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claim_id int64 0 1.41k	claim stringlengths 26 249	abstract_id int64 5.84k 196M	title stringlengths 7 264	abstract listlengths 3 25	verdict stringclasses 3 values	evidence listlengths 0 5
458	Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.	597,790	Deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice	[ "Although mast cell functions have classically been related to allergic responses, recent studies indicate that these cells contribute to other common diseases such as multiple sclerosis, rheumatoid arthritis, atherosclerosis, aortic aneurysm and cancer.", "This study presents evidence that mast cells also contri...	SUPPORT	[ 3 ]
461	Genetic deletion of JAM-A increases gut permeability.	40,096,222	Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.	[ "Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colitis.", "To investigate the contribution of adaptive immune compensation in response to increased intes...	SUPPORT	[ 0 ]
463	Genomic aberrations of metastases provide information for targeted therapy.	19,736,671	Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers	[ "Human tumors show a high level of genetic heterogeneity, but the processes that influence the timing and route of metastatic dissemination of the subclones are unknown.", "Here we have used whole-exome sequencing of 103 matched benign, malignant and metastatic skin tumors from genetically heterogeneous mice to d...	SUPPORT	[ 5 ]
466	Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.	22,544,171	Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome	[ "Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian cell nucleus.", "The HGPS mutation activates an aberrant cryptic splice site in LMNA pre-mRNA, leading t...	CONTRADICT	[ 0, 4, 5 ]
469	Glial calcium waves influence seizures.	1,410,197	An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold	[ "Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that arises at restricted brain sites and subsequently spreads to large portions of the brain.", "Despite intense experimental research in this field, the earlier cellular events that initiate and sustain a focal seizure are st...	SUPPORT	[ 6, 10 ]
470	Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.	12,685,434	Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma	[ "Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown.", "Epidermal growth factor receptor (EGFR) activation by amplification or mutation is one of the most frequent genetic lesions in a variety of human tumors.", "These ...	SUPPORT	[ 2 ]
472	Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.	7,185,591	Sir2-Independent Life Span Extension by Calorie Restriction in Yeast	[ "Calorie restriction slows aging and increases life span in many organisms.", "In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2.", "Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit ...	NEI	[]
472	Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.	26,330,861	Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.	[ "Calorie restriction extends life-span in a wide variety of organisms.", "Although it has been suggested that calorie restriction may work by reducing the levels of reactive oxygen species produced during respiration, the mechanism by which this regimen slows aging is uncertain.", "Here, we mimicked calorie res...	NEI	[]
472	Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.	4,414,481	Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration	[ "Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals.", "We established a model of CR in budding yeast Saccharomyces cerevisiae.", "In this system, lifespan can be extended by limiting glucose or by reducing the activity of ...	NEI	[]
473	Glycan adaptation involves insertion-deletion events.	4,373,433	Broad neutralization coverage of HIV by multiple highly potent antibodies	[ "Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses.", "Here we probed the neutralizing antibody repertoires of four human immunodeficiency virus (HIV)-infected donors with remarkably broad and potent neutralizing re...	NEI	[]
474	Glycan adaptation is rarely observed in the B-cell repertoire.	4,373,433	Broad neutralization coverage of HIV by multiple highly potent antibodies	[ "Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses.", "Here we probed the neutralizing antibody repertoires of four human immunodeficiency virus (HIV)-infected donors with remarkably broad and potent neutralizing re...	NEI	[]
479	Gpr124 increases BBB breakdown in mouse models of ischemic stroke.	6,325,527	Gpr124 is essential for blood–brain barrier integrity in central nervous system disease	[ "Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined.", "The endothelial G-protein-coupled receptor (GPCR) Gpr124 has been reported to be required for normal forebrain...	CONTRADICT	[ 2 ]
480	Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.	6,325,527	Gpr124 is essential for blood–brain barrier integrity in central nervous system disease	[ "Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined.", "The endothelial G-protein-coupled receptor (GPCR) Gpr124 has been reported to be required for normal forebrain...	SUPPORT	[ 2 ]
481	Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain	14,706,752	Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor	[ "The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas.", "Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75(NTR) is required for p75(NTR)-mediated glioma i...	NEI	[]
482	Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.	10,991,183	The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins	[ "How individual cells respond to mechanical forces is of considerable interest to biologists as force affects many aspects of cell behaviour.", "The application of force on integrins triggers cytoskeletal rearrangements and growth of the associated adhesion complex, resulting in increased cellular stiffness, also...	SUPPORT	[ 3 ]
483	H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.	22,703,082	Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium	[ "Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer.", "Here we show that infection of gastric epithelial cells with 'cag' pathogenicity island (cagPAI)-positive H. pylori induced aberrant expression of activation-induced cytidine deaminase (AID), a member of the...	SUPPORT	[ 2, 3 ]
484	H4 G94P proteins induce chromatin assembly, which increases free histones.	14,637,235	Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis	[ "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops.", "Although chromosomal histones are stable, excess (non-chromatin bound) histon...	NEI	[]
485	H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.	14,637,235	Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis	[ "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops.", "Although chromosomal histones are stable, excess (non-chromatin bound) histon...	NEI	[]
486	H4 G94P proteins inhibit chromatin assembly, which decreases free histones.	14,637,235	Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis	[ "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops.", "Although chromosomal histones are stable, excess (non-chromatin bound) histon...	NEI	[]
487	H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.	14,637,235	Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis	[ "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops.", "Although chromosomal histones are stable, excess (non-chromatin bound) histon...	NEI	[]
488	HAND2 methylation is a key step in early endometrial carcinogenesis.	1,780,819	Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development	[ "BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics.", "Much of the risk for endometrial cancer development is influenced by the environment and lifestyle.", "Accumulating evidence suggests that the epigenome serves as the interface between the ...	SUPPORT	[ 4, 7, 9, 11 ]
489	HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.	6,625,693	Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex	[ "The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited by many physiological side effects.", "Here we report that inflammatory and neuropathic hypersensitivity can be suppressed by inhibiting the binding of collapsin response mediator protein 2 (CRMP-2) to CaV2.2 and thereby r...	NEI	[]
490	HNF4A mutations are associated with macrosomia in infancy.	56,893,404	Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene	[ "Background Macrosomia is associated with considerable neonatal and maternal morbidity.", "Factors that predict macrosomia are poorly understood.", "The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secr...	NEI	[]
492	HOXB4 facilitates HSC expansion when co-cultured with HSCs.	19,583,924	Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells	[ "Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of crucial questions of stem cell biology.", "Here we show, using microarray studies, that the HSC-supportive mouse fetal liver CD3+ cells specifically express the proteins angiopo...	NEI	[]
493	HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.	19,583,924	Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells	[ "Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of crucial questions of stem cell biology.", "Here we show, using microarray studies, that the HSC-supportive mouse fetal liver CD3+ cells specifically express the proteins angiopo...	NEI	[]
494	HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.	34,873,974	Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis	[ "OBJECTIVE To obtain summary estimates of the accuracy of a single baseline measurement of the Elecsys Troponin T high-sensitive assay (Roche Diagnostics) for the diagnosis of acute myocardial infarction in patients presenting to the emergency department. \n", "DESIGN Systematic review and meta-analysis of diag...	NEI	[]
495	Having a main partner improves HIV outcomes.	17,077,004	Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.	[ "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). \n", "DESIGN Prospective cohort study of adults with HIV (Swiss HIV cohort study). \n", "SETTING Seven outpatient clinics throughout Switz...	SUPPORT	[ 7, 9 ]
498	Having a main partner worsens HIV outcomes.	17,077,004	Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.	[ "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). \n", "DESIGN Prospective cohort study of adults with HIV (Swiss HIV cohort study). \n", "SETTING Seven outpatient clinics throughout Switz...	CONTRADICT	[ 7, 9 ]
499	HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).	26,064,662	Association of Sickle Cell Trait With Hemoglobin A1c in African Americans	[ "Importance Hemoglobin A1c (HbA1c) reflects past glucose concentrations, but this relationship may differ between those with sickle cell trait (SCT) and those without it.", "Objective To evaluate the association between SCT and HbA1c for given levels of fasting or 2-hour glucose levels among African Americans.", ...	CONTRADICT	[ 10, 11, 13, 14, 15 ]
500	Headaches are correlated with cognitive impairment.	17,930,286	Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study	[ "OBJECTIVE To evaluate the association of overall and specific headaches with volume of white matter hyperintensities, brain infarcts, and cognition. \n", "DESIGN Population based, cross sectional study. \n", "SETTING Epidemiology of Vascular Ageing study, Nantes, France. \n", "PARTICIPANTS 780 particip...	CONTRADICT	[ 12 ]
504	Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.	10,883,736	Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.	[ "CONTEXT The mechanisms that drive progression from fatty liver to steatohepatitis and cirrhosis are unknown.", "In animal models, obese mice with fatty livers are vulnerable to liver adenosine triphosphate (ATP) depletion and necrosis, suggesting that altered hepatic energy homeostasis may be involved. \n", ...	CONTRADICT	[ 11 ]
505	Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.	22,703,082	Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium	[ "Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer.", "Here we show that infection of gastric epithelial cells with 'cag' pathogenicity island (cagPAI)-positive H. pylori induced aberrant expression of activation-induced cytidine deaminase (AID), a member of the...	SUPPORT	[ 1, 3 ]
506	Helminths interfere with immune system control of coinfections by microbial pathogens 16.	7,433,668	Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway	[ "Tuberculosis and helminthic infections coexist in many parts of the world, yet the impact of helminth-elicited Th2 responses on the ability of the host to control Mycobacterium tuberculosis (Mtb) infection has not been fully explored.", "We show that mice infected with the intestinal helminth Nippostrongylus bra...	SUPPORT	[ 1, 2, 7 ]
509	Hematopoietic Stem Cell purification reaches purity rates above 90%.	13,980,338	Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations	[ "Heterogeneity within the self-renewal durability of adult hematopoietic stem cells (HSCs) challenges our understanding of the molecular framework underlying HSC function.", "Gene expression studies have been hampered by the presence of multiple HSC subtypes and contaminating non-HSCs in bulk HSC populations.", ...	NEI	[]
515	High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).	29,564,505	Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease.	[ "IMPORTANCE Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease (COPD) have profound and long-lasting adverse effects on patients. \n", "OBJECTIVE To test the hypothesis that elevated levels of inflammatory biomarkers in individuals with stable COPD are associated with an increased ri...	SUPPORT	[ 8, 13 ]
523	Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.	14,803,797	Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis	[ "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).", "We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat...	CONTRADICT	[ 1, 5 ]
524	Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.	14,803,797	Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis	[ "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).", "We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat...	SUPPORT	[ 1, 5 ]
526	Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.	3,863,543	Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.	[ "Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and relevance to human disease remain poorly defined.", "Here, we show that perturbation of mesenchymal cells in a mouse model of the pre-leukemic disorder Shwachman-...	NEI	[]
529	Human embryonic stem cells give rise to cell types from all three embryonic germ layers.	10,546,779	Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.	[ "Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition.", "In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst.", "The SCNT-hES-1 cells displayed typical ES cell ...	SUPPORT	[ 2 ]
529	Human embryonic stem cells give rise to cell types from all three embryonic germ layers.	25,413,327	Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.	[ "Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture.", "Here we describe the clonal derivation of two human ES cell lines, H9.1 and H9.2.", "At the time of the clonal derivation of the...	SUPPORT	[ 0, 5 ]
529	Human embryonic stem cells give rise to cell types from all three embryonic germ layers.	36,651,210	Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst.	[ "Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers.", "These cells have, therefore, potential for in vitro differentiation studies, gene function, and so on.", ...	SUPPORT	[ 0 ]
530	Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.	10,546,779	Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.	[ "Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition.", "In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst.", "The SCNT-hES-1 cells displayed typical ES cell ...	CONTRADICT	[ 2 ]
530	Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.	25,413,327	Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.	[ "Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture.", "Here we describe the clonal derivation of two human ES cell lines, H9.1 and H9.2.", "At the time of the clonal derivation of the...	CONTRADICT	[ 0, 5 ]
530	Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.	36,651,210	Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst.	[ "Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers.", "These cells have, therefore, potential for in vitro differentiation studies, gene function, and so on.", ...	CONTRADICT	[ 0 ]
530	Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.	87,610,599	Characterization and culture of human embryonic stem cells	[ "Objective To explore the in vitro maintenance and characterization of human embryonic stem cells(hESCs).Methods hESCs were cultured on feeder layer with ES culture medium,which consists of 20% Knockout Serum Replacement,Knockout DMEM and 10 ng/mL bFGF.Undifferentiated status of hESCs was identified by cell morphol...	NEI	[]
531	Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.	10,546,779	Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.	[ "Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition.", "In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst.", "The SCNT-hES-1 cells displayed typical ES cell ...	SUPPORT	[ 2 ]
531	Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.	25,413,327	Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.	[ "Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture.", "Here we describe the clonal derivation of two human ES cell lines, H9.1 and H9.2.", "At the time of the clonal derivation of the...	SUPPORT	[ 0 ]
531	Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.	36,651,210	Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst.	[ "Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers.", "These cells have, therefore, potential for in vitro differentiation studies, gene function, and so on.", ...	SUPPORT	[ 0 ]
537	Hypocretin neurones suppress panicprone state in rats.	16,056,514	A KEY ROLE FOR OREXIN IN PANIC ANXIETY	[ "Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks.", "In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic...	CONTRADICT	[ 4 ]
541	Hypothalamic glutamate neurotransmission is unrelated to energy balance.	45,154,987	Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.	[ "The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis.", "However, the neurotransmitter(s) that mediate MC4R function remain largely unknown; as a result, little is known about the second-order neurons of the MC4R neural pathway.", "Single-minded 1 (Sim1)-expressing brain...	CONTRADICT	[ 7, 8 ]
541	Hypothalamic glutamate neurotransmission is unrelated to energy balance.	11,886,686	Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.	[ "The importance of neuropeptides in the hypothalamus has been experimentally established.", "Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown.", "Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are r...	CONTRADICT	[ 5 ]
541	Hypothalamic glutamate neurotransmission is unrelated to energy balance.	25,007,443	Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting	[ "In the hypothalamic arcuate nucleus (ARC), pro-opiomelanocortin (POMC) neurons inhibit feeding and neuropeptide-Y (NPY) neurons stimulate feeding.", "We tested whether neurons in the ventromedial hypothalamic nucleus (VMH), a known satiety center, activate anorexigenic neuronal pathways in the ARC by projecting ...	NEI	[]
542	IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.	19,688,024	IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes	[ "Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).", "Other putative DNA receptors have been described, but whether their functions are redundant, tissue-specific o...	CONTRADICT	[ 3 ]
545	IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.	24,221,369	A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.	[ "The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA).", "Although endogenous mRNA is also 5'-triphosphorylated, backbone modifications and the 5'-ppp-linked methylguanosine ((m7)G) cap prevent immunorecog...	NEI	[]
547	IL-10 production by monocytes inhibits CD4 + T cell response.	10,648,422	Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection	[ "Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection.", "Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection.", "Blocki...	SUPPORT	[ 4, 5 ]
548	IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.	18,199,839	Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies	[ "BACKGROUND Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease.", "Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades.", "To assess whether this pathway is causally relevant to coronary heart disease, we studi...	SUPPORT	[ 8, 9, 11 ]
550	ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).	33,499,189	Full activation of the T cell receptor requires both clustering and conformational changes at CD3.	[ "T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits.", "The mechanism by which TCRalphabeta ligand binding confers conformational changes to CD3 is unknown.", "By using well-defined ligands, we showed that induction of t...	NEI	[]
553	IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.	1,471,041	High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions	[ "Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or HLA-DQ8 (ref.", "3).", "We assessed in a comprehensive and nonbiased manne...	CONTRADICT	[ 3 ]
555	Immune complex triggered cell death leads to extracellular release of nuclear DNA.	1,049,501	Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease	[ "Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear.", "Ribonucleoprotein immune complexes (RNP ICs), inducers of NETosis, require mitochondrial reactive oxygen species (ROS) for maximal NET stimulation.", "Afte...	NEI	[]
557	Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.	1,049,501	Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease	[ "Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear.", "Ribonucleoprotein immune complexes (RNP ICs), inducers of NETosis, require mitochondrial reactive oxygen species (ROS) for maximal NET stimulation.", "Afte...	NEI	[]
559	Immune responses in immune cells are geographically segregated.	3,475,317	Inflammatory signaling in human Tuberculosis granulomas is spatially organized	[ "Granulomas are the pathological hallmark of tuberculosis (TB).", "However, their function and mechanisms of formation remain poorly understood.", "To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiased manner.", "Using laser-capture ...	SUPPORT	[ 7 ]
562	Improvements in OER catalysts show stable activity over several hundred hours.	20,101,846	Homogeneously dispersed multimetal oxygen-evolving catalysts	[ "Earth-abundant first-row (3d) transition metal–based catalysts have been developed for the oxygen-evolution reaction (OER); however, they operate at overpotentials substantially above thermodynamic requirements.", "Density functional theory suggested that non-3d high-valency metals such as tungsten can modulate ...	SUPPORT	[ 4 ]
563	In British Men, haplogroup I decreases risk of cardiovascular disease.	2,867,345	Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome	[ "BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women.", "We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity. \n", "METHODS We genotyped 11 markers of ...	CONTRADICT	[ 7 ]
564	In British Men, haplogroup I increases risk of cardiovascular disease by 50%.	2,867,345	Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome	[ "BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women.", "We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity. \n", "METHODS We genotyped 11 markers of ...	SUPPORT	[ 7 ]
565	In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.	16,120,395	Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.	[ "Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity.", "We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed in iron-replete conditions in the absence of the S. cerevisiae RNas...	SUPPORT	[ 1, 2, 3, 4 ]
566	In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.	16,120,395	Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.	[ "Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity.", "We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed in iron-replete conditions in the absence of the S. cerevisiae RNas...	CONTRADICT	[ 1, 2, 3, 4 ]
568	In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.	23,418,635	Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells	[ "Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiSCs; ref. ).", "In the naive state of ESCs, the genome has an unusual open conformation and possesses a minimum of repressive epigenetic marks.", ...	SUPPORT	[ 5, 6, 7 ]
570	In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.	20,333,864	Regulation of in situ to invasive breast carcinoma transition.	[ "The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression.", "Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors.", "Progressi...	SUPPORT	[ 2, 3 ]
571	In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.	20,333,864	Regulation of in situ to invasive breast carcinoma transition.	[ "The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression.", "Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors.", "Progressi...	CONTRADICT	[ 2, 3 ]
572	In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.	4,447,055	Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury	[ "Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal regeneration and functional plasticity.", "It is well established that an upregulation of glial-derived chondroitin sulphate proteoglycans (CSPGs) within the glial scar and perineuronal net creates a barrier to axonal regro...	NEI	[]
573	In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.	10,300,888	Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts	[ "Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection and where the plethora of industrial strains originates from.", "Here, we present the genomes and phenomes of 157 industri...	NEI	[]
574	In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.	10,300,888	Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts	[ "Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection and where the plethora of industrial strains originates from.", "Here, we present the genomes and phenomes of 157 industri...	NEI	[]
576	In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.	4,468,861	Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer	[ "Immune checkpoint inhibitors result in impressive clinical responses, but optimal results will require combination with each other and other therapies.", "This raises fundamental questions about mechanisms of non-redundancy and resistance.", "Here we report major tumour regressions in a subset of patients with...	SUPPORT	[ 4 ]
579	In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.	34,139,429	Carvedilol for children and adolescents with heart failure: a randomized controlled trial.	[ "CONTEXT Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents. \n", "OBJECTIVE To prospectively evaluate the effects of carvedilol in children and adolescents with symptomatic systemic ventricular systolic dysfunct...	CONTRADICT	[ 13 ]
580	In pediatric tissue, most T cells are naive T cell emigrants from the thymus.	23,460,562	Early life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues	[ "It is unclear how the immune response in early life becomes appropriately stimulated to provide protection while also avoiding excessive activation as a result of diverse new antigens.", "T cells are integral to adaptive immunity; mouse studies indicate that tissue localization of T cell subsets is important for...	SUPPORT	[ 4 ]
582	In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.	14,260,013	Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir	[ "BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission.", "Pre-exposure prophylaxis (PrEP) with antiretroviral drugs could prove to be an effective intervention strategy if highly efficacious and cost-effective PrEP...	NEI	[]
584	In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.	14,260,013	Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir	[ "BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission.", "Pre-exposure prophylaxis (PrEP) with antiretroviral drugs could prove to be an effective intervention strategy if highly efficacious and cost-effective PrEP...	SUPPORT	[ 9 ]
585	In the UK, drowning affects boys and girls equally.	42,291,761	Preventing deaths by drowning in children in the United Kingdom: have we made progress in 10 years? Population based incidence study.	[ "Detailed information on drowning in children is not routinely collected by offices of national statistics.", "Few studies have been carried out in the United Kingdom, and none has been done on British children abroad. ", "In 1988-9, two of the authors (AMK and JRS) combined information from national statistic...	NEI	[]
588	In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.	16,999,023	Cell Stem Cell Article In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2 + Neural Stem Cells in the Adult Hippocampus	[ "To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgenic mice.", "Sox2-GFP cells in the subgranular zone (SGZ) express markers specific for progenitors, but they represent two morphologically distinct populations that differ in proliferation levels.", "Len...	NEI	[]
590	In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.	10,984,005	ADHD medications and risk of serious cardiovascular events in young and middle-aged adults.	[ "CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD).", "These agents can increase heart rate and blood pressure, raising concerns about their cardiovascular safety. \n", "OBJECTIVE To examine whether current use...	CONTRADICT	[ 9, 10, 12 ]
591	Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.	14,682,243	Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study	[ "BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia than in high-income countries.", "We assessed incidence of dementia according to criteria from the 10/66 Dementia Research Group and Diagnostic and Statistical Manual of Mental Dis...	SUPPORT	[ 8 ]
592	Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.	14,682,243	Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study	[ "BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia than in high-income countries.", "We assessed incidence of dementia according to criteria from the 10/66 Dementia Research Group and Diagnostic and Statistical Manual of Mental Dis...	CONTRADICT	[ 8 ]
594	Incidence of heart failure increased by 10% in women since 1979.	19,675,911	Trends in heart failure incidence and survival in a community-based population.	[ "CONTEXT The epidemic of heart failure has yet to be fully investigated, and data on incidence, survival, and sex-specific temporal trends in community-based populations are limited. \n", "OBJECTIVE To test the hypothesis that the incidence of heart failure has declined and survival after heart failure diagnosi...	CONTRADICT	[ 5 ]
595	Incidence of sepsis has fallen substantially from 2009 to 2014.	4,824,840	Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014	[ "Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing.", "However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time.", "Objective To estimate...	CONTRADICT	[ 9, 13 ]
600	Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).	12,258,338	Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.	[ "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs.", "However, whether pharmacist participation in the ICU at the time of drug prescribing reduces adverse events has not been studied. \n", "OBJE...	CONTRADICT	[ 11, 14 ]
601	Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).	12,258,338	Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.	[ "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs.", "However, whether pharmacist participation in the ICU at the time of drug prescribing reduces adverse events has not been studied. \n", "OBJE...	SUPPORT	[ 11, 14 ]
602	Increase of p62 in prostate tumor stroma results in defective autophagy.	3,701,541	p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.	[ "Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC).", "Vitamin D receptor (VDR) activation in HSCs inhibits liver inflammation and fibrosis.", "We found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC-associated HSCs...	NEI	[]
603	Increased LDL receptors plays a role in the reduction of plasma Lp(a).	6,540,064	Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans	[ "BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB).", "Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCS...	SUPPORT	[ 9, 10, 11, 16 ]
606	Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.	712,078	Pharmacological correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice	[ "Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical chloride channel that supports bicarbonate transport.", "Individuals with cystic fibrosis show retained, thickened mucus that plugs airways and obstructs luminal o...	NEI	[]
607	Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.	4,506,414	Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people	[ "BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been compared.", "In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease. \n", "MET...	SUPPORT	[ 9 ]
609	Increased flux of microbial products provokes immune responses.	40,096,222	Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.	[ "Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colitis.", "To investigate the contribution of adaptive immune compensation in response to increased intes...	NEI	[]
610	Increased flux of microbial products suppresses immune responses.	40,096,222	Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.	[ "Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colitis.", "To investigate the contribution of adaptive immune compensation in response to increased intes...	NEI	[]
611	Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.	32,408,470	Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo	[ "Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia.", "However, the mechanisms behind these effects are unclear.", "Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated pro...	NEI	[]
612	Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.	9,638,032	Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations	[ "Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease.", "LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules.", "Defective microtubule-based axonal transport is hypothesized to contribute to Parkinso...	CONTRADICT	[ 4 ]
614	Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.	9,638,032	Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations	[ "Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease.", "LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules.", "Defective microtubule-based axonal transport is hypothesized to contribute to Parkinso...	SUPPORT	[ 4, 5 ]
615	Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.	9,638,032	Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations	[ "Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease.", "LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules.", "Defective microtubule-based axonal transport is hypothesized to contribute to Parkinso...	CONTRADICT	[ 4, 5 ]
616	Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.	18,670	The DNA Methylome of Human Peripheral Blood Mononuclear Cells	[ "DNA methylation plays an important role in biological processes in human health and disease.", "Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells.", "Using whole-genome bisulfite sequencing at 24.7-fold coverage (12.3-fold per strand...	NEI	[]
617	Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.	18,670	The DNA Methylome of Human Peripheral Blood Mononuclear Cells	[ "DNA methylation plays an important role in biological processes in human health and disease.", "Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells.", "Using whole-genome bisulfite sequencing at 24.7-fold coverage (12.3-fold per strand...	NEI	[]
618	Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.	6,836,086	Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli	[ "Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents.", "The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins.", "Assembly of this essential organelle occurs outside the c...	NEI	[]
620	Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.	2,565,138	Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer	[ "OBJECTIVE Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery.", "This study examines the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan (HA), as a novel therapeutic target ...	NEI	[]

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