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train · 919 rows

claim_id int64 0 1.41k	claim stringlengths 26 249	abstract_id int64 5.84k 196M	title stringlengths 7 264	abstract listlengths 3 25	verdict stringclasses 3 values	evidence listlengths 0 5
1,067	ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.	4,429,668	Pif1 family helicases suppress genome instability at G-quadruplex motifs	[ "The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans.", "Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases.", "Moreover, Pif1 helicases from organisms separated by more tha...	NEI	[]
1,068	ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.	4,429,668	Pif1 family helicases suppress genome instability at G-quadruplex motifs	[ "The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans.", "Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases.", "Moreover, Pif1 helicases from organisms separated by more tha...	NEI	[]
1,069	Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.	4,200,695	Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study	[ "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression. \n", "DESIGN R...	SUPPORT	[ 11, 12, 14 ]
1,070	Self-advocacy training is effective at decreasing homelessness.	25,649,714	Mental health problems of homeless children and families: longitudinal study.	[ "OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. \n", "DESIGN Cross sectional, longitudinal study. \n", "SETTING City of Birmingham. ", "SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 comparison families of low socioeco...	NEI	[]
1,072	Sepsis related mortality has remained stable between 2009-2014.	4,824,840	Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014	[ "Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing.", "However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time.", "Objective To estimate...	SUPPORT	[ 10, 13 ]
1,073	Sepsis related mortality has risen from 2009 to 2014.	4,824,840	Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014	[ "Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing.", "However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time.", "Objective To estimate...	CONTRADICT	[ 10, 13 ]
1,074	Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.	14,658,685	Enhancer Evolution across 20 Mammalian Species	[ "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals.", "Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling...	NEI	[]
1,075	Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.	14,658,685	Enhancer Evolution across 20 Mammalian Species	[ "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals.", "Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling...	NEI	[]
1,081	Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.	5,691,302	Antidepressant use and risk of adverse outcomes in older people: population based cohort study	[ "OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and dose. \n", "DESIGN Cohort study of people aged 65 and over diagnosed as having depressi...	CONTRADICT	[ 10, 13 ]
1,084	Side effects associated with antidepressants increases risk of stroke.	5,691,302	Antidepressant use and risk of adverse outcomes in older people: population based cohort study	[ "OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and dose. \n", "DESIGN Cohort study of people aged 65 and over diagnosed as having depressi...	SUPPORT	[ 10 ]
1,085	Side effects associated with antidepressants lower risk of myocardial infarction.	5,691,302	Antidepressant use and risk of adverse outcomes in older people: population based cohort study	[ "OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and dose. \n", "DESIGN Cohort study of people aged 65 and over diagnosed as having depressi...	NEI	[]
1,087	Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.	39,281,140	Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial.	[ "CONTEXT Sexual dysfunction is a common adverse effect of antidepressants that frequently results in treatment noncompliance. \n", "OBJECTIVE To assess the efficacy of sildenafil citrate in men with sexual dysfunction associated with the use of selective and nonselective serotonin reuptake inhibitor (SRI) antid...	CONTRADICT	[ 7, 9 ]
1,090	Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.	17,628,888	ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair	[ "Modification of proteins by SUMO is essential for the maintenance of genome integrity.", "During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction.", "The Mms21 SUMO ligase docks to the arm ...	CONTRADICT	[ 7 ]
1,091	Sn is present on mature DCs during inflammation in vivo.	2,603,304	Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides	[ "Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens.", "However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells.", "Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4(+) T cells through a process termed tran...	NEI	[]
1,096	Specialized functional cell types can be derived from human pluripotent stem cells.	29,638,116	Complex Tissue and Disease Modeling using hiPSCs.	[ "Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening.", "Many of these models assume cell-autonomous mechanisms of disease but it is possible that disease phenotypes or drug responses will only be evident if all cellular and ...	NEI	[]
1,097	Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.	26,851,674	Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.	[ "We generated a series of knockin mouse lines, in which the cytokine receptor gp130-dependent STAT3 and/or SHP2 signals were disrupted, by replacing the mouse gp130 gene with human gp130 mutant cDNAs.", "The SHP2 signal-deficient mice (gp130F759/F759 were born normal but displayed splenomegaly and lymphadenopathy...	SUPPORT	[ 1 ]
1,098	Stacking is more stable when a purine is present in the +5 position (C1698).	13,552,682	Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes	[ "In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes.", "We present structures of the mammalian ribosome engaged with decoding factor⋅GTPase complexes representing intermediates of translation elongat...	NEI	[]
1,101	Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.	3,874,000	Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.	[ "Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate.", "Embryogenesis is guided by cell-cell and cell-matrix interactions, but it is unclear how these physical cues influence stem cells in culture.", "We used human em...	CONTRADICT	[ 5 ]
1,102	Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.	3,874,000	Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.	[ "Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate.", "Embryogenesis is guided by cell-cell and cell-matrix interactions, but it is unclear how these physical cues influence stem cells in culture.", "We used human em...	SUPPORT	[ 5 ]
1,103	Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.	3,898,784	Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality	[ "Importance Although non–vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to prevent thromboembolic disease, there are limited data on NOAC-related intracerebral hemorrhage (ICH).", "Objective To assess the association between preceding oral anticoagulant use (warfarin, NOACs, and no oral an...	CONTRADICT	[ 8, 9, 10, 13 ]
1,105	Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.	6,710,713	Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study	[ "OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misconduct. \n", "DESIGN Matched case-control study.", "Setting Records from medical schools and the General Medical Council (GMC). \n", "PARTICIPANTS 59 doctors who...	SUPPORT	[ 7, 8, 9 ]
1,106	Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.	6,710,713	Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study	[ "OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misconduct. \n", "DESIGN Matched case-control study.", "Setting Records from medical schools and the General Medical Council (GMC). \n", "PARTICIPANTS 59 doctors who...	CONTRADICT	[ 7, 8, 9 ]
1,109	Suboptimal nutrition is a leading cause of premature death	13,770,184	Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015	[ "BACKGROUND The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease.", "By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the i...	SUPPORT	[ 13 ]
1,109	Suboptimal nutrition is a leading cause of premature death	8,582,337	The state of US health, 1990-2010: burden of diseases, injuries, and risk factors.	[ "IMPORTANCE Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. \n", "OBJECTIVES To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measur...	SUPPORT	[ 13 ]
1,111	Sudden death can occur in patients with complex ventricular arrhythmias.	1,686,881	Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy.	[ "BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy.", "The disease usually does not induce heart failure but is associated with sudden death, conduction disturbances, and an increased risk of complications during anesthesia.", ...	NEI	[]
1,112	Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.	1,686,881	Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy.	[ "BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy.", "The disease usually does not induce heart failure but is associated with sudden death, conduction disturbances, and an increased risk of complications during anesthesia.", ...	NEI	[]
1,114	Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.	12,824,568	From Cell Differentiation to Cell Collectives: Bacillus subtilis Uses Division of Labor to Migrate	[ "The organization of cells, emerging from cell-cell interactions, can give rise to collective properties.", "These properties are adaptive when together cells can face environmental challenges that they separately cannot.", "One particular challenge that is important for microorganisms is migration.", "In thi...	SUPPORT	[ 6, 7 ]
1,115	Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.	44,048,701	Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: the PROFHER randomized clinical trial.	[ "IMPORTANCE The need for surgery for the majority of patients with displaced proximal humeral fractures is unclear, but its use is increasing. \n", "OBJECTIVE To evaluate the clinical effectiveness of surgical vs nonsurgical treatment for adults with displaced fractures of the proximal humerus involving the sur...	SUPPORT	[ 11, 12, 13, 15 ]
1,118	Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.	23,351,136	Detection of sweet and umami taste in the absence of taste receptor T1r3.	[ "The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells.", "Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate re...	NEI	[]
1,119	Sympathetic nerve activity is elevated throughout normal pregnancy.	5,323,845	Sympathetic neural mechanisms in normal and hypertensive pregnancy in humans.	[ "BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE).", "It is unknown whether sympathetic drive is altered in normal pregnancy, when arterial blood pressure can be normal or relatively low.", "Th...	SUPPORT	[ 4, 10 ]
1,119	Sympathetic nerve activity is elevated throughout normal pregnancy.	18,997,216	Sympathetic baroreflex gain in normotensive pregnant women.	[ "Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting.", "We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregnant women relative to nonpregnant matched controls....	SUPPORT	[ 0, 3 ]
1,119	Sympathetic nerve activity is elevated throughout normal pregnancy.	13,907,928	Regulation of sympathetic nerve activity during the cold pressor test in normotensive pregnant and nonpregnant women.	[ "Baseline neurovascular transduction is reduced in normotensive pregnancy; however, little is known about changes to neurovascular transduction during periods of heightened sympathetic activation.", "We tested the hypothesis that, despite an exacerbated muscle sympathetic nerve activity (microneurography) respons...	SUPPORT	[ 3, 4 ]
1,120	Sympathetic nerve activity is reduced throughout normal pregnancy.	5,323,845	Sympathetic neural mechanisms in normal and hypertensive pregnancy in humans.	[ "BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE).", "It is unknown whether sympathetic drive is altered in normal pregnancy, when arterial blood pressure can be normal or relatively low.", "Th...	CONTRADICT	[ 4, 10 ]
1,120	Sympathetic nerve activity is reduced throughout normal pregnancy.	18,997,216	Sympathetic baroreflex gain in normotensive pregnant women.	[ "Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting.", "We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregnant women relative to nonpregnant matched controls....	CONTRADICT	[ 0, 3 ]
1,120	Sympathetic nerve activity is reduced throughout normal pregnancy.	13,907,928	Regulation of sympathetic nerve activity during the cold pressor test in normotensive pregnant and nonpregnant women.	[ "Baseline neurovascular transduction is reduced in normotensive pregnancy; however, little is known about changes to neurovascular transduction during periods of heightened sympathetic activation.", "We tested the hypothesis that, despite an exacerbated muscle sympathetic nerve activity (microneurography) respons...	CONTRADICT	[ 3, 4 ]
1,125	Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)	21,009,874	Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study.	[ "CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. \n", "OBJECTIVE To assess whether immunosuppressive drugs increase mortality. \n", "DESIGN Retrospective cohort study evaluating overall and cancer mortality in relation to immunosuppressive drug exposure among patients with...	SUPPORT	[ 12, 15 ]
1,126	Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)	21,009,874	Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study.	[ "CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. \n", "OBJECTIVE To assess whether immunosuppressive drugs increase mortality. \n", "DESIGN Retrospective cohort study evaluating overall and cancer mortality in relation to immunosuppressive drug exposure among patients with...	CONTRADICT	[ 12, 15 ]
1,127	Systemic lupus erythematosus is a risk factor for cardiovascular disease.	27,466,734	Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study	[ "Objectives To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors.", "Design Prospective open cohort study.", "Setting General practices in England providing data for the QResearch database."...	SUPPORT	[ 7 ]
1,128	T cell receptor /CD3 microdomains are required to induce the immunologic synapse.	33,499,189	Full activation of the T cell receptor requires both clustering and conformational changes at CD3.	[ "T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits.", "The mechanism by which TCRalphabeta ligand binding confers conformational changes to CD3 is unknown.", "By using well-defined ligands, we showed that induction of t...	SUPPORT	[ 0, 4 ]
1,128	T cell receptor /CD3 microdomains are required to induce the immunologic synapse.	9,283,422	T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.	[ "T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activation cluster (cSMAC).", "We showed that the cSMAC formed by fusion of microclusters contained more CD45 than microclusters and is a site ...	NEI	[]
1,133	TMEM27 is a marker for beta cells.	24,142,891	Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.	[ "The signals and molecular mechanisms that regulate the replication of terminally differentiated beta cells are unknown.", "Here, we report the identification and characterization of transmembrane protein 27 (Tmem27, collectrin) in pancreatic beta cells.", "Expression of Tmem27 is reduced in Tcf1(-/-) mice and ...	SUPPORT	[ 1, 4, 6 ]
1,134	TNFAIP3 is a glioblastoma tumor enhancer.	33,370	Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth	[ "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs).", "GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets.", "We determined that A20 (TNFAIP3), a regulator of cell sur...	SUPPORT	[ 4, 9 ]
1,135	TNFAIP3 is a glioblastoma tumor suppressor.	33,370	Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth	[ "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs).", "GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets.", "We determined that A20 (TNFAIP3), a regulator of cell sur...	CONTRADICT	[ 4, 9 ]
1,136	TNFAIP3 is a tumor enhancer in glioblastoma.	33,370	Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth	[ "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs).", "GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets.", "We determined that A20 (TNFAIP3), a regulator of cell sur...	SUPPORT	[ 6, 9 ]
1,138	TRAP+ osteoclasts regulate mature osteoblast maintenance.	6,796,297	PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis	[ "Osteogenesis during bone modeling and remodeling is coupled with angiogenesis.", "A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), couples angiogenesis and osteogenesis.", "Here, we found that platelet-derived growth factor-BB (PDGF-BB) secreted by ...	SUPPORT	[ 3 ]
1,139	Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.	12,009,265	Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.	[ "CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements.", "A large-scale randomized trial suggested that vitamin E may reduce risk of prostate cancer; however, few trials have been powered to address...	SUPPORT	[ 9, 14 ]
1,141	Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.	12,009,265	Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.	[ "CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements.", "A large-scale randomized trial suggested that vitamin E may reduce risk of prostate cancer; however, few trials have been powered to address...	CONTRADICT	[ 9, 10, 14 ]
1,142	Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.	5,260,382	An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice	[ "Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer’s disease (AD).", "We show that in an aged transgenic AD mouse model (APP/PS1 plaque-bearing mice), the antidepressant citalopram, a selective serotonin reuptake inhibitor, decreased Aβ in brain interstitial fl...	SUPPORT	[ 5 ]
1,145	Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.	10,071,552	Averting Obesity and Type 2 Diabetes in India through Sugar-Sweetened Beverage Taxation: An Economic-Epidemiologic Modeling Study	[ "BACKGROUND Taxing sugar-sweetened beverages (SSBs) has been proposed in high-income countries to reduce obesity and type 2 diabetes.", "We sought to estimate the potential health effects of such a fiscal strategy in the middle-income country of India, where there is heterogeneity in SSB consumption, patterns of ...	SUPPORT	[ 4, 5, 8 ]
1,148	Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.	4,828,631	Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults	[ "BACKGROUND High body-mass index (BMI) predisposes to several site-specific cancers, but a large-scale systematic and detailed characterisation of patterns of risk across all common cancers adjusted for potential confounders has not previously been undertaken.", "We aimed to investigate the links between BMI and ...	SUPPORT	[ 10 ]
1,153	The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.	7,370,282	Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2	[ "To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN).", "PDPN is expressed by lymphatic endothelial and fibroblastic reticular cells and promotes blood-lymph separation during dev...	SUPPORT	[ 5, 6 ]
1,156	The DESMOND program caused substantial weight loss in most participants.	12,584,053	Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care	[ "OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. \n", "DESIGN Three year follow-up of a multicentre cluster randomised controlled trial in primary care, with randomisat...	CONTRADICT	[ 13 ]
1,157	The DESMOND program demonstrates no significant impact on biochemical outcomes.	12,584,053	Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care	[ "OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. \n", "DESIGN Three year follow-up of a multicentre cluster randomised controlled trial in primary care, with randomisat...	SUPPORT	[ 9, 10, 13 ]
1,158	The DESMOND program demonstrates no significant impact on lifestyles outcomes.	12,584,053	Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care	[ "OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. \n", "DESIGN Three year follow-up of a multicentre cluster randomised controlled trial in primary care, with randomisat...	SUPPORT	[ 13 ]
1,159	The DESMOND program demonstrates no significant impact on weight loss.	12,584,053	Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care	[ "OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. \n", "DESIGN Three year follow-up of a multicentre cluster randomised controlled trial in primary care, with randomisat...	SUPPORT	[ 13 ]
1,161	The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.	13,048,272	Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.	[ "Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation.", "Here, we report the genome-wide binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1...	NEI	[]
1,162	The DdrB protein from Deinococcus radiodurans functions as a pentamer.	15,305,881	The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins	[ "Deinococcus spp. are renowned for their amazing ability to recover rapidly from severe genomic fragmentation as a result of exposure to extreme levels of ionizing radiation or desiccation.", "Despite having been originally characterized over 50 years ago, the mechanism underlying this remarkable repair process i...	SUPPORT	[ 4 ]
1,164	The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.	4,455,466	ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression	[ "Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin.", "H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the transcribed regions after RNA polymerase II elongation.", "In yeast, this mark in turn recruits epigenetic regulators to reset ...	NEI	[]
1,165	The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.	4,455,466	ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression	[ "Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin.", "H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the transcribed regions after RNA polymerase II elongation.", "In yeast, this mark in turn recruits epigenetic regulators to reset ...	NEI	[]
1,166	The H2A-H2B eviction defect is compensated for by other histone chaperone(s).	9,889,151	FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.	[ "FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone.", "We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic regions near the C termini of each subunit.", "Mutations throughout these regions affect binding and cause correlated phenotypes that r...	NEI	[]
1,168	The HSV-2 infection is typically asymptomatic.	8,563,659	Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition	[ "To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV-2 lesions from patients on and off antiviral therapy.", "CD4(+) and CD8(+) T cells and a mixed population of plasmacyt...	NEI	[]
1,169	The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.	4,319,174	Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis	[ "All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environments.", "In the prevailing model of thermogenesis, when the hypothalamus senses cold temperatures it triggers sympathetic discharge, resulting in th...	SUPPORT	[ 5, 6 ]
1,170	The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.	18,956,141	NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions	[ "Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD).", "IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired antimicrobial f...	CONTRADICT	[ 3, 4 ]
1,171	The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.	18,956,141	NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions	[ "Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD).", "IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired antimicrobial f...	SUPPORT	[ 3, 4 ]
1,173	The PDPN gene deactivates the C-type lectin receptor (CLEC-2).	7,370,282	Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2	[ "To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN).", "PDPN is expressed by lymphatic endothelial and fibroblastic reticular cells and promotes blood-lymph separation during dev...	CONTRADICT	[ 1, 6 ]
1,174	The PPR MDA5 has twenty N-terminal CARD domains.	31,272,411	Immune signaling by RIG-I-like receptors.	[ "The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity.", "The RLRs detect viral RNA ligands or processed self RNA in the cytoplasm to trigger innate immunity and inflammation and to impart gene expression tha...	NEI	[]
1,176	The PRDM1 gene is a key determinant of primordial germ cells.	13,910,150	The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells	[ "Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells.", "They together initiate epigenetic reprogramming in early germ cells toward an underlying pluripotent state, which is equivalent to embryoni...	SUPPORT	[ 0 ]
1,177	The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.	13,910,150	The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells	[ "Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells.", "They together initiate epigenetic reprogramming in early germ cells toward an underlying pluripotent state, which is equivalent to embryoni...	SUPPORT	[ 0 ]
1,178	The PRR MDA5 has a C-terminal domain.	31,272,411	Immune signaling by RIG-I-like receptors.	[ "The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity.", "The RLRs detect viral RNA ligands or processed self RNA in the cytoplasm to trigger innate immunity and inflammation and to impart gene expression tha...	NEI	[]
1,181	The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).	301,838	Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium	[ "The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance.", "...	SUPPORT	[ 1, 3 ]
1,181	The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).	2,734,421	The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.	[ "Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens.", "However, signals underlying mTEC development remain largely unclear.", "Here, we demonstrate crucial regulation of mTEC development by...	SUPPORT	[ 2, 3, 4, 5 ]
1,181	The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).	39,128,592	The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.	[ "The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance.", "Positive selection is essential for thymic medulla formation via a previously unknown mechanism.", "Here ...	SUPPORT	[ 2 ]
1,181	The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).	3,952,288	RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla	[ "Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities.", "Here we demonstrate a novel role for a CD4+3− inducer cell population, previously ...	SUPPORT	[ 3, 4 ]
1,182	The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).	14,541,844	Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator	[ "Highly conserved among eukaryotic cells, the AMP-activated kinase (AMPK) is a central regulator of carbon metabolism.", "To map the complete network of interactions around AMPK in yeast (Snf1) and to evaluate the role of its regulatory subunit Snf4, we measured global mRNA, protein and metabolite levels in wild ...	SUPPORT	[ 3 ]
1,183	The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.	1,967,017	A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis	[ "Correction for: Kurreeman FAS, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, et al. (2007)", "A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis.", "PLoS Med 4(9): e278.", "doi:10.1371/journal.pmed.0040278 In Table 1, the allele ratio in column eigh...	NEI	[]
1,184	The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.	16,737,210	Kidney paired donation and optimizing the use of live donor organs.	[ "CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.", "Kidney paired donation (KPD) offers incompatible donor/recipient pairs the opportunity to match for compatible transplants.", "Despite its increasing popularit...	CONTRADICT	[ 10 ]
1,186	The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.	7,485,455	Using Routine Surveillance Data to Estimate the Epidemic Potential of Emerging Zoonoses: Application to the Emergence of US Swine Origin Influenza A H3N2v Virus	[ "BACKGROUND Prior to emergence in human populations, zoonoses such as SARS cause occasional infections in human populations exposed to reservoir species.", "The risk of widespread epidemics in humans can be assessed by monitoring the reproduction number R (average number of persons infected by a human case).", ...	NEI	[]
1,188	The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.	4,394,817	E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells	[ "In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably portrayed as the ultimate effectors of a transcriptional program that commit cells to en...	NEI	[]
1,190	The amount of publicly available DNA data doubles every 10 months.	30,655,442	The EMBL nucleotide sequence database.	[ "The EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl. html ) constitutes Europe's primary nucleotide sequence resource.", "DNA and RNA sequences are directly submitted from researchers and genome sequencing groups and collected from the scientific literature and patent applications (Fig. 1).", "In ...	NEI	[]
1,193	The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.	20,532,591	Tracking adipogenesis during white adipose tissue development, expansion and regeneration	[ "White adipose tissue displays high plasticity.", "We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse.", "We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure.", "During cold-induced 'browning' of subcuta...	NEI	[]
1,195	The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.	26,283,293	Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria	[ "Eukaryotic cells are compartmentalized into membrane-bounded organelles whose functions rely on lipid trafficking to achieve membrane-specific compositions of lipids.", "Here we focused on the Ups1-Mdm35 system, which mediates phosphatidic acid (PA) transfer between the outer and inner mitochondrial membranes, a...	NEI	[]
1,205	The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.	5,558,754	Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study	[ "OBJECTIVES To quantify the diagnostic accuracy of selected inflammatory markers in addition to symptoms and signs for predicting pneumonia and to derive a diagnostic tool. \n", "DESIGN Diagnostic study performed between 2007 and 2010.", "Participants had their history taken, underwent physical examination an...	CONTRADICT	[ 10, 17 ]
1,206	The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.	18,909,530	Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.	[ "Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics.", "Here, mass spectrometry-calibrated intracellular flow cytometry of human hematopoiesis reveals MIIB to ...	NEI	[]
1,208	The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.	10,284,593	Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation	[ "Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation.", "However, whether inflammation is the cause or the consequence of atrial fibrillation and which specific inflammatory mediators may increase the atria's susceptibility to fibrillation ...	NEI	[]
1,209	The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.	4,347,374	Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts	[ "Viral replication usually requires that innate intracellular lines of defence be overcome, a task usually accomplished by specialized viral gene products.", "The virion infectivity factor (Vif) protein of human immunodeficiency virus (HIV) is required during the late stages of viral production to counter the ant...	SUPPORT	[ 3, 5 ]
1,210	The density of cytokine receptor bearing cells affects the distance over which cytokines act.	4,928,282	A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System	[ "&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known.", "Here, we used theoretical considerations and experimental models of immune responses in vitro and in vivo to quantify the spatial extent of cy...	SUPPORT	[ 9 ]
1,211	The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.	4,928,282	A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System	[ "&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known.", "Here, we used theoretical considerations and experimental models of immune responses in vitro and in vivo to quantify the spatial extent of cy...	CONTRADICT	[ 9 ]
1,212	The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.	6,493,422	The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.	[ "Precise control of myeloid cell activation is required for optimal host defense.", "However, this activation process must be under exquisite control to prevent uncontrolled inflammation.", "Herein, we identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vi...	NEI	[]
1,212	The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.	44,724,517	Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation.	[ "Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage.", "Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation.", "As an approximately 30% to 50% reduction in...	NEI	[]
1,214	The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.	6,493,422	The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.	[ "Precise control of myeloid cell activation is required for optimal host defense.", "However, this activation process must be under exquisite control to prevent uncontrolled inflammation.", "Herein, we identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vi...	NEI	[]
1,214	The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.	14,407,673	Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis.	[ "RATIONALE Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has been shown previously to augment atherosclerosis in hypercholesterolemic mice.", "However, the cell type responsible for the increased atherosclerosis due to KLF2 deficiency has not been identified.", "This study exami...	NEI	[]
1,215	The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.	16,355,392	Modification of kidney barrier function by the urokinase receptor	[ "Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease.", "Therapies aimed at the cellular level of the disease are currently not available.", "Here we show that induction of urokinase receptor (uPAR) signaling in podocytes leads...	NEI	[]
1,218	The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.	15,635,366	The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.	[ "L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has not been defined.", "Here we show that disruption of L3mbtl2 results in embryonic lethality with failure of gastrulation.", "This correlates with compromised proliferation and abnormal differentia...	NEI	[]
1,219	The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.	9,393,969	DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity	[ "Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival.", "The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses, but despite its importance little is known about how it regulate...	NEI	[]
1,219	The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.	14,864,285	YOKO HONDA AND SHUJI HONDA 1	[ "Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans.", "Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) formation phenotype.", ...	NEI	[]
1,220	The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.	13,023,410	BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.	[ "The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells.", "We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases.", "These l...	SUPPORT	[ 0, 1, 5 ]
1,223	The innate immune response struggles to remove small numbers of parasites.	5,289,038	Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.	[ "Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia, which in turn affect disease severity and transmission.", "Quantitatively partitioning the relative roles of these effects through time is challenging.", "Using data from rodent malaria, ...	CONTRADICT	[ 3 ]
1,224	The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.	21,932,050	Microarrays for the study of viral gene expression during human cytomegalovirus latent infection.	[ "Human cytomegalovirus (HCMV) is one of the largest known DNA viruses.", "It is ubiquitous, and following resolution of primary productive infection, it persists in the human host by establishing a lifelong latent infection in myeloid lineage cells such as monocytes and their progenitors.", "Most adults with HC...	SUPPORT	[ 3 ]
1,224	The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.	34,016,987	Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage.	[ "Monocytes are primary targets for human CMV (HCMV) infection and are proposed to be responsible for hematogenous dissemination of the virus.", "Monocytes acquire different functional traits during polarization to the classical proinflammatory M1 macrophage or the alternative antiinflammatory M2 macrophage.", "...	SUPPORT	[ 4, 5, 9 ]
1,227	The mean suicide rate in women is higher after miscarriage than live birth.	25,641,414	Suicides after pregnancy in Finland, 1987-94: register linkage study.	[ "OBJECTIVE To determine rates of suicide associated with pregnancy by the type of pregnancy. \n", "DESIGN Register linkage study.", "Information on suicides in women of reproductive age was linked with the Finnish birth, abortion, and hospital discharge registers to find out how many women who committed suici...	SUPPORT	[ 7 ]

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