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TITLE: Evaluation of the functional efficacy of an antioxidative probiotic in healthy volunteers
ABSTRACT.BACKGROUND:
In persons without clinical symptom it is difficult to assess an impact of probiotics regarding its effect on health. We evaluated the functional efficacy of the probiotic Lactobacillus fermentum ... | Intervention: L. fermentum ME-3 fermented goat milk
Comparator: goat milk
Outcome: Total Antioxidative Activity | 1 | {"evidence_spans": [{"end": 1735, "start": 1371, "text": " groups. Faecal recovery of ME-3 was documented by molecular methods only in fermented milk group, however the significant improvement of blood TAA (Total Antioxidative Activity) and TAS (Total Antioxidative Status) indices was seen both in case of fermented goa... |
TITLE: A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change
ABSTRACT.BACKGROUND:
To examine the effects of a 6 month lifestyle intervention on quality of life, depression, self-efficacy and eating behavior changes in overwe... | Intervention: lost weight
Comparator: no weight lost
Outcome: depression | -1 | {"evidence_spans": [{"end": 20425, "start": 20314, "text": "and 1.0 in women who did not lose weight. Women who lost weight had improvement in depression (2.3 versus 1.2) "}], "id": "961", "pmcid": "2656477", "prompt_id": "961", "split_group_id": "2656477", "votes": {"-1": 1}} |
TITLE: Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability
ABSTRACT:
The beneficial health effects of cranberries have been attributed to their (poly)phenol content. Recent studies have investigated the absorption, metabol... | Intervention: cranberry juices
Comparator: nothing
Outcome: flavonols, valerolactones, benzoic acids, cinnamic acids, phenylacetic acids, benzaldehydes | 1 | {"evidence_spans": [{"end": 12779, "start": 12385, "text": " in the interventions. Linear regression analysis was performed between the TP level in the intervention and the AUC of each class of compounds. The AUC for flavonols produced the highest r2 (0.97, p < 0.001), followed by the valerolactones (r2 = 0.89, p < 0.... |
TITLE: Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability
ABSTRACT:
The beneficial health effects of cranberries have been attributed to their (poly)phenol content. Recent studies have investigated the absorption, metabol... | Intervention: cranberry juices
Comparator: nothing
Outcome: 12 (poly)phenol metabolites | 1 | {"evidence_spans": [{"end": 14445, "start": 14151, "text": "he other juices (p < 0.001). A positive, linear dose response for total excretion over 24 h of each urinary metabolite was assessed and of the 60 identified metabolites, 12 (poly)phenol metabolites displayed a positive linear dose-response curve (r2 \u2265 0.... |
TITLE: The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis (OA): a knowledge translation (KT) randomized controlled trial (RCT): Part I: The Uptake of the Ottawa Panel clinical practice guidelines (CPGs)
ABSTRACT.BACKGROUND:
The implementation of evidence based... | Intervention: Walking and Behavioural intervention (WB)
Comparator: Self-directed control (C)
Outcome: Short-term adherence to the program at 3 months | 1 | {"evidence_spans": [{"end": 1794, "start": 1708, "text": "ESULTS:\r\nShort-term program adherence was greater in WB compared to C (p<0.012) after "}, {"end": 31535, "start": 31351, "text": "rop out and were reported as means (+/\u2212standard deviation) for each time period between groups (Table \r\n4). Statistically s... |
TITLE: The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis (OA): a knowledge translation (KT) randomized controlled trial (RCT): Part I: The Uptake of the Ottawa Panel clinical practice guidelines (CPGs)
ABSTRACT.BACKGROUND:
The implementation of evidence based... | Intervention: Walking and Behavioural intervention (WB)
Comparator: Self-directed control (C)
Outcome: Total adherence to the program | 0 | {"evidence_spans": [{"end": 1933, "start": 1795, "text": " months. No statistical significance (p> 0.05) was observed for long-term adherence (6 to 12 months), and total adherence between the thre"}], "id": "971", "pmcid": "3491047", "prompt_id": "971", "split_group_id": "3491047", "votes": {"0": 2}} |
TITLE: Treatment costs associated with interventional cancer clinical trials conducted at a single UK institution over 2 years (2009–2010)
ABSTRACT.BACKGROUND::
The conduct of clinical trials should be an integral part of routine patient care. Treating patients in trials incurs additional costs over and above sta... | Intervention: Academic, non-commercial sponsored trials
Comparator: Commercial sponsored trials
Outcome: Extra clinic visits and CT scans assessments | -1 | {"evidence_spans": [{"end": 15404, "start": 15215, "text": " in addition to SOC. The contribution of extra clinic visits and investigations, in particular CT scans used for response assessment, was significantly higher for commercial compared with n"}], "id": "976", "pmcid": "3798949", "prompt_id": "976", "split_group_... |
TITLE: The effect of aerobic exercise in the maintenance treatment of depression
ABSTRACT:
We investigated the efficacy of aerobic exercise alongside antidepressant medication as an adjuvant maintenance treatment for depression. Fifty patients in remission were randomly assigned to either medication only or medic... | Intervention: Medication plus exercise
Comparator: Medication only
Outcome: Improvement in Presumptive Stressful Life Events Scale | 0 | {"evidence_spans": [{"end": 6800, "start": 6708, "text": " (P = 0.02, t = 2.42); there was no significant difference between the groups' PSLES scores "}], "id": "979", "pmcid": "5619630", "prompt_id": "979", "split_group_id": "5619630", "votes": {"0": 2}} |
TITLE: The effect of aerobic exercise in the maintenance treatment of depression
ABSTRACT:
We investigated the efficacy of aerobic exercise alongside antidepressant medication as an adjuvant maintenance treatment for depression. Fifty patients in remission were randomly assigned to either medication only or medic... | Intervention: Medication plus exercise
Comparator: Medication only
Outcome: Relapse rates | 0 | {"evidence_spans": [{"end": 8433, "start": 7966, "text": "6 (5.4) 2.42 41 0.02 Relapse rates were also recorded via subjective reports and as a measured increase of >50% from baseline HRSD scores (Neumeister et al, 1997). In total, nine patients relapsed, two from the medication-plus-exercise group (both in week 18) ... |
TITLE: Singing teaching as a therapy for chronic respiratory disease - a randomised controlled trial and qualitative evaluation
ABSTRACT.BACKGROUND:
Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies ... | Intervention: Singing classes
Comparator: Usual care
Outcome: Improvement in HAD anxiety score | 1 | {"evidence_spans": [{"end": 1135, "start": 1044, "text": " = 0.02. Singers also had a significant fall in HAD anxiety score; -1.1(2.7) vs. +0.8(1.7) "}], "id": "987", "pmcid": "2920262", "prompt_id": "987", "split_group_id": "2920262", "votes": {"1": 2}} |
TITLE: The Effect of Stretching Exercises on Severity of Restless Legs Syndrome in Patients on Hemodialysis
ABSTRACT.BACKGROUND:
The restless legs syndrome is a sensorimotor disorder that is very common in patients on hemodialysis. Due to pharmacological treatments which have their own side effects, nowadays, stu... | Intervention: Stretching exercises
Comparator: No exercises
Outcome: Symptom severity after 4 weeks | 0 | {"evidence_spans": [{"end": 12203, "start": 12010, "text": "P < 0.001); B and C, SN (P < 0.001). Also the results of t-test show that the changes in the severity of RLS symptoms before intervention and after 4 weeks were not statistically meaningful b"}], "id": "1009", "pmcid": "5003313", "prompt_id": "1009", "split_... |
TITLE: Comparing the Hemodynamic Effects of Spinal Anesthesia in Preeclamptic and Healthy Parturients During Cesarean Section
ABSTRACT.BACKGROUND:
Despite controversies about the safest anesthetic technique for cesarean delivery in severely preeclamptic women, there is evidence that supports the use of spinal ane... | Intervention: Low-dose bupivacaine spinal anesthesia in pre-eclamptic parturients
Comparator: Low-dose bupivacaine spinal anesthesia in healthy parturients
Outcome: Five-minute Apgar score | 0 | {"evidence_spans": [{"end": 2043, "start": 1822, "text": "(P = 0.02). The one-minute Apgar score was significantly lower for the preeclamptic parturients (8.4 \u00b1 0.7 versus 7.2 \u00b1 1.5) (P = 0.001), but there was no significant difference in the five-minute Apgar scores between the"}, {"end": 2043, "start": 1952... |
TITLE: The Effect of Desmopressin on the Amount of Bleeding in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Cardiopulmonary Bypass Pump After Taking Anti-Platelet Medicine
ABSTRACT.BACKGROUND:
Coronary artery bypass grafting (CABG) is a common surgical intervention at the end-stages of coronary... | Intervention: Desmopressin
Comparator: Placebo
Outcome: Bleeding rate after surgery | 0 | {"evidence_spans": [{"end": 2127, "start": 1944, "text": "(P > 0.05). No significant difference was noted between the groups regarding the rate of bleeding after surgery (359.3 \u00b1 266.2 in group D vs. 406.3 \u00b1 341.6 in group P (control group);"}], "id": "1015", "pmcid": "5101425", "prompt_id": "1015", "split_gr... |
TITLE: The Effect of Desmopressin on the Amount of Bleeding in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Cardiopulmonary Bypass Pump After Taking Anti-Platelet Medicine
ABSTRACT.BACKGROUND:
Coronary artery bypass grafting (CABG) is a common surgical intervention at the end-stages of coronary... | Intervention: Desmopressin
Comparator: Placebo
Outcome: Hb levels | 0 | {"evidence_spans": [{"end": 14269, "start": 14079, "text": "rtial thromboplastin time. a Independent T-test. b ANCOVA. c Paired T-test. A paired T-test revealed that the Hb levels decreased significantly in each group after surgery (P = 0.0001), bu"}, {"end": 14269, "start": 14109, "text": "ndependent T-test. b ANCOV... |
TITLE: Management of
ABSTRACT.INTRODUCTION::
Prevalence of diabetes and its complications have been a burden to the society from the ancient times, in the present and also will be in the future unless proper measures are taken to prevent its manifestation. There have been an increasing number of death associated... | Intervention: Katupila Kalka with Tila Taila
Comparator: Betadine ointment
Outcome: Healing of diabetic wounds | 1 | {"evidence_spans": [{"end": 1370, "start": 1149, "text": ".RESULTS::\r\nIn Group A, diabetic wounds treated with Katupila paste got healed within 28 days with minimal scar formation without any complications, whereas in Group B, wound was healed completely only in two patients wit"}, {"end": 13451, "start": 13310, "tex... |
TITLE: A randomised controlled trial to prevent smoking relapse among recently quit smokers enrolled in employer and health plan sponsored quitlines
ABSTRACT.OBJECTIVE:
To test adding an interactive voice response (IVR)-supported protocol to standard quitline treatment to prevent relapse among recently quit smoke... | Intervention: Technology Enhanced Quitline-10 and Technology Enhanced Quitline-20
Comparator: Standard quitline treatment
Outcome: Time to relapse | 0 | {"evidence_spans": [{"end": 33697, "start": 33613, "text": "0, Technology Enhanced Quitline-10. \r\n\r\nBODY.RESULTS.TIME TO RELAPSE:\r\nThere was no "}, {"end": 33708, "start": 33613, "text": "0, Technology Enhanced Quitline-10. \r\n\r\nBODY.RESULTS.TIME TO RELAPSE:\r\nThere was no significant"}], "id": "1027", "pmcid... |
TITLE: Tranexamic acid for patients with traumatic brain injury: a randomized, double-blinded, placebo-controlled trial
ABSTRACT.BACKGROUND:
Traumatic brain injury (TBI) is commonly accompanied by intracranial bleeding which can worsen after hospital admission. Tranexamic acid (TXA) has been shown to reduce bleed... | Intervention: Tranexamic acid
Comparator: Placebo
Outcome: Risk of death | 0 | {"evidence_spans": [{"end": 1846, "start": 1690, "text": " 1.05)]. There were no significant difference in the risk of death from all causes in patients allocated to TXA compared with placebo [RR = 0.69 (95% CI 0.3"}, {"end": 1949, "start": 1690, "text": " 1.05)]. There were no significant difference in the risk of dea... |
TITLE: Tranexamic acid for patients with traumatic brain injury: a randomized, double-blinded, placebo-controlled trial
ABSTRACT.BACKGROUND:
Traumatic brain injury (TBI) is commonly accompanied by intracranial bleeding which can worsen after hospital admission. Tranexamic acid (TXA) has been shown to reduce bleed... | Intervention: Tranexamic acid
Comparator: Placebo
Outcome: Risk of thromboembolic events | 0 | {"evidence_spans": [{"end": 2050, "start": 1950, "text": " 1.27)]. There was no evidence of increased risk of thromboembolic events in those patients allocate"}], "id": "1031", "pmcid": "4221638", "prompt_id": "1031", "split_group_id": "4221638", "votes": {"0": 2}} |
TITLE: How do patients with severe mental diagnosis cope in everyday life - a qualitative study comparing patients’ experiences of self-referral inpatient treatment with treatment as usual?
ABSTRACT.BACKGROUND:
Several hospitals in Norway provide short self-referral inpatient treatment to patients with severe men... | Intervention: Self-referral treatment
Comparator: Inpatient treatment
Outcome: Negative feelings | -1 | {"evidence_spans": [{"end": 1560, "start": 1438, "text": "ategies. Patients with a contract also expressed less resignation, hopelessness and powerlessness than patients without a "}], "id": "1033", "pmcid": "4138383", "prompt_id": "1033", "split_group_id": "4138383", "votes": {"-1": 1}} |
TITLE: Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes
ABSTRACT.BACKGROUND:
This randomized, partially single-blinded, 6-period crossover clinical study of adult smokers compared the nicotine pharmacokinetics, impacts on smoki... | Intervention: E-cigarettes
Comparator: Conventional tobacco cigarette
Outcome: Baseline nicotine concentrations | 0 | {"evidence_spans": [{"end": 24175, "start": 23920, "text": "ne concentration-time profiles are presented in Fig. 1. Baseline nicotine concentrations were below the limit of quantification in the majority of subjects and mean baseline nicotine concentrations were comparable across study products, all representing l"}, {... |
TITLE: Physiological effects of invasive ventilation with neurally adjusted ventilatory assist (NAVA) in a crossover study
ABSTRACT.BACKGROUND:
Neurally Adjusted Ventilatory Assist (NAVA) is a mode of assisted mechanical ventilation that delivers inspiratory pressure proportionally to the electrical activity of t... | Intervention: Neurally Adjusted Ventilatory Assist
Comparator: Conventional Ventilation
Outcome: Peak inspiratory pressures | -1 | {"evidence_spans": [{"end": 1655, "start": 1531, "text": "= 0.34). Ventilation with NAVA delivered lower peak inspiratory pressures than with CV: -32.7 % (95 % CI: -48.2 to \u201317.1 %, "}, {"end": 1656, "start": 1531, "text": "= 0.34). Ventilation with NAVA delivered lower peak inspiratory pressures than with CV: -32... |
TITLE: Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study
ABSTRACT:
The aim of this study was to investigate the safety of injection of bone marrow aspirate concentrate during core decompression and to study its clinical (visual an... | Intervention: core decompression with the application of bone marrow aspirate concentrate
Comparator: core decompression only
Outcome: clinical outcome | 0 | {"evidence_spans": [{"end": 897, "start": 811, "text": "d. However, there was no difference in the clinical outcome between the two study grou"}, {"end": 10440, "start": 10336, "text": "ation period was observed. However, there was no difference in the clinical outcome between the two stud"}], "id": "1069", "pmcid": "4... |
TITLE: Attenuating effect of
ABSTRACT.BACKGROUND/OBJECTIVES:
Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in... | Intervention: Capsules (300 mg) containing Lactobacillus brevis G101 (1×1010 CFU/individual)
Comparator: maltodextrin (placebo)
Outcome: The intensity of the MSG symptom complex (characterized by unpleasant reactions such as numbness, tingling, headaches, muscle tightness, general weakness, and flushing ) | -1 | {"evidence_spans": [{"end": 1036, "start": 837, "text": "tudy. The intensity of the MSG symptom complex was significantly reduced in respondents of the G101 intake group (2.87 \u00b1 0.73) compared to that in those treated with the placebo (3.63 \u00b1 1.03) (P = 0."}, {"end": 6638, "start": 6531, "text": "(1 = none, 5... |
TITLE: Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma
ABSTRACT.PURPOSE:
To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) ≥ 6 clock... | Intervention: laser peripheral iridotomy (LPI) group 1
Comparator: primary trabeculectomy group 2
Outcome: Cataract progression | 0 | {"evidence_spans": [{"end": 11411, "start": 11224, "text": "umber needed to harm (NNH) is 50. Cataract progression as defined was documented in 2 eyes (5.3%, CI: \u22121.8%\u201312.4%) in group 1 and 16 eyes (14.4%, CI: 7.9%\u201320.9%) in group 2 (Pearson's ch"}], "id": "1085", "pmcid": "5610854", "prompt_id": "1085"... |
TITLE: A randomized, double-blind comparison of OROS
ABSTRACT.BACKGROUND:
Long-acting opioid formulations are advocated for maintaining pain control in chronic cancer pain. OROS® hydromorphone is a sustained-release formulation of hydromorphone that requires dosing once daily to maintain therapeutic concentration... | Intervention: hydromorphone
Comparator: morphine
Outcome: mean ± SD investigator global assessment scores | 0 | {"evidence_spans": [{"end": 24868, "start": 24587, "text": "he end of each study phase (Figure 7). Mean \u00b1 SD patient global assessment scores at the end of the SR phase were 3.2 \u00b1 1.14 for the OROS\u00ae hydromorphone group and 3.3 \u00b1 0.98 for the CR morphine group (p = 0.6696); mean \u00b1 SD investigato... |
TITLE: A randomized, double-blind comparison of OROS
ABSTRACT.BACKGROUND:
Long-acting opioid formulations are advocated for maintaining pain control in chronic cancer pain. OROS® hydromorphone is a sustained-release formulation of hydromorphone that requires dosing once daily to maintain therapeutic concentration... | Intervention: hydromorphone
Comparator: morphine
Outcome: mean scores for the secondary efficacy variables and MMSE and ECOG scores | 0 | {"evidence_spans": [{"end": 22102, "start": 21868, "text": "RESULTS.EFFICACY.SECONDARY ENDPOINTS:\r\nAt the end of the IR phase, mean scores for the secondary efficacy variables (other assessments of pain from the BPI [Table 3 and Figure 4], and MMSE and ECOG scores [data not shown]) were simila"}, {"end": 22210, "star... |
TITLE: A randomized, double-blind comparison of OROS
ABSTRACT.BACKGROUND:
Long-acting opioid formulations are advocated for maintaining pain control in chronic cancer pain. OROS® hydromorphone is a sustained-release formulation of hydromorphone that requires dosing once daily to maintain therapeutic concentration... | Intervention: hydromorphone
Comparator: morphine
Outcome: 'pain now PM' | -1 | {"evidence_spans": [{"end": 1933, "start": 1749, "text": "lations. BPI 'pain now PM' was significantly lower with OROS\u00ae hydromorphone compared with controlled-release morphine (least-squares mean difference [95% CI], -0.77 [-1.49, -0.05]; p ="}, {"end": 22986, "start": 22804, "text": "age pain', and 'pain now AM';... |
TITLE: Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: a randomized, double-blind study
ABSTRACT.OBJECTIVE:
Despite the many complications of succinylcholine, it is still widely used as a superior muscle relaxant for rapid sequence induction. One of these com... | Intervention: Group K, 0.5 mg/kg of ketamine was injected intravenously,
Comparator: Group N, the same volume (5 mL) of normal saline was injected
Outcome: Postoperative myalgia (POM) | -1 | {"evidence_spans": [{"end": 1621, "start": 1459, "text": "P>0.05). Overall, the incidence of POM in Group K was significantly less, when compared with Group N (P<0.05), but both groups were comparable based on the grade "}], "id": "1108", "pmcid": "4940009", "prompt_id": "1108", "split_group_id": "4940009", "votes": {"... |
TITLE: Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: a randomized, double-blind study
ABSTRACT.OBJECTIVE:
Despite the many complications of succinylcholine, it is still widely used as a superior muscle relaxant for rapid sequence induction. One of these com... | Intervention: Group K, 0.5 mg/kg of ketamine was injected intravenously,
Comparator: Group N, the same volume (5 mL) of normal saline was injected
Outcome: Changes in heart rate after induction and intubation | 0 | {"evidence_spans": [{"end": 10158, "start": 9956, "text": "oth groups (P>0.05). Changes in heart rate after induction and intubation between the two groups were compared and repeated measures of variance analysis showed no significant difference in the two grou"}], "id": "1109", "pmcid": "4940009", "prompt_id": "1109",... |
TITLE: Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: a randomized, double-blind study
ABSTRACT.OBJECTIVE:
Despite the many complications of succinylcholine, it is still widely used as a superior muscle relaxant for rapid sequence induction. One of these com... | Intervention: Group K, 0.5 mg/kg of ketamine was injected intravenously,
Comparator: Group N, the same volume (5 mL) of normal saline was injected
Outcome: the incidence of POM | -1 | {"evidence_spans": [{"end": 1560, "start": 1459, "text": "P>0.05). Overall, the incidence of POM in Group K was significantly less, when compared with Group N "}, {"end": 1621, "start": 1459, "text": "P>0.05). Overall, the incidence of POM in Group K was significantly less, when compared with Group N (P<0.05), but both... |
TITLE: Clinical efficacy of
ABSTRACT:
Aging has become one of the distinctive demographic phenomena in the 21st century and its social, economic and health implications are the most challenging issues. Senile Memory Impairment is a common condition characterized by mild symptoms of cognitive decline and occurs a... | Intervention: administered with the Granules of Guduchyadi Medhya Rasayana (GMR), which contains Guduchi (Tinospora cordifolia Wild.), Apamarga (Achyranthes aspera Linn.), Vidanga (Embelia ribes Burm. f.), Shankhapushpi (Convolvulus pluricaulis Chois.), Vaca (Acorus calamus Linn.), Haritaki (Terminalia chebula Zetz.), ... | -1 | {"evidence_spans": [{"end": 12189, "start": 11974, "text": " hematological parameters in Group A (n=43) With regard to the biochemical parameters, Group A showed highly significant decrease (P`0.01) in serum cholesterol, serum triglyceride, low density lipoprotein (LDL), a"}, {"end": 12397, "start": 12017, "text": " ... |
TITLE: Clinical efficacy of
ABSTRACT:
Aging has become one of the distinctive demographic phenomena in the 21st century and its social, economic and health implications are the most challenging issues. Senile Memory Impairment is a common condition characterized by mild symptoms of cognitive decline and occurs a... | Intervention: administered with the Granules of Guduchyadi Medhya Rasayana (GMR), which contains Guduchi (Tinospora cordifolia Wild.), Apamarga (Achyranthes aspera Linn.), Vidanga (Embelia ribes Burm. f.), Shankhapushpi (Convolvulus pluricaulis Chois.), Vaca (Acorus calamus Linn.), Haritaki (Terminalia chebula Zetz.), ... | 1 | {"evidence_spans": [{"end": 12893, "start": 12633, "text": "on biochemical parameters in Group A (n=43) Regarding the overall effect, Group A showed marked improvement in 18.6% patients, moderate improvement in 74.4% patients and mild improvement in 7.0% patients, while Group B showed moderate improvement in 32.2% pa... |
TITLE: Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients
ABSTRACT.INTRODUCTION:
Physical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise ... | Intervention: high-intensity interval training (HIT) for 12-weeks in patients NYHA II-III
Comparator: continuous training (CT) 12-weeks inpatients NYHA II-III
Outcome: brachial and superficial femoral artery diameter, peak blood flow, and FMD | 0 | {"evidence_spans": [{"end": 21948, "start": 21828, "text": "up and time*group P-values. \r\n\r\nBODY.RESULTS.IMPACT OF EXERCISE TRAINING.VASCULAR FUNCTION/STRUCTURE:\r\nWe found no si"}], "id": "1135", "pmcid": "4627811", "prompt_id": "1135", "split_group_id": "4627811", "votes": {"0": 2}} |
TITLE: Efficacy and Safety of Tiropramide in the Treatment of Patients With Irritable Bowel Syndrome: A Multicenter, Randomized, Double-blind, Non-inferiority Trial, Compared With Octylonium
ABSTRACT.BACKGROUND/AIMS:
Antispasmodics such as octylonium are widely used to manage irritable bowel syndrome (IBS) sympto... | Intervention: tiropramide 100
Comparator: octylonium 20 mg
Outcome: The VAS scores of abdominal pain at week 4 | 0 | {"evidence_spans": [{"end": 1447, "start": 1255, "text": "ESULTS:\r\nThe VAS scores of abdominal pain at week 4, were significantly decreased in both tiropramide and octylonium groups, but the change from baseline did not differ between the 2 groups (d"}, {"end": 1464, "start": 1448, "text": "fference,-0.26 m"}, {"end"... |
TITLE: Benefits of different postoperative treatments in patients undergoing knee arthroscopic debridement
ABSTRACT.PURPOSE:
To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal p... | Intervention: five injections of HA1 (Suprahyal®/Adant®)
Comparator: standard care (control)
Outcome: At early follow-up (3 months), total WOMAC scores Western Ontario and McMaster Universities Arthritis Index (WOMAC) | -1 | {"evidence_spans": [{"end": 14734, "start": 14510, "text": "tient was possible.\r\n\r\nBODY.EFFICACY:\r\nAt early follow-up (3 months), total WOMAC scores improved as compared to baseline, in all groups with reductions of 44.79% (HA1), 24.0% (HA2), 40.38% (HA3), 39.77% (PRP), and 27.64% (c"}], "id": "1147", "pmcid": "5... |
TITLE: Benefits of different postoperative treatments in patients undergoing knee arthroscopic debridement
ABSTRACT.PURPOSE:
To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal p... | Intervention: three injections of HA3 (Synvisc®)
Comparator: standard care (control)
Outcome: At 18 months, the higher improvement in total WOMAC | 1 | {"evidence_spans": [{"end": 1568, "start": 1318, "text": "to HA2). At 18 months, the higher improvement in total WOMAC was in HA1 with a 65.20% reduction, followed by PRP (55.01%), HA3 (49.57%), and HA2 (29.82%), whereas the control group had a 14.55% increase over baseline (p=0.001 control compared to HA1 "}], "id": "... |
TITLE: Benefits of different postoperative treatments in patients undergoing knee arthroscopic debridement
ABSTRACT.PURPOSE:
To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal p... | Intervention: four injections of HA2 (Orthovisc®)
Comparator: standard care (control)
Outcome: At 18 months, the higher improvement in total WOMAC | 0 | {"evidence_spans": [{"end": 15118, "start": 14736, "text": "trol), (p=0.002 HA1 compared to HA2). At 18 months, a higher improvement in total WOMAC was observed in HA1 with a 65.20% reduction, followed by PRP (55.01%), HA3 (49.57%), and HA2 (29.82%), whereas the control group had a 14.5% increase over baseline despite... |
TITLE: Benefits of different postoperative treatments in patients undergoing knee arthroscopic debridement
ABSTRACT.PURPOSE:
To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal p... | Intervention: 1) five injections of HA1 (Suprahyal®/Adant®); 2) four injections of HA2 (Orthovisc®); 3) three injections of HA3 (Synvisc®); 4) a single injection of PRP (GPSTM II);
Comparator: standard care (control)
Outcome: The percentage of patients achieving the MCII for both pain and function at 18 months | 1 | {"evidence_spans": [{"end": 15745, "start": 15326, "text": "40% (HA3), 30% PRP, and 30% (control). At the end of follow-up, a growing number of patients experienced a clinically significant improvement in HA1 with a 100% responders rate, followed by HA3 (80%). In the group treated with HA2 and in those treated with PRP... |
TITLE: Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes
ABSTRACT.BACKGROUND:
Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent pati... | Intervention: neurally adjusted ventilatory assist (NAVA)
Comparator: pressure support ventilation (PSV)
Outcome: Proportions of REM sleep duration | 1 | {"evidence_spans": [{"end": 1709, "start": 1552, "text": "f sleep. Proportions of REM sleep duration were different in the two ventilatory modes (4.5% (range, 3-11%) in PSV and 16.5% (range, 13-29%) during NAVA (p ="}, {"end": 1834, "start": 1552, "text": "f sleep. Proportions of REM sleep duration were different in th... |
TITLE: Repair of Giant Midline Abdominal Wall Hernias: “Components Separation Technique” versus Prosthetic Repair
ABSTRACT.BACKGROUND:
Reconstruction of giant midline abdominal wall hernias is difficult, and no data are available to decide which technique should be used. It was the aim of this study to compare th... | Intervention: components separation technique (CST)
Comparator: prosthetic repair with e-PTFE patch (PR)
Outcome: Reherniation | 0 | {"evidence_spans": [{"end": 16301, "start": 16239, "text": "ed during the first 7 months after implantation. Reherniation "}], "id": "668", "pmcid": "1913177", "prompt_id": "668", "split_group_id": "1913177", "votes": {"0": 1}} |
TITLE: Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies
ABSTRACT.INTRODUCTION:
To examine pooled efficacy data from three, large phase III studies comparing mirabegron (50... | Intervention: mirabegron (50 and 100 mg)
Comparator: placebo
Outcome: the Treatment Satisfaction-Visual Analogue Scale (TS-VAS) | 1 | {"evidence_spans": [{"end": 29839, "start": 29441, "text": "7, 2.09), respectively (p < 0.05). In health-related quality of life outcomes, mirabegron 50 and 100 mg was associated with a statistically significant improvement in the TS-VAS score at Final Visit compared with placebo (p < 0.05; Table 2). The adjusted mean... |
TITLE: Effects of a balance-based exergaming intervention using the Kinect sensor on posture stability in individuals with Parkinson’s disease: a single-blinded randomized controlled trial
ABSTRACT.BACKGROUND:
The present study examined the effects of a balance-based exergaming intervention using the Kinect senso... | Intervention: a balance-based exergaming group for an 8-week balance training period.
Comparator: a balance training group for an 8-week balance training period.
Outcome: directional control in the LOS test | 1 | {"evidence_spans": [{"end": 1408, "start": 1201, "text": "ormance. Furthermore, balance-based exergaming training resulted in significantly better performance in directional control in the LOS test (78.9 \u00b1 7.65 %) compared with conventional balance training (70.6 \u00b1"}], "id": "1181", "pmcid": "5002324", "promp... |
TITLE: The Effect of Breathing Exercises on the Nocturnal Enuresis in the Children with the Sleep-Disordered Breathing
ABSTRACT.BACKGROUND:
The nocturnal enuresis is one of the most common complaints of childhood. Upper airway obstruction and nocturnal snoring affect the nocturnal enuresis in children.
ABSTRAC... | Intervention: breathing exercises were performed for 45 minutes, and were pursued for four weeks in the morning following and prior to sleeping
Comparator: no breathing exercises
Outcome: The nocturnal enuresis | -1 | {"evidence_spans": [{"end": 1494, "start": 1385, "text": " < 0.0001). The nocturnal enuresis decreased significantly in the case group, compared to the control group ("}, {"end": 13338, "start": 13198, "text": "ian of nocturnal enuresis frequency was similar in both groups (P > 0.001). After intervention, the median of... |
TITLE: An Open Label, Randomised Trial of Artesunate+Amodiaquine, Artesunate+Chlorproguanil-Dapsone and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria
ABSTRACT.BACKGROUND:
Artesunate+amodiaquine (AS+AQ) and artemether-lumefantrine (AL) are now the most frequently recommended first line treatme... | Intervention: Artesunate+amodiaquine (AS+AQ)
Comparator: artemether-lumefantrine (AL) and Artesunate+chlorproguanil-dapsone (AS+CD)
Outcome: the parasitological and clinical failure rate at day 28 post treatment | 0 | {"evidence_spans": [{"end": 1722, "start": 1535, "text": "omiting. However, the PCF28 corrected for re-infection was lower, though not significantly, in the AS+AQ group compared to the AL or the AS+CD groups (AS+AQ 18.3%; AL 24.2%; AS+CD 20.8%, "}], "id": "678", "pmcid": "2430614", "prompt_id": "678", "split_group_id":... |
TITLE: Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet
ABSTRACT:
Oxidative stress has previously been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications. In the present study, the effects ... | Intervention: high-fat diet enriched with ground flaxseed 15 g/100 g of food, rich in ALA;
Comparator: received a high-fat diet (40% energy as fat), deficient in ?-linolenic acid (ALA)
Outcome: HDL-C levels | 1 | {"evidence_spans": [{"end": 11656, "start": 11486, "text": "ompared with those in the control group. Flaxseed supplementation significantly decreased serum TC and non-HDL-C levels and increased HDL-C levels (Table II) compared wit"}, {"end": 11656, "start": 11488, "text": "pared with those in the control group. Flaxsee... |
TITLE: Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet
ABSTRACT:
Oxidative stress has previously been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications. In the present study, the effects ... | Intervention: high-fat diet enriched with ground flaxseed 15 g/100 g of food, rich in ALA; or enriched with vitamin E, 40 mg ?-tocopherol/100 g of food
Comparator: received a high-fat diet (40% energy as fat), deficient in ?-linolenic acid (ALA)
Outcome: the aortic cholesterol content | -1 | {"evidence_spans": [{"end": 12163, "start": 12019, "text": "th those in the control group (Table II). Flaxseed or/and vitamin E supplementation of the diet significantly decreased the aortic cholesterol c"}], "id": "1207", "pmcid": "4280954", "prompt_id": "1207", "split_group_id": "4280954", "votes": {"-1": 2}} |
TITLE: The display effects of patients’ self-assessment on traumatic acute pain on the proportion and timing of analgesics administration in the emergency department
ABSTRACT.BACKGROUND:
Acute pain assessment in the emergency department (ED) is important in particular during the triage process. Early pain assessm... | Intervention: pain score display group
Comparator: not displayed in the control.
Outcome: The proportion of patients who received analgesics | 0 | {"evidence_spans": [{"end": 1165, "start": 972, "text": "ESULTS:\r\nThe proportion of patients who received analgesics when pain score was displayed was 6.5% more than when pain score was not displayed. This difference was however not statistically sig"}], "id": "1209", "pmcid": "4306068", "prompt_id": "1209", "split_g... |
TITLE: Implementing a structured education program for children with diabetes: lessons learnt from an integrated process evaluation
ABSTRACT.BACKGROUND:
There is recognition of an urgent need for clinic-based interventions for young people with type 1 diabetes mellitus that improve glycemic control and quality of... | Intervention: The Child and Adolescent Structured Competencies Approach to Diabetes Education (CASCADE) is a structured educational group program, using psychological techniques, delivered primarily by diabetes nurses.
Comparator: control
Outcome: HbA1c at 12 or 24?months. | 0 | {"evidence_spans": [{"end": 1805, "start": 1696, "text": "disease. The results of the trial showed that the intervention did not significantly improve HbA1c at 12 or 2"}, {"end": 10018, "start": 9722, "text": " assessed by the trial.11 Given that the trial found no evidence of benefits on venous HbA1c at 12 and 24 mont... |
TITLE: Cost-effectiveness of ranibizumab in treatment of diabetic macular oedema (DME) causing visual impairment: evidence from the RESTORE trial
ABSTRACT.BACKGROUND/AIMS:
To evaluate the cost-effectiveness of ranibizumab as either monotherapy or combined with laser therapy, compared with laser monotherapy, in th... | Intervention: ranibizumab
Comparator: ranibizumab combined with laser therapy
Outcome: ICER (incremental cost-effectiveness ratio) | -1 | {"evidence_spans": [{"end": 19699, "start": 19341, "text": "rected visual acuity. Ranibizumab monotherapy was associated with an incremental gain of 0.17 QALY and cost of \u00a34 191, corresponding to an ICER of \u00a324 028 per QALY gained relative to laser monotherapy (table 3). Combination therapy provided an incre... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Having a bath or shower | 0 | {"evidence_spans": [{"end": 13145, "start": 12958, "text": "those randomized to surgery (Table \r\n2\r\n). The two behaviours for which there was no evidence of a difference in the time to recover between the trial arms were 'having a bath or shower'"}], "id": "830", "pmcid": "4819709", "prompt_id": "830", "split_grou... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Partial return to normal work/employment | 1 | {"evidence_spans": [], "id": "835", "pmcid": "4819709", "prompt_id": "835", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Full return to normal work/employment | 1 | {"evidence_spans": [], "id": "836", "pmcid": "4819709", "prompt_id": "836", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Going out socially | 1 | {"evidence_spans": [], "id": "837", "pmcid": "4819709", "prompt_id": "837", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Sporting activity or exercise | 1 | {"evidence_spans": [], "id": "838", "pmcid": "4819709", "prompt_id": "838", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Statin efficacy in the treatment of hepatitis C genotype I
ABSTRACT.BACKGROUND::
Lipid metabolism is one of the hepatitis C virus (HCV) life cycle steps. Statins can reduce cholesterol level and finally can decrease HCV replication. Thus, we assessed the effect of Statins in combination with standard antiv... | Intervention: 20 mg atorvastatin nightly for 3 months
Comparator: placebo
Outcome: mean of HCV-RNA numbers in 12 weeks of therapy | 0 | {"evidence_spans": [{"end": 1354, "start": 1155, "text": "SULTS::\r\nWe didn't find any significant differences in the mean of HCV-RNA numbers between statin and placebo groups in 12th week of treatment, in the end of treatment and 6 months after treatment (P"}, {"end": 8142, "start": 7996, "text": "n and placebo, also... |
TITLE: How to avoid discontinuation of antihypertensive treatment. The experience in São Paulo, Brazil
ABSTRACT.OBJECTIVES::
To evaluate the importance of providing guidelines to patients via active telephone calls for blood pressure control and for preventing the discontinuation of treatment among hypertensive p... | Intervention: phone calls" group
Comparator: "no phone calls" group
Outcome: percentage of patients with controlled blood pressure | 0 | {"evidence_spans": [{"end": 1530, "start": 1346, "text": " p<0.0094). There was no difference in the percentage of patients with controlled blood pressure in the \"phone calls\" group and \"no phone calls\" group or in the \"traditional\" and \"curr"}, {"end": 15301, "start": 15112, "text": "ditional\" and \"current\" ... |
TITLE: How quick is soon? Early response to continuous positive airway pressure: a randomized controlled trial
ABSTRACT:
BODY.INTRODUCTION:
Numerous studies have confirmed that using non-invasive continuous positive airway pressure (nCPAP) for chronic obstructive pulmonary disease and congestive heart failur... | Intervention: CPAP + standard of care (nCPAP group)
Comparator: standard group
Outcome: hospital and ICU length of stay | -1 | {"evidence_spans": [{"end": 2285, "start": 2140, "text": "spectively. The nCPAP group also had a shorter hospital and ICU length of stay compared with the standard group (4 vs 5 days, and 2 vs 3 days, re"}], "id": "879", "pmcid": "4088715", "prompt_id": "879", "split_group_id": "4088715", "votes": {"-1": 1}} |
TITLE: Belatacept-Based Immunosuppression in
ABSTRACT:
This exploratory phase II study evaluated the safety and efficacy of belatacept in de novo adult liver transplant recipients. Patients were randomized (N = 260) to one of the following immunosuppressive regimens: (i) basiliximab + belatacept high dose [HD] +... | Intervention: belatacept groups
Comparator: tacrolimus groups
Outcome: The proportion of patients who met the primary end point (composite of acute rejection, graft loss, death by month 6) | 1 | {"evidence_spans": [{"end": 821, "start": 487, "text": "ids. Demographic characteristics were similar among groups. The proportion of patients who met the primary end point (composite of acute rejection, graft loss, death by month 6) was higher in the belatacept groups (42\u201348%) versus tacrolimus groups (15\u201338... |
TITLE: Evaluation of the functional efficacy of an antioxidative probiotic in healthy volunteers
ABSTRACT.BACKGROUND:
In persons without clinical symptom it is difficult to assess an impact of probiotics regarding its effect on health. We evaluated the functional efficacy of the probiotic Lactobacillus fermentum ... | Intervention: L. fermentum ME-3 fermented goat milk
Comparator: goat milk
Outcome: glutathione red-ox ratio | 0 | {"evidence_spans": [{"end": 20319, "start": 19930, "text": " from the effect of the ME-3 in capsule-form (ANOVA): \u2021p \u2264 0.001 The effect of goat-milk consumption on the TAA and TAS values was significantlyhigher (p < 0.001) than by the consumption of the capsulated probiotic (Fig. 3). The decrease of the glut... |
TITLE: Efficacy and Safety of a Lidocaine Gel in Patients from 6 Months up to 8 Years with Acute Painful Sites in the Oral Cavity: A Randomized, Placebo-Controlled, Double-Blind, Comparative Study
ABSTRACT:
Lidocaine is a well-accepted topical anaesthetic, also used in minors to treat painful conditions on mucosa... | Intervention: lidocaine gel (2%)
Comparator: placebo
Outcome: pain in the paediatric population | -1 | {"evidence_spans": [{"end": 1159, "start": 941, "text": "ted. In group I, pain was reduced significantly after treatment with verum compared to placebo at both time points. In group II, the individual pain rating shift showed statistically significant lower pain after treatm"}, {"end": 13089, "start": 12921, "text": "i... |
TITLE: A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β
ABSTRACT.BACKGROUND:
Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA i... | Intervention: Abediterol
Comparator: salbutamol
Outcome: peak FEV1 | 0 | {"evidence_spans": [{"end": 1676, "start": 1585, "text": " doses). Abediterol 0.625, 1.25, and 2.5 \u03bcg had similar magnitude of peak FEV1 effect to sa"}, {"end": 1677, "start": 1585, "text": " doses). Abediterol 0.625, 1.25, and 2.5 \u03bcg had similar magnitude of peak FEV1 effect to sal"}, {"end": 2529, "start": ... |
TITLE: The efficacy of resiniferatoxin in prevention of catheter related bladder discomfort in patients after TURP - a pilot, randomized, open study
ABSTRACT.BACKGROUND:
Resiniferatoxin (RTX) has been shown to have variable efficacy in the treatment of intractable lower urinary tract symptoms and symptoms associa... | Intervention: received, intravesically, 40 mL of 20 nM Resiniferatoxin 20 hours before operation.
Comparator: no treatment before operation.
Outcome: catheter related bladder discomfort During the first three days of post-operative period | -1 | {"evidence_spans": [{"end": 8203, "start": 8030, "text": "SULTS.EFFECT OF RTX ON CRBD:\r\nDuring the first three days of post-operative period, the incidence of patients' CRBD was lower in Group I than that in Group II (25% vs. 75%, "}], "id": "913", "pmcid": "4713214", "prompt_id": "913", "split_group_id": "4713214", ... |
TITLE: The efficacy of resiniferatoxin in prevention of catheter related bladder discomfort in patients after TURP - a pilot, randomized, open study
ABSTRACT.BACKGROUND:
Resiniferatoxin (RTX) has been shown to have variable efficacy in the treatment of intractable lower urinary tract symptoms and symptoms associa... | Intervention: received, intravesically, 40 mL of 20 nM Resiniferatoxin 20 hours before operation.
Comparator: no treatment before operation.
Outcome: required tolterodine | -1 | {"evidence_spans": [{"end": 1864, "start": 1775, "text": "erative. Finally, less patients in RTX group required tolterodine, compared with control,"}], "id": "914", "pmcid": "4713214", "prompt_id": "914", "split_group_id": "4713214", "votes": {"-1": 2}} |
TITLE: The efficacy of resiniferatoxin in prevention of catheter related bladder discomfort in patients after TURP - a pilot, randomized, open study
ABSTRACT.BACKGROUND:
Resiniferatoxin (RTX) has been shown to have variable efficacy in the treatment of intractable lower urinary tract symptoms and symptoms associa... | Intervention: received, intravesically, 40 mL of 20 nM Resiniferatoxin 20 hours before operation.
Comparator: no treatment before operation.
Outcome: catheter related bladder discomfort On the fifth day after surgery | 0 | {"evidence_spans": [{"end": 1993, "start": 1865, "text": "P=0.009. Interestingly, the difference of CRBD incidence between Group RTX (50%) and control (75%) diminished 5 days after TURP,"}, {"end": 8411, "start": 8204, "text": "=0.001, Fisher's exact test). On the fifth day after surgery, although the incidence of CRBD... |
TITLE: Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population
ABSTRACT:
Haptoglobin's (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular d... | Intervention: daily doses of 400 IU of vitamin E and 1000 mg of vitamin C from 9-16 weeks gestation until delivery.
Comparator: placebo from 9-16 weeks gestation until delivery.
Outcome: risk of the primary outcome or preeclampsia | 0 | {"evidence_spans": [{"end": 1779, "start": 1666, "text": "n. Vitamin supplementation did not reduce the risk of the primary outcome or preeclampsia in women of any phenoty"}], "id": "917", "pmcid": "3616124", "prompt_id": "917", "split_group_id": "3616124", "votes": {"0": 2}} |
TITLE: Cluster Randomized Trial of Text Message Reminders to Retail Staff in Tanzanian Drug Shops Dispensing Artemether-Lumefantrine: Effect on Dispenser Knowledge and Patient Adherence
ABSTRACT:
Artemisinin combination therapies are available in private outlets, but patient adherence might be compromised by poor... | Intervention: receive text message reminders about what advice to provide when dispensing artemether-lumefantrine (AL).
Comparator: no text message
Outcome: patient adherence | 0 | {"evidence_spans": [{"end": 19838, "start": 19770, "text": "irst dose of AL at the ADDO. There was no difference in patient adh"}], "id": "929", "pmcid": "4183415", "prompt_id": "929", "split_group_id": "4183415", "votes": {"0": 1}} |
TITLE: Cluster Randomized Trial of Text Message Reminders to Retail Staff in Tanzanian Drug Shops Dispensing Artemether-Lumefantrine: Effect on Dispenser Knowledge and Patient Adherence
ABSTRACT:
Artemisinin combination therapies are available in private outlets, but patient adherence might be compromised by poor... | Intervention: receive text message reminders about what advice to provide when dispensing artemether-lumefantrine (AL).
Comparator: no text message
Outcome: Completed treatment | 0 | {"evidence_spans": [{"end": 20133, "start": 19839, "text": "rence between arms (Table 6). Completed treatment was 70% in the control arm and 68% in the intervention arm (adjusted risk ratio [aRR] = 0.96 [95% CI: 0.82, 1.1]; p [adjusted] = 0.6), with a similar percentage of patients adherent to each of the four age-appr... |
TITLE: Effects of transcranial direct current stimulation on temperature and pain perception
ABSTRACT:
Transcranial direct current stimulation modifies cortical excitability and in consequence some cerebral functions. In the present study we aimed to elucidate whether tDCS could affect temperature and pain percep... | Intervention: 2?mA anodal tDCS when applied over the Pcor for 15?minutes
Comparator: baseline
Outcome: cold perception threshold, warm perception threshold, cold pain threshold and heat pain threshold | 0 | {"evidence_spans": [{"end": 19802, "start": 19505, "text": "ex). Error bars are standard deviations. *p < 0.05.\r\n Moreover, 2 mA anodal tDCS when applied over the Pcor for 15 minutes induced no significant changes in all the studied parameters (one-way follow-up ANOVA for cold perception: F(2,18) = 3,33; p = 0.058),... |
TITLE: Continued stabilization of trabecular metal tibial monoblock total knee arthroplasty components at 5 years—measured with radiostereometric analysis
ABSTRACT.BACKGROUND AND PURPOSE:
The trabecular metal tibial monoblock component (TM) is a relatively new option available for total knee arthroplasty. We hav... | Intervention: The trabecular metal tibial monoblock component (TM)
Comparator: cemented component.
Outcome: subsidence | 1 | {"evidence_spans": [{"end": 1325, "start": 1229, "text": " = 0.9). The TM components had significantly greater subsidence than the cemented components (p "}], "id": "950", "pmcid": "3278655", "prompt_id": "950", "split_group_id": "3278655", "votes": {"1": 2}} |
TITLE: Continued stabilization of trabecular metal tibial monoblock total knee arthroplasty components at 5 years—measured with radiostereometric analysis
ABSTRACT.BACKGROUND AND PURPOSE:
The trabecular metal tibial monoblock component (TM) is a relatively new option available for total knee arthroplasty. We hav... | Intervention: The trabecular metal tibial monoblock component (TM)
Comparator: cemented component.
Outcome: The proportion of "at risk" components at 5 years | 0 | {"evidence_spans": [{"end": 1448, "start": 1326, "text": " 0.001). The proportion of \"at risk\" components at 5 years was 2 of 18 in the cemented group and 0 of 27 in the TM group ("}], "id": "951", "pmcid": "3278655", "prompt_id": "951", "split_group_id": "3278655", "votes": {"0": 2}} |
TITLE: Assessing the Effect of an Integrated Control Strategy for Schistosomiasis Japonica Emphasizing Bovines in a Marshland Area of Hubei Province, China: A Cluster Randomized Trial
ABSTRACT.INTRODUCTION:
More than 80% of schistosomiasis patients in China live in the lake and marshland regions. The purpose of o... | Intervention: The routine interventions included praziquantel chemotherapy and controlling snails plus new interventions, mainly consisting of building fences to limit the grazing area for bovines, building safe pastures for grazing, improving the residents' health conditions and facilities,
Comparator: The routine int... | -1 | {"evidence_spans": [{"end": 1305, "start": 1021, "text": "ages. Results showed that the rate of S. japonicum infection in humans, bovines, snails, cow dung and mice in the intervention group decreased from 3.41% in 2008 to 0.81% in 2011, 3.3% to none, 11 of 6,219 to none, 3.9% to none and 31.7% to 1.7%, respectively (P... |
TITLE: Assessing the Effect of an Integrated Control Strategy for Schistosomiasis Japonica Emphasizing Bovines in a Marshland Area of Hubei Province, China: A Cluster Randomized Trial
ABSTRACT.INTRODUCTION:
More than 80% of schistosomiasis patients in China live in the lake and marshland regions. The purpose of o... | Intervention: The routine interventions included praziquantel chemotherapy and controlling snails plus new interventions, mainly consisting of building fences to limit the grazing area for bovines, building safe pastures for grazing, improving the residents' health conditions and facilities,
Comparator: The routine int... | -1 | {"evidence_spans": [{"end": 1748, "start": 1495, "text": "ons). Moreover, a generalized linear model showed that there was a higher infection risk in humans in the control group than in the intervention group (OR = 1.250, P = 0.001) and an overall significant downward trend in infection risk during the study p"}, {"end... |
TITLE: Comparison of the Effects of Maternal Supportive Care and Acupressure (at BL32 Acupoint) on Labor Length and Infant's Apgar Score
ABSTRACT.BACKGROUND AND OBJECTIVES::
Prolonged labor leads to increase of cesarean deliveries, reduction of fetal heart rate, and maternal as well as infantile complications. Th... | Intervention: supportive care or acupuncture group
Comparator: control groups
Outcome: The mean length of the first and second stages of labor | -1 | {"evidence_spans": [{"end": 1204, "start": 951, "text": "SULTS::\r\nThe mean length of the first and second stages of labor was respectively 157.0\u00b129.5 and 58.9\u00b125.8 minutes in the supportive care group, 161.7\u00b137.3 and 56.1\u00b131.4 minutes in the acupressure group, ad 281.0\u00b179.8 and 128.4\u00b144.... |
TITLE: Clinical evaluation of the AutoPulse automated chest compression device for out-of-hospital cardiac arrest in the northern district of Shanghai, China
ABSTRACT.INTRODUCTION:
Whether the AutoPulse automated chest compression device is worthy of clinical use for out-of-hospital cardiac arrest (OHCA) remains ... | Intervention: AutoPulse automated chest compression device
Comparator: manual chest compression for cardiopulmonary resuscitation (CPR) of out-of-hospital cardiac arrest (OHCA)
Outcome: return of spontaneous circulation (ROSC) | 1 | {"evidence_spans": [{"end": 1314, "start": 1168, "text": "ESULTS:\r\nThe ROSC rate of patients with OHCA was significantly higher in the AutoPulse CPR group than in the Manual CPR group (44.9% vs. 23.4%; p "}, {"end": 14801, "start": 14677, "text": "erms of the primary endpoint, the ROSC rate was significantly higher i... |
TITLE: Clinical evaluation of the AutoPulse automated chest compression device for out-of-hospital cardiac arrest in the northern district of Shanghai, China
ABSTRACT.INTRODUCTION:
Whether the AutoPulse automated chest compression device is worthy of clinical use for out-of-hospital cardiac arrest (OHCA) remains ... | Intervention: AutoPulse automated chest compression device
Comparator: manual chest compression for cardiopulmonary resuscitation (CPR) of out-of-hospital cardiac arrest (OHCA)
Outcome: The 24-h survival rate of OHCA | 1 | {"evidence_spans": [{"end": 1464, "start": 1315, "text": " 0.009). The 24-h survival rate of OHCA patients was significantly higher in the AutoPulse CPR group than in the Manual CPR group (39.1% vs. 21.9%; p"}], "id": "963", "pmcid": "4889691", "prompt_id": "963", "split_group_id": "4889691", "votes": {"1": 2}} |
TITLE: Clinical evaluation of the AutoPulse automated chest compression device for out-of-hospital cardiac arrest in the northern district of Shanghai, China
ABSTRACT.INTRODUCTION:
Whether the AutoPulse automated chest compression device is worthy of clinical use for out-of-hospital cardiac arrest (OHCA) remains ... | Intervention: AutoPulse automated chest compression device
Comparator: manual chest compression for cardiopulmonary resuscitation (CPR) of out-of-hospital cardiac arrest (OHCA)
Outcome: The proportion of patients with OHCA and a cerebral performance category score of 1 or 2 points at hospital discharge | 0 | {"evidence_spans": [{"end": 1895, "start": 1628, "text": "= 0.03). The proportion of patients with OHCA and a cerebral performance category score of 1 or 2 points at hospital discharge was higher in the AutoPulse CPR group than in the Manual CPR group, but the difference was not statistically significant (16.2% vs. 13.... |
TITLE: The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis (OA): a knowledge translation (KT) randomized controlled trial (RCT): Part I: The Uptake of the Ottawa Panel clinical practice guidelines (CPGs)
ABSTRACT.BACKGROUND:
The implementation of evidence based... | Intervention: Walking and Behavioural intervention (WB)
Comparator: Self-directed control (C)
Outcome: Long-term adherence to the program | 0 | {"evidence_spans": [{"end": 1933, "start": 1795, "text": " months. No statistical significance (p> 0.05) was observed for long-term adherence (6 to 12 months), and total adherence between the thre"}], "id": "970", "pmcid": "3491047", "prompt_id": "970", "split_group_id": "3491047", "votes": {"0": 2}} |
TITLE: Treatment costs associated with interventional cancer clinical trials conducted at a single UK institution over 2 years (2009–2010)
ABSTRACT.BACKGROUND::
The conduct of clinical trials should be an integral part of routine patient care. Treating patients in trials incurs additional costs over and above sta... | Intervention: Academic, non-commercial sponsored trials
Comparator: Commercial sponsored trials
Outcome: Treatment cost | 1 | {"evidence_spans": [{"end": 19024, "start": 18838, "text": " TCs between protocols. The average TC for 27 non-commercial trials was an excess of \u00a3431 (range \u00a36393 excess to \u00a36005 saving) and for 26 commercial trials was an average saving of \u00a39294"}], "id": "974", "pmcid": "3798949", "prompt_id": "97... |
TITLE: The effect of aerobic exercise in the maintenance treatment of depression
ABSTRACT:
We investigated the efficacy of aerobic exercise alongside antidepressant medication as an adjuvant maintenance treatment for depression. Fifty patients in remission were randomly assigned to either medication only or medic... | Intervention: Medication plus exercise
Comparator: Medication only
Outcome: Improvement in the Hamilton Rating Scale for Depression at 12 weeks | 1 | {"evidence_spans": [{"end": 6706, "start": 6413, "text": "l 6-weekly follow-ups. The medication-plus-exercise group showed a greater improvement in HRSD scores (change in score from baseline) than the medication-only group from the first follow-up, at 6 weeks, and this difference became statistically significant at wee... |
TITLE: Singing teaching as a therapy for chronic respiratory disease - a randomised controlled trial and qualitative evaluation
ABSTRACT.BACKGROUND:
Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies ... | Intervention: Singing classes
Comparator: Usual care
Outcome: Single breath counting and functional exercise capacity | 0 | {"evidence_spans": [{"end": 10758, "start": 10634, "text": "vs. +5.3(5.7) sec (p = 0.03). There was no significant difference in single breath counting, functional exercise capacity or"}, {"end": 10769, "start": 10634, "text": "vs. +5.3(5.7) sec (p = 0.03). There was no significant difference in single breath counting,... |
TITLE: Singing teaching as a therapy for chronic respiratory disease - a randomised controlled trial and qualitative evaluation
ABSTRACT.BACKGROUND:
Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies ... | Intervention: Singing classes
Comparator: Usual care
Outcome: Recovery time after incremental shuttle walk test | 0 | {"evidence_spans": [{"end": 10758, "start": 10634, "text": "vs. +5.3(5.7) sec (p = 0.03). There was no significant difference in single breath counting, functional exercise capacity or"}, {"end": 10769, "start": 10634, "text": "vs. +5.3(5.7) sec (p = 0.03). There was no significant difference in single breath counting,... |
TITLE: Comparing the Hemodynamic Effects of Spinal Anesthesia in Preeclamptic and Healthy Parturients During Cesarean Section
ABSTRACT.BACKGROUND:
Despite controversies about the safest anesthetic technique for cesarean delivery in severely preeclamptic women, there is evidence that supports the use of spinal ane... | Intervention: Low-dose bupivacaine spinal anesthesia in pre-eclamptic parturients
Comparator: Low-dose bupivacaine spinal anesthesia in healthy parturients
Outcome: IV ephedrine total dosage | -1 | {"evidence_spans": [{"end": 1821, "start": 1623, "text": "(P < 0.05). The total doses of IV ephedrine for treating hypotension were significantly lower among the preeclamptic patients (3.2 mg in preeclamptic patients versus 7.6 mg in normotensive patients)"}], "id": "1011", "pmcid": "5018157", "prompt_id": "1011", "spl... |
TITLE: Comparing the Hemodynamic Effects of Spinal Anesthesia in Preeclamptic and Healthy Parturients During Cesarean Section
ABSTRACT.BACKGROUND:
Despite controversies about the safest anesthetic technique for cesarean delivery in severely preeclamptic women, there is evidence that supports the use of spinal ane... | Intervention: Low-dose bupivacaine spinal anesthesia in pre-eclamptic parturients
Comparator: Low-dose bupivacaine spinal anesthesia in healthy parturients
Outcome: One-minute Apgar score | -1 | {"evidence_spans": [{"end": 1946, "start": 1822, "text": "(P = 0.02). The one-minute Apgar score was significantly lower for the preeclamptic parturients (8.4 \u00b1 0.7 versus 7.2 \u00b1 1.5)"}, {"end": 2043, "start": 1822, "text": "(P = 0.02). The one-minute Apgar score was significantly lower for the preeclamptic pa... |
TITLE: Management of
ABSTRACT.INTRODUCTION::
Prevalence of diabetes and its complications have been a burden to the society from the ancient times, in the present and also will be in the future unless proper measures are taken to prevent its manifestation. There have been an increasing number of death associated... | Intervention: Katupila Kalka with Tila Taila
Comparator: Betadine ointment
Outcome: Adverse reactions | 0 | {"evidence_spans": [{"end": 1507, "start": 1371, "text": "in 28 days. In both the groups, no patients reported any adverse drug reaction during the entire course of treatment as well as in follo"}], "id": "1021", "pmcid": "4895766", "prompt_id": "1021", "split_group_id": "4895766", "votes": {"0": 2}} |
TITLE: Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
ABSTRACT.AIMS:
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safe... | Intervention: ticagrelor
Comparator: clopidogrel
Outcome: stroke incidence | 0 | {"evidence_spans": [{"end": 17437, "start": 17308, "text": "; 95% CI = 0.74\u20130.99; P = 0.0419), whereas stroke incidence did not differ significantly between treatment arms (1.3 vs. 1.4%; HR"}, {"end": 17437, "start": 17316, "text": " = 0.74\u20130.99; P = 0.0419), whereas stroke incidence did not differ significan... |
TITLE: Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
ABSTRACT.AIMS:
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safe... | Intervention: ticagrelor
Comparator: clopidogrel
Outcome: major bleeding | 0 | {"evidence_spans": [{"end": 1341, "start": 1239, "text": ".90). Major bleeding rate was similar between treatment groups (13.4 vs. 12.6%; HR 1.07; 95% CI = 0.95"}, {"end": 19643, "start": 19479, "text": " clopidogrel.\r\n\r\nBODY.RESULTS.SAFETY:\r\nWith ticagrelor when compared with clopidogrel, there was no significan... |
TITLE: Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
ABSTRACT.AIMS:
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safe... | Intervention: ticagrelor
Comparator: clopidogrel
Outcome: the rate of life-threatening or fatal bleeding or the rate of intracranial bleeding | 0 | {"evidence_spans": [{"end": 20113, "start": 19808, "text": "ry material online, Figure S2A and B). There was no significant difference in the rate of life-threatening or fatal bleeding (6.6 vs. 6.5%; HR 1.05; 95% CI = 0.90\u20131.22, P = 0.56), nor any significant difference in the rate of intracranial bleeding with ti... |
TITLE: Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
ABSTRACT.AIMS:
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safe... | Intervention: ticagrelor
Comparator: clopidogrel
Outcome: major or minor bleeding (by TIMI criteria) | 0 | {"evidence_spans": [{"end": 20429, "start": 20278, "text": "1.14; 95% CI = 1.03\u20131.25, P = 0.0078). When assessed by TIMI criteria, there was no significant difference in major or minor bleeding (13.2 vs. 12.3%; "}, {"end": 20429, "start": 20279, "text": ".14; 95% CI = 1.03\u20131.25, P = 0.0078). When assessed by ... |
TITLE: A Comparison of Two Delivery Modalities of a Mobile Phone-Based Assessment for Serious Mental Illness: Native Smartphone Application vs Text-Messaging Only Implementations
ABSTRACT.BACKGROUND:
Mobile phone–based assessment may represent a cost-effective and clinically effective method of monitoring psychot... | Intervention: completing 6 days of assessment (four sets of questions per day) with a native smartphone application
Comparator: completing 6 days of assessment (four sets of questions per day) with the SMS text-only implementation
Outcome: proportion of data points | 1 | {"evidence_spans": [{"end": 2221, "start": 2055, "text": "T.RESULTS:\r\nA greater proportion of data points were completed with the native smartphone application in comparison to the SMS text-only implementation (\u03b2 = -.25, SE="}, {"end": 2301, "start": 2055, "text": "T.RESULTS:\r\nA greater proportion of data poin... |
TITLE: Oxaliplatin and Bolus-Modulated 5-Fluorouracil as a Second-Line Treatment for Advanced Pancreatic Cancer: Can Bolus Regimens Replace FOLFOX When Considered for Second Line?
ABSTRACT:
Objective. Comparing activity of 2 regimens combining oxaliplatin to bolus modulated fluorouracil as second line treatment... | Intervention: receive FU 500 mg/m2 IV bolus weekly ×6 weeks plus leucovorin 500?mg/m2 IV weekly for 6 weeks during each 8-week cycle plus oxaliplatin 85?mg/m2 IV on weeks 1, 3, and 5 of each 8-week (FLOX)
Comparator: receive weekly intravenous infusions of oxaliplatin 40?mg/m2, 5-FU 500 mg/m2, and leucovorin 250?mg/m2... | 0 | {"evidence_spans": [{"end": 12721, "start": 12515, "text": "5\u201313) as shown in Figures 1(a) and 1(b). There was no statistical significance in progression-free survival between the 2 regimens (P value by log rank test = .4619), and so was the situation in overall su"}], "id": "1305", "pmcid": "3596913", "prompt_id... |
TITLE: A controlled study of community-based exercise training in patients with moderate COPD
ABSTRACT.BACKGROUND:
The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study... | Intervention: 12-weeks of progressive endurance and strength training at a local health club
Comparator: continuation of unsupervised habitual physical activity
Outcome: Mean SGRQ scores | 0 | {"evidence_spans": [{"end": 1378, "start": 1343, "text": " 0.001). SGRQ was not significantly"}], "id": "1318", "pmcid": "4124480", "prompt_id": "1318", "split_group_id": "4124480", "votes": {"0": 1}} |
TITLE:
ABSTRACT:
Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was genotyped in 742 obese adults who were ... | Intervention: assigned to the dietary fat components who carried the AA genotype of FTO rs1558902
Comparator: assigned to the dietary fat components without this genotype
Outcome: total fat, FM%, and percentage of trunk fat | 0 | {"evidence_spans": [{"end": 15473, "start": 15191, "text": "2 years (total n = 105). We did not find significant genetic effects and interactions on changes in fat distribution in subgroups treated by different dietary fat components (all P > 0.05; Supplementary Table 2 and Supplementary Fig. 2).Similar results were ... |
TITLE: Rotary instruments in the treatment of chronic periodontitis: A randomized clinical trial
ABSTRACT.BACKGROUND::
The study aimed at comparing the effectiveness of rotary instruments with hand instruments in non-surgical treatment of chronic periodontitis.
ABSTRACT.MATERIALS AND METHODS::
Thirty-eight pa... | Intervention: received treatment with rotary instruments
Comparator: received scaling and root planing with hand instruments
Outcome: Probing depth (PD), Gingival recession (GR), Clinical attachment level (CAL) | 0 | {"evidence_spans": [{"end": 9041, "start": 8666, "text": "uced from 4.5 \u00b1 0.3 to 3.4 \u00b1 1.1 [Table 2]. At deep pocket site (initial PD > 6 mm), in the rotary instrument group, PD reduced from 7.2 \u00b1 1.5 to 6.5 \u00b1 1.8 and in the Gracey curette group, it reduced from 6.7 \u00b1 0.9 to 5.4 \u00b1 1.8. But... |
TITLE: Feto-maternal outcomes and Glycemic control in Metformin versus insulin treated Gestational Diabetics
ABSTRACT.OBJECTIVE::
To evaluate and compare feto-maternal outcomes and glycemic control in metformin versus insulin treated gestational diabetics.
ABSTRACT.METHODS::
The study was conducted in 2010- 2... | Intervention: oral metformin 500 mg TDS (Group-A)
Comparator: insulin 0.8-0.9 mg/kg/day in two divided doses subcutaneously (Group-B)
Outcome: HbA1C | -1 | {"evidence_spans": [{"end": 1111, "start": 1026, "text": "=0.021). There were two intrauterine deaths and significantly higher HbA1C at term in"}, {"end": 1121, "start": 1026, "text": "=0.021). There were two intrauterine deaths and significantly higher HbA1C at term in Group-B. "}], "id": "1336", "pmcid": "5673730", "... |
TITLE: Thromboelastographic changes during laparoscopic fundoplication
ABSTRACT.INTRODUCTION:
Thromboelastography (TEG) is a technique that measures coagulation processes and surveys the properties of a viscoelastic blood clot, from its formation to lysis.
ABSTRACT.AIM:
To determine the possible hypercoagulab... | Intervention: Low-molecular-weight heparin before and after the surgery
Comparator: Low-molecular-weight heparin only before the surgery
Outcome: Alpha-angle values | 0 | {"evidence_spans": [{"end": 17379, "start": 17247, "text": "aroscopic operation (Tables II and III). There were no significant changes in \u03b1-angle and maximum amplitude values during or after "}, {"end": 17380, "start": 17247, "text": "aroscopic operation (Tables II and III). There were no significant changes in ... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound?guided foam sclerotherapy
Comparator: surgery
Outcome: Driving a car | 1 | {"evidence_spans": [], "id": "831", "pmcid": "4819709", "prompt_id": "831", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Effect of acupressure on fatigue in patients on hemodialysis
ABSTRACT.BACKGROUND::
Fatigue is considered as a major problem in hemodialysis patients and can impair their quality of life. The purpose of this study was to investigate the effectiveness of acupressure on fatigue in hemodialysis patients.
AB... | Intervention: Routine unit care
Comparator: Placebo
Outcome: Total score of fatigue | 0 | {"evidence_spans": [{"end": 12063, "start": 11724, "text": " groups (P < 0.001). Post-hoc Duncan test showed that in the study group, total score of fatigue and score of fatigue in emotional, cognitive, and behavioral dimensions were significantly less than in the two groups of placebo and control after intervention (P... |
TITLE: Managing migraine headaches experienced by patients who self–report with menstrually related migraine: a prospective, placebo–controlled study with oral sumatriptan
ABSTRACT:
The objective was to evaluate the efficacy and tolerability of oral sumatriptan (100 mg) in patients who self–reported with menstrua... | Intervention: sumatriptan for 2 months
Comparator: placebo for 2 months
Outcome: headache relief for attacks occurring inside and outside the menstrual period (migraine attacks) | 1 | {"evidence_spans": [{"end": 1269, "start": 1049, "text": "dow. For the first attack, significantly more patients receiving sumatriptan than placebo reported headache relief for attacks occurring inside (67% vs. 33%, p=0.007) and outside (79% vs. 31%, p<0.001) the menstrual peri"}, {"end": 1269, "start": 1051, "text": "... |
TITLE: Impact of handwriting training on fluency, spelling and text quality among third graders
ABSTRACT:
As recent studies and theoretical assumptions suggest that the quality of texts composed by children and adolescents is affected by their transcription skills, this experimental field trial aims at investigat... | Intervention: the combined and in the pure handwriting group
Comparator: the spelling training and the reading groups
Outcome: increase of fluency in the double loops tasks | 1 | {"evidence_spans": [{"end": 39155, "start": 38801, "text": "ting only training group nor did they differ from the improvements of the reading control group. One of the exceptions mentioned above was a marked increase of fluency in the double loops tasks observed in the combined and in the pure handwriting group from p... |
TITLE: Intrathecal Morphine Plus General Anesthesia in Cardiac Surgery: Effects on Pulmonary Function, Postoperative Analgesia, and Plasma Morphine Concentration
ABSTRACT.OBJECTIVES::
To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac... | Intervention: 400 ?g of intrathecal morphine followed by general anesthesia
Comparator: general anesthesia
Outcome: pain intensity | -1 | {"evidence_spans": [{"end": 1807, "start": 1610, "text": "o (p=0.08). The morphine group reported less pain intensity (evaluated using a visual numeric scale), especially when coughing (18 hours postoperatively: control group= 4.73 and morphine group= 1.8"}], "id": "1230", "pmcid": "2694465", "prompt_id": "1230", "spli... |
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