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claim_id int64 0 1.41k	claim stringlengths 26 249	abstract_id int64 5.84k 196M	title stringlengths 7 264	abstract listlengths 3 25	verdict stringclasses 3 values	evidence listlengths 0 5
1,228	The mean suicide rate in women is lower after miscarriage than live birth.	25,641,414	Suicides after pregnancy in Finland, 1987-94: register linkage study.	[ "OBJECTIVE To determine rates of suicide associated with pregnancy by the type of pregnancy. \n", "DESIGN Register linkage study.", "Information on suicides in women of reproductive age was linked with the Finnish birth, abortion, and hospital discharge registers to find out how many women who committed suici...	CONTRADICT	[ 7 ]
1,229	The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.	1,676,568	CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover	[ "Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement.", "In collectively migrating human keratinocytes, FAs assemble near the leading edge, grow and mature as a result of contractile forces and disassemble underneath the advancing cell bo...	SUPPORT	[ 4 ]
1,230	The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.	13,905,670	Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway	[ "The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals.", "This variability critically determines the impact a disease has on a patient's life but is very poorly understood.", "Here, we exploit existing genome-wide association study data to ga...	SUPPORT	[ 4 ]
1,231	The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.	13,905,670	Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway	[ "The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals.", "This variability critically determines the impact a disease has on a patient's life but is very poorly understood.", "Here, we exploit existing genome-wide association study data to ga...	SUPPORT	[ 3 ]
1,234	The minor G allele of FOXO3 up-regulates IL-10.	13,905,670	Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway	[ "The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals.", "This variability critically determines the impact a disease has on a patient's life but is very poorly understood.", "Here, we exploit existing genome-wide association study data to ga...	SUPPORT	[ 4 ]
1,235	The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.	17,973,161	Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice	[ "Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production.", "UCP1 is also found outside classical brown adipose tissue depots, in adipocytes that are termed 'brite' (brown-in-white) or 'beige'.", "In humans, the presen...	NEI	[]
1,236	The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.	17,973,161	Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice	[ "Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production.", "UCP1 is also found outside classical brown adipose tissue depots, in adipocytes that are termed 'brite' (brown-in-white) or 'beige'.", "In humans, the presen...	NEI	[]
1,237	The most prevalent adverse events to Semaglutide are cardiovascular.	3,654,468	Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial	[ "Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an injection.", "Objectives To compare the effects of oral semaglutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemi...	CONTRADICT	[ 12 ]
1,238	The most prevalent adverse events to Semaglutide are gastrointestinal.	3,654,468	Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial	[ "Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an injection.", "Objectives To compare the effects of oral semaglutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemi...	SUPPORT	[ 12 ]
1,239	The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.	21,387,297	Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.	[ "Cardiovascular disease is a leading cause of death worldwide.", "The limited capability of heart tissue to regenerate has prompted methodological developments for creating de novo cardiomyocytes, both in vitro and in vivo.", "Beyond uses in cell replacement therapy, patient-specific cardiomyocytes may find app...	NEI	[]
1,239	The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.	4,427,392	Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population	[ "The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells.", "Studies in the mouse embryo and the mouse embryonic stem cell differentiation model have provided evidence indicating that these three lineages develop from a c...	CONTRADICT	[ 1 ]
1,244	The number of unfertilized oocytes in mated hermaphrodites increases with age.	18,949,516	TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance	[ "Reproductive cessation is perhaps the earliest aging phenotype that humans experience.", "Similarly, reproduction of Caenorhabditis elegans ceases in mid-adulthood.", "Although somatic aging has been studied in both worms and humans, mechanisms regulating reproductive aging are not yet understood.", "Here, w...	NEI	[]
1,246	The one-child policy has created a hospitable environment for female infants.	7,662,395	Perinatal mortality in rural China: retrospective cohort study.	[ "OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999-2000. \n", "DESIGN Retrospective cohort study.", "Pregnancies in a cohort of women followed from registration of pregnancy to outcome of infan...	CONTRADICT	[ 10 ]
1,247	The origin of the CRF01_1b2k protein occurred between 1923 and 1956.	5,114,282	The Global Spread of Hepatitis C Virus 1a and 1b: A Phylodynamic and Phylogeographic Analysis	[ "BACKGROUND Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide.", "Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa.", "Previous attempts to estimate the spatiotemporal parameters of the virus, both globally...	NEI	[]
1,248	The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.	7,209,559	Incidence of childhood distal forearm fractures over 30 years: a population-based study.	[ "CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time of a transient deficit in cortical bone mass due to the increased calcium demand during maximal skeletal growth.", "Changes in physical activi...	SUPPORT	[ 0 ]
1,249	The peak incidence of fractures occurs in toddlers.	7,209,559	Incidence of childhood distal forearm fractures over 30 years: a population-based study.	[ "CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time of a transient deficit in cortical bone mass due to the increased calcium demand during maximal skeletal growth.", "Changes in physical activi...	CONTRADICT	[ 0 ]
1,253	The predominant localization of Linc00173 is in mononuclear macrophage nuclei.	3,321,943	The non-coding RNA landscape of human hematopoiesis and leukemia	[ "Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions.", "However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood.", "Here we present a comprehensive resource defining the non-coding RNA land...	NEI	[]
1,254	The proliferative capacity of neural progenitors differs across species.	16,939,583	2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.	[ "Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals.", "Here we compare cortical progenitor cell output in humans and three nonhuman primates using directed differentiation of pluripotent stem cells (PSCs) in adherent two-...	SUPPORT	[ 2, 3 ]
1,255	The proliferative capacity of progenitors is regulated cell-autonomously.	16,939,583	2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.	[ "Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals.", "Here we compare cortical progenitor cell output in humans and three nonhuman primates using directed differentiation of pluripotent stem cells (PSCs) in adherent two-...	SUPPORT	[ 4 ]
1,257	The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.	581,832	Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015	[ "BACKGROUND Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress...	NEI	[]
1,258	The recruitment of Wdr5 to its target loci depends on Kat8.	12,040,627	The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network.	[ "Pluripotent embryonic stem cells (ESCs) maintain self-renewal and the potential for rapid response to differentiation cues.", "Both ESC features are subject to epigenetic regulation.", "Here we show that the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and plurip...	SUPPORT	[ 7 ]
1,260	The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.	24,341,590	Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.	[ "CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen.", "The formation of active metabolites is catalyzed by the polymorphic cytochrome P450 2D6 (CYP2D6) enzyme. \n", "OB...	CONTRADICT	[ 11, 12, 13 ]
1,261	The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.	13,023,410	BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.	[ "The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells.", "We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases.", "These l...	CONTRADICT	[ 0, 1, 5 ]
1,263	The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.	3,981,729	Structural basis for sequence-specific recognition of DNA by TAL effectors.	[ "TAL (transcription activator-like) effectors, secreted by phytopathogenic bacteria, recognize host DNA sequences through a central domain of tandem repeats.", "Each repeat comprises 33 to 35 conserved amino acids and targets a specific base pair by using two hypervariable residues [known as repeat variable dires...	SUPPORT	[ 0, 1 ]
1,265	The risk of breast cancer among parous women decreases with placental weight of pregnancies.	37,480,103	Pregnancy characteristics and maternal risk of breast cancer.	[ "CONTEXT During pregnancy, serum levels of estrogen, progesterone, and other hormones are markedly higher than during other periods of life.", "Pregnancy hormones primarily are produced in the placenta, and signs of placental impairment may serve as indirect markers of hormone exposures during pregnancy.", "Dur...	CONTRADICT	[ 10, 12 ]
1,268	The risk of cancer rises with level of alcohol consumption.	52,072,815	Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016	[ "Summary Background Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions.", "With our comprehensive approach to health accounting within the Global Burden of D...	SUPPORT	[ 8, 11 ]
1,269	The risk of female prisoners harming themselves is ten times that of male prisoners.	13,900,610	Self-harm in prisons in England and Wales: an epidemiological study of prevalence, risk factors, clustering, and subsequent suicide	[ "BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant.", "Furthermore, understanding how frequently self-harm is followed by suicide, and in which prisoners this progression is most likely to happen, is impo...	SUPPORT	[ 7, 8 ]
1,275	The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.	27,731,651	A view to a kill: the bacterial type VI secretion system.	[ "The bacterial type VI secretion system (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail.", "Recent studies determined that a rapid conformational change in the structure of a sheath protein complex propels T6SS spike and tube c...	NEI	[]
1,276	The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.	3,475,317	Inflammatory signaling in human Tuberculosis granulomas is spatially organized	[ "Granulomas are the pathological hallmark of tuberculosis (TB).", "However, their function and mechanisms of formation remain poorly understood.", "To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiased manner.", "Using laser-capture ...	SUPPORT	[ 5 ]
1,284	Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events	3,578,380	Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010	[ "Importance Postmarket safety events of novel pharmaceuticals and biologics occur when new safety risks are identified after initial regulatory approval of these therapeutics.", "These safety events can change how novel therapeutics are used in clinical practice and inform patient and clinician decision making.",...	CONTRADICT	[ 9 ]
1,288	There is a positive correlation between hip fractures and statin use.	4,687,948	HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients.	[ "CONTEXT Recent animal studies have found that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lipid-lowering drugs (statins) substantially increase bone formation, but whether statin use in humans results in clinically meaningful bone formation or a reduction in the risk of osteoporotic fractures is not known. \...	CONTRADICT	[ 7, 9, 10, 13 ]
1,289	There is a relation between Erythromycin use and hypertrophic pyloric stenosis.	21,239,672	Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study	[ "OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth and infantile hypertrophic pyloric stenosis (IHPS). \n", "DESIGN Nationwide register based cohort study. \n", "SETTING Denmark, 1996-2011. \n", "PARTICIPANTS 9...	SUPPORT	[ 9, 10 ]
1,291	There is no association between HNF4A mutations and diabetes risks.	56,893,404	Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene	[ "Background Macrosomia is associated with considerable neonatal and maternal morbidity.", "Factors that predict macrosomia are poorly understood.", "The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secr...	NEI	[]
1,293	There is no increased risk of hypospadias with clomiphene.	43,329,366	Use of clomifene during early pregnancy and risk of hypospadias: population based case-control study.	[ "Clomifene is widely used for inducing ovulation.1 It is structurally related to diethylstilbestrol, which has been linked to vaginal and cervical clear cell adenocarcinoma in women exposed in utero.", "The adverse effect is less severe in sons, although links to testicular cancer and urogenital anomalies, such a...	CONTRADICT	[ 1 ]
1,294	There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.	2,078,658	Oct4 links multiple epigenetic pathways to the pluripotency network	[ "Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming.", "However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-protein interactions that dictate Oct4's critical regulator...	CONTRADICT	[ 3 ]
1,294	There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.	30,507,607	An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells	[ "Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity.", "Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners is underexplored.", "Here, we use an improved affinity prot...	CONTRADICT	[ 3 ]
1,295	There is no relation between Erythromycin use and hypertrophic pyloric stenosis.	21,239,672	Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study	[ "OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth and infantile hypertrophic pyloric stenosis (IHPS). \n", "DESIGN Nationwide register based cohort study. \n", "SETTING Denmark, 1996-2011. \n", "PARTICIPANTS 9...	CONTRADICT	[ 9, 10 ]
1,297	There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.	9,167,230	Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis	[ "BACKGROUND The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown.", "We aimed to estimate the incidence of admissions and deaths for such infections in children younger than 5 years in 2010. \n", "METHODS...	SUPPORT	[ 5 ]
1,300	Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.	6,421,792	Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL	[ "Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors.", "Despite intensive chemotherapy, 20% of pediatric patients and over 50% of adult patients with ALL do not achieve a complete remission or relapse after intensified chemot...	NEI	[]
1,302	Tirasemtiv has no effect on cardiac muscle.	12,631,697	Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases	[ "Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission.", "We developed a small-molecule fast-skeletal-troponin activator, CK-2017357, as a means...	NEI	[]
1,304	Tirasemtiv targets cardiac muscle.	12,631,697	Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases	[ "Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission.", "We developed a small-molecule fast-skeletal-troponin activator, CK-2017357, as a means...	NEI	[]
1,305	Tirasemtiv targets fast-twitch muscle.	12,631,697	Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases	[ "Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission.", "We developed a small-molecule fast-skeletal-troponin activator, CK-2017357, as a means...	SUPPORT	[ 1, 2 ]
1,306	Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.	6,000,423	The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.	[ "Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis.", "We report that a hallmark of MDSs is activation of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death.", "Independent of genotype, MDS hematopoi...	NEI	[]
1,306	Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.	5,836	Induction of myelodysplasia by myeloid-derived suppressor cells.	[ "Myelodysplastic syndromes (MDS) are age-dependent stem cell malignancies that share biological features of activated adaptive immune response and ineffective hematopoiesis.", "Here we report that myeloid-derived suppressor cells (MDSC), which are classically linked to immunosuppression, inflammation, and cancer,...	NEI	[]
1,307	Tonic signaling from the scFv induces constitutive stimulation.	18,231,807	4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors	[ "Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens.", "It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of hematologic ...	NEI	[]
1,308	Tonic signaling from the scFv is amplified by MyD88/CD40.	18,231,807	4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors	[ "Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens.", "It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of hematologic ...	NEI	[]
1,309	Tonic signaling from the scFv prevents constitutive stimulation.	18,231,807	4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors	[ "Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens.", "It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of hematologic ...	NEI	[]
1,310	Traditional reviews are biased in their interpretations.	8,042,158	Systematic reviews from astronomy to zoology: myths and misconceptions.	[ "Systematic literature reviews are widely used as an aid to evidence based decision making.", "For example, reviews of randomised controlled trials are regularly used to answer questions about the effectiveness of healthcare interventions.", "The high profile of systematic reviews as a cornerstone of evidence b...	NEI	[]
1,311	Trans-acting factors, such as lncRNAs, influence mRNA translation.	13,763,195	LincRNA-p21 suppresses target mRNA translation.	[ "Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription.", "Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation.", "Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, l...	SUPPORT	[ 1, 3, 4, 5, 6 ]
1,312	Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.	24,177,706	Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.	[ "Animal host defense against infection requires the expression of defense genes at the right place and the right time.", "Understanding such tight control of host defense requires the elucidation of the transcription factors involved.", "By using an unbiased approach in the model Caenorhabditis elegans, we disc...	SUPPORT	[ 4 ]
1,314	Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.	13,072,112	Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.	[ "A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate (nucleotide additions per min) and processivity (nucleotide additions per initiation event) in vivo are poorly understood.", "Here, we show ...	NEI	[]
1,314	Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.	16,237,005	Single-RNA counting reveals alternative modes of gene expression in yeast	[ "Proper execution of transcriptional programs is a key requirement of gene expression regulation, demanding accurate control of timing and amplitude.", "How precisely the transcription machinery fulfills this task is not known.", "Using an in situ hybridization approach that detects single mRNA molecules, we me...	NEI	[]
1,315	Transcription rates in S. cerevisiae range between 7 and 12 kb/min.	13,072,112	Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.	[ "A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate (nucleotide additions per min) and processivity (nucleotide additions per initiation event) in vivo are poorly understood.", "Here, we show ...	NEI	[]
1,315	Transcription rates in S. cerevisiae range between 7 and 12 kb/min.	16,237,005	Single-RNA counting reveals alternative modes of gene expression in yeast	[ "Proper execution of transcriptional programs is a key requirement of gene expression regulation, demanding accurate control of timing and amplitude.", "How precisely the transcription machinery fulfills this task is not known.", "Using an in situ hybridization approach that detects single mRNA molecules, we me...	NEI	[]
1,322	Transplanted human glial progenitor cells can mature in their host animal.	16,284,655	Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.	[ "Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution.", "To assess the cell-autonomous and species-selective properties of human glia, we engrafted human glial progenitor cells (GPCs) into neonatal immunodefic...	SUPPORT	[ 2 ]
1,323	Treatment with a protein named FN impairs regenerative abilities of aged muscles.	19,912,367	Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice	[ "Age-related changes in the niche have long been postulated to impair the function of somatic stem cells.", "Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN), leading to detrimental consequences for the function and maintenance of muscl...	CONTRADICT	[ 2, 4 ]
1,324	Treatment with a protein named FN restores regenerative abilities of aged muscles.	19,912,367	Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice	[ "Age-related changes in the niche have long been postulated to impair the function of somatic stem cells.", "Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN), leading to detrimental consequences for the function and maintenance of muscl...	SUPPORT	[ 2, 4 ]
1,325	Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.	40,476,126	Functional role of high-affinity anandamide transport, as revealed by selective inhibition.	[ "Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated.", "Anandamide inactivation is not completely understood, but it may occur by transport into cells or by enzymatic hydrolysis.", "The compound N-(4-hydroxyphenyl)arachidonylami...	NEI	[]
1,327	Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.	24,241,932	Ecological analysis of ethnic differences in relation between tuberculosis and poverty.	[ "OBJECTIVE To examine the effect of ethnicity on the relation between tuberculosis and deprivation. \n", "DESIGN Retrospective ecological study comparing incidence of tuberculosis in white and south Asian residents of the 39 electoral wards in Birmingham with ethnic specific indices of deprivation. \n", "SE...	CONTRADICT	[ 6, 7 ]
1,327	Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.	22,194,407	Tuberculosis mortality in England and Wales during 1982-1992: its association with poverty, ethnicity and AIDS.	[ "This paper seeks to establish the strength of association between contemporary tuberculosis (TB) in England and Wales and several potential aetiological factors.", "It presents an ecological analysis of standardised annual TB mortality rates for the 403 local authority districts between 1982 and 1992, disaggrega...	CONTRADICT	[ 3, 9 ]
1,328	Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.	3,475,317	Inflammatory signaling in human Tuberculosis granulomas is spatially organized	[ "Granulomas are the pathological hallmark of tuberculosis (TB).", "However, their function and mechanisms of formation remain poorly understood.", "To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiased manner.", "Using laser-capture ...	SUPPORT	[ 4, 5, 7 ]
1,330	Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.	14,075,252	Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.	[ "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival.", "Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet ac...	NEI	[]
1,331	Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.	14,075,252	Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.	[ "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival.", "Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet ac...	NEI	[]
1,333	Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.	1,649,738	Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma	[ "Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs).", "We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults.", "The variants comprise ...	SUPPORT	[ 1 ]
1,334	Type 1 Diabetes is associated with subtle perturbations in T reg development.	13,923,140	Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity	[ "Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation.", "Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory cytokine interleukin-2 (IL-2).", "...	NEI	[]
1,334	Type 1 Diabetes is associated with subtle perturbations in T reg development.	13,940,200	Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes	[ "Genome-wide association studies are now identifying disease-associated chromosome regions.", "However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequencing, extensive genotyping and statistical analyses in large sample sets leading to targeted functiona...	SUPPORT	[ 2, 3 ]
1,334	Type 1 Diabetes is associated with subtle perturbations in T reg development.	11,899,391	Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.	[ "Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared with nondiseased, control individuals.", "Treg dysfu...	SUPPORT	[ 0 ]
1,340	Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.	15,482,274	Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.	[ "OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging can reduce traumatic procedures, insertion attempts, and needle redirections. \n", "DESIGN Systematic revi...	SUPPORT	[ 9, 10 ]
1,341	Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.	15,482,274	Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.	[ "OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging can reduce traumatic procedures, insertion attempts, and needle redirections. \n", "DESIGN Systematic revi...	SUPPORT	[ 7, 8, 9, 10 ]
1,342	Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.	8,148,122	Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation	[ "DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase.", "Cytogenetic studies show that these \"replicon clusters\" coalesce as subchromosomal units that persist through multiple cell generatio...	NEI	[]
1,345	Up-regulation of the p53 pathway and related molecular events speeds cancer progression.	9,559,146	Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors	[ "Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin.", "This response, termed cellular senescence, is controlled by the p53 and RB tumor suppressor ...	NEI	[]
1,346	Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.	9,505,402	Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M	[ "Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) AZD9291.", "We first performed next-generation sequencing of cfDNA from seven subjects and detected a...	SUPPORT	[ 1, 3 ]
1,347	Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.	19,005,293	Memory CD4+ T cells induce innate responses independently of pathogen	[ "Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses.", "We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses.", "We found that the response of memory, but not naive, CD4+...	CONTRADICT	[ 2 ]
1,348	Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.	19,005,293	Memory CD4+ T cells induce innate responses independently of pathogen	[ "Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses.", "We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses.", "We found that the response of memory, but not naive, CD4+...	SUPPORT	[ 2 ]
1,349	Upregulation of PD1 causes the downmodulation of Satb1.	5,377,642	SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells	[ "&NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined.", "We found that the chromatin organizer special AT‐rich sequence‐binding protein‐1 (Satb1) restrains PD‐1 expression induced upon T cell activatio...	NEI	[]
1,350	Upregulation of PD1 causes the upregulation of Satb1.	5,377,642	SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells	[ "&NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined.", "We found that the chromatin organizer special AT‐rich sequence‐binding protein‐1 (Satb1) restrains PD‐1 expression induced upon T cell activatio...	NEI	[]
1,351	Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.	28,369,117	Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons	[ "Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain.", "Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da)...	CONTRADICT	[ 4 ]
1,353	Urbanization is an important risk factor related to the transmission of dengue fever.	18,816,720	Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages	[ "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and environment.", "An improved understanding of variation in transmission patte...	NEI	[]
1,355	V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.	5,256,564	Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models	[ "The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine.", "However, therapeutic targeting of cancer metabolism has led to surprisingly few new drugs to date.", "The neutral amino acid glutamine serves as a key intermediate ...	CONTRADICT	[ 4 ]
1,356	Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.	13,764,090	Large intestine-targeted nanoparticle-releasing oral vaccine to control genitorectal viral infection	[ "Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms.", "Vaccination through large intestinal mucosa, previously proven protective for both of these mucosal sites in animal studies, can be achieved successfully by direct intracolorectal (i.c.r.) administration, but ...	SUPPORT	[ 1, 3, 5 ]
1,360	Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.	11,614,737	Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.	[ "IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. \n", "OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers. \n", "DESIGN, SETT...	CONTRADICT	[ 9 ]
1,361	Varying expression levels of EBI2 affect the positioning and migration of B cells.	15,488,881	Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.	[ "Humoral immunity depends on both rapid and long-term antibody production against invading pathogens.", "This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, but the signals that guide responding B cells to these alternative c...	SUPPORT	[ 2, 3 ]
1,361	Varying expression levels of EBI2 affect the positioning and migration of B cells.	15,058,155	7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases	[ "EBI2, aka GPR183, is a G-couple receptor originally identified in 1993 as one of main genes induced in Burkitt's lymphoma cell line BL41 by Epstein-Barr virus (EBV) infection.", "After it was reported in 2009 that the receptor played a key role in regulating B cell migration and responses, we initiated an effort...	SUPPORT	[ 3 ]
1,364	Venules have less significant tunica adventitia than arterioles.	8,290,953	Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue.	[ "BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium over regions of infarcted cardiac tissue to stimulate revascularization of the damaged tissue.", "These experiments used a scaffold-based 3D human dermal fibroblast culture (3DFC) as an epicardial patch.", "The 3DFC conta...	NEI	[]
1,366	VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.	4,406,819	PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike	[ "The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria.", "T6SS is responsible for translocation of a wide range of toxic effector molecules, allowing predatory cells to kill both prokaryotic...	SUPPORT	[ 2, 4 ]
1,367	Vitamin D deficiency effects birth weight.	2,425,364	Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies.	[ "OBJECTIVE To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. \n", "DESIGN Systematic review and meta-analysis. \n", "DATA SOURCES Medline (1966 to August 2012), PubMed (2008 to August 2012), Embase (1980 to August 2012), CINAHL (1981 to August 2012), the ...	SUPPORT	[ 10, 12 ]
1,371	Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.	16,256,507	Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.	[ "CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known.", "Serum 25-hydroxyvitamin D is the generally accepted indicator of vitamin D status, but no universal reference level has been reached. \n", "OBJECTIVE To inv...	SUPPORT	[ 7, 8 ]
1,372	Walking in traffic areas in London did not improve lung function in elderly adults.	21,003,930	Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study	[ "BACKGROUND Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from isch...	SUPPORT	[ 10, 11, 12, 15 ]
1,373	Walking in traffic areas in London improves lung function in elderly adults.	21,003,930	Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study	[ "BACKGROUND Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from isch...	CONTRADICT	[ 10, 11, 12, 15 ]
1,374	Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.	21,993,510	Accuracy of weighed dietary records in studies of diet and health.	[ "OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies investigating the links between diet and health. \n", "DESIGN Subjects who had previously participated in the Norther...	NEI	[]
1,375	Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.	21,993,510	Accuracy of weighed dietary records in studies of diet and health.	[ "OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies investigating the links between diet and health. \n", "DESIGN Subjects who had previously participated in the Norther...	NEI	[]
1,376	Whole brain radiotherapy increases the occurrence of new brain metastases.	3,944,632	Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.	[ "CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. \n", "OBJECTIVE To determine if WBRT combined with SRS results in improvem...	CONTRADICT	[ 6, 10 ]
1,378	Women are more susceptible to death due to pneumonia when compared to men.	2,488,880	Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.	[ "CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studied. \n", "OBJECTIVE To investigate the role of gender among hospitalized patients treated for infection. \n", "DESIGN Observational cohort study c...	SUPPORT	[ 10 ]
1,380	Women with a lower birth weight are more likely to develop breast cancer later in life.	16,322,674	Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies	[ "BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent.", "We re-analysed individual participant data from published and unpublished studies to obtain more precise estimates of the ma...	CONTRADICT	[ 5, 6 ]
1,380	Women with a lower birth weight are more likely to develop breast cancer later in life.	23,557,241	Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence.	[ "BACKGROUND Emerging evidence suggests an association between female prenatal experience and her subsequent risk of developing breast cancer.", "Potential underlying mechanisms include variation in amounts of maternal endogenous sex hormones and growth hormones, germ-cell mutations, formation of cancer stem-cells...	CONTRADICT	[ 6 ]
1,380	Women with a lower birth weight are more likely to develop breast cancer later in life.	17,450,673	Intrauterine environments and breast cancer risk: meta-analysis and systematic review	[ "INTRODUCTION Various perinatal factors, including birth weight, birth order, maternal age, gestational age, twin status, and parental smoking, have been postulated to affect breast cancer risk in daughters by altering the hormonal environment of the developing fetal mammary glands.", "Despite ample biologic plau...	CONTRADICT	[ 5 ]
1,381	YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.	13,481,880	YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration	[ "Tissue regeneration requires dynamic cellular adaptation to the wound environment.", "It is currently unclear how this is orchestrated at the cellular level and how cell fate is affected by severe tissue damage.", "Here we dissect cell fate transitions during colonic regeneration in a mouse dextran sulfate sod...	SUPPORT	[ 4, 5 ]
1,383	aPKCz causes tumour suppression by affecting glutamine metabolism.	17,755,060	Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis	[ "Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress.", "We show that PKCζ deficiency promotes the plasticity necessary for cancer cells to reprogram their metabolism to utilize glutamine throug...	SUPPORT	[ 3, 5 ]
1,386	cSMAC formation represses weak ligand signalling.	306,006	The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.	[ "T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands.", "The factors that determine the stimulatory potency of a pMHC molecule remain unclear.", "We describe results showing that a peptide exhibiting many hallmarks of a weak agonist ...	CONTRADICT	[ 4 ]
1,387	eRNAs influence is linked to senescence, aging, and carcinogenesis.	9,669,099	eRNAs are required for p53-dependent enhancer activity and gene transcription.	[ "Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression.", "Using genome-wide chromatin-binding profiles, we describe binding of p53 also to regions located distantly from any known p53 targ...	NEI	[]

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