metadata
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
replitali
Final RepliTali model estimating relative cumulative replicative history from methylation in common partially methylated domains; it was fitted to normalized population doublings across serially cultured primary human cells.
Model weights retain the original authors' terms; the pyaging software license does not relicense them.
| Predicts | replicative history |
| Species | Homo sapiens |
| Tissue | cultured primary human cells |
| Data type | DNA methylation |
| Model type | elastic net regression |
| Year | 2022 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["replitali"])
Browse every clock in the pyaging Clock Catalogue.
Citation
Endicott, J.L., Nolte, P.A., Shen, H. & Laird, P.W. Cell division drives DNA methylation loss in late-replicating domains in primary human cells. Nature Communications 13, 6659 (2022).