with ground flaxseed 15 g/100 g of food, rich in ALA;
Comparator: received a high-fat diet (40% energy as fat), deficient in ?-linolenic acid (ALA)
Outcome: serum TC and non-HDL-C levels | -1 | {"evidence_spans": [{"end": 11566, "start": 11488, "text": "pared with those in the control group. Flaxseed supplementation significantly "}, {"end": 11656, "start": 11488, "text": "pared with those in the control group. Flaxseed supplementation significantly decreased serum TC and non-HDL-C levels and increased HDL-C ... |
TITLE: Attenuating effect of
ABSTRACT.BACKGROUND/OBJECTIVES:
Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in... | Intervention: Capsules (300 mg) containing Lactobacillus brevis G101 (1×1010 CFU/individual)
Comparator: maltodextrin (placebo)
Outcome: the appearance time of the MSG symptom complex | 0 | {"evidence_spans": [{"end": 1347, "start": 1175, "text": "roup. Although there was no significant difference in the appearance time of the MSG symptom complex between subjects orally administered G101 and those administered the pl"}, {"end": 1346, "start": 1184, "text": "hough there was no significant difference in the... |
TITLE: Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma
ABSTRACT.PURPOSE:
To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) ≥ 6 clock... | Intervention: laser peripheral iridotomy (LPI) group 1
Comparator: primary trabeculectomy group 2
Outcome: intraocular pressure (IOP)-lowering medications | 1 | {"evidence_spans": [{"end": 1172, "start": 1046, "text": "lectomy. 17 of the 38 eyes in group 1 (44.7%) required IOP-lowering medications as compared to seven of the 111 eyes in group "}, {"end": 10046, "start": 9685, "text": "tly lower in group 2 (p < 0.001). Five eyes in group 1 required trabeculectomy: 1 eye at 6 m... |
TITLE: Changes in proprioception and pain in patients with neck pain after upper
thoracic manipulation
ABSTRACT:
[Purpose] The purpose of this study was to conduct cervical stability training and upper
thoracic manipulation for patients with chronic neck pain and then investigate the changes
of cervical propri... | Intervention: upper thoracic manipulation (UTM)
Comparator: cervical stability training (CST)
Outcome: reduction in pain | 1 | {"evidence_spans": [{"end": 10322, "start": 10163, "text": "ectively in the manipulation group, and 62.89 kg,\r\n168.13 cm and 21.93 kg/m2, respectively in the control group. The UTM showed\r\nsignificantly smaller repositi"}], "id": "1087", "pmcid": "4395717", "prompt_id": "1087", "split_group_id": "4395717", "votes":... |
TITLE: A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial
ABSTRACT.BACKGROUND:
Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol.... | Intervention: single serving of curry meal
Comparator: spice-free control meal
Outcome: flow-mediated vasodilation (FMD) | 1 | {"evidence_spans": [{"end": 1241, "start": 1132, "text": " 0.039). On the other hand, the consumption of the curry meal increased FMD from 5.2 \u00b1 2.5% to 6.6 \u00b1 2.0% (P "}], "id": "1088", "pmcid": "4082484", "prompt_id": "1088", "split_group_id": "4082484", "votes": {"1": 2}} |
TITLE: A randomized, double-blind comparison of OROS
ABSTRACT.BACKGROUND:
Long-acting opioid formulations are advocated for maintaining pain control in chronic cancer pain. OROS® hydromorphone is a sustained-release formulation of hydromorphone that requires dosing once daily to maintain therapeutic concentration... | Intervention: hydromorphone
Comparator: morphine
Outcome: Mean ± SD patient global assessment scores at the end of the SR phase | 0 | {"evidence_spans": [{"end": 24761, "start": 24587, "text": "he end of each study phase (Figure 7). Mean \u00b1 SD patient global assessment scores at the end of the SR phase were 3.2 \u00b1 1.14 for the OROS\u00ae hydromorphone group and 3.3 \u00b1 0.98 "}], "id": "1091", "pmcid": "2644667", "prompt_id": "1091", "split... |
TITLE: The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis (OA): a knowledge translation (KT) randomized controlled trial (RCT): Part I: The Uptake of the Ottawa Panel clinical practice guidelines (CPGs)
ABSTRACT.BACKGROUND:
The implementation of evidence based... | Intervention: Walking and Behavioural intervention (WB)
Comparator: Walking intervention (W)
Outcome: Long-term adherence to the program | 0 | {"evidence_spans": [{"end": 1887, "start": 1795, "text": " months. No statistical significance (p> 0.05) was observed for long-term adherence (6 to 12"}, {"end": 1933, "start": 1795, "text": " months. No statistical significance (p> 0.05) was observed for long-term adherence (6 to 12 months), and total adherence betwee... |
TITLE: The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis (OA): a knowledge translation (KT) randomized controlled trial (RCT): Part I: The Uptake of the Ottawa Panel clinical practice guidelines (CPGs)
ABSTRACT.BACKGROUND:
The implementation of evidence based... | Intervention: Walking and Behavioural intervention (WB)
Comparator: Walking intervention (W)
Outcome: Total adherence to the program | 0 | {"evidence_spans": [{"end": 1933, "start": 1795, "text": " months. No statistical significance (p> 0.05) was observed for long-term adherence (6 to 12 months), and total adherence between the thre"}], "id": "973", "pmcid": "3491047", "prompt_id": "973", "split_group_id": "3491047", "votes": {"0": 2}} |
TITLE: Treatment costs associated with interventional cancer clinical trials conducted at a single UK institution over 2 years (2009–2010)
ABSTRACT.BACKGROUND::
The conduct of clinical trials should be an integral part of routine patient care. Treating patients in trials incurs additional costs over and above sta... | Intervention: Academic, non-commercial sponsored trials
Comparator: Commercial sponsored trials
Outcome: Savings in drugs and dispensing costs | -1 | {"evidence_spans": [{"end": 1737, "start": 1545, "text": "ith SOC, the average treatment cost per patient was an excess of \u00a3431 for a non-commercial trial (range \u00a36393 excess to \u00a36005 saving) and a saving of \u00a39294 for a commercial trial (range \u00a30 to "}, {"end": 2118, "start": 1926, "text": "NCL... |
TITLE: The effect of aerobic exercise in the maintenance treatment of depression
ABSTRACT:
We investigated the efficacy of aerobic exercise alongside antidepressant medication as an adjuvant maintenance treatment for depression. Fifty patients in remission were randomly assigned to either medication only or medic... | Intervention: Medication plus exercise
Comparator: Medication only
Outcome: Improvement in the Hamilton Rating Scale for Depression at 24 weeks | 1 | {"evidence_spans": [{"end": 585, "start": 462, "text": "n. The medication-plus-exercise group showed significantly more improvement at 12 and 24 weeks than the medication-only gro"}, {"end": 6706, "start": 6413, "text": "l 6-weekly follow-ups. The medication-plus-exercise group showed a greater improvement in HRSD scor... |
TITLE: Singing teaching as a therapy for chronic respiratory disease - a randomised controlled trial and qualitative evaluation
ABSTRACT.BACKGROUND:
Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies ... | Intervention: Singing classes
Comparator: Usual care
Outcome: Improvement in SF-36 physical component score | 1 | {"evidence_spans": [{"end": 1043, "start": 900, "text": "the RCT, the physical component score of the SF36 improved in the singers (n = 15) compared to the controls (n = 13); +7.5(14.6) vs. -3.8(8.4) "}, {"end": 10502, "start": 10331, "text": " on long term oxygen therapy. In singers, there was a significant improvemen... |
TITLE: Singing teaching as a therapy for chronic respiratory disease - a randomised controlled trial and qualitative evaluation
ABSTRACT.BACKGROUND:
Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies ... | Intervention: Singing classes
Comparator: Usual care
Outcome: Breath hold time | -1 | {"evidence_spans": [{"end": 10633, "start": 10503, "text": "14.6) vs. -3.8(8.4) p = 0.02. Breath hold time actually increased in the control group relative to the singing group -0.3(6.9) sec"}], "id": "989", "pmcid": "2920262", "prompt_id": "989", "split_group_id": "2920262", "votes": {"-1": 1}} |
TITLE: Effect of a randomised exclusive breastfeeding counselling intervention nested into the MINIMat prenatal nutrition trial in Bangladesh
ABSTRACT.ABSTRACT.AIM:
It is unknown whether maternal malnutrition reduces the effect of counselling on exclusive breastfeeding. This study evaluated the effect of breastfe... | Intervention: receive exclusive breastfeeding counselling from the counsellors
Comparator: receive the usual health messages from the Matlab regular health staff
Outcome: The median duration of exclusive breastfeeding | 1 | {"evidence_spans": [{"end": 19414, "start": 19191, "text": "y 72 hours, almost all babies in both groups had been breastfed. The median duration of exclusive breastfeeding was longer in the breastfeeding counselling group (135 days, 95% CI: 131\u2013139) than in usual health message grou"}], "id": "1117", "pmcid": "521... |
TITLE: Social Presence and Use of Internet-Delivered Interventions: A Multi-Method Approach
ABSTRACT.OBJECTIVE:
Internet-delivered interventions can effectively change health risk behaviors and their determinants, but adherence to intervention websites once they are accessed is very low. This study tests whether ... | Intervention: website with social presence elements.
Comparator: website without social presence elements.
Outcome: website use and terms of the number of pages visited and terms of time on the website | 0 | {"evidence_spans": [{"end": 1407, "start": 1196, "text": "p<.001), but did not differ in website use in comparison with the control condition; neither in terms of the number of pages visited (t(456) = 1.44, p = .15), nor in terms of time on the website (t(456) = 0.01, "}, {"end": 1407, "start": 1200, "text": "01), but ... |
TITLE: Social Presence and Use of Internet-Delivered Interventions: A Multi-Method Approach
ABSTRACT.OBJECTIVE:
Internet-delivered interventions can effectively change health risk behaviors and their determinants, but adherence to intervention websites once they are accessed is very low. This study tests whether ... | Intervention: website with social presence elements.
Comparator: website without social presence elements.
Outcome: focused on the social presence elements in terms of frequency and duration | 1 | {"evidence_spans": [{"end": 1194, "start": 1017, "text": "ESULTS:\r\nParticipants in the experimental condition focused on the social presence elements, both in terms of frequency (F(1, 98) = 40.34, p<.001) and duration (F(1, 88) = 39.99"}, {"end": 1196, "start": 1017, "text": "ESULTS:\r\nParticipants in the experiment... |
TITLE: Comparative utility of disability progression measures in PPMS
ABSTRACT.OBJECTIVE::
To assess the comparative utility of disability progression measures in primary progressive MS (PPMS) using the PROMiSe trial data set.
ABSTRACT.METHODS::
Data for patients randomized to placebo (n = 316) in the PROMiSe... | Intervention: EDSS/T25FW/9HPT
Comparator: EDSS/T25FW or EDSS/9HPT
Outcome: confirmed disability progression | 1 | {"evidence_spans": [{"end": 13642, "start": 13393, "text": "igher disability rates than 9HPT 20%. The 3-part combination measure (EDSS or T25FW 20% or 9HPT 20%) was associated with more 3-month CDP events (41.4% and 63.9% of patients as 12 and 24 months, respectively) than the 2-part measure (EDSS or T25FW 2"}], "id": ... |
TITLE: Clinical efficacy of
ABSTRACT:
Aging has become one of the distinctive demographic phenomena in the 21st century and its social, economic and health implications are the most challenging issues. Senile Memory Impairment is a common condition characterized by mild symptoms of cognitive decline and occurs a... | Intervention: administered with the Granules of Guduchyadi Medhya Rasayana (GMR), which contains Guduchi (Tinospora cordifolia Wild.), Apamarga (Achyranthes aspera Linn.), Vidanga (Embelia ribes Burm. f.), Shankhapushpi (Convolvulus pluricaulis Chois.), Vaca (Acorus calamus Linn.), Haritaki (Terminalia chebula Zetz.), ... | -1 | {"evidence_spans": [{"end": 10074, "start": 9416, "text": "on the symptoms of Senile Memory Impairment In comparison to Group B, Group A showed highly significant relief in symptoms such as names forgotten (63.56%), numbers forgotten (61.62%), and memory impairment in recalling special events in life (59.71%) at a le... |
TITLE: Effect of
ABSTRACT.BACKGROUND:
To evaluate the value of KRAS codon 13 mutations in patients with advanced colorectal cancer (advanced CRC) treated with oxaliplatin and fluoropyrimidines.
ABSTRACT.METHODS:
Tumor specimens from 201 patients with advanced CRC from a randomized, phase III trial comparing ... | Intervention: FUFOX
Comparator: CAPOX
Outcome: Overall survival | 0 | {"evidence_spans": [{"end": 12840, "start": 12722, "text": "erall survival according to KRAS status. Evaluating the different treatment arms separately, we found comparable surv"}], "id": "1006", "pmcid": "3442969", "prompt_id": "1006", "split_group_id": "3442969", "votes": {"0": 1}} |
TITLE: First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens
ABSTRACT:
Background. We report the first-in-human safety and immunogenicit... | Intervention: SLA and SHA groups
Comparator: ASH group
Outcome: the Gag response rate | 1 | {"evidence_spans": [{"end": 17055, "start": 16797, "text": "boost (Supplementary Table 6). In the SLA and SHA groups combined, the Gag response rate was significantly higher 2 weeks after the second vaccination (95.7%), compared with the rate in the ASH group 2 weeks after either the Ad35-GRIN prime or the SeV-Gag bo"}... |
TITLE: The Effect of Stretching Exercises on Severity of Restless Legs Syndrome in Patients on Hemodialysis
ABSTRACT.BACKGROUND:
The restless legs syndrome is a sensorimotor disorder that is very common in patients on hemodialysis. Due to pharmacological treatments which have their own side effects, nowadays, stu... | Intervention: Stretching exercises
Comparator: No exercises
Outcome: Symptom severity after 8 weeks | -1 | {"evidence_spans": [{"end": 1338, "start": 1180, "text": "s syndrome. The symptom severity of this syndrome meaningfully changed eight weeks after intervention in the intervention group compared to the control group "}], "id": "1008", "pmcid": "5003313", "prompt_id": "1008", "split_group_id": "5003313", "votes": {"-1":... |
TITLE: Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients
ABSTRACT.INTRODUCTION:
Physical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise ... | Intervention: high-intensity interval training (HIT) for 12-weeks in patients NYHA II-III
Comparator: continuous training (CT) 12-weeks inpatients NYHA II-III
Outcome: VO2peak tended | 0 | {"evidence_spans": [{"end": 20651, "start": 20573, "text": "k (%), maximal workload, oxygen uptake at the AT and maximal oxygen pulse (Tab"}], "id": "1134", "pmcid": "4627811", "prompt_id": "1134", "split_group_id": "4627811", "votes": {"0": 1}} |
TITLE: Comparing the Hemodynamic Effects of Spinal Anesthesia in Preeclamptic and Healthy Parturients During Cesarean Section
ABSTRACT.BACKGROUND:
Despite controversies about the safest anesthetic technique for cesarean delivery in severely preeclamptic women, there is evidence that supports the use of spinal ane... | Intervention: Low-dose bupivacaine spinal anesthesia in pre-eclamptic parturients
Comparator: Low-dose bupivacaine spinal anesthesia in healthy parturients
Outcome: Risk of hypotension | -1 | {"evidence_spans": [{"end": 9804, "start": 9680, "text": "ve-minute APGAR score between the two groups. The incidence rate of hypotension in the preeclamptic patients (55.8%) was le"}, {"end": 9926, "start": 9680, "text": "ve-minute APGAR score between the two groups. The incidence rate of hypotension in the preeclam... |
TITLE: Efficacy and Safety of Tiropramide in the Treatment of Patients With Irritable Bowel Syndrome: A Multicenter, Randomized, Double-blind, Non-inferiority Trial, Compared With Octylonium
ABSTRACT.BACKGROUND/AIMS:
Antispasmodics such as octylonium are widely used to manage irritable bowel syndrome (IBS) sympto... | Intervention: tiropramide 100
Comparator: octylonium 20 mg
Outcome: Abdominal pain and discomfort assessed using VAS scores, diaries, and IBS-QoL | 0 | {"evidence_spans": [{"end": 1447, "start": 1255, "text": "ESULTS:\r\nThe VAS scores of abdominal pain at week 4, were significantly decreased in both tiropramide and octylonium groups, but the change from baseline did not differ between the 2 groups (d"}, {"end": 1464, "start": 1448, "text": "fference,-0.26 m"}, {"end"... |
TITLE: The Effect of Desmopressin on the Amount of Bleeding in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Cardiopulmonary Bypass Pump After Taking Anti-Platelet Medicine
ABSTRACT.BACKGROUND:
Coronary artery bypass grafting (CABG) is a common surgical intervention at the end-stages of coronary... | Intervention: Desmopressin
Comparator: Placebo
Outcome: Thrombocytopenia rate | -1 | {"evidence_spans": [{"end": 2331, "start": 2217, "text": " different. The analysis revealed that the rate of thrombocytopenia after surgery was higher in the control group "}], "id": "1014", "pmcid": "5101425", "prompt_id": "1014", "split_group_id": "5101425", "votes": {"-1": 2}} |
TITLE: School Age Effects of the Newborn Individualized Developmental Care and Assessment Program for Medically Low-Risk Preterm Infants: Preliminary Findings
ABSTRACT.BACKGROUND::
By school-age, even low-risk moderately preterm-born children show more neuro-cognitive deficits, motor impairments, academic underac... | Intervention: E-group - The Newborn Individualized Developmental Care and Assessment Program (NIDCAP) provides a system of NICU care and environmental structure that supports preterm infants' early brain development.
Comparator: C-group - the Newborn Intensive Care Unit (NICU) experience (exposure to bright lights, hei... | 1 | {"evidence_spans": [{"end": 1386, "start": 1260, "text": ".RESULTS::\r\nE-performed significantly better than C-group children on the Kaufman Assessment Battery for Children-Second Editi"}, {"end": 15414, "start": 15245, "text": "jects (8C; 15E) completed neuropsychological testing. E-performed significantly better tha... |
TITLE: Management of
ABSTRACT.INTRODUCTION::
Prevalence of diabetes and its complications have been a burden to the society from the ancient times, in the present and also will be in the future unless proper measures are taken to prevent its manifestation. There have been an increasing number of death associated... | Intervention: Katupila Kalka with Tila Taila
Comparator: Betadine ointment
Outcome: Control of foul smell | 1 | {"evidence_spans": [{"end": 10391, "start": 10206, "text": "pila treated cases\r\n\r\nBODY.DISCUSSION:\r\nIn this study, foul smell was controlled after 3 days in Group A patients, which was found statistically significant (P < 0.001). In Group B, fou"}], "id": "1023", "pmcid": "4895766", "prompt_id": "1023", "split_gr... |
TITLE: Management of
ABSTRACT.INTRODUCTION::
Prevalence of diabetes and its complications have been a burden to the society from the ancient times, in the present and also will be in the future unless proper measures are taken to prevent its manifestation. There have been an increasing number of death associated... | Intervention: Katupila Kalka with Tila Taila
Comparator: Betadine ointment
Outcome: Control of infection | 0 | {"evidence_spans": [{"end": 13124, "start": 13025, "text": " infection was relieved in 41% by the end of 28th day. Both drugs have shown statistically highly s"}], "id": "1024", "pmcid": "4895766", "prompt_id": "1024", "split_group_id": "4895766", "votes": {"0": 1}} |
TITLE: A randomised controlled trial to prevent smoking relapse among recently quit smokers enrolled in employer and health plan sponsored quitlines
ABSTRACT.OBJECTIVE:
To test adding an interactive voice response (IVR)-supported protocol to standard quitline treatment to prevent relapse among recently quit smoke... | Intervention: Technology Enhanced Quitline-10 and Technology Enhanced Quitline-20
Comparator: Standard quitline treatment
Outcome: Programme engagement | 1 | {"evidence_spans": [{"end": 25541, "start": 25409, "text": "\n\r\nBODY.RESULTS.PROGRAMME ENGAGEMENT AND POSITIVE RISK SCREENS:\r\nProgramme engagement was measured as the number of counselling call"}, {"end": 25957, "start": 25542, "text": " completed by participants:1 planned programme counselling calls,2 participant-... |
TITLE: A randomised controlled trial to prevent smoking relapse among recently quit smokers enrolled in employer and health plan sponsored quitlines
ABSTRACT.OBJECTIVE:
To test adding an interactive voice response (IVR)-supported protocol to standard quitline treatment to prevent relapse among recently quit smoke... | Intervention: Technology Enhanced Quitline-10 and Technology Enhanced Quitline-20
Comparator: Standard quitline treatment
Outcome: Tobacco abstinence | 0 | {"evidence_spans": [{"end": 38706, "start": 38490, "text": "moking relapse among recently quit tobacco users enrolled in the QFL programme, there were no differences in tobacco abstinence rates between the control (standard QFL) and technology-enhanced (IVR-delivered risk ass"}], "id": "1028", "pmcid": "4486943", "prom... |
TITLE: Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes
ABSTRACT.BACKGROUND:
This randomized, partially single-blinded, 6-period crossover clinical study of adult smokers compared the nicotine pharmacokinetics, impacts on smoki... | Intervention: E-cigarettes
Comparator: Conventional tobacco cigarette
Outcome: Serious adverse events | 0 | {"evidence_spans": [{"end": 32618, "start": 32527, "text": "f the study, a total of 38 subjects were exposed to one or more of the study products. Ther"}], "id": "1038", "pmcid": "4588874", "prompt_id": "1038", "split_group_id": "4588874", "votes": {"0": 2}} |
TITLE: Efficacy of Web-Based Weight Loss Maintenance Programs: A Randomized Controlled Trial Comparing Standard Features Versus the Addition of Enhanced Personalized Feedback over 12 Months
ABSTRACT:
Few randomized controlled trials (RCT) have evaluated the efficacy of web-based programs targeting maintenance of ... | Intervention: Enhanced weight loss maintenance program
Comparator: Basic weight loss maintenance program
Outcome: Weight rebound after 12 months | 0 | {"evidence_spans": [{"end": 1054, "start": 909, "text": "d. There was no significant weight rebound from the start of weight loss maintenance to 12 months for either group (mean: basic 1.3%, enhanced 1."}, {"end": 1115, "start": 909, "text": "d. There was no significant weight rebound from the start of weight loss main... |
TITLE: Efficacy of Web-Based Weight Loss Maintenance Programs: A Randomized Controlled Trial Comparing Standard Features Versus the Addition of Enhanced Personalized Feedback over 12 Months
ABSTRACT:
Few randomized controlled trials (RCT) have evaluated the efficacy of web-based programs targeting maintenance of ... | Intervention: Enhanced weight loss maintenance program
Comparator: Basic weight loss maintenance program
Outcome: Change in body mass index | 0 | {"evidence_spans": [{"end": 1270, "start": 1116, "text": "m. There were no significant between-group differences in the primary outcome of change in BMI (basic \u22120.5 (1.9) kg/m2, enhanced \u22120.5 (1.6) kg/m2, p = 0.9"}, {"end": 1271, "start": 1116, "text": "m. There were no significant between-group differences i... |
TITLE: Randomised controlled trial to evaluate the efficacy and usability of a computerised phone-based lifestyle coaching system for primary and secondary prevention of stroke
ABSTRACT.BACKGROUND:
One of the most effective current approaches to preventing stroke events is the reduction of lifestyle risk factors,... | Intervention: CAPSYS system
Comparator: Standard care
Outcome: Triglyceride levels | -1 | {"evidence_spans": [{"end": 1857, "start": 1397, "text": "ESULTS:\r\nThe statistical evaluation of primary measures revealed significant decreases of systolic blood pressure (mean of the differences = \u20139 mmHg; p = 0.03; 95 % CI = [\u201317.29, \u20130.71]), LDL (pseudo-median of the differences = \u20137.9 mg/dl; ... |
TITLE: Randomized comparison of etoposide pharmacokinetics after oral etoposide phosphate and oral etoposide.
ABSTRACT:
Etoposide phosphate is a water-soluble prodrug of etoposide. The plasma pharmacokinetics of etoposide following oral administration of etoposide phosphate or oral etoposide were compared. Sevent... | Intervention: Oral etoposide phosphate
Comparator: Oral etoposide
Outcome: Median AUC(inf) | 0 | {"evidence_spans": [{"end": 1113, "start": 749, "text": "s. The median AUC(inf) (area under the concentration vs time curve from zero to infinity) of etoposide was 77.7 mg l(-1) h after etoposide phosphate (95% CI 61.3-100.5) and 62.0 mg l(-1) h after oral etoposide (95% CI 52.2-76.9). The difference in favour of etopo... |
TITLE: Effects of Neuromuscular Electrical Stimulation Combined with Exercises versus an Exercise Program on the Pain and the Function in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
ABSTRACT:
Objectives. To investigate the effect of 8 weeks of NMES + Ex (neuromuscular electrical stimulation... | Intervention: NMES plus exercise
Comparator: Exercise alone
Outcome: Numerical Rating Scale | 0 | {"evidence_spans": [{"end": 1311, "start": 935, "text": "s. Following the interventions, a statistically significant improvement in both groups was observed in all outcomes assessed. For the comparison between the groups, no statistically significant difference was found between the NMES + Ex and the Ex groups in NRS (... |
TITLE: Effects of Neuromuscular Electrical Stimulation Combined with Exercises versus an Exercise Program on the Pain and the Function in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
ABSTRACT:
Objectives. To investigate the effect of 8 weeks of NMES + Ex (neuromuscular electrical stimulation... | Intervention: NMES plus exercise
Comparator: Exercise alone
Outcome: Western Ontario and McMaster Universities Osteoarthritis Index for stiffness | 0 | {"evidence_spans": [{"end": 1311, "start": 1057, "text": "ed. For the comparison between the groups, no statistically significant difference was found between the NMES + Ex and the Ex groups in NRS (P = 0.52), TUG test (P = 0.12), and aspects of WOMAC: pain (P = 0.26), function (P = 0.23), and stiffness (P = 0."}, {"en... |
TITLE: Physiological effects of invasive ventilation with neurally adjusted ventilatory assist (NAVA) in a crossover study
ABSTRACT.BACKGROUND:
Neurally Adjusted Ventilatory Assist (NAVA) is a mode of assisted mechanical ventilation that delivers inspiratory pressure proportionally to the electrical activity of t... | Intervention: Neurally Adjusted Ventilatory Assist
Comparator: Conventional Ventilation
Outcome: Blood pH levels | 0 | {"evidence_spans": [{"end": 1530, "start": 1382, "text": "with CV. There were no statistically significant differences on blood pH levels between the two modes of ventilation (7.32 \u00b1 0.02 vs. 7.32 \u00b1 0.04, P"}, {"end": 1531, "start": 1382, "text": "with CV. There were no statistically significant differences o... |
TITLE: Physiological effects of invasive ventilation with neurally adjusted ventilatory assist (NAVA) in a crossover study
ABSTRACT.BACKGROUND:
Neurally Adjusted Ventilatory Assist (NAVA) is a mode of assisted mechanical ventilation that delivers inspiratory pressure proportionally to the electrical activity of t... | Intervention: Neurally Adjusted Ventilatory Assist
Comparator: Conventional Ventilation
Outcome: Systolic arterial pressure | 1 | {"evidence_spans": [{"end": 1782, "start": 1657, "text": "= 0.04). With regard to hemodynamics, systolic arterial pressures were higher using NAVA: +8.4 % (95 % CI: +3.3 to +13.6 %, P"}, {"end": 1783, "start": 1657, "text": "= 0.04). With regard to hemodynamics, systolic arterial pressures were higher using NAVA: +8.4 ... |
TITLE: The effect of hip abduction on the EMG activity of vastus medialis obliquus, vastus lateralis longus and vastus lateralis obliquus in healthy subjects
ABSTRACT.STUDY DESIGN:
Controlled laboratory study.
ABSTRACT.OBJECTIVES:
The purposes of this paper were to investigate (d) whether vastus medialis obli... | Intervention: knee extension at 90° of flexion
Comparator: hip abduction at 0° and 30°
Outcome: vastus medialis obliquus (VMO) EMG activity | 1 | {"evidence_spans": [{"end": 13063, "start": 12883, "text": "tion at 0\u00b0 and 30\u00b0 of abduction. A) Significantly higher VMO activity for both male and female subjects performing MVIC knee extension at 90\u00b0 of flexion when compared to MVIC hip a"}], "id": "1074", "pmcid": "1562433", "prompt_id": "1074", "spli... |
TITLE: The effect of hip abduction on the EMG activity of vastus medialis obliquus, vastus lateralis longus and vastus lateralis obliquus in healthy subjects
ABSTRACT.STUDY DESIGN:
Controlled laboratory study.
ABSTRACT.OBJECTIVES:
The purposes of this paper were to investigate (d) whether vastus medialis obli... | Intervention: knee extension at 90° of flexion
Comparator: hip abduction at 0° and 30°
Outcome: vastus lateralis longus (VLL) EMG activity | 0 | {"evidence_spans": [{"end": 13149, "start": 13067, "text": "tion at 0\u00b0 and 30\u00b0 of abduction. B) VLL EMG activity without significant differenc"}], "id": "1075", "pmcid": "1562433", "prompt_id": "1075", "split_group_id": "1562433", "votes": {"0": 1}} |
TITLE: Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy
ABSTRACT:
This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperative pain management in dogs. Twenty dogs undergoing mastectomy were randomized to receive perioperative oral pla... | Intervention: gabapentin (10 mg/kg)
Comparator: Placebo
Outcome: morphine doses | -1 | {"evidence_spans": [{"end": 883, "start": 727, "text": "). Dogs in the Placebo group received significantly more morphine doses than the Gabapentin group (P=0.021), despite no significant differences in pain scor"}, {"end": 982, "start": 727, "text": "). Dogs in the Placebo group received significantly more morphine do... |
TITLE: Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma
ABSTRACT.PURPOSE:
To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) ≥ 6 clock... | Intervention: laser peripheral iridotomy (LPI) group 1
Comparator: primary trabeculectomy group 2
Outcome: The absolute risk for ?2 lost lines of vision | 0 | {"evidence_spans": [{"end": 11125, "start": 10988, "text": "hi-square value 0.098, p = 0.755). The absolute risk for \u22652 lost lines of vision in the trabeculectomy group was 18% (20 of 111) compared"}], "id": "1084", "pmcid": "5610854", "prompt_id": "1084", "split_group_id": "5610854", "votes": {"0": 1}} |
TITLE: Changes in proprioception and pain in patients with neck pain after upper
thoracic manipulation
ABSTRACT:
[Purpose] The purpose of this study was to conduct cervical stability training and upper
thoracic manipulation for patients with chronic neck pain and then investigate the changes
of cervical propri... | Intervention: upper thoracic manipulation (UTM)
Comparator: cervical stability training (CST)
Outcome: repositioning error in flexion and right and left side-bending and reduction in pain | -1 | {"evidence_spans": [{"end": 1207, "start": 1024, "text": "in. [Results] After the intervention, the error angle was significantly\r\nsmaller in flexion and right left side-bending, and pain was significantly reduced in the\r\nupper thoracic mani"}, {"end": 10322, "start": 10163, "text": "ectively in the manipulation gr... |
TITLE: A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial
ABSTRACT.BACKGROUND:
Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol.... | Intervention: single serving of curry meal
Comparator: spice-free control meal
Outcome: postprandial FMD | 1 | {"evidence_spans": [{"end": 1344, "start": 1132, "text": " 0.039). On the other hand, the consumption of the curry meal increased FMD from 5.2 \u00b1 2.5% to 6.6 \u00b1 2.0% (P = 0.001), and the postprandial FMD after the curry meal was higher than that after the control meal (P "}, {"end": 15723, "start": 15592, "text... |
TITLE: Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: a randomized, double-blind study
ABSTRACT.OBJECTIVE:
Despite the many complications of succinylcholine, it is still widely used as a superior muscle relaxant for rapid sequence induction. One of these com... | Intervention: Group K, 0.5 mg/kg of ketamine was injected intravenously,
Comparator: Group N, the same volume (5 mL) of normal saline was injected
Outcome: grade 2 of POM | 0 | {"evidence_spans": [{"end": 1621, "start": 1459, "text": "P>0.05). Overall, the incidence of POM in Group K was significantly less, when compared with Group N (P<0.05), but both groups were comparable based on the grade "}, {"end": 1620, "start": 1565, "text": "05), but both groups were comparable based on the grade"}]... |
TITLE: Comparative utility of disability progression measures in PPMS
ABSTRACT.OBJECTIVE::
To assess the comparative utility of disability progression measures in primary progressive MS (PPMS) using the PROMiSe trial data set.
ABSTRACT.METHODS::
Data for patients randomized to placebo (n = 316) in the PROMiSe... | Intervention: timed 25-foot walk [T25FW],
Comparator: 9-hole peg test [9HPT]
Outcome: confirmed disability progression | 1 | {"evidence_spans": [{"end": 976, "start": 890, "text": " months. CDP rates defined by T25FW or EDSS score were higher than those defined by 9H"}], "id": "1122", "pmcid": "5489138", "prompt_id": "1122", "split_group_id": "5489138", "votes": {"1": 1}} |
TITLE: Clinical efficacy of
ABSTRACT:
Aging has become one of the distinctive demographic phenomena in the 21st century and its social, economic and health implications are the most challenging issues. Senile Memory Impairment is a common condition characterized by mild symptoms of cognitive decline and occurs a... | Intervention: administered with the Granules of Guduchyadi Medhya Rasayana (GMR), which contains Guduchi (Tinospora cordifolia Wild.), Apamarga (Achyranthes aspera Linn.), Vidanga (Embelia ribes Burm. f.), Shankhapushpi (Convolvulus pluricaulis Chois.), Vaca (Acorus calamus Linn.), Haritaki (Terminalia chebula Zetz.), ... | 1 | {"evidence_spans": [{"end": 6734, "start": 6276, "text": "BODY.MATERIALS AND METHODS.GROUP A (TRIAL GROUP):\r\nPatients of this group were administered with the Granules of Guduchyadi Medhya Rasayana (GMR), which contains Guduchi (Tinospora cordifolia Wild.), Apamarga (Achyranthes aspera Linn.), Vidanga (Embelia ribes ... |
TITLE: Applicability Evaluation of Simplified Cognitive Behavioral Therapy
ABSTRACT.BACKGROUND:
We have developed a structured cognitive behavioral therapy manual for anxiety disorder in China, and the present study evaluated the applicability of simplified cognitive behavioral therapy based on our previous resea... | Intervention: simplified cognitive behavioral therapy (SCBT) on generalized anxiety disorder (GAD)
Comparator: the SCBT with medication group or regular medication group
Outcome: drop-out rates | 0 | {"evidence_spans": [{"end": 1077, "start": 996, "text": "SULTS:\r\n(1) There was no significant difference among the drop-out rates in the t"}, {"end": 11462, "start": 11194, "text": "LUATION OF SCBT.3.2.1 DROP-OUT RATE:\r\nAs stated in Table 2, there was no significant difference among the drop-out rates of the three ... |
TITLE: Applicability Evaluation of Simplified Cognitive Behavioral Therapy
ABSTRACT.BACKGROUND:
We have developed a structured cognitive behavioral therapy manual for anxiety disorder in China, and the present study evaluated the applicability of simplified cognitive behavioral therapy based on our previous resea... | Intervention: simplified cognitive behavioral therapy (SCBT) on generalized anxiety disorder (GAD)
Comparator: the SCBT with medication group
Outcome: quality of treatment, the duration and the number of session, or whether their expectations for treatment had been met. | 0 | {"evidence_spans": [{"end": 11098, "start": 10825, "text": "d 45 participants from the SCBT with medication group). As stated in Table 1, participants in the SCBT group and SCBT with medication group were not significantly different in satisfaction factors, such as the quality of treatment, the duration and the number... |
TITLE: First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens
ABSTRACT:
Background. We report the first-in-human safety and immunogenicit... | Intervention: groups primed with SeV-Gag and boosted with Ad35-GRIN (SLA and SHA)
Comparator: a single dose of Ad35-GRIN or SeV-Gag
Outcome: Gag-specific IFN-? enzyme-linked immunospot–determined response rates and geometric mean responses | 1 | {"evidence_spans": [{"end": 1752, "start": 1297, "text": "d. Gag-specific IFN-\u03b3 enzyme-linked immunospot\u2013determined response rates and geometric mean responses were higher (96% and 248 spot-forming units, respectively) in groups primed with SeV-Gag and boosted with Ad35-GRIN (SLA and SHA) than those after a s... |
TITLE: First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens
ABSTRACT:
Background. We report the first-in-human safety and immunogenicit... | Intervention: ASH group
Comparator: SLA, SHA, SHSH, and placebo groups,
Outcome: The GMTs | 1 | {"evidence_spans": [{"end": 28649, "start": 28415, "text": " (ie, they were \u2264100) after prime and boost. The GMTs were significantly higher (P < .0001, by the Kruskal-Wallis test) in the ASH group after the SeV boost than in the other groups (53, 53, 245, 50, and 59 in the SLA, SHA, ASH, SHSH,"}], "id": "1132", "p... |
TITLE: Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients
ABSTRACT.INTRODUCTION:
Physical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise ... | Intervention: high-intensity interval training (HIT) for 12-weeks in patients NYHA II-III
Comparator: continuous training (CT) 12-weeks inpatients NYHA II-III
Outcome: Quality of life | 0 | {"evidence_spans": [{"end": 27171, "start": 27104, "text": "elocity during early filling/peak mitral annulus velocity during ea"}, {"end": 27342, "start": 27168, "text": " early filling, lateral/septal. \r\n\r\nBODY.RESULTS.IMPACT OF EXERCISE TRAINING.QUALITY OF LIFE:\r\nThere was no significant change in the SF-36 tot... |
TITLE: Efficacy and Safety of Tiropramide in the Treatment of Patients With Irritable Bowel Syndrome: A Multicenter, Randomized, Double-blind, Non-inferiority Trial, Compared With Octylonium
ABSTRACT.BACKGROUND/AIMS:
Antispasmodics such as octylonium are widely used to manage irritable bowel syndrome (IBS) sympto... | Intervention: tiropramide 100
Comparator: octylonium 20 mg
Outcome: The incidence of adverse events | 0 | {"evidence_spans": [{"end": 1778, "start": 1652, "text": " differ. The incidence of adverse events was similar in the 2 groups, and no severe adverse events involving either drug were "}], "id": "1141", "pmcid": "3895597", "prompt_id": "1141", "split_group_id": "3895597", "votes": {"0": 2}} |
TITLE: Efficacy and Safety of Tiropramide in the Treatment of Patients With Irritable Bowel Syndrome: A Multicenter, Randomized, Double-blind, Non-inferiority Trial, Compared With Octylonium
ABSTRACT.BACKGROUND/AIMS:
Antispasmodics such as octylonium are widely used to manage irritable bowel syndrome (IBS) sympto... | Intervention: tiropramide 100
Comparator: octylonium 20 mg
Outcome: the degree of symptom reduction in abdominal pain using symptom diaries from week 1 | 1 | {"evidence_spans": [{"end": 14158, "start": 13984, "text": "sistency was improved by treatment. Furthermore, the degree of symptom reduction in abdominal pain using symptom diaries was higher in the tiropramide group than in the octyl"}], "id": "1142", "pmcid": "3895597", "prompt_id": "1142", "split_group_id": "3895597... |
TITLE: Co-morbidities, complications and causes of death among people with femoral neck fracture – a three-year follow-up study
ABSTRACT.BACKGROUND:
The poor outcome after a hip fracture is not fully understood. The aim of the study was to describe the prevalence of co-morbidities, complications and causes of de... | Intervention: pulmonary emboli or cancer or cardiac failure or cardiovascular disease or dementia or dependence in P-ADL
Comparator: no comorbidities
Outcome: mortality in old people with femoral neck fracture. | 1 | {"evidence_spans": [{"end": 17078, "start": 16700, "text": "m were all associated with time to death. In the final model (Model C.) all significant variables in the two multivariate models above were combined; pulmonary emboli (HR 69.396, CI: 7.107\u2013677.632), cancer (HR 3.393, CI: 1.959\u20135.877), cardiac failure... |
TITLE: Acute effect of Ethanol and Taurine on frontal cortex absolute beta power before and after exercise
ABSTRACT:
Ethanol (ET) is a substance that modulates the Central Nervous System (CNS). Frequently, ET intake occurs combined with energy drinks, which contain taurine (TA), an important amino acid found in t... | Intervention: Taurine combined with Ethanol (TA+ET)
Comparator: Placebo—PL
Outcome: absolute beta power (ABP) after exercise | 1 | {"evidence_spans": [{"end": 1214, "start": 1126, "text": "e. However, in the ET+TA treatment, ABP values were greater after exercise, except for F"}], "id": "1145", "pmcid": "5851630", "prompt_id": "1145", "split_group_id": "5851630", "votes": {"1": 2}} |
TITLE: Pioglitazone Decreases Hepatitis C Viral Load in Overweight, Treatment Naïve, Genotype 4 Infected-Patients: A Pilot Study
ABSTRACT.BACKGROUND:
Insulin resistance (IR) is induced by chronic hepatitis C virus (HCV) genotypes 1 and 4 infections. It is not known whether drugs that affect IR such as Pioglitazon... | Intervention: Pioglitazone (30 mg/day for 14 days)
Comparator: baseline
Outcome: HCV RNA at day-14 | -1 | {"evidence_spans": [{"end": 1681, "start": 1534, "text": "roup. Pioglitazone was effective in decreasing serum HCV RNA at day-14 (n = 10; difference of means = 205,618 IU/ml; 95% CI 26,600 to 384,600; P<0."}], "id": "1156", "pmcid": "3296686", "prompt_id": "1156", "split_group_id": "3296686", "votes": {"-1": 1}} |
TITLE: Pioglitazone Decreases Hepatitis C Viral Load in Overweight, Treatment Naïve, Genotype 4 Infected-Patients: A Pilot Study
ABSTRACT.BACKGROUND:
Insulin resistance (IR) is induced by chronic hepatitis C virus (HCV) genotypes 1 and 4 infections. It is not known whether drugs that affect IR such as Pioglitazon... | Intervention: Pioglitazone (30 mg/day for 14 days)
Comparator: baseline
Outcome: day-14 fasting serum glucose and the 2-hr glucose (Glucose-120 min) after an OGTT | -1 | {"evidence_spans": [{"end": 20239, "start": 20012, "text": "028) and at day-7 (mean change = 152,772 IU/ml; P = 0.044) (\r\nTable 3\r\n).\r\n\r\nBODY.RESULTS.EFFECT OF PIOGLITAZONE ON INDICES OF INSULIN RESISTANCE:\r\nPioglitazone treatment decreased by day-14 fasting serum glucose (Glucose-0) (m"}], "id": "1158", "pmc... |
TITLE: Sensitivity to scale of willingness‐to‐pay within the context of menorrhagia
ABSTRACT.ABSTRACT.OBJECTIVES:
Willingness‐to‐pay (WTP) provides a broad assessment of well‐being, capturing benefits beyond health. However, the validity of the approach has been questioned and the evidence relating to the sensiti... | Intervention: after treatment
Comparator: before treatment
Outcome: willingness?to?pay. | 1 | {"evidence_spans": [{"end": 20610, "start": 20270, "text": "ons, Ltd \r\n\r\nBODY.RESULTS.TREATMENT RESPONSE:\r\nThe average maximum WTP for treatment for menorrhagia was approximately \u00a327 (US$41) per month (see Table 2). The average combined MMAS score for treatment doubled from approximately 43 at pre\u2010treat... |
TITLE: Evaluation of different sodium bicarbonate regimens for the prevention of contrast medium-induced nephropathy
ABSTRACT.INTRODUCTION:
The rapid decline in renal function caused by radiographic contrast agents usually is transient, but it can result in chronic kidney disease. The pathophysiology of contrast-... | Intervention: sodium bicarbonate solution using the short regimen (intravenous bolus 3 mL/kg/h of 166 mEq/L sodium bicarbonate for 1 hour immediately before radiocontrast)
Comparator: sodium bicarbonate solution using the long regimen (initial intravenous bolus of 3 mL/kg/h of 166 mEq/L sodium bicarbonate for 6 hr).
Ou... | 0 | {"evidence_spans": [{"end": 13312, "start": 13017, "text": "bolic acidosis (20). Regarding the pH of urine, we found that it was (5.95 \u00b1 0.26) in group 1 and (5.97 \u00b1 0.24) in group 2, showing no statistical difference and highlighting the fact that both regimen had almost the same alkalinizing efficacy with n... |
TITLE: Evaluation of different sodium bicarbonate regimens for the prevention of contrast medium-induced nephropathy
ABSTRACT.INTRODUCTION:
The rapid decline in renal function caused by radiographic contrast agents usually is transient, but it can result in chronic kidney disease. The pathophysiology of contrast-... | Intervention: sodium bicarbonate solution using the short regimen (intravenous bolus 3 mL/kg/h of 166 mEq/L sodium bicarbonate for 1 hour immediately before radiocontrast)
Comparator: sodium bicarbonate solution using the long regimen (initial intravenous bolus of 3 mL/kg/h of 166 mEq/L sodium bicarbonate for 6 hr).
Ou... | 1 | {"evidence_spans": [{"end": 1779, "start": 1572, "text": "ESULTS:\r\nThere was a significant increase in serum creatinine and a decrease in eGFR 48 hr post-intervention in group 1 (short regimen) with no statically difference regarding those parameters group 2 (long "}, {"end": 11462, "start": 10924, "text": "ar contra... |
TITLE: Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies
ABSTRACT.INTRODUCTION:
To examine pooled efficacy data from three, large phase III studies comparing mirabegron (50... | Intervention: mirabegron (50 and 100 mg)
Comparator: placebo
Outcome: mean volume voided/micturition, mean level of urgency, mean number of urgency episodesand mean number of urgency incontinence episodes/24 h | -1 | {"evidence_spans": [{"end": 27453, "start": 27007, "text": "0 and 100 mg groups, respectively. Both 50 and 100 mg mirabegron doses were associated with statistically significant improvements from baseline to Final Visit compared with placebo for the key secondary efficacy end-points of mean volume voided/micturition (... |
TITLE: Effects of a balance-based exergaming intervention using the Kinect sensor on posture stability in individuals with Parkinson’s disease: a single-blinded randomized controlled trial
ABSTRACT.BACKGROUND:
The present study examined the effects of a balance-based exergaming intervention using the Kinect senso... | Intervention: a balance-based exergaming group for an 8-week balance training period.
Comparator: a balance training group for an 8-week balance training period.
Outcome: the limits of stability (LOS) performance and one-leg stance (OLS) tests | 1 | {"evidence_spans": [{"end": 1129, "start": 961, "text": "ESULTS:\r\nAfter training, participants in the balance-based exergaming group showed significant improvements in LOS performance, and in the eyes-closed condition of the "}, {"end": 19176, "start": 18787, "text": "dition in the OLS test, the BBS and the TUG test.... |
TITLE: The evaluation of effects two different doses of hydrocortisone on the intensity of perioperative shivering in elective surgery under spinal anesthesia: A double-blind randomized controlled trial study
ABSTRACT.BACKGROUND::
Post- and intra-operative shivering is one of the most complications of spinal anes... | Intervention: received 1 mg/kg and 2 mg/kg hydrocortisone
Comparator: received normal saline
Outcome: Mean central temperature, Mean peripheral temperature, Mean blood pressure, Mean heart rate | 0 | {"evidence_spans": [{"end": 14365, "start": 14014, "text": "0.82 and P = 0.77). Figure 1Mean central temperature from 0 to 60 min recovery in the three groups (P = 0.64) Figure 2Mean peripheral temperature from 0 to 60 min recovery in the three groups (P = 0.31) Figure 3Mean blood pressure from 0 to 60 min recovery ... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: mean daily number of moderate to severe hot flushes at week 12 | -1 | {"evidence_spans": [{"end": 11147, "start": 10703, "text": "cebo group. At week 12, BZA 20 mg/CE 0.45 mg and BZA 20 mg/CE 0.625 mg were associated with a decrease (P < 0.001) in the adjusted mean daily number of moderate to severe hot flushes, reaching a 74% and a 80% reduction, respectively, representing a clinically ... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: mean proportion of superficial cells | 1 | {"evidence_spans": [{"end": 14397, "start": 14235, "text": "al atrophy.19 BZA 20 mg/CE 0.45 or 0.625 mg showed a significantly greater increase from baseline in the mean proportion of superficial cells compared with place"}], "id": "1192", "pmcid": "3743641", "prompt_id": "1192", "split_group_id": "3743641", "votes": ... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: reduction from baseline in the mean proportion of parabasal cells | 1 | {"evidence_spans": [{"end": 14530, "start": 14398, "text": "o (P < 0.001). Both BZA/CE groups also showed a significantly greater reduction from baseline in the mean proportion of parabasal ce"}], "id": "1193", "pmcid": "3743641", "prompt_id": "1193", "split_group_id": "3743641", "votes": {"1": 1}} |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: vaginal pH | -1 | {"evidence_spans": [{"end": 14814, "start": 14679, "text": "eeks 4 and 12. Additionally, treatment with BZA 20 mg/CE 0.625 mg resulted in a significantly greater decrease from baseline in vaginal"}, {"end": 14948, "start": 14679, "text": "eeks 4 and 12. Additionally, treatment with BZA 20 mg/CE 0.625 mg resulted in a s... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: sexual function and total scores | 1 | {"evidence_spans": [{"end": 15918, "start": 15652, "text": "s scale.17,19 Additionally, in SMART-3 (subjects with vulvovaginal atrophy), the Menopause-Specific Quality of Life questionnaire results at week 12 showed significant improvements in sexual function and total scores with both BZA/CE doses versus placebo or B... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: lumbar spine bone mineral density (BMD) | 1 | {"evidence_spans": [{"end": 16714, "start": 16112, "text": "ODY.BONE EFFECTS:\r\nTwo clinical trials (SMART-1 and SMART-5) evaluated the safety and efficacy of BZA/CE for the prevention of osteoporosis.17,20 Among subjects \u22645 years since menopause (substudy II of SMART-1 and SMART-5), significant (P < 0.001) incre... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: risk for serious adverse events, such as venous thromboembolism, cardiovascular events, endometrial cancer, or breast cancer, | 0 | {"evidence_spans": [{"end": 27174, "start": 26977, "text": "an acceptable safety profile. No apparent increased risk for serious adverse events, such as venous thromboembolism, cardiovascular events, endometrial cancer, or breast cancer, was observed with e"}], "id": "1201", "pmcid": "3743641", "prompt_id": "1201", "sp... |
TITLE: Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet
ABSTRACT:
Oxidative stress has previously been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications. In the present study, the effects ... | Intervention: high-fat diet enriched with ground flaxseed 15 g/100 g of food, rich in ALA; or enriched with vitamin E, 40 mg ?-tocopherol/100 g of food
Comparator: received a high-fat diet (40% energy as fat), deficient in ?-linolenic acid (ALA)
Outcome: serum glucose | -1 | {"evidence_spans": [{"end": 11251, "start": 11087, "text": "A).\r\n\r\nBODY.RESULTS.SERUM GLUCOSE:\r\nThe addition of flaxseed or/and vitamin E to the high-fat diet led to significant reductions of serum glucose levels compared wi"}], "id": "1203", "pmcid": "4280954", "prompt_id": "1203", "split_group_id": "4280954", "... |
TITLE: Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech
ABSTRACT:
Background: Detecting early signs of Alzheimer's disease (AD) and mild cognitive impairment (MCI) during the pre-symptomatic phase is becoming increasingly important for cost-effective clinical ... | Intervention: mild cognitive impairment (MCI)
Comparator: healthy
Outcome: proportion of words out of the total number of words | 1 | {"evidence_spans": [{"end": 1977, "start": 1789, "text": "ts: Compared to those with normal cognitive function, MCI participants generated a greater proportion of words out of the total number of words during the timed conversation sessions (p=0."}, {"end": 13587, "start": 13369, "text": "oken by participants. The aver... |
TITLE: The display effects of patients’ self-assessment on traumatic acute pain on the proportion and timing of analgesics administration in the emergency department
ABSTRACT.BACKGROUND:
Acute pain assessment in the emergency department (ED) is important in particular during the triage process. Early pain assessm... | Intervention: pain score display group
Comparator: not displayed in the control.
Outcome: The mean timing to analgesic administration | 0 | {"evidence_spans": [{"end": 1541, "start": 1353, "text": "d group. The mean timing to analgesic administration for the displayed and non-displayed groups were 81.3 \u00b1 41.2 (95% C.I 65.9, 96.7) and 88.7 \u00b1 45.4 (95% C.I 69.0, 108.3), respectively (p"}, {"end": 11011, "start": 10708, "text": "sing Mantel-Hanszel ... |
TITLE: Randomized Trial Comparing Esomeprazole and Rabeprazole in First-line Eradication Therapy for
ABSTRACT.OBJECTIVE :
CYP2C19 metabolic activity influences the efficacy of Helicobacter pylori eradication therapies comprising PPIs. Rabeprazole (RPZ) and esomeprazole (EPZ) are PPIs not extensively metabolized ... | Intervention: amoxicillin (750 mg), clarithromycin (200 mg), and either esomeprazole (20 mg) (EAC group), twice a day for one week.
Comparator: amoxicillin (750 mg), clarithromycin (200 mg), and rabeprazole (10 mg) (RAC group), twice a day for one week.
Outcome: Eradication of H. pylori with homo EM genotype and those ... | 0 | {"evidence_spans": [{"end": 1280, "start": 1105, "text": "=0.488). The eradication rates of the EAC and RAC regimens were not significantly different between patients with the homo EM genotype (p=0.999) or hetero IM or PM genotypes ("}, {"end": 9601, "start": 9137, "text": "n to the CYP2C19 polymorphism. The eradicatio... |
TITLE: Non-Invasive Brain Stimulation for Children with Autism Spectrum Disorders: A Short-Term Outcome Study
ABSTRACT:
Non-Invasive Brain Stimulation (NIBS) is a relatively new therapeutic approach that has shown beneficial effects in Autism Spectrum Disorder (ASD). One question to be answered is how enduring it... | Intervention: after Non-Invasive Brain Stimulation (NIBS)
Comparator: before Non-Invasive Brain Stimulation (NIBS)
Outcome: ADI-R (algorithm for current condition), the Autism Behavioral Checklist (ABC), and the Autism Treatment Evaluation Checklist (ATEC) after 1 month | -1 | {"evidence_spans": [{"end": 15790, "start": 15523, "text": " ONE MONTH AFTER THE INTERVENTION:\r\nAs a global result (G1 + G2), a significant decrease in the total score was observed in ADI-R, ABC, and ATEC scales one month after the intervention (Wilcoxon matched pair test; ABC, Z = 3.823, p = 0.000131; ADI-R, 3.337, ... |
TITLE: Belatacept-Based Immunosuppression in
ABSTRACT:
This exploratory phase II study evaluated the safety and efficacy of belatacept in de novo adult liver transplant recipients. Patients were randomized (N = 260) to one of the following immunosuppressive regimens: (i) basiliximab + belatacept high dose [HD] +... | Intervention: belatacept groups
Comparator: tacrolimus groups
Outcome: Mean calculated GFR at 1 year. | 1 | {"evidence_spans": [{"end": 26014, "start": 25850, "text": "or tacrolimus + MMF and 62 mL/min for tacrolimus). The proportion of patients with >10 mL/min improvement in cGFR from baseline to month 12 was 47\u201365% in the belata"}], "id": "896", "pmcid": "4140547", "prompt_id": "896", "split_group_id": "4140547", "vot... |
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