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claim_id int64 0 1.41k	claim stringlengths 26 249	abstract_id int64 5.84k 196M	title stringlengths 7 264	abstract listlengths 3 25	verdict stringclasses 3 values	evidence listlengths 0 5
306	DUSP4 decreases apoptosis.	7,821,634	Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance	[ "Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer.", "However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR.", "We hypothesiz...	CONTRADICT	[ 6 ]
308	DUSP4 downregulation deactivates the Ras-ERK pathway	7,821,634	Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance	[ "Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer.", "However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR.", "We hypothesiz...	CONTRADICT	[ 4, 5, 9 ]
309	DUSP4 increases apoptosis.	7,821,634	Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance	[ "Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer.", "However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR.", "We hypothesiz...	SUPPORT	[ 6 ]
310	De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.	6,173,523	A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.	[ "IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management.", "However, traditional culture-based diagnosis can be difficult, particularly if no specific diagnostic test is available for an outbreak strain. \n", "OBJECTIVE To explore the potential of metagenomics, wh...	NEI	[]
313	De novo assembly of sequence data has shorter contigs than unassembled sequence data.	6,173,523	A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.	[ "IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management.", "However, traditional culture-based diagnosis can be difficult, particularly if no specific diagnostic test is available for an outbreak strain. \n", "OBJECTIVE To explore the potential of metagenomics, wh...	NEI	[]
315	Decrease of p62 in prostate tumor stroma results in defective autophagy.	3,701,541	p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.	[ "Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC).", "Vitamin D receptor (VDR) activation in HSCs inhibits liver inflammation and fibrosis.", "We found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC-associated HSCs...	NEI	[]
316	Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.	712,078	Pharmacological correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice	[ "Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical chloride channel that supports bicarbonate transport.", "Individuals with cystic fibrosis show retained, thickened mucus that plugs airways and obstructs luminal o...	NEI	[]
317	Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.	4,506,414	Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people	[ "BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been compared.", "In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease. \n", "MET...	CONTRADICT	[ 9 ]
323	Deleting Raptor increases G-CSF levels.	2,014,909	Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation	[ "Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression.", "MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms governing such heterogeneity are largely unknown.", "Here, integrating human tumour gen...	NEI	[]
325	Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.	40,349,336	Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.	[ "Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR).", "Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (Seckel syndrome).", "Here we show that eliminating ATR in adult mi...	NEI	[]
326	Deletion of ATM and Rad3 related protein leads to acute tissue loss.	40,349,336	Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.	[ "Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR).", "Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (Seckel syndrome).", "Here we show that eliminating ATR in adult mi...	NEI	[]
330	Deltex has no known interactions with eIF3f.	9,505,448	The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation	[ "Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcriptionally active molecule.", "The Notch1 receptor was proposed ...	CONTRADICT	[ 6 ]
331	Deltex interacts with eIF3. There is no known interaction between Deltex and elF3	9,505,448	The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation	[ "Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcriptionally active molecule.", "The Notch1 receptor was proposed ...	CONTRADICT	[ 6 ]
332	Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.	29,023,309	Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut	[ "Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia.", "Here we show that simian immunodeficiency virus (SIV) infection results in depletion of T helper type 17 (TH17) cells in the ileal mucosa of rhesu...	CONTRADICT	[ 1, 3 ]
333	Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.	29,023,309	Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut	[ "Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia.", "Here we show that simian immunodeficiency virus (SIV) infection results in depletion of T helper type 17 (TH17) cells in the ileal mucosa of rhesu...	SUPPORT	[ 1, 3 ]
334	Depletion of nitric oxide is responsible for vasospasm.	25,079,962	Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.	[ "CONTEXT Delayed cerebral vasospasm causes permanent neurological deficits or death in at least 15% of patients following otherwise successful treatment for ruptured intracranial aneurysm.", "Decreased bioavailability of nitric oxide has been associated with the development of cerebral vasospasm. \n", "OBJECT...	SUPPORT	[ 1, 10, 12 ]
335	Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.	1,780,819	Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development	[ "BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics.", "Much of the risk for endometrial cancer development is influenced by the environment and lifestyle.", "Accumulating evidence suggests that the epigenome serves as the interface between the ...	SUPPORT	[ 10 ]
336	Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.	2,097,256	Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis	[ "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas.", "We analysed the interaction between human population density and lack of tap water as a cause of dengue feve...	NEI	[]
337	Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.	2,097,256	Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis	[ "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas.", "We analysed the interaction between human population density and lack of tap water as a cause of dengue feve...	NEI	[]
339	Dexamethasone increases risk of postoperative bleeding.	23,349,986	Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial.	[ "CONTEXT Dexamethasone is widely used to prevent postoperative nausea and vomiting (PONV) in pediatric tonsillectomy. \n", "OBJECTIVE To assess whether dexamethasone dose-dependently reduces the risk of PONV at 24 hours after tonsillectomy. \n", "DESIGN, SETTING, AND PATIENTS Randomized placebo-controlled t...	SUPPORT	[ 10, 11, 12, 15 ]
340	Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.	7,098,463	Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.	[ "CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. \n", "OBJECTIVE To determine if surgically induced weight loss results in better glycemic control and less need for diabetes medications than conventional approaches to weight loss and dia...	SUPPORT	[ 9, 10, 14 ]
341	Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.	7,098,463	Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.	[ "CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. \n", "OBJECTIVE To determine if surgically induced weight loss results in better glycemic control and less need for diabetes medications than conventional approaches to weight loss and dia...	CONTRADICT	[ 9, 10, 14 ]
342	Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.	7,873,737	Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes.	[ "BACKGROUND Diabetes mellitus is a major risk factor for adverse outcomes after acute coronary syndromes (ACS).", "Because this disease may be associated with increased platelet aggregation, we investigated whether diabetic patients with ACS derive particular benefit from platelet glycoprotein (GP) IIb/IIIa recep...	NEI	[]
342	Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.	5,884,524	Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.	[ "BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown.", "This is particularly true for patients with diabetes mellitus, who are known to have a high morbidity and mortality after an...	CONTRADICT	[ 5 ]
345	Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.	4,394,817	E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells	[ "In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably portrayed as the ultimate effectors of a transcriptional program that commit cells to en...	NEI	[]
346	Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.	11,902,109	Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila	[ "The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, crystal cells and lamellocytes--the functions of which are reminiscent of mammalian myeloid ...	CONTRADICT	[ 5 ]
347	Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.	11,902,109	Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila	[ "The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, crystal cells and lamellocytes--the functions of which are reminiscent of mammalian myeloid ...	SUPPORT	[ 5 ]
349	Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.	13,497,630	Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age	[ "Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential.", "Objective To determine the associations between biomarkers of ovarian reserve and reproductive potential among women of late reproductive age.", "Design, Set...	CONTRADICT	[ 7, 8, 9, 11 ]
351	Distant CREs are important for transcriptional regulation.	14,658,685	Enhancer Evolution across 20 Mammalian Species	[ "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals.", "Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling...	NEI	[]
352	Distant CREs are less conserved among species.	14,658,685	Enhancer Evolution across 20 Mammalian Species	[ "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals.", "Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling...	NEI	[]
355	Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.	12,800,122	Increased Cell Bond Tension Governs Cell Sorting at the Drosophila Anteroposterior Compartment Boundary	[ "Subdividing proliferating tissues into compartments is an evolutionarily conserved strategy of animal development [1-6].", "Signals across boundaries between compartments can result in local expression of secreted proteins organizing growth and patterning of tissues [1-6].", "Sharp and straight interfaces betw...	SUPPORT	[ 8 ]
355	Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.	38,380,061	Localization and requirement for Myosin II at the dorsal-ventral compartment boundary of the Drosophila wing.	[ "As organisms develop, their tissues can become separated into distinct cell populations through the establishment of compartment boundaries.", "Compartment boundaries have been discovered in a wide variety of tissues, but in many cases the molecular mechanisms that separate cells remain poorly understood.", "I...	SUPPORT	[ 3 ]
356	Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.	6,144,337	AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System	[ "Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern.", "Here we report a novel role of an alternatively spliced hypervariable immunoglobulin domain-encoding gene, Dscam, in generat...	SUPPORT	[ 1, 3, 5, 6 ]
357	During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.	18,111,172	The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining	[ "Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined.", "We sought to address this question by analysing cellular NHEJ of ends with systematically mispaired and damaged termini.", "...	NEI	[]
358	During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.	18,111,172	The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining	[ "Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined.", "We sought to address this question by analysing cellular NHEJ of ends with systematically mispaired and damaged termini.", "...	NEI	[]
361	During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.	38,587,347	Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.	[ "Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells or, after organizing into a germinal center (GC), high-affinity plasma cells and memory B cells.", "Remarkably, each of these events occurs in associa...	NEI	[]
363	EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.	5,386,514	Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors	[ "The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T lymphocytes.", "Here we show that dying tumor cells release ATP, which then acts on P2X7 purinergic receptors from DCs...	NEI	[]
364	EGR2 is important to myelination of the peripheral nervous system.	1,550,937	The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells	[ "Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology.", "However, the intrinsic mechanisms regulating these responses are unknown.", "Here, we report that deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with exc...	NEI	[]
365	ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.	600,437	Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P	[ "VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-anchored protein that helps generate tethers between the ER and other membranes through which lipids are exchanged across adjacent bilayers.", "Here, we report that by regulating PI4P levels on endosomes, VAP affects WASH-dependent act...	NEI	[]
366	ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.	13,956,305	Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1	[ "Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive.", "To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases...	SUPPORT	[ 5 ]
367	Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.	27,099,731	Association Between Early Screening for Patent Ductus Arteriosus and In-Hospital Mortality Among Extremely Preterm Infants.	[ "IMPORTANCE There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infants.", "Less pharmacological closure and more supportive management have been observed without evidence to support these changes. \n", "OBJECTIVE To evaluate the association b...	SUPPORT	[ 10, 13 ]
368	Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.	27,099,731	Association Between Early Screening for Patent Ductus Arteriosus and In-Hospital Mortality Among Extremely Preterm Infants.	[ "IMPORTANCE There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infants.", "Less pharmacological closure and more supportive management have been observed without evidence to support these changes. \n", "OBJECTIVE To evaluate the association b...	CONTRADICT	[ 10, 13 ]
369	Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.	6,826,100	The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.	[ "Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells.", "Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation.", "Reliably hi...	SUPPORT	[ 4 ]
370	Egr2 regulates the homeostasis of B and T cells.	1,550,937	The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells	[ "Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology.", "However, the intrinsic mechanisms regulating these responses are unknown.", "Here, we report that deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with exc...	SUPPORT	[ 2, 3, 4, 5 ]
371	Egr3 regulates the homeostasis of B and T cells.	1,550,937	The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells	[ "Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology.", "However, the intrinsic mechanisms regulating these responses are unknown.", "Here, we report that deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with exc...	SUPPORT	[ 2, 3, 4, 5 ]
372	Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.	24,922,825	A chikungunya fever vaccine utilizing an insect-specific virus platform	[ "Traditionally, vaccine development involves tradeoffs between immunogenicity and safety.", "Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines.", "In contrast, the inability of inactivated vaccines to replicate enhances safety at th...	SUPPORT	[ 7, 8 ]
375	Elevated cell-free mitochondrial DNA levels are associated with mortality.	1,522,647	Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation	[ "BACKGROUND Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system.", "However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU).", "We hypothesized that circulating cell-free mtDNA levels would be associated with mortality and ...	SUPPORT	[ 5, 7, 9 ]
376	Eliminating the last sporadic cases of malaria requires considerable funding.	22,401,061	Costs and financial feasibility of malaria elimination	[ "The marginal costs and benefits of converting malaria programmes from a control to an elimination goal are central to strategic decisions, but empirical evidence is scarce.", "We present a conceptual framework to assess the economics of elimination and analyse a central component of that framework-potential shor...	NEI	[]
377	Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.	18,810,195	Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation	[ "How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear.", "We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic biosynthesis by controlling intracellular levels of its substrate 3-phosphoglycerate and product 2-pho...	NEI	[]
378	Energy balance requires hypothalamic glutamate neurotransmission.	45,154,987	Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.	[ "The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis.", "However, the neurotransmitter(s) that mediate MC4R function remain largely unknown; as a result, little is known about the second-order neurons of the MC4R neural pathway.", "Single-minded 1 (Sim1)-expressing brain...	SUPPORT	[ 5, 7, 8 ]
378	Energy balance requires hypothalamic glutamate neurotransmission.	10,534,299	Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone	[ "AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite.", "However, the role of excitatory glutamatergic input in controlling these neurons is unknown.", "To address this question, we generated mice lacking NMDA receptors (NMDARs) on either AgRP or POMC neuron...	SUPPORT	[ 3, 4, 5, 6 ]
378	Energy balance requires hypothalamic glutamate neurotransmission.	11,886,686	Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.	[ "The importance of neuropeptides in the hypothalamus has been experimentally established.", "Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown.", "Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are r...	SUPPORT	[ 7 ]
378	Energy balance requires hypothalamic glutamate neurotransmission.	25,007,443	Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting	[ "In the hypothalamic arcuate nucleus (ARC), pro-opiomelanocortin (POMC) neurons inhibit feeding and neuropeptide-Y (NPY) neurons stimulate feeding.", "We tested whether neurons in the ventromedial hypothalamic nucleus (VMH), a known satiety center, activate anorexigenic neuronal pathways in the ARC by projecting ...	NEI	[]
378	Energy balance requires hypothalamic glutamate neurotransmission.	17,150,648	Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.	[ "Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance.", "Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphology.", "...	SUPPORT	[ 2, 3, 4 ]
379	Enhanced early production of inflammatory chemokines damages viral control in the lung.	19,005,293	Memory CD4+ T cells induce innate responses independently of pathogen	[ "Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses.", "We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses.", "We found that the response of memory, but not naive, CD4+...	CONTRADICT	[ 2 ]
381	Environmental factors can influence the development of breast cancer.	18,340,282	Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study	[ "BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer).", "To test for evidence of gene-environment interactions, we comp...	SUPPORT	[ 2, 6 ]
382	Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.	11,659,421	Human iPSC-based modeling of late-onset disease via progerin-induced aging.	[ "Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders.", "In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages and apply it...	SUPPORT	[ 1, 2, 4, 5 ]
383	Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.	13,770,184	Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015	[ "BACKGROUND The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease.", "By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the i...	NEI	[]
389	Ethanol stress increases the expression of IBP in bacteria.	1,148,122	Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli	[ "Understanding the genetic basis of adaptation is a central problem in biology.", "However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may contribute relatively little.", "We have developed a combined expe...	NEI	[]
390	Ethanol stress increases the expression of PSP in bacteria.	1,148,122	Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli	[ "Understanding the genetic basis of adaptation is a central problem in biology.", "However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may contribute relatively little.", "We have developed a combined expe...	NEI	[]
391	Ethanol stress increases the expression of SRL in bacteria.	1,148,122	Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli	[ "Understanding the genetic basis of adaptation is a central problem in biology.", "However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may contribute relatively little.", "We have developed a combined expe...	NEI	[]
392	Ethanol stress lowers the expression of PSP in bacteria.	1,148,122	Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli	[ "Understanding the genetic basis of adaptation is a central problem in biology.", "However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may contribute relatively little.", "We have developed a combined expe...	NEI	[]
393	Ethanol stress reduces the expression of SRL in bacteria.	1,148,122	Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli	[ "Understanding the genetic basis of adaptation is a central problem in biology.", "However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may contribute relatively little.", "We have developed a combined expe...	NEI	[]
394	Excess gestational weight gain is associated with obesity-related pregnancy outcomes.	11,360,768	Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence	[ "OBJECTIVE To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes. \n", "DESIGN Systematic review and meta-analysis. \n", "DATA SOURCES Major databases from inception to January 2012 wi...	SUPPORT	[ 8, 11, 12 ]
396	Exercise increases cancer mortality rates among Chinese citizens.	1,456,068	Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study	[ "BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premature death, little is known about the combined impact on mortality outcomes, in particular among Chi...	CONTRADICT	[ 8, 10, 11 ]
397	Exercise reduces cancer mortality rates among Chinese citizens.	1,456,068	Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study	[ "BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premature death, little is known about the combined impact on mortality outcomes, in particular among Chi...	SUPPORT	[ 8, 10, 11 ]
398	Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.	8,883,846	Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions	[ "The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses.", "The goals of this workshop were to identify key scientific issues, gaps,...	NEI	[]
400	Exposure to fine particulate air pollution is unrelated to anxiety prevalence.	791,050	The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study	[ "OBJECTIVE To determine whether higher past exposure to particulate air pollution is associated with prevalent high symptoms of anxiety. \n", "DESIGN Observational cohort study. \n", "SETTING Nurses' Health Study. \n", "PARTICIPANTS 71,271 women enrolled in the Nurses' Health Study residing throughout t...	CONTRADICT	[ 7, 11 ]
401	Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.	5,633,876	BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages	[ "BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast.", "The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology.", "Here we readdressed BMP function in hESCs and mouse epiblast-derived cells.", "We found that BMP4 cooperates ...	NEI	[]
403	Expression of oncolytic virus antigens as peptides makes relapse more likely.	1,921,218	Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence	[ "Tumor recurrence represents a major clinical challenge.", "Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their originating primary tumors.", "This phenotype allows them to evade a host-derived innate immune response elicited by the progression from minimal re...	NEI	[]
404	Expression of oncolytic virus antigens as peptides permits additional protection against relapse.	1,921,218	Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence	[ "Tumor recurrence represents a major clinical challenge.", "Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their originating primary tumors.", "This phenotype allows them to evade a host-derived innate immune response elicited by the progression from minimal re...	NEI	[]
406	F4/80+ macrophages regulate mature osteoblast maintenance.	6,796,297	PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis	[ "Osteogenesis during bone modeling and remodeling is coupled with angiogenesis.", "A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), couples angiogenesis and osteogenesis.", "Here, we found that platelet-derived growth factor-BB (PDGF-BB) secreted by ...	NEI	[]
407	FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.	9,889,151	FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.	[ "FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone.", "We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic regions near the C termini of each subunit.", "Mutations throughout these regions affect binding and cause correlated phenotypes that r...	NEI	[]
413	Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.	6,309,659	Reproductive period and risk of dementia in postmenopausal women.	[ "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women.", "A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. \n", "OBJECTIVE To determine whether a longer reproductive period, as an indicator of longer exp...	CONTRADICT	[ 12 ]
414	Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.	6,309,659	Reproductive period and risk of dementia in postmenopausal women.	[ "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women.", "A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. \n", "OBJECTIVE To determine whether a longer reproductive period, as an indicator of longer exp...	SUPPORT	[ 12 ]
416	Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.	6,309,659	Reproductive period and risk of dementia in postmenopausal women.	[ "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women.", "A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. \n", "OBJECTIVE To determine whether a longer reproductive period, as an indicator of longer exp...	SUPPORT	[ 12 ]
417	Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.	6,309,659	Reproductive period and risk of dementia in postmenopausal women.	[ "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women.", "A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. \n", "OBJECTIVE To determine whether a longer reproductive period, as an indicator of longer exp...	CONTRADICT	[ 12 ]
418	Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.	16,660,256	Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration	[ "Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogenous muscle fiber repair has been unclear.", "The transcription factor Pax7 marks satellite cells and is critical for establishing the adult satellite cell pool."...	NEI	[]
420	Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.	9,315,213	Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice	[ "BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity.", "It acts as a key downstream target of both peroxisome proliferator-activated receptor α and γ, the agonists of which have been used for lipid lowering and ins...	SUPPORT	[ 5 ]
422	Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.	11,172,205	Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo	[ "A solid tumor is an organ composed of cancer and host cells embedded in an extracellular matrix and nourished by blood vessels.", "A prerequisite to understanding tumor pathophysiology is the ability to distinguish and monitor each component in dynamic studies.", "Standard fluorophores hamper simultaneous intr...	NEI	[]
423	Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.	8,595,678	Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials	[ "BACKGROUND The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke.", "A previous overview showed that the effects were greatest in regions with low dietary folate consumption, but differentiation between the effect of folate and small-study bias was ...	NEI	[]
425	For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.	33,257,464	Changes in the prevalence of cerebral palsy for children born very prematurely within a population-based program over 30 years.	[ "CONTEXT Although cerebral palsy (CP) among extremely premature infants has been reported as a major morbidity outcome, there are difficulties comparing published CP rates from many sites over various birth years. \n", "OBJECTIVE To assess the changes in population-based, gestational age-specific prevalence rat...	NEI	[]
426	Forkhead 0 (fox0) transcription factors are involved in apoptosis.	16,728,949	Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System	[ "The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism.", "Several recent studies indicate that FoxO-dependent signaling is required for long-term regenerative pot...	SUPPORT	[ 0 ]
428	Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.	16,728,949	Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System	[ "The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism.", "Several recent studies indicate that FoxO-dependent signaling is required for long-term regenerative pot...	SUPPORT	[ 0 ]
429	Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.	36,540,079	Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.	[ "Deamidation of N-terminal Gln by Nt(Q)-amidase, an N-terminal amidohydrolase, is a part of the N-end rule pathway of protein degradation.", "We detected the activity of Nt(Q)-amidase, termed Ntaq1, in mouse tissues, purified Ntaq1 from bovine brains, identified its gene, and began analyzing this enzyme.", "Nta...	NEI	[]
430	FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).	28,937,856	Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.	[ "The Sir2 deacetylase modulates organismal life-span in various species.", "However, the molecular mechanisms by which Sir2 increases longevity are largely unknown.", "We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of Fork...	CONTRADICT	[ 5 ]
432	Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.	8,002,887	Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs	[ "Autophagy is the primary catabolic process triggered in response to starvation.", "Although autophagic regulation within the cytosolic compartment is well established, it is becoming clear that nuclear events also regulate the induction or repression of autophagy.", "Nevertheless, a thorough understanding of t...	SUPPORT	[ 3, 5 ]
434	Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.	9,500,590	Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict	[ "Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and extrathymically (peripheral, pTreg), and their deficiency results in fatal autoimmunity.", "Here, we demonstrate that a Foxp3 enhancer, conserve...	NEI	[]
435	Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.	9,500,590	Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict	[ "Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and extrathymically (peripheral, pTreg), and their deficiency results in fatal autoimmunity.", "Here, we demonstrate that a Foxp3 enhancer, conserve...	NEI	[]
441	G-CSF increases the expansion and infiltration of MDSCs into tumors.	2,014,909	Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation	[ "Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression.", "MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms governing such heterogeneity are largely unknown.", "Here, integrating human tumour gen...	SUPPORT	[ 2 ]
444	GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.	10,165,258	GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.	[ "Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells.", "Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+)CD48(-)) are quiescent, with only a small percentage of the LT-HSCs i...	SUPPORT	[ 5, 6 ]
445	GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.	10,165,258	GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.	[ "Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells.", "Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+)CD48(-)) are quiescent, with only a small percentage of the LT-HSCs i...	SUPPORT	[ 4, 6 ]
447	Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.	2,052,720	Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.	[ "OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. \n", "DESIGN Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases.", "Presence of H pylori ant...	CONTRADICT	[ 6, 7 ]
448	Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.	2,052,720	Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.	[ "OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. \n", "DESIGN Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases.", "Presence of H pylori ant...	SUPPORT	[ 6, 7 ]
449	Gastric lavage is an effective treatment for acute paraquat poisoning.	12,209,494	Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial	[ "BACKGROUND The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants.", "We therefore aimed to assess whether routine treatment with multiple-dose activated charcoal, t...	NEI	[]
449	Gastric lavage is an effective treatment for acute paraquat poisoning.	3,430,789	Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning.	[ "The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination.", "The results indicated that 7 patients died and 12 survived.", "Non-oliguric renal failure occurred in...	NEI	[]
453	General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.	4,200,695	Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study	[ "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression. \n", "DESIGN R...	CONTRADICT	[ 11 ]
454	General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.	4,200,695	Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study	[ "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression. \n", "DESIGN R...	CONTRADICT	[ 11, 12, 14 ]
455	Genes involved in pre-mRNA splicing have a significant impact on genome stability.	12,643,937	A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.	[ "Signaling pathways that respond to DNA damage are essential for the maintenance of genome stability and are linked to many diseases, including cancer.", "Here, a genome-wide siRNA screen was employed to identify additional genes involved in genome stabilization by monitoring phosphorylation of the histone varian...	SUPPORT	[ 3 ]
456	Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.	30,507,607	An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells	[ "Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity.", "Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners is underexplored.", "Here, we use an improved affinity prot...	NEI	[]

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