metadata
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
dnamic
Whole-blood DNA-methylation predictor of intrinsic capacity, an average score across cognition, locomotion, psychological, sensory, and vitality domains; trained with tenfold cross-validated elastic net on INSPIRE-T and returning higher values for better capacity.
Model weights retain the original authors' terms; the pyaging software license does not relicense them.
| Predicts | intrinsic capacity |
| Species | Homo sapiens |
| Tissue | whole blood |
| Data type | DNA methylation |
| Model type | elastic net regression |
| Year | 2025 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["dnamic"])
Browse every clock in the pyaging Clock Catalogue.
Citation
Fuentealba, M., Rouch, L., Guyonnet, S. et al. A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. Nature Aging 5, 1207–1216 (2025).