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train · 919 rows

claim_id int64 0 1.41k	claim stringlengths 26 249	abstract_id int64 5.84k 196M	title stringlengths 7 264	abstract listlengths 3 25	verdict stringclasses 3 values	evidence listlengths 0 5
946	Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.	26,112,696	Maximal aerobic capacity in African-American and Caucasian prepubertal children.	[ "The purpose of this study was to examine differences in resting, submaximal, and maximal (VO2max) oxygen consumption (VO2) in African-American (n = 44) and Caucasian (n = 31) prepubertal children aged 5-10 yr.", "Resting VO2 was measured via indirect calorimetry in the fasted state.", "Submaximal VO2 and VO2ma...	NEI	[]
946	Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.	4,463,588	Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents.	[ "BACKGROUND Little is known about how the intensity of exercise influences cardiovascular fitness and body composition, especially in obese adolescents. \n", "OBJECTIVE Our goal was to determine the effects of physical training intensity on the cardiovascular fitness, percentage of body fat (%BF), and visceral ...	NEI	[]
946	Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.	13,083,189	Determinants of adolescent physical activity and inactivity patterns.	[ "OBJECTIVES Despite recognition of the important influence of environmental determinants on physical activity patterns, minimal empirical research has been done to assess the impact of environmental/contextual determinants of physical activity.", "This article aims to investigate environmental and sociodemographi...	NEI	[]
949	Physical injury represses transgultaminase activity.	13,578,199	Transglutaminase 2 Undergoes a Large Conformational Change upon Activation	[ "Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac sprue.", "Although vertebrate transglutaminases have been studied ex...	NEI	[]
951	Piezo1 channels are sensors for cell migration in epithelial cells.	21,414,718	Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro	[ "Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility.", "Recently, we screened Piezo1 as a candidate TFF1-binding protein.", "We aimed to confirm Piezo1 as a novel TFF1 binding protein and to assess the role of this interaction in medi...	SUPPORT	[ 3, 7, 8, 11 ]
952	Pioglitazone use is not associated with an increased risk of prostate cancer.	3,355,397	Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.	[ "IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. \n", "OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. \n", "DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analyses among persons with diabete...	CONTRADICT	[ 12, 16 ]
953	Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.	3,355,397	Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.	[ "IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. \n", "OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. \n", "DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analyses among persons with diabete...	SUPPORT	[ 12, 13, 16 ]
954	Pioglitazone use is significantly associated with an increased risk of prostate cancer.	3,355,397	Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.	[ "IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. \n", "OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. \n", "DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analyses among persons with diabete...	SUPPORT	[ 12, 16 ]
955	Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.	2,078,658	Oct4 links multiple epigenetic pathways to the pluripotency network	[ "Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming.", "However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-protein interactions that dictate Oct4's critical regulator...	SUPPORT	[ 3 ]
955	Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.	30,507,607	An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells	[ "Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity.", "Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners is underexplored.", "Here, we use an improved affinity prot...	SUPPORT	[ 3 ]
959	Polymeal nutrition increases cardiovascular mortality.	8,780,599	The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.	[ "OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls.", "The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal. \n", "M...	CONTRADICT	[ 6, 8 ]
962	Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.	13,931,771	GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules	[ "Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix.", "GRSF1 (G-rich sequence factor 1) is an RNA binding protein that was previously reported to localize in the cytosol.", "We found that an isoform...	SUPPORT	[ 6 ]
962	Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.	935,538	The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.	[ "RNA-binding proteins are at the heart of posttranscriptional gene regulation, coordinating the processing, storage, and handling of cellular RNAs.", "We show here that GRSF1, previously implicated in the binding and selective translation of influenza mRNAs, is targeted to mitochondria where it forms granules tha...	SUPPORT	[ 1, 5 ]
962	Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.	4,306,711	The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly.	[ "Human mitochondrial ribosomes are specialized in the synthesis of 13 proteins, which are fundamental components of the oxidative phosphorylation system.", "The pathway of mitoribosome biogenesis, the compartmentalization of the process, and factors involved remain largely unknown.", "Here, we have identified t...	SUPPORT	[ 2, 6 ]
963	Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.	4,162,857	Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns	[ "RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing.", "Using an in vitro transcription/splicing assay, we demonstrate that an association of RNA polymerase II (Pol II) transcription and pre-mRNA splicing is requi...	CONTRADICT	[ 5 ]
963	Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.	29,828,242	Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays.	[ "The development of in vitro assays to analyze pre-mRNA splicing resulted in the discovery of many fundamental features characterizing splicing signals and the machinery that completes this process.", "Because in vitro assays can be manipulated by various biochemical approaches, the versatility of investigating a...	NEI	[]
964	Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.	4,162,857	Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns	[ "RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing.", "Using an in vitro transcription/splicing assay, we demonstrate that an association of RNA polymerase II (Pol II) transcription and pre-mRNA splicing is requi...	SUPPORT	[ 5 ]
964	Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.	29,828,242	Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays.	[ "The development of in vitro assays to analyze pre-mRNA splicing resulted in the discovery of many fundamental features characterizing splicing signals and the machinery that completes this process.", "Because in vitro assays can be manipulated by various biochemical approaches, the versatility of investigating a...	NEI	[]
965	Prescribed exercise training improves quality of life.	40,817,021	Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial.	[ "CONTEXT Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent. \n", "OBJECTIVE To test the effects of exercise training on health status among patients with heart failure. \n", "DESIGN, SETTING, AND PATIENTS Multicenter, randomized contr...	SUPPORT	[ 10, 12, 14 ]
969	PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.	19,356,271	hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.	[ "Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily.", "Here, we characterize a previously unrecognized prim-pol in human cells, which we designate hPrimpol1 (human primase-polymerase 1).", "hPrimpol1 possesses primase and DNA polymerase activ...	NEI	[]
969	PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.	17,368,516	PrimPol, an Archaic Primase/Polymerase Operating in Human Cells	[ "We describe a second primase in human cells, PrimPol, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotides.", "Moreover, PrimPol is also a DNA polymerase tailored to bypass the most common oxidative lesions in DNA, such as abasic sites and...	NEI	[]
970	PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.	19,356,271	hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.	[ "Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily.", "Here, we characterize a previously unrecognized prim-pol in human cells, which we designate hPrimpol1 (human primase-polymerase 1).", "hPrimpol1 possesses primase and DNA polymerase activ...	NEI	[]
970	PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.	17,368,516	PrimPol, an Archaic Primase/Polymerase Operating in Human Cells	[ "We describe a second primase in human cells, PrimPol, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotides.", "Moreover, PrimPol is also a DNA polymerase tailored to bypass the most common oxidative lesions in DNA, such as abasic sites and...	NEI	[]
972	Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.	46,695,481	Human papillomavirus and Papanicolaou tests to screen for cervical cancer.	[ "BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical epithelial neoplasia or ce...	CONTRADICT	[ 0, 9 ]
972	Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.	27,873,158	Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial.	[ "BACKGROUND Human papillomavirus (HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN).", "We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing. \n", "METHODS Between March, 2004, and December...	CONTRADICT	[ 0, 15, 21 ]
972	Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.	28,617,573	Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer.	[ "More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods.", "A summary is given from recent meta-analyses and systematic reviews on 3 possible clinical applications of human papillomavirus (HPV) t...	CONTRADICT	[ 8 ]
972	Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.	9,764,256	Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial.	[ "BACKGROUND Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV by DNA screening in two screening rounds 5 years apart has not been assessed.", "The aim of this study was to assess whether HPV DNA testing in the first screen ...	CONTRADICT	[ 13 ]
973	Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.	27,446,873	Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme.	[ "OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions. \n", "DESIGN Randomised trial. \n", "SETTING Population based screening programme for cervical can...	SUPPORT	[ 7, 10 ]
973	Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.	27,873,158	Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial.	[ "BACKGROUND Human papillomavirus (HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN).", "We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing. \n", "METHODS Between March, 2004, and December...	SUPPORT	[ 0, 21 ]
973	Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.	28,617,573	Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer.	[ "More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods.", "A summary is given from recent meta-analyses and systematic reviews on 3 possible clinical applications of human papillomavirus (HPV) t...	SUPPORT	[ 7, 8 ]
973	Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.	9,764,256	Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial.	[ "BACKGROUND Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV by DNA screening in two screening rounds 5 years apart has not been assessed.", "The aim of this study was to assess whether HPV DNA testing in the first screen ...	SUPPORT	[ 13, 16 ]
976	Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.	5,304,891	Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi	[ "Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals.", "To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect of genetic variation on cytokine production, we profiled cytokines produced by peri...	NEI	[]
977	Pro-inflammatory cytokines are up regulated during tumor development.	14,075,252	Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.	[ "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival.", "Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet ac...	NEI	[]
977	Pro-inflammatory cytokines are up regulated during tumor development.	39,264,456	Impact of TNF-alpha and IL-6 levels on development of cachexia in newly diagnosed NSCLC patients.	[ "OBJECTIVES We investigated the role of cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in cachexia development in newly diagnosed nonsmall cell lung cancer (NSCLC) patients. \n", "METHODS : We evaluated 44 (M/F:41/3) NSCLC patients and 12 (M/F:10/2) age matched healthy smokers.", "...	SUPPORT	[ 8, 9 ]
978	Pro-inflammatory cytokines are up repressed during tumor development.	14,075,252	Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.	[ "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival.", "Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet ac...	NEI	[]
979	Progerin induces premature aging in stem cells.	11,659,421	Human iPSC-based modeling of late-onset disease via progerin-induced aging.	[ "Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders.", "In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages and apply it...	SUPPORT	[ 3, 5 ]
980	Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.	20,128,547	Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury	[ "Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying degrees of spontaneous functional recovery during the first months after injury.", "Such recovery is widely attributed to axons spared from injury that descend from the brain and bypass incomplete lesions, but its me...	SUPPORT	[ 3, 4 ]
984	Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.	6,828,370	A coding-independent function of gene and pseudogene mRNAs regulates tumour biology	[ "The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis.", "However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete for microRNA binding, independently of their protein-...	SUPPORT	[ 3 ]
988	Pseudoknots are not evolutionarily conserved in most eukaryotes.	3,033,830	Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes	[ "RNases P and MRP are ribonucleoprotein complexes involved in tRNA and rRNA processing, respectively.", "The RNA subunits of these two enzymes are structurally related to each other and play an essential role in the enzymatic reaction.", "Both of the RNAs have a highly conserved helical region, P4, which is imp...	NEI	[]
989	Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.	9,988,425	Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell	[ "Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions.", "In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions.", "Ex vivo expansion of pure populations of tissue st...	NEI	[]
990	Pyridostatin decreases telomere fragility in BRCA2-deficient cells.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	CONTRADICT	[ 4 ]
992	Pyridostatin deregulates G2/M progression.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	SUPPORT	[ 5 ]
994	Pyridostatin encourages proliferation of homologous recombination - defective cells.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	CONTRADICT	[ 5 ]
996	Pyridostatin induces checkpoint activation.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	SUPPORT	[ 5 ]
997	Pyridostatin induces double-strand breaks accumulation.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	SUPPORT	[ 5 ]
998	Pyridostatin prevents double-strand breaks accumulation.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	CONTRADICT	[ 5 ]
999	Pyridostatin reduces proliferation of homologous recombination - defective cells.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	SUPPORT	[ 5 ]
1,000	Pyridostatin stabilizes the G - quadruplex in the telomeric region.	16,472,469	Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds	[ "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers.", "Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks.", "We have previously show...	SUPPORT	[ 4 ]
1,001	R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.	5,702,790	Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.	[ "Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA.", "What makes the two Dicers specific for their biological substrates?", "We find that purified Dicer-2 can efficiently cleave pre-miRNA, but that inor...	NEI	[]
1,002	RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.	13,639,330	Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors	[ "Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown.", "Here we report an unexpected and general strat...	NEI	[]
1,003	RAD52 is involved in break-induced DNA replication (BIR).	14,332,945	Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks	[ "Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks.", "To better understand BIR, we performed a targeted siRNA screen for genes whose depletion inhibit...	SUPPORT	[ 6 ]
1,003	RAD52 is involved in break-induced DNA replication (BIR).	4,319,844	Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.	[ "Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers.", "By analyzing telomerase-positive cells and their human TERC knockout-derived ALT human cell lines, we show that ALT cells harbor more fragile telomeres representing telomer...	SUPPORT	[ 2 ]
1,003	RAD52 is involved in break-induced DNA replication (BIR).	4,899,981	Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism	[ "Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress.", "At CFSs, this fragility is associated with a delay in the completion of DNA replication until early mitosis, whereupon cells are proposed to switch to ...	SUPPORT	[ 1, 5 ]
1,004	RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.	301,838	Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium	[ "The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance.", "...	CONTRADICT	[ 1, 3 ]
1,004	RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.	2,734,421	The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.	[ "Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens.", "However, signals underlying mTEC development remain largely unclear.", "Here, we demonstrate crucial regulation of mTEC development by...	CONTRADICT	[ 2, 3, 4, 5 ]
1,004	RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.	3,952,288	RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla	[ "Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities.", "Here we demonstrate a novel role for a CD4+3− inducer cell population, previously ...	CONTRADICT	[ 3, 4 ]
1,005	RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.	301,838	Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium	[ "The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance.", "...	SUPPORT	[ 1, 3 ]
1,005	RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.	2,734,421	The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.	[ "Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens.", "However, signals underlying mTEC development remain largely unclear.", "Here, we demonstrate crucial regulation of mTEC development by...	SUPPORT	[ 2, 3, 4, 5 ]
1,005	RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.	3,952,288	RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla	[ "Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities.", "Here we demonstrate a novel role for a CD4+3− inducer cell population, previously ...	SUPPORT	[ 3, 4 ]
1,006	RTEL1 interacts with TRF2 through a C4C4 motif	4,926,049	TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding	[ "The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres.", "An interaction between RTEL1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to promote t-loop unwinding is unclear.", "Here, we esta...	SUPPORT	[ 3 ]
1,008	RUNX is not expressed in skin tissue.	2,547,636	Human epidermal stem cell function is regulated by circadian oscillations.	[ "Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown.", "Here we show that in human epidermal stem cells and their differentiated counterparts, core clock genes peak in a successive and ph...	NEI	[]
1,009	RUNX1 is downregulated or mutated in TLX1 T-ALL.	1,982,286	Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL	[ "The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL).", "Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3.", "This systems biology analysis ...	SUPPORT	[ 3, 5 ]
1,011	Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.	9,745,001	Radioiodine treatment of multinodular non-toxic goitre.	[ "OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. \n", "DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 mont...	CONTRADICT	[ 6, 12 ]
1,015	Rapamycin delays aging in fruit flies.	6,277,638	Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster	[ "The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals.", "The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and we...	SUPPORT	[ 2 ]
1,016	Rapamycin increases the concentration of triacylglycerols in fruit flies.	6,277,638	Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster	[ "The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals.", "The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and we...	NEI	[]
1,018	Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.	11,603,066	Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex	[ "Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges.", "Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reacti...	SUPPORT	[ 6 ]
1,023	Recognition of start codons depends on the translation initiation factor IF3.	16,927,286	Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation	[ "In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit.", "Here, we report 11 single-particle cryo-electron microscopy (cryoEM) reconstructions of the complex of bacterial 30S subunit with ini...	SUPPORT	[ 4 ]
1,025	Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.	32,408,470	Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo	[ "Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia.", "However, the mechanisms behind these effects are unclear.", "Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated pro...	NEI	[]
1,026	Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.	3,113,630	Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia	[ "Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene.", "Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration.", "Nuclear HDAC4 binds to chromatin, as well as ...	NEI	[]
1,027	Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.	3,113,630	Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia	[ "Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene.", "Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration.", "Nuclear HDAC4 binds to chromatin, as well as ...	NEI	[]
1,028	Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.	13,923,140	Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity	[ "Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation.", "Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory cytokine interleukin-2 (IL-2).", "...	SUPPORT	[ 2, 3 ]
1,028	Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.	11,899,391	Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.	[ "Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared with nondiseased, control individuals.", "Treg dysfu...	SUPPORT	[ 6 ]
1,030	Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.	6,441,369	MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency.	[ "The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements.", "However, it is unclear whether intrinsic epigenetic events can drive reprogramming to naive pluripotency or if distinct chromatin states are instead simply a reflection of discrete pluripotent ...	SUPPORT	[ 2 ]
1,031	Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.	12,486,491	Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning	[ "Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation.", "Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transform...	SUPPORT	[ 2 ]
1,032	Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.	6,836,086	Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli	[ "Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents.", "The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins.", "Assembly of this essential organelle occurs outside the c...	NEI	[]
1,033	Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.	6,836,086	Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli	[ "Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents.", "The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins.", "Assembly of this essential organelle occurs outside the c...	NEI	[]
1,034	Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.	4,547,102	H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.	[ "Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA).", "Bovine eight-cell SCNT embryos exhibit global hypermethylation of histone H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrinsic reason...	CONTRADICT	[ 3 ]
1,035	Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.	4,547,102	H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.	[ "Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA).", "Bovine eight-cell SCNT embryos exhibit global hypermethylation of histone H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrinsic reason...	SUPPORT	[ 3 ]
1,036	Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.	4,547,102	H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.	[ "Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA).", "Bovine eight-cell SCNT embryos exhibit global hypermethylation of histone H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrinsic reason...	SUPPORT	[ 3 ]
1,037	Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.	16,287,725	Reprogramming of human fibroblasts to pluripotency with lineage specifiers.	[ "Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process.", "However, unlike in mouse, OCT4 has not been replaced successfully ...	NEI	[]
1,038	Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.	16,287,725	Reprogramming of human fibroblasts to pluripotency with lineage specifiers.	[ "Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process.", "However, unlike in mouse, OCT4 has not been replaced successfully ...	NEI	[]
1,040	Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.	25,254,425	Nucleosome stability mediated by histone variants H3.3 and H2A.Z.	[ "Nucleosomes containing the histone variant H3.3 tend to be clustered in vivo in the neighborhood of transcriptionally active genes and over regulatory elements.", "It has not been clear, however, whether H3.3-containing nucleosomes possess unique properties that would affect transcription.", "We report here th...	SUPPORT	[ 3 ]
1,040	Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.	16,626,264	Genome-Wide Dynamics of Htz1, a Histone H2A Variant that Poises Repressed/Basal Promoters for Activation through Histone Loss	[ "Histone variants help specialize chromatin regions; however, their impact on transcriptional regulation is largely unknown.", "Here, we determined the genome-wide localization and dynamics of Htz1, the yeast histone H2A variant.", "Htz1 localizes to hundreds of repressed/basal Pol II promoters and prefers TATA...	NEI	[]
1,042	Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.	17,421,851	Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability.	[ "BACKGROUND Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties.", "Its expression and role in atherosclerosis, however, are unknown. \n", "METHODS AND RESULTS In the present study, we examined stable and unstable human carotid atherosclerotic plaques retrieved by en...	CONTRADICT	[ 6, 7 ]
1,043	Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)	17,671,145	ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer	[ "The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC).", "However, the determinants of AR overexpression in CRPC are poorly defined.", "Here we show that retinoic acid receptor-related orphan receptor γ (ROR-γ) is overexpressed and amplified in meta...	SUPPORT	[ 6, 7 ]
1,044	Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.	22,500,262	Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis	[ "During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis.", "Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphoryl...	SUPPORT	[ 4, 5 ]
1,045	Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.	22,500,262	Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis	[ "During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis.", "Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphoryl...	SUPPORT	[ 2, 3, 4, 5 ]
1,046	Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.	418,246	Pathway connectivity and signaling coordination in the yeast stress-activated signaling network	[ "Stressed cells coordinate a multi-faceted response spanning many levels of physiology.", "Yet knowledge of the complete stress-activated regulatory network as well as design principles for signal integration remains incomplete.", "We developed an experimental and computational approach to integrate available p...	NEI	[]
1,046	Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.	4,324,278	The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.	[ "The rapamycin-sensitive TOR signalling pathway in Saccharomyces cerevisiae activates a cell-growth program in response to nutrients such as nitrogen and carbon.", "The TOR1 and TOR2 kinases (TOR) control cytoplasmic protein synthesis and degradation through the conserved TAP42 protein.", "Upon phosphorylation ...	NEI	[]
1,046	Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.	16,712,164	Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling	[ "Healthy cells utilize intricate systems to monitor their environment and mount robust responses in the event of cellular stress.", "Whether stress arises from external insults or defects due to mutation and disease, cells must be able to respond precisely to mount the appropriate defenses.", "Multi-faceted str...	NEI	[]
1,047	Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain	14,706,752	Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor	[ "The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas.", "Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75(NTR) is required for p75(NTR)-mediated glioma i...	NEI	[]
1,048	Ribosomopathies have a high degree of cell and tissue specific pathology.	12,486,491	Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning	[ "Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation.", "Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transform...	SUPPORT	[ 5, 6 ]
1,050	Risedronate increases risk of vertebral and non-vertebral fractures.	19,878,070	Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.	[ "CONTEXT Risedronate, a potent bisphosphonate, has been shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases but, to our knowledge, it has not been evaluated in the treatment of established postmenopausal osteoporosis. \n", "OBJECTIVE To test the efficacy and safety ...	CONTRADICT	[ 8, 10 ]
1,052	Rising temperatures caused by global warming increases risk of dengue fever transmission.	18,816,720	Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages	[ "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and environment.", "An improved understanding of variation in transmission patte...	NEI	[]
1,053	Rising temperatures caused by global warming lowers the risk of dengue fever transmission.	18,816,720	Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages	[ "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and environment.", "An improved understanding of variation in transmission patte...	NEI	[]
1,054	Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.	10,072,941	Cardiovascular protection with antihypertensive drugs in dialysis patients: systematic review and meta-analysis.	[ "Epidemiological studies demonstrate that a lower blood pressure and decline in blood pressure over months or years are associated with higher mortality in dialysis patients.", "In contrast, randomized, controlled trials lack power to establish benefits of antihypertensive therapy.", "Patients on long-term dial...	SUPPORT	[ 4 ]
1,055	Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.	13,906,581	Patient Outcomes with Teaching Versus Nonteaching Healthcare: A Systematic Review	[ "Background Extensive debate exists in the healthcare community over whether outcomes of medical care at teaching hospitals and other healthcare units are better or worse than those at the respective nonteaching ones.", "Thus, our goal was to systematically evaluate the evidence pertaining to this question. ...	SUPPORT	[ 6, 13 ]
1,056	Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.	4,200,695	Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study	[ "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression. \n", "DESIGN R...	SUPPORT	[ 11 ]
1,058	Roughly 55% of women with chronic pelvic pain have no underlying pathology.	13,027,590	Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial.	[ "CONTEXT Chronic pelvic pain is a common condition with a major effect on health-related quality of life, work productivity, and health care use.", "Operative interruption of nerve trunks in the uterosacral ligaments by laparoscopic uterosacral nerve ablation (LUNA) is a treatment option for patients with chronic...	NEI	[]
1,065	Satellite cell dysfunction is a key factor in sarcopenia development.	20,418,809	Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia	[ "A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength.", "Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which are endogenous muscle stem cells, and impaired muscle regenera...	CONTRADICT	[ 3, 4 ]

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