metadata
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
downsyndrome
Implementation-derived Down-syndrome-associated methylation projection score: pyaging computes a zero-intercept weighted sum of 652 neonatal blood-spot beta values using the paper's autosomal EWAS beta_overall effect estimates. The paper presents an EWAS, not a trained or validated Down syndrome classifier.
Model weights retain the original authors' terms; the pyaging software license does not relicense them.
| Predicts | Down syndrome methylation score |
| Species | Homo sapiens |
| Tissue | neonatal blood spots |
| Data type | DNA methylation |
| Model type | weighted linear score |
| Year | 2021 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["downsyndrome"])
Browse every clock in the pyaging Clock Catalogue.
Citation
Muskens, Ivo S., et al. "The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis." Nature Communications 12 (2021): 821.