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TITLE: Efficacy and Safety of 5-Fluorouracil 0.5%/Salicylic Acid 10% in the Field-Directed Treatment of Actinic Keratosis: A Phase III, Randomized, Double-Blind, Vehicle-Controlled Trial
ABSTRACT.INTRODUCTION:
Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clin... | Intervention: 5-fluorouracil (5-FU) 0.5%/salicylic acid 10%
Comparator: vehicle
Outcome: the TSQM convenience and side effect domain scores | 0 | {"evidence_spans": [{"end": 19108, "start": 18915, "text": " (P = 0.0019); 70.8 vs. 59.2 (P = 0.0064), respectively]. No statistically significant differences were observed between the study arms for the TSQM convenience (70.7 and 71.2, respectively) an"}], "id": "1440", "pmcid": "5336430", "prompt_id": "1440", "split_... |
TITLE: Social Media under the Skin: Facebook Use after Acute Stress Impairs Cortisol Recovery
ABSTRACT:
Social media's influence on stress remains largely unknown. Conflicting research suggests that Facebook use may both enhance and undermine psychosocial constructs related to well-being. Using novel experimental... | Intervention: use their own Facebook profile
Comparator: quietly read
Outcome: tension, anxiety, well-being | 0 | {"evidence_spans": [{"end": 26751, "start": 26488, "text": " and anxiety and increases in well-being. There were no significant condition differences for tension F(1, 91) = 1.56, p = 0.21, 95% CI [\u20130.29, 1.25], \u03b72 = 0.02; anxiety F(1, 88) = 0.004, p = 0.95, 95% CI [\u20131.01, 0.95], \u03b72 = 0.00; or well-b... |
TITLE: Readiness to Be Physically Active and Self-Reported Physical Activity in Low-Income Latinas, California WISEWOMAN, 2006-2007
ABSTRACT.INTRODUCTION:
Latinas are more likely to be inactive than non-Hispanic white women. Although 74% of Latinas report no leisure-time activity, few interventions have been desi... | Intervention: enhanced intervention (EIG) - The enhanced intervention was delivered by CHWs as 3 individually tailored, one-on-one counseling sessions. The sessions occurred approximately 1 month, 2 months, and 6 months after screening. Each session averaged 50 minutes. Participants received transportation tokens and g... | 1 | {"evidence_spans": [{"end": 16633, "start": 16416, "text": "ory of self-reported physical activity (Table 3). The EIG was approximately twice as likely to report engaging in moderate physical activity at follow-up as at baseline; 71% of women in this group reported moderate ph"}], "id": "1452", "pmcid": "3406743", "pro... |
TITLE: Readiness to Be Physically Active and Self-Reported Physical Activity in Low-Income Latinas, California WISEWOMAN, 2006-2007
ABSTRACT.INTRODUCTION:
Latinas are more likely to be inactive than non-Hispanic white women. Although 74% of Latinas report no leisure-time activity, few interventions have been desi... | Intervention: usual care (UCG)
Comparator: baseline
Outcome: engaging in moderate physical activity | 0 | {"evidence_spans": [{"end": 16633, "start": 16416, "text": "ory of self-reported physical activity (Table 3). The EIG was approximately twice as likely to report engaging in moderate physical activity at follow-up as at baseline; 71% of women in this group reported moderate ph"}, {"end": 16786, "start": 16634, "text": ... |
TITLE: Readiness to Be Physically Active and Self-Reported Physical Activity in Low-Income Latinas, California WISEWOMAN, 2006-2007
ABSTRACT.INTRODUCTION:
Latinas are more likely to be inactive than non-Hispanic white women. Although 74% of Latinas report no leisure-time activity, few interventions have been desi... | Intervention: enhanced intervention (EIG)
Comparator: baseline
Outcome: readiness to engage in vigorous physical activity | 1 | {"evidence_spans": [{"end": 1963, "start": 1731, "text": "ONCLUSION:\r\nA culturally tailored adaptation of the WISEWOMAN program that used community health workers significantly improved both self-reported readiness to engage in physical activity and vigorous physical activity among low-inc"}, {"end": 15830, "start": ... |
TITLE: A prospective randomised radiostereometric analysis trial of SmartSet HV and Palacos R bone cements in primary total hip arthroplasty
ABSTRACT.BACKGROUND:
Introduction of new bone cements into clinical practice should include radiostereometric studies.
ABSTRACT.MATERIALS AND METHODS:
A prospective rand... | Intervention: SmartSet HV acrylic bone cements (without antibiotics)
Comparator: Palacos R acrylic bone cements (without antibiotics)
Outcome: The Merle d'Aubigne Postel score | 0 | {"evidence_spans": [{"end": 1120, "start": 1026, "text": "lacos R. The Merle d'Aubigne Postel score was the maximum of 18 points for all patients in bot"}], "id": "1466", "pmcid": "2837815", "prompt_id": "1466", "split_group_id": "2837815", "votes": {"0": 2}} |
TITLE: A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults
ABSTRACT.BACKGROUND:
The behavioral outcome of food ingestion is a complex process that involves psychological and biologic... | Intervention: consumed a standardized breakfast with Avocado Added (AA)
Comparator: consumed a standardized breakfast [Control (C)avocado-free]
Outcome: desire to eat for the AUC(0-5h) | -1 | {"evidence_spans": [{"end": 1791, "start": 1641, "text": "alysis. Compared to the C test meal, the AA test meal increased satisfaction by 23% (P=0.05) and decreased the desire to eat by 28% (P=0.04) for the A"}, {"end": 18648, "start": 18462, "text": ".05) in the mixed model analysis (Figure 2). Post-hoc testing reveal... |
TITLE: Do research findings on schema-based instruction translate to the classroom?
ABSTRACT.INTRODUCTION:
Schema-based instruction has been shown to improve diagnostic performance and reduce cognitive load. However, to date, this has only been studied in controlled research settings. More distractions in classro... | Intervention: schema-based lecture
Comparator: traditional
Outcome: performance on the diagnostic performance test | 1 | {"evidence_spans": [{"end": 10441, "start": 10303, "text": "ed to the schema-based lecture. Schema-based instruction was associated with increased performance on the diagnostic performance test (64"}], "id": "1478", "pmcid": "4673066", "prompt_id": "1478", "split_group_id": "4673066", "votes": {"1": 2}} |
TITLE: Adequate Initial Heparin Dosage for Atrial Fibrillation Ablation in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants
ABSTRACT.BACKGROUND AND OBJECTIVE:
During atrial fibrillation ablation, heparin is required and is guided by the activated clotting time (ACT). Differences in the ACT before a... | Intervention: rivaroxaban or apixaban or dabigatran
Comparator: control (warfarin)
Outcome: protamine usage for haemostasis | 0 | {"evidence_spans": [{"end": 24706, "start": 24509, "text": "ticoagulants groups. The vertical bars indicate one standard deviation No significant differences in protamine usage for haemostasis were found among the control and three NOAC groups (control, 13"}], "id": "1492", "pmcid": "5021748", "prompt_id": "1492", "sp... |
TITLE: Adequate Initial Heparin Dosage for Atrial Fibrillation Ablation in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants
ABSTRACT.BACKGROUND AND OBJECTIVE:
During atrial fibrillation ablation, heparin is required and is guided by the activated clotting time (ACT). Differences in the ACT before a... | Intervention: rivaroxaban or apixaban or dabigatran
Comparator: control (warfarin)
Outcome: heparin dosages required to produce an ACT 15 min after the initial bolus that was identical to the control (110U/kg) | 0 | {"evidence_spans": [{"end": 1465, "start": 1181, "text": "groups. The initial bolus heparin dosages required to produce an ACT 15 min after the initial bolus that was identical to the control (333 \u00b1 32 s) were 120 U/kg (318 \u00b1 29 s) and 130 U/kg (339 \u00b1 43 s) for dabigatran, 130 U/kg (314 \u00b1 31 s) for ... |
TITLE: Endometrial safety of ospemifene: results of the phase 2/3 clinical development program
ABSTRACT.ABSTRACT.OBJECTIVE:
This study aims to assess the endometrial safety of ospemifene based on phase 2/3 clinical trials of postmenopausal women with up to 52 weeks of exposure to ospemifene 60 mg/day versus place... | Intervention: ospemifene 60 mg/day
Comparator: placebo
Outcome: The mean (SD) increase in endometrial thickness based on TVUS | 1 | {"evidence_spans": [{"end": 18798, "start": 18349, "text": ".RESULTS.ENDOMETRIAL THICKNESS:\r\nThe mean (SD) increase in endometrial thickness based on TVUS was 0.51 (1.5) versus 0.06 (1.2) mm at 12 weeks, 0.56 (1.6) versus 0.05 (1.3) mm at 6 months, and 0.81 (1.5) versus 0.07 (1.2) mm at 12 months for participants in ... |
TITLE: Endometrial safety of ospemifene: results of the phase 2/3 clinical development program
ABSTRACT.ABSTRACT.OBJECTIVE:
This study aims to assess the endometrial safety of ospemifene based on phase 2/3 clinical trials of postmenopausal women with up to 52 weeks of exposure to ospemifene 60 mg/day versus place... | Intervention: ospemifene 60 mg/day
Comparator: placebo
Outcome: vaginal bleeding | 0 | {"evidence_spans": [{"end": 17908, "start": 17627, "text": "Y.RESULTS.VAGINAL BLEEDING:\r\nVaginal bleeding or spotting was reported in 10 of 851 women (1.2%) with an intact uterus in the ospemifene 60 mg/day group (incidence rate, 2.17 per 100 patient-years) and in 5 of 543 women (0.9%) in the placebo group (incidence... |
TITLE: Endometrial safety of ospemifene: results of the phase 2/3 clinical development program
ABSTRACT.ABSTRACT.OBJECTIVE:
This study aims to assess the endometrial safety of ospemifene based on phase 2/3 clinical trials of postmenopausal women with up to 52 weeks of exposure to ospemifene 60 mg/day versus place... | Intervention: ospemifene 60 mg/day
Comparator: placebo
Outcome: endometrial cancer | 0 | {"evidence_spans": [{"end": 22343, "start": 22226, "text": "\r\nBODY.RESULTS.ENDOMETRIAL HISTOLOGY:\r\nThere were no cases of endometrial cancer observed with exposure of up to 52 w"}], "id": "1496", "pmcid": "4274342", "prompt_id": "1496", "split_group_id": "4274342", "votes": {"0": 2}} |
TITLE: Endometrial safety of ospemifene: results of the phase 2/3 clinical development program
ABSTRACT.ABSTRACT.OBJECTIVE:
This study aims to assess the endometrial safety of ospemifene based on phase 2/3 clinical trials of postmenopausal women with up to 52 weeks of exposure to ospemifene 60 mg/day versus place... | Intervention: ospemifene 60 mg/day
Comparator: placebo
Outcome: pelvic organ prolapse | 0 | {"evidence_spans": [{"end": 25030, "start": 24941, "text": ".\r\n\r\nBODY.RESULTS.PELVIC ORGAN PROLAPSE:\r\nThere were rare cases of pelvic organ prolapse "}, {"end": 25177, "start": 24941, "text": ".\r\n\r\nBODY.RESULTS.PELVIC ORGAN PROLAPSE:\r\nThere were rare cases of pelvic organ prolapse in both the ospemifene and... |
TITLE: Comparison of Local Anesthetic Effect of Bupivacaine versus Bupivacaine plus Dexamethasone in Nasal Surgery
ABSTRACT.INTRODUCTION::
Adequate pain control is an important consideration in the post-surgical management of patients. Local nerve blockade added to general anesthesia can provide excellent pain c... | Intervention: bupivacaine plus dexamethasone
Comparator: bupivacaine
Outcome: The analgesic requirement | -1 | {"evidence_spans": [{"end": 1355, "start": 1262, "text": "B group. The analgesic requirement was significantly lower in the B+D group compared with the"}, {"end": 6516, "start": 6309, "text": "st surgery 8.3\u00b11.6 6.2\u00b11.3 0.221 The analgesic requirement was significantly lower in the B+D group compared with t... |
TITLE: Comparison of Local Anesthetic Effect of Bupivacaine versus Bupivacaine plus Dexamethasone in Nasal Surgery
ABSTRACT.INTRODUCTION::
Adequate pain control is an important consideration in the post-surgical management of patients. Local nerve blockade added to general anesthesia can provide excellent pain c... | Intervention: bupivacaine plus dexamethasone
Comparator: bupivacaine
Outcome: At 1, 2, 4, 6, and 12 h post surgery, VAS pain scores | -1 | {"evidence_spans": [{"end": 1261, "start": 1145, "text": "2 years. At 1, 2, 4, 6, and 12 h post surgery, VAS pain values were significantly lower in the B+D group than in the"}, {"end": 5488, "start": 5309, "text": "surgery (Table 1). At 1, 2, 4, 6, and 12 h post surgery, VAS pain scores were significantly lower in t... |
TITLE: Effect of Calcium Supplementation on Blood Lead Levels in Pregnancy: A Randomized Placebo-Controlled Trial
ABSTRACT.BACKGROUND:
Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate fetal exposure by inhibiting mobilization of materna... | Intervention: ingest 1,200 mg dietary calcium
Comparator: ingest placebo
Outcome: maternal blood lead concentrations | -1 | {"evidence_spans": [{"end": 16120, "start": 15917, "text": "ported LGC use by treatment group. In the intent-to-treat analysis (n = 557), calcium supplementation was associated with an overall average reduction of 11% in maternal blood lead concentrations relati"}], "id": "1501", "pmcid": "2627861", "prompt_id": "1501... |
TITLE: A randomized controlled trial of multi-session online interpretation bias modification training: Short- and long-term effects on anxiety and depression in unselected adolescents
ABSTRACT.INTRODUCTION:
Negatively biased interpretations play an important role in anxiety and depression, which are highly preva... | Intervention: Cognitive Bias Modification for Interpretations (CBM-I) training
Comparator: placebo training
Outcome: anxiety and depressive symptoms | 0 | {"evidence_spans": [{"end": 36857, "start": 36628, "text": " = .224. \r\n\r\nBODY.RESULTS.PRIMARY OUTCOME MEASURES:\r\nOur first and primary hypothesis, that CBM-I would result in reduced anxiety and depressive symptoms compared to Placebo, was not confirmed, as no significant Condition x Time"}], "id": "1503", "pmcid... |
TITLE: A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer
ABSTRACT.BACKGROUND::
Pertuzumab plus trastuzumab provides a more comprehensive blockade of HER2 signalling than trastuzumab ... | Intervention: pertuzumab 840 mg for cycle 1 and 420 mg q3w for cycles 2–6 (Arm A)
Comparator: pertuzumab 840 mg q3w for six cycles (Arm B)
Outcome: The safety profiles | 0 | {"evidence_spans": [{"end": 1198, "start": 1119, "text": " cancer. The safety profiles were similar between arms and treatment was well t"}, {"end": 19944, "start": 19641, "text": "rm A, study day 22 (22\u201356) in Arm B). The total number of grade \u2a7e3 AEs was 78 in Arm A and 60 in Arm B and the most frequent gra... |
TITLE: A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer
ABSTRACT.BACKGROUND::
Pertuzumab plus trastuzumab provides a more comprehensive blockade of HER2 signalling than trastuzumab ... | Intervention: pertuzumab 840 mg for cycle 1 and 420 mg q3w for cycles 2–6 (Arm A)
Comparator: pertuzumab 840 mg q3w for six cycles (Arm B)
Outcome: Partial responses | 1 | {"evidence_spans": [{"end": 21273, "start": 21036, "text": "ient in each arm had progressive disease. At the end of cycle 6, a partial response was observed in 12 (86%) and 6 (55%) patients in Arms A and B, respectively, whereas 2 (14%) and 3 (27%) patients, respectively, had stable disease. Two "}], "id": "1511", "pmc... |
TITLE: A meta-analysis of two randomised trials of early chemotherapy in asymptomatic metastatic colorectal cancer
ABSTRACT:
This report constitutes a prospectively planned meta-analysis combining two almost identical trials undertaken in Australasia and Canada to study the effect of starting chemotherapy immedia... | Intervention: receive immediate treatment
Comparator: receive delayed treatment
Outcome: Median survival | 0 | {"evidence_spans": [{"end": 1315, "start": 1148, "text": "d. Median survival was not significantly better with immediate treatment (median 13.0 vs 11.0 months; hazard ratio, 1.15; 95% confidence interval (CI) 0.79\u20131.72; P=0.4"}, {"end": 17639, "start": 17354, "text": "46% for delayed treatment. Median survival was... |
TITLE: A meta-analysis of two randomised trials of early chemotherapy in asymptomatic metastatic colorectal cancer
ABSTRACT:
This report constitutes a prospectively planned meta-analysis combining two almost identical trials undertaken in Australasia and Canada to study the effect of starting chemotherapy immedia... | Intervention: receive immediate treatment
Comparator: receive delayed treatment
Outcome: time to disease progression or survival | 0 | {"evidence_spans": [{"end": 16111, "start": 15953, "text": "O DISEASE PROGRESSION:\r\nThe time to disease progression from randomisation to after chemotherapy was similar in the immediate- and delayed-treatment groups fo"}], "id": "1515", "pmcid": "2361520", "prompt_id": "1515", "split_group_id": "2361520", "votes": {"... |
TITLE: Effects of Substituting Soybean Meal for Sunflower Cake in the Diet on the Growth and Carcass Traits of Crossbred Boer Goat Kids
ABSTRACT:
The present study was conducted to determine the best level of substitution of soybean meal by sunflower cake in diets for kids through the evaluation of quantitative c... | Intervention: sunflower cake
Comparator: soybean meal
Outcome: goats body weight at slaughter | 0 | {"evidence_spans": [{"end": 1419, "start": 685, "text": "d. There was no influence of the treatments on any of the mean values of the evaluated measures (p>0.05): 21.78 kg (body weight at slaughter), 8.65 kg (hot carcass weight), 8.59 kg (cold carcass weight), 40.27% (hot carcass yield), 39.20% (cold carcass yield), 7.... |
TITLE: Effects of Substituting Soybean Meal for Sunflower Cake in the Diet on the Growth and Carcass Traits of Crossbred Boer Goat Kids
ABSTRACT:
The present study was conducted to determine the best level of substitution of soybean meal by sunflower cake in diets for kids through the evaluation of quantitative c... | Intervention: sunflower cake
Comparator: soybean meal
Outcome: Weights, carcass yields, rib eye area of goats | 0 | {"evidence_spans": [{"end": 10184, "start": 10046, "text": " slaughter. Weights and carcass yields as well as rib eye area showed no differences (p>0.05) with the substitution of soybean meal by su"}], "id": "1526", "pmcid": "4092926", "prompt_id": "1526", "split_group_id": "4092926", "votes": {"0": 2}} |
TITLE: Tranexamic acid for patients with traumatic brain injury: a randomized, double-blinded, placebo-controlled trial
ABSTRACT.BACKGROUND:
Traumatic brain injury (TBI) is commonly accompanied by intracranial bleeding which can worsen after hospital admission. Tranexamic acid (TXA) has been shown to reduce bleed... | Intervention: Tranexamic acid
Comparator: Placebo
Outcome: Risk of unfavorable outcome on the Glasgow Outcome Score | 0 | {"evidence_spans": [{"end": 1949, "start": 1690, "text": " 1.05)]. There were no significant difference in the risk of death from all causes in patients allocated to TXA compared with placebo [RR = 0.69 (95% CI 0.35 to 1.39)] and the risk of unfavourable outcome on the Glasgow Outcome Scale [RR = 0.76 (95% CI 0.46 t"},... |
TITLE: Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
ABSTRACT.AIMS:
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safe... | Intervention: ticagrelor
Comparator: clopidogrel
Outcome: The composite of major or minor bleeding (by PLATO criteria) | 1 | {"evidence_spans": [{"end": 20277, "start": 20114, "text": "R 2.01; 95% CI = 0.81\u20134.99; P = 0.13). The composite of major or minor bleeding (by PLATO criteria) occurred more often in the ticagrelor group (18.2 vs. 16.3%; HR"}], "id": "1289", "pmcid": "4132637", "prompt_id": "1289", "split_group_id": "4132637", "vo... |
TITLE: Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes
ABSTRACT.BACKGROUND:
This randomized, partially single-blinded, 6-period crossover clinical study of adult smokers compared the nicotine pharmacokinetics, impacts on smoki... | Intervention: E-cigarettes
Comparator: Conventional tobacco cigarette
Outcome: Urge to smoke | 0 | {"evidence_spans": [{"end": 29959, "start": 29602, "text": " 30 min. Table 4 summarizes the change in smoking urge PD parameters. No statistically significant differences were found in the maximal smoking urge reduction parameters Emax0\u201330 and Emaxreduction0\u201330 (all differences within 11 %) or the overall sm... |
TITLE: The status of serum γ-interferonand antiviral antibodies in patients with type I and type 2 diabetes: A comparative study
ABSTRACT.OBJECTIVES::
There is an association between viral infection and development of diabetes mellitus. This study aimed to investigate the role of rubella virus, cytomegalovirus an... | Intervention: type 1 DM
Comparator: type 2 DM
Outcome: serum level of IgM | 0 | {"evidence_spans": [{"end": 8106, "start": 7856, "text": "ve anti-viral antibody. There are no significant differences between serum level of IgM between patients with T1D and T2D (181.1 \u00b1 58.8 vs 183.8 \u00b1 54.1 mg/dl respectively) and these values are less than reference value of healthy subjects in the labo"}... |
TITLE: Efficacy and Safety of Subcutaneous Golimumab in Methotrexate‐Naive Patients With Rheumatoid Arthritis: Five‐Year Results of a Randomized Clinical Trial
ABSTRACT.OBJECTIVE:
To evaluate the safety and efficacy of golimumab through 5 years in adults with active rheumatoid arthritis (RA) who had not previousl... | Intervention: Golimumab plus?MTX
Comparator: Placebo?plus MTX or Golimumab
Outcome: Improvement in patient?reported outcomes at the end of treatment | 0 | {"evidence_spans": [{"end": 20602, "start": 20484, "text": "1 at 12 weeks after dose escalation. Improvements from baseline to week 256 in patient\u2010reported outcomes were general"}, {"end": 20612, "start": 20484, "text": "1 at 12 weeks after dose escalation. Improvements from baseline to week 256 in patient\u2010... |
TITLE: Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy
ABSTRACT.OBJECTIVE:
Identification of pretreatment patient characteristics predictive of psychotherapy outcome could help to guide treatment choices. This study evaluates patients' initial level of imma... | Intervention: Short-term psychotherapy
Comparator: Long-term psychotherapy
Outcome: Decrease in symptoms among patients with low immature defense style after 1 year | 1 | {"evidence_spans": [{"end": 22280, "start": 22004, "text": "elation to the level of immature defense style. During the first year of the follow-up, a statistically larger symptom reduction in the short-term therapy group than in the long-term therapy group (18\u201345% vs. 9\u201331%, respectively) was found among pati... |
TITLE: Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies
ABSTRACT.INTRODUCTION:
To examine pooled efficacy data from three, large phase III studies comparing mirabegron (50... | Intervention: mirabegron (50 and 100 mg)
Comparator: placebo
Outcome: mean number of nocturia episodes/24 h | -1 | {"evidence_spans": [{"end": 28210, "start": 27871, "text": "I, full analysis set-incontinence. Significant improvements were also evident in the pooled efficacy analysis with respect to the change from baseline to Final Visit (95% CI) in the mean number of nocturia episodes/24 h in the mirabegron 50 mg [\u22120.55 (\u... |
TITLE: Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy
ABSTRACT.OBJECTIVE:
Identification of pretreatment patient characteristics predictive of psychotherapy outcome could help to guide treatment choices. This study evaluates patients' initial level of imma... | Intervention: Short-term psychotherapy
Comparator: Long-term psychotherapy
Outcome: Overall symptom reduction after 3 years | 0 | {"evidence_spans": [{"end": 21637, "start": 21430, "text": "sonality disorder: main diagnoses on Axis II. During the 3-year follow-up, a statistically significant symptom reduction was found in all six outcome measures (BDI, HDRS, SCL-90-Anx, HARS, SCL-90-GSI, GAF)"}], "id": "1053", "pmcid": "4075638", "prompt_id": "... |
TITLE: Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)
ABSTRACT.INTRODUCTION:
The aim of the study was to assess the clinical efficacy, safety, and disease-modification effects of tramiprosate (homotaurine, ALZHEMEDTM) i... | Intervention: 78-week treatment with tramiprosate 100 mg
Comparator: 78-week treatment with placebo
Outcome: adverse effects | 0 | {"evidence_spans": [{"end": 1761, "start": 1693, "text": " placebo. The incidence of adverse events was similar across treatme"}, {"end": 16870, "start": 16766, "text": " weight decrease appeared to be dose-related. However, the incidence of these AEs in the 100 mg BID grou"}], "id": "1311", "pmcid": "3258678", "prompt... |
TITLE: A controlled study of community-based exercise training in patients with moderate COPD
ABSTRACT.BACKGROUND:
The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study... | Intervention: 12-weeks of progressive endurance and strength training at a local health club
Comparator: continuation of unsupervised habitual physical activity
Outcome: total weight lifted | 1 | {"evidence_spans": [{"end": 1342, "start": 1223, "text": " 0.001). The CBE group increased muscle strength (weight lifted) by 11.8 kilograms per subject per week of training (P "}, {"end": 15063, "start": 14864, "text": "s in the control group (P = 0.041). Patients who participated in the CBE arm lifted significantly m... |
TITLE: Effects of Neuromuscular Electrical Stimulation Combined with Exercises versus an Exercise Program on the Pain and the Function in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
ABSTRACT:
Objectives. To investigate the effect of 8 weeks of NMES + Ex (neuromuscular electrical stimulation... | Intervention: NMES plus exercise
Comparator: Exercise alone
Outcome: Western Ontario and McMaster Universities Osteoarthritis Index for physical function | 0 | {"evidence_spans": [{"end": 1311, "start": 1057, "text": "ed. For the comparison between the groups, no statistically significant difference was found between the NMES + Ex and the Ex groups in NRS (P = 0.52), TUG test (P = 0.12), and aspects of WOMAC: pain (P = 0.26), function (P = 0.23), and stiffness (P = 0."}, {"en... |
TITLE: A controlled study of community-based exercise training in patients with moderate COPD
ABSTRACT.BACKGROUND:
The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study... | Intervention: 12-weeks of progressive endurance and strength training at a local health club
Comparator: continuation of unsupervised habitual physical activity
Outcome: Mean treadmill endurance times | 1 | {"evidence_spans": [{"end": 16885, "start": 16627, "text": "week. NA: not applicable. Figure 2Mean treadmill endurance times for the two groups at baseline and after 12 weeks. Mean changes were a decrease of 59 seconds for the control group compared with an increase of 134 seconds for those completing the community"}... |
TITLE: Physiological effects of invasive ventilation with neurally adjusted ventilatory assist (NAVA) in a crossover study
ABSTRACT.BACKGROUND:
Neurally Adjusted Ventilatory Assist (NAVA) is a mode of assisted mechanical ventilation that delivers inspiratory pressure proportionally to the electrical activity of t... | Intervention: Neurally Adjusted Ventilatory Assist
Comparator: Conventional Ventilation
Outcome: Cardiac index improvement | 0 | {"evidence_spans": [{"end": 1889, "start": 1783, "text": "= 0.03). There were no statistically significant differences on cardiac index between the two modes of ven"}, {"end": 15543, "start": 15473, "text": "of the diaphragm, ScvO\r\n2 central venous oxygen saturation\r\n Cardiac "}], "id": "1065", "pmcid": "5100099",... |
TITLE: The efficacy of duloxetine: A comprehensive summary of results from MMRM and LOCF_ANCOVA in eight clinical trials
ABSTRACT.BACKGROUND:
A mixed-effects model repeated measures approach (MMRM) was specified as the primary analysis in the Phase III clinical trials of duloxetine for the treatment of major depr... | Intervention: A mixed-effects model repeated measures approach (MMRM)
Comparator: analysis of covariance (ANOVA or ANCOVA) with missing data imputed by the last observation carried forward approach (LOCF_ANCOVA)
Outcome: Standard errors | 1 | {"evidence_spans": [{"end": 23047, "start": 22889, "text": "ter than those from MMRM. Standard errors from LOCF_ANCOVA were approximately 5% smaller than the Week 9 standard errors from MMRM for both the HAMD17 total "}], "id": "1068", "pmcid": "520750", "prompt_id": "1068", "split_group_id": "520750", "votes": {"1": ... |
TITLE: Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination
ABSTRACT:
Loss of estrogen production in women during menopause results in a state of estrogen deficiency which has been associated with multiple problems, including vasomotor symptoms, symptoms of vul... | Intervention: BZA/CE combines bazedoxifene (BZA), a selective estrogen receptor modulator, with conjugated estrogens (CE),
Comparator: placebo
Outcome: breast tenderness | 0 | {"evidence_spans": [{"end": 23183, "start": 22355, "text": ".SAFETY.BREAST SAFETY:\r\nThe effect of BZA/CE regimens on the incidence of breast pain/tenderness was evaluated in SMART-1, SMART-2, and SMART-5.17,18,20 In these studies, breast pain/tenderness was measured by daily subject diaries. Both the BZA 20 mg/CE 0.4... |
TITLE: Effects of lifestyle physical activity on perceived symptoms and physical function in adults with fibromyalgia: results of a randomized trial
ABSTRACT.INTRODUCTION:
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated... | Intervention: lifestyle physical activity (LPA) - 30 minutes of self-selected moderate-intensity LPA, five to seven days per week
Comparator: fibromyalgia (FM) education control (FME) group - received information and support
Outcome: Number of tender points | 0 | {"evidence_spans": [{"end": 21141, "start": 21024, "text": "k test approached significance (P = .067; Cohen's d = .53). There were no significant differences between the groups "}, {"end": 22360, "start": 22228, "text": " \u00b1 11.3 .4 (-5.3 to 4.6) 0.888 .04 Number of tender points \u2003Baseline 84 16.2 \u00b1 2.3 1... |
TITLE: Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet
ABSTRACT:
Oxidative stress has previously been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications. In the present study, the effects ... | Intervention: high-fat diet enriched with vitamin E, 40 mg ?-tocopherol/100 g of food
Comparator: received a high-fat diet (40% energy as fat), deficient in ?-linolenic acid (ALA)
Outcome: TC, non-HDL-C and TG levels | -1 | {"evidence_spans": [{"end": 11819, "start": 11657, "text": " those in the unsupplemented DM group. The addition of vitamin E to the flaxseed-rich diet significantly decreased TC, non-HDL-C and TG levels but did not improve"}, {"end": 18375, "start": 18139, "text": " levels in diabetic hamsters fed an atherogenic diet. ... |
TITLE: Feto-maternal outcomes and Glycemic control in Metformin versus insulin treated Gestational Diabetics
ABSTRACT.OBJECTIVE::
To evaluate and compare feto-maternal outcomes and glycemic control in metformin versus insulin treated gestational diabetics.
ABSTRACT.METHODS::
The study was conducted in 2010- 2... | Intervention: oral metformin 500 mg TDS (Group-A)
Comparator: insulin 0.8-0.9 mg/kg/day in two divided doses subcutaneously (Group-B)
Outcome: newborns weight | -1 | {"evidence_spans": [{"end": 930, "start": 840, "text": "SULTS::\r\nWhen groups were compared, newborns in Group-B were significantly more in weight "}, {"end": 7611, "start": 7488, "text": "bin at enrollment. When fetal outcomes were evaluated the babies of Group-B were significantly more in weight as compared"}], "i... |
TITLE: Resistant starch lowers postprandial glucose and leptin in overweight adults consuming a moderate-to-high-fat diet: a randomized-controlled trial
ABSTRACT.BACKGROUND:
High-amylose maize resistant starch type 2 (HAM-RS2) stimulates gut-derived satiety peptides and reduces adiposity in animals. Human studies... | Intervention: muffins enriched with 30 g HAM-RS2
Comparator: muffins enriched with 0 g HAM-RS2 (control)
Outcome: body composition | 0 | {"evidence_spans": [{"end": 2437, "start": 2196, "text": "ONCLUSION:\r\nConsuming 30 g HAM-RS2 daily for 6 weeks can improve glucose homeostasis, lower leptin concentrations, and increase fasting PYY in healthy overweight adults without impacting body composition and may aid in the prevention of chro"}, {"end": 19943, ... |
TITLE: A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial
ABSTRACT.BACKGROUND:
Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol.... | Intervention: single serving of curry meal
Comparator: spice-free control meal
Outcome: systemic and forearm hemodynamics, or any biochemical parameters including oxidative stress markers | 0 | {"evidence_spans": [{"end": 1518, "start": 1345, "text": " 0.002). Presence of spices in the curry did not alter significantly the systemic and forearm hemodynamics, or any biochemical parameters including oxidative stress markers "}], "id": "1090", "pmcid": "4082484", "prompt_id": "1090", "split_group_id": "4082484", ... |
TITLE: Handwriting training in Parkinson’s disease: A trade-off between size, speed and fluency
ABSTRACT.BACKGROUND:
In previous work, we found that intensive amplitude training successfully improved micrographia in Parkinson's disease (PD). Handwriting abnormalities in PD also express themselves in stroke durati... | Intervention: Amplitude training
Comparator: Placebo
Outcome: Normalized jerk | 1 | {"evidence_spans": [{"end": 13476, "start": 13221, "text": ".AUTOMATIZATION TASK.NORMALIZED JERK:\r\nA significant Time x Group interaction was found for the normalized jerk in the large-amplitude condition (F = 8.928, p < 0.001) (Fig 1C). Further analysis revealed a higher normalized jerk in the EXP group compared "},... |
TITLE: A randomized, double-blind comparison of OROS
ABSTRACT.BACKGROUND:
Long-acting opioid formulations are advocated for maintaining pain control in chronic cancer pain. OROS® hydromorphone is a sustained-release formulation of hydromorphone that requires dosing once daily to maintain therapeutic concentration... | Intervention: hydromorphone
Comparator: morphine
Outcome: the time to withdrawal, irrespective of phase | 0 | {"evidence_spans": [{"end": 30468, "start": 30299, "text": "e (6 OROS\u00ae hydromorphone, 4 CR morphine). There was no statistically significant difference between treatment groups in the time to withdrawal, irrespective of phase (IR"}], "id": "1095", "pmcid": "2644667", "prompt_id": "1095", "split_group_id": "2644667... |
TITLE: A Randomized, Open-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIV-1-Infected Adults
ABSTRACT:
Supplemental Digital Content is Available in the Text.
BODY.INTRODUCTION:
Morbidity and mortality in HIV infection ... | Intervention: elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) 150/150/200/10 mg plus DRV 800 mg (Janssen) once daily
Comparator: stay on their baseline regimen
Outcome: mean HIV treatment satisfaction total scores at weeks 24 and 48 | 1 | {"evidence_spans": [{"end": 18671, "start": 18307, "text": "RESULTS.PATIENT-REPORTED OUTCOMES:\r\nAlthough both arms showed improved patient-reported outcome scores, participants in the E/C/F/TAF plus DRV group reported statistically significantly higher mean HIV treatment satisfaction total scores at weeks 24 and 48 (... |
TITLE: A Randomized, Open-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIV-1-Infected Adults
ABSTRACT:
Supplemental Digital Content is Available in the Text.
BODY.INTRODUCTION:
Morbidity and mortality in HIV infection ... | Intervention: elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) 150/150/200/10 mg plus DRV 800 mg (Janssen) once daily
Comparator: stay on their baseline regimen
Outcome: days with missed doses | -1 | {"evidence_spans": [{"end": 19176, "start": 18672, "text": " with the treatment more favorably. Based on the visual analog scale adherence questionnaire, participants on E/C/F/TAF plus DRV consistently reported fewer days with missed doses, whereas those on their baseline regimen reported a higher number of days with m... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Time to first COPD exacerbation | 1 | {"evidence_spans": [{"end": 22032, "start": 21810, "text": "E PULMONARY DISEASE (COPD) EXACERBATIONS:\r\nTime to first COPD exacerbation was significantly prolonged with both budesonide/formoterol dosages compared with placebo (p \u2264 0.004) and with budesonide/formoterol 320/9 \u03bcg compa"}], "id": "345", "pmcid":... |
TITLE: Effect of a randomised exclusive breastfeeding counselling intervention nested into the MINIMat prenatal nutrition trial in Bangladesh
ABSTRACT.ABSTRACT.AIM:
It is unknown whether maternal malnutrition reduces the effect of counselling on exclusive breastfeeding. This study evaluated the effect of breastfe... | Intervention: receive exclusive breastfeeding counselling from the counsellors
Comparator: receive the usual health messages from the Matlab regular health staff
Outcome: received colostrum as the first food | 1 | {"evidence_spans": [{"end": 19124, "start": 18956, "text": "an (SD) unless indicated to be n/n (%). John Wiley & Sons, Ltd In the breastfeeding counselling group, 95.5% of the babies had received colostrum as the first food, c"}], "id": "1116", "pmcid": "5215617", "prompt_id": "1116", "split_group_id": "5215617", "vo... |
TITLE: Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive
ABSTRACT.BACKGROUND:
Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the saf... | Intervention: Acidform twice daily for 14 consecutive days
Comparator: hydroxyethylcellulose (HEC) placebo gel twice daily for 14 consecutive days
Outcome: G. vaginalis | 0 | {"evidence_spans": [{"end": 1867, "start": 1681, "text": "ication. There were no significant changes in Lactobacillus crispatus or Lactobacillus jensenii in either group but there was a decrease in Gardnerella vaginalis in the Acidform group (p"}, {"end": 31261, "start": 31070, "text": " bacteria recovered by PCR in th... |
TITLE: Social Presence and Use of Internet-Delivered Interventions: A Multi-Method Approach
ABSTRACT.OBJECTIVE:
Internet-delivered interventions can effectively change health risk behaviors and their determinants, but adherence to intervention websites once they are accessed is very low. This study tests whether ... | Intervention: website with social presence elements.
Comparator: website without social presence elements.
Outcome: efficiency, effectiveness, enjoyment, active trust, and interest | 0 | {"evidence_spans": [{"end": 25935, "start": 25674, "text": "bsite (sec) 151.0 117.4 150.8 107.8 0.01 .99 0.00 \r\n\r\nBODY.RESULTS.USER PERCEPTIONS:\r\nThere were no differences between conditions in terms of efficiency (F(1, 456) = 0.84, p = .36), effectiveness (F(1, 456) = 0.03, p = .87), enjoyment (F(1, 456) = 0.08,... |
TITLE: Comparative utility of disability progression measures in PPMS
ABSTRACT.OBJECTIVE::
To assess the comparative utility of disability progression measures in primary progressive MS (PPMS) using the PROMiSe trial data set.
ABSTRACT.METHODS::
Data for patients randomized to placebo (n = 316) in the PROMiSe... | Intervention: timed 25-foot walk [T25FW],
Comparator: Expanded Disability Status Scale [EDSS]
Outcome: confirmed disability progression | 1 | {"evidence_spans": [{"end": 890, "start": 778, "text": "SULTS::\r\nCDP rates defined by a \u226520% increase in T25FW were higher than those defined by EDSS score at 12 and 24"}], "id": "1121", "pmcid": "5489138", "prompt_id": "1121", "split_group_id": "5489138", "votes": {"1": 1}} |
TITLE: Learning to experience side effects after antidepressant intake – Results from a randomized, controlled, double-blind study
ABSTRACT.BACKGROUND:
Side effects play a key role in patients' failure to take antidepressants. There is evidence that verbal suggestions and informed consent elicit expectations that... | Intervention: amitriptyline
Comparator: placebo pill
Outcome: medication-attributed, antidepressant-specific side effect score | 1 | {"evidence_spans": [{"end": 22885, "start": 22576, "text": "ECTS.GASE-AD-MA (MEDICATION-ATTRIBUTED ANTIDEPRESSANT-SPECIFIC SIDE EFFECTS):\r\nWe found that the amitriptyline group's medication-attributed, antidepressant-specific side effect score was significantly higher after the acquisition phase (p \u2264 .001; g = 1... |
TITLE: First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens
ABSTRACT:
Background. We report the first-in-human safety and immunogenicit... | Intervention: groups primed with SeV-Gag and boosted with Ad35-GRIN (SLA and SHA)
Comparator: a single dose of Ad35-GRIN or SeV-Gag
Outcome: Functional CD8+ T-cell responses with greater breadth, magnitude, and frequency in a viral inhibition assay | 1 | {"evidence_spans": [{"end": 1979, "start": 1753, "text": "n. Functional CD8+ T-cell responses with greater breadth, magnitude, and frequency in a viral inhibition assay were also seen in the SLA and SHA groups after Ad35-GRIN boost, compared with those who received either vaccine alo"}], "id": "1131", "pmcid": "5225252... |
TITLE: Messaging to Increase Public Support for Naloxone Distribution Policies in the United States: Results from a Randomized Survey Experiment
ABSTRACT.BACKGROUND:
Barriers to public support for naloxone distribution include lack of knowledge, concerns about potential unintended consequences, and lack of sympat... | Intervention: receiving the combination of the sympathetic narrative and factual information
Comparator: factual information alon
Outcome: support all policies: providing naloxone to friends and family members, training first responders to use naloxone, passing laws to protect people if they administer naloxone, and pa... | 1 | {"evidence_spans": [{"end": 1933, "start": 1400, "text": "aloxone. Participants receiving the combination of the sympathetic narrative and factual information, compared to factual information alone, were more likely to support all policies: providing naloxone to friends and family members (OR: 2.0 [95% CI: 1.4 to 2.9])... |
TITLE: Effect of
ABSTRACT.BACKGROUND:
To evaluate the value of KRAS codon 13 mutations in patients with advanced colorectal cancer (advanced CRC) treated with oxaliplatin and fluoropyrimidines.
ABSTRACT.METHODS:
Tumor specimens from 201 patients with advanced CRC from a randomized, phase III trial comparing ... | Intervention: FUFOX
Comparator: CAPOX
Outcome: Progression-free survival in patients with codon 13 mutations | -1 | {"evidence_spans": [{"end": 15156, "start": 14867, "text": "fferent in the three KRAS mutational groups. Interestingly, we found a substantial difference in PFS between patients with codon 12 and 13 mutant tumors when looking at infusional 5-FU versus capecitabine based regimens. Patients with codon 13 mutations seem t... |
TITLE: Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients
ABSTRACT.INTRODUCTION:
Physical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise ... | Intervention: high-intensity interval training (HIT) for 12-weeks in patients NYHA II-III
Comparator: continuous training (CT) 12-weeks inpatients NYHA II-III
Outcome: maximal oxygen uptake | 0 | {"evidence_spans": [{"end": 1438, "start": 1197, "text": "ESULTS:\r\nTraining improved maximal workload, peak oxygen uptake (VO2peak) related to the predicted VO2peak, oxygen uptake at the anaerobic threshold, and maximal oxygen pulse (all P<0.05), whilst no differences were present between HIT and C"}, {"end": 29028, ... |
TITLE: Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients
ABSTRACT.INTRODUCTION:
Physical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise ... | Intervention: training for 12-weeks in patients NYHA II-III
Comparator: no training for 12-weeks inpatients NYHA II-III
Outcome: maximal workload, peak oxygen uptake (VO2peak) related to the predicted VO2peak, oxygen uptake at the anaerobic threshold, and maximal oxygen pulse | 1 | {"evidence_spans": [{"end": 1376, "start": 1197, "text": "ESULTS:\r\nTraining improved maximal workload, peak oxygen uptake (VO2peak) related to the predicted VO2peak, oxygen uptake at the anaerobic threshold, and maximal oxygen pulse (all"}], "id": "1138", "pmcid": "4627811", "prompt_id": "1138", "split_group_id": "46... |
TITLE: The Effect of Desmopressin on the Amount of Bleeding in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Cardiopulmonary Bypass Pump After Taking Anti-Platelet Medicine
ABSTRACT.BACKGROUND:
Coronary artery bypass grafting (CABG) is a common surgical intervention at the end-stages of coronary... | Intervention: Desmopressin
Comparator: Placebo
Outcome: Complications | 0 | {"evidence_spans": [{"end": 1943, "start": 1731, "text": "T.RESULTS:\r\nThere was no significant difference between the groups regarding age, gender, pump time, clamp time, duration of surgery, complications, and the changes in hemoglobin and coagulation test measurements"}, {"end": 11079, "start": 10893, "text": "tic ... |
TITLE: Comparison of paracetamol and fentanyl for pain relief during and after suction termination
ABSTRACT.OBJECTIVES::
To compare the combination of paracetamol (20 mg/kg) and propofol to fentanyl (1 μg/kg) and propofol in terms of providing adequate analgesia and a comparable recovery profile in suction termin... | Intervention: fentanyl (1 μg/kg) and propofol
Comparator: paracetamol (20 mg/kg) and propofol
Outcome: the modified Aldrete scores at 60 minutes, systolic pressures at 0 minutes, oxygen saturation at 10, 15, 20 minutes, diastolic blood pressure at 10, 15, 20 minutes, heart rates, and visual analogue scores | 0 | {"evidence_spans": [{"end": 1232, "start": 947, "text": "SULTS::\r\nWhen the modified Aldrete scores at 60 minutes, systolic pressures at 0 minutes, oxygen saturation at 10, 15, 20 minutes, diastolic blood pressure at 10, 15, 20 minutes, heart rates, and visual analogue scores were compared, there was no significant di... |
TITLE: Comparison of paracetamol and fentanyl for pain relief during and after suction termination
ABSTRACT.OBJECTIVES::
To compare the combination of paracetamol (20 mg/kg) and propofol to fentanyl (1 μg/kg) and propofol in terms of providing adequate analgesia and a comparable recovery profile in suction termin... | Intervention: fentanyl (1 μg/kg) and propofol
Comparator: paracetamol (20 mg/kg) and propofol
Outcome: systolic blood pressures at 5, 10, 15, and 20 minutes | -1 | {"evidence_spans": [{"end": 1417, "start": 1233, "text": "p>0.05). In the fentanyl group, systolic blood pressures at 5, 10, 15, 20 minutes and diastolic blood pressure at 5 minutes and oxygen saturation at 5 minutes were significantly lower "}, {"end": 7473, "start": 7333, "text": "p>0.05) (Figure 2). In the fentanyl ... |
TITLE: Benefits of different postoperative treatments in patients undergoing knee arthroscopic debridement
ABSTRACT.PURPOSE:
To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal p... | Intervention: five injections of HA1 (Suprahyal®/Adant®)
Comparator: standard care (control)
Outcome: At 18 months, the higher improvement in total WOMAC | 1 | {"evidence_spans": [{"end": 1568, "start": 1318, "text": "to HA2). At 18 months, the higher improvement in total WOMAC was in HA1 with a 65.20% reduction, followed by PRP (55.01%), HA3 (49.57%), and HA2 (29.82%), whereas the control group had a 14.55% increase over baseline (p=0.001 control compared to HA1 "}], "id": "... |
TITLE: A Double-Blind Study on Acupuncture Sensations with Japanese Style of Acupuncture: Comparison between Penetrating and Placebo Needles
ABSTRACT:
To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch placebo needles were randomly admin... | Intervention: Acupuncture
Comparator: Placebo
Outcome: Needle pain intensity | 0 | {"evidence_spans": [{"end": 921, "start": 699, "text": "s. There were no significant differences in number of sensations elicited, MASS index, range of spreading, and intensity of needle pain for 5 mm penetration versus 1 mm skin press and 10 mm penetration versus 2 mm skin pre"}], "id": "1536", "pmcid": "5941723", "pr... |
TITLE: A Double-Blind Study on Acupuncture Sensations with Japanese Style of Acupuncture: Comparison between Penetrating and Placebo Needles
ABSTRACT:
To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch placebo needles were randomly admin... | Intervention: Acupuncture
Comparator: Placebo
Outcome: Severe adverse events | 0 | {"evidence_spans": [{"end": 16591, "start": 16478, "text": "3. RESULTS.3.5. ADVERSE EVENTS:\r\nDot haemorrhage occurred in three cases with the 10 mm penetrating needle. There"}, {"end": 16591, "start": 16553, "text": "th the 10 mm penetrating needle. There"}], "id": "1537", "pmcid": "5941723", "prompt_id": "1537", "sp... |
TITLE: Quality of care for remote orthopaedic consultations using telemedicine: a randomised controlled trial
ABSTRACT.BACKGROUND:
Decentralised services using outreach clinics or modern technology are methods to reduce both patient transports and costs to the healthcare system. Telemedicine consultations via vid... | Intervention: video-assisted remote consultations
Comparator: standard consultation (UNN)
Outcome: The mean consultation duration | 0 | {"evidence_spans": [{"end": 24741, "start": 24648, "text": "I 0.14\u20130.27).\r\n\r\nBODY.RESULTS.ANCILLARY ANALYSES:\r\nAdditional analyses are shown in Table 4. "}], "id": "1665", "pmcid": "5017045", "prompt_id": "1665", "split_group_id": "5017045", "votes": {"0": 2}} |
TITLE: Quality of care for remote orthopaedic consultations using telemedicine: a randomised controlled trial
ABSTRACT.BACKGROUND:
Decentralised services using outreach clinics or modern technology are methods to reduce both patient transports and costs to the healthcare system. Telemedicine consultations via vid... | Intervention: video-assisted remote consultations
Comparator: standard consultation (UNN)
Outcome: The mean consultation duration in the subgroup patients who required casting | 1 | {"evidence_spans": [{"end": 24947, "start": 24742, "text": "he mean consultation duration was not significantly different between the groups (p = 0.60). In the subgroup analyses restricted to patients who required casting, we observed a significantly longer mean co"}], "id": "1666", "pmcid": "5017045", "prompt_id": "16... |
TITLE: Quality of care for remote orthopaedic consultations using telemedicine: a randomised controlled trial
ABSTRACT.BACKGROUND:
Decentralised services using outreach clinics or modern technology are methods to reduce both patient transports and costs to the healthcare system. Telemedicine consultations via vid... | Intervention: video-assisted remote consultations
Comparator: standard consultation
Outcome: number of operated patients | 0 | {"evidence_spans": [{"end": 25406, "start": 25298, "text": "ting time and did not need the planned surgery and one did not appear for an unknown reason. There were no s"}], "id": "1667", "pmcid": "5017045", "prompt_id": "1667", "split_group_id": "5017045", "votes": {"0": 2}} |
TITLE: Comparison of vinorelbine with cisplatin in concomitant chemoradiotherapy in head and neck carcinoma
ABSTRACT.AIM::
Head and neck cancer is one of the most commonly occurring malignancies in the world. In India, the most commonly occurring head and neck cancers are those of the oral cavity and the pharynx.... | Intervention: Cisplatin 40mg/m2
Comparator: Vinorelbine 6mg/m2
Outcome: Skin reaction | 1 | {"evidence_spans": [{"end": 7893, "start": 7808, "text": "y significant, P-value 0.05). Skin reaction was also lower in the Vinorelbine arm whe"}], "id": "1672", "pmcid": "2941605", "prompt_id": "1672", "split_group_id": "2941605", "votes": {"1": 1}} |
TITLE: The effect of different types of insoles or shoe modifications on medial loading of the knee in persons with medial knee osteoarthritis: a randomised trial
ABSTRACT.ABSTRACT:
Many conservative treatments exist for medial knee osteoarthritis (OA) which aims to reduce the external knee adduction moment (EKAM... | Intervention: barefoot walking
Comparator: control shoe
Outcome: early stance peak EKAM | -1 | {"evidence_spans": [{"end": 16050, "start": 15815, "text": " Wiley Periodicals, Inc. When we examined the effects of the conditions on measures of medial loading (Tables 1 and 2, Fig. 3), we found that barefoot walking had the greatest effect on early stance peak EKAM, lowering it by \u22127.6% (p "}], "id": "1674", "... |
TITLE: The effect of different types of insoles or shoe modifications on medial loading of the knee in persons with medial knee osteoarthritis: a randomised trial
ABSTRACT.ABSTRACT:
Many conservative treatments exist for medial knee osteoarthritis (OA) which aims to reduce the external knee adduction moment (EKAM... | Intervention: lateral wedge insoles
Comparator: control condition
Outcome: second peak in EKAM during late stance | -1 | {"evidence_spans": [{"end": 18833, "start": 18663, "text": " Wiley Periodicals, Inc. For the second peak in EKAM during late stance, both of the lateral wedge insoles significantly reduced the magnitude of this peak in comparison"}], "id": "1675", "pmcid": "4737200", "prompt_id": "1675", "split_group_id": "4737200", "... |
TITLE: The effect of different types of insoles or shoe modifications on medial loading of the knee in persons with medial knee osteoarthritis: a randomised trial
ABSTRACT.ABSTRACT:
Many conservative treatments exist for medial knee osteoarthritis (OA) which aims to reduce the external knee adduction moment (EKAM... | Intervention: barefoot conditions
Comparator: control condition
Outcome: mobility | 0 | {"evidence_spans": [{"end": 18936, "start": 18834, "text": "to the control condition. There was no difference in the mobility or barefoot conditions in comparison"}], "id": "1676", "pmcid": "4737200", "prompt_id": "1676", "split_group_id": "4737200", "votes": {"0": 2}} |
TITLE: High-Intensity Interval Training as an Efficacious Alternative to Moderate-Intensity Continuous Training for Adults with Prediabetes
ABSTRACT:
Aims. High-intensity interval training (HIIT) leads to improvements in various markers of cardiometabolic health but adherence to HIIT following a supervised labo... | Intervention: High-intensity interval training
Comparator: Traditional moderate-intensity continuous training
Outcome: Changes in fitness measures | 0 | {"evidence_spans": [{"end": 22380, "start": 22164, "text": "atory fitness assessed at one-month follow-up. There were no main effects for group or group by time interactions for these fitness parameter variables, indicating that there were no differences in the degree of chan"}], "id": "1550", "pmcid": "4396724", "prom... |
TITLE: High-Intensity Interval Training as an Efficacious Alternative to Moderate-Intensity Continuous Training for Adults with Prediabetes
ABSTRACT:
Aims. High-intensity interval training (HIIT) leads to improvements in various markers of cardiometabolic health but adherence to HIIT following a supervised labo... | Intervention: High-intensity interval training
Comparator: Traditional moderate-intensity continuous training
Outcome: Maximal heart rate at the end of the test | 0 | {"evidence_spans": [{"end": 22587, "start": 22382, "text": " experienced between HIIT and MICT over time. Maximal heart rate achieved at the end of the graded exercise test, body mass, and waist circumference did not change significantly from baseline to one-month"}], "id": "1551", "pmcid": "4396724", "prompt_id": "15... |
TITLE: The effect of different types of insoles or shoe modifications on medial loading of the knee in persons with medial knee osteoarthritis: a randomised trial
ABSTRACT.ABSTRACT:
Many conservative treatments exist for medial knee osteoarthritis (OA) which aims to reduce the external knee adduction moment (EKAM... | Intervention: supported wedge
Comparator: control condition
Outcome: knee adduction angular impulse (KAAI) | -1 | {"evidence_spans": [{"end": 19207, "start": 18937, "text": "to the control condition. For the knee adduction angular impulse (KAAI), the barefoot condition and the two lateral wedge conditions were significantly different in comparison to the control condition (barefoot \u22124.3%, p = 0.023; typical wedge \u22127.95%,... |
TITLE: A Randomised Trial of Subcutaneous Intermittent Interleukin-2 without Antiretroviral Therapy in HIV-Infected Patients: The UK–Vanguard Study
ABSTRACT.OBJECTIVE::
The objective of the trial was to evaluate in a pilot setting the safety and efficacy of interleukin-2 (IL-2) therapy when used without concomita... | Intervention: IL-2 injection at 4.5 MIU dose
Comparator: No treatment
Outcome: Increase in CD4 T lymphocyte count | 1 | {"evidence_spans": [{"end": 1772, "start": 1556, "text": "mm3; p = 0.0009). Compared to the control group, significant increases in CD4 cell count were observed for both IL-2 dose groups: 104.2/mm3 (p = 0.008) and 128.4 cells/mm3 (p = 0.002) for the 4.5 and 7.5 MIU dose gro"}], "id": "1554", "pmcid": "1488892", "prompt... |
TITLE: A Randomised Trial of Subcutaneous Intermittent Interleukin-2 without Antiretroviral Therapy in HIV-Infected Patients: The UK–Vanguard Study
ABSTRACT.OBJECTIVE::
The objective of the trial was to evaluate in a pilot setting the safety and efficacy of interleukin-2 (IL-2) therapy when used without concomita... | Intervention: IL-2 injection at 7.5 MIU dose
Comparator: No treatment
Outcome: Increase in CD4 T lymphocyte count | 1 | {"evidence_spans": [{"end": 1772, "start": 1556, "text": "mm3; p = 0.0009). Compared to the control group, significant increases in CD4 cell count were observed for both IL-2 dose groups: 104.2/mm3 (p = 0.008) and 128.4 cells/mm3 (p = 0.002) for the 4.5 and 7.5 MIU dose gro"}], "id": "1555", "pmcid": "1488892", "prompt... |
TITLE: L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, randomized, cross-over pilot study
ABSTRACT.BACKGROUND:
Accumulating evidence suggests that the brain's nitric oxide (NO) signalling system may be involved in the pathophysiology of schizophrenia and could thus constitute a ... | Intervention: L-lysine
Comparator: Placebo
Outcome: Adverse side effects | 0 | {"evidence_spans": [{"end": 14633, "start": 14516, "text": "e responders (n = 8) in the statistical analysis. Furthermore, the L-lysine treatment was not found to induce any adv"}, {"end": 14635, "start": 14528, "text": " (n = 8) in the statistical analysis. Furthermore, the L-lysine treatment was not found to induce a... |
TITLE: L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, randomized, cross-over pilot study
ABSTRACT.BACKGROUND:
Accumulating evidence suggests that the brain's nitric oxide (NO) signalling system may be involved in the pathophysiology of schizophrenia and could thus constitute a ... | Intervention: L-lysine
Comparator: Placebo
Outcome: Symptom severity by PANSS measure | 0 | {"evidence_spans": [{"end": 18827, "start": 18283, "text": " Test 2). The rationale behind this approach was that given a biologically significant effect of L-lysine, a major part of the improvement in the testing score should be attributed to the L-lysine treatment period, and less to the placebo period and this effec... |
TITLE: Effect of Improving Dietary Quality on Arterial Stiffness in Subjects with Type 1 and Type 2 Diabetes: A 12 Months Randomised Controlled Trial
ABSTRACT:
People with diabetes have accelerated arterial stiffening. The aim of this study was to determine the effect of increasing fruit, vegetable and dairy inta... | Intervention: Increased intake of fruits, vegetables and dairy
Comparator: Usual diet
Outcome: Augmentation index (AIx) | 0 | {"evidence_spans": [{"end": 1330, "start": 1198, "text": "s. After adjustment for baseline measurements there was no time by treatment effect for central systolic or diastolic BP, AIx or cfP"}, {"end": 1777, "start": 1534, "text": "s. In the cohort with type 1 and type 2 diabetes, improving dietary quality by increasin... |
TITLE: The impact of urinary bladder catheterisation after ureterorenoscopic stone removal on the postoperative course
ABSTRACT.INTRODUCTION:
The most frequent reason for ureterorenoscopy is the necessity to remove calculi from the ureter and/or kidney. After completing this procedure the Foley catheter is insert... | Intervention: With catheter (group II)
Comparator: Without catheter (group I)
Outcome: Pain intensity | 1 | {"evidence_spans": [{"end": 1385, "start": 1308, "text": "ESULTS:\r\nIntensity of pain measured by the Visual Analog Scale was higher in "}, {"end": 4936, "start": 4822, "text": "able 1 and Figure 1. It was confirmed that the catheterised patients had sensed more intensive pain than the non-c"}], "id": "1573", "pmcid":... |
TITLE: The impact of urinary bladder catheterisation after ureterorenoscopic stone removal on the postoperative course
ABSTRACT.INTRODUCTION:
The most frequent reason for ureterorenoscopy is the necessity to remove calculi from the ureter and/or kidney. After completing this procedure the Foley catheter is insert... | Intervention: With catheter (group II)
Comparator: Without catheter (group I)
Outcome: Hospital stay after surgery | 0 | {"evidence_spans": [{"end": 6274, "start": 6128, "text": "ly in men and women. There was also no significant difference in the post-operative hospital stay between the groups, both in total and separately"}], "id": "1574", "pmcid": "5791393", "prompt_id": "1574", "split_group_id": "5791393", "votes": {"0": 2}} |
TITLE: The impact of urinary bladder catheterisation after ureterorenoscopic stone removal on the postoperative course
ABSTRACT.INTRODUCTION:
The most frequent reason for ureterorenoscopy is the necessity to remove calculi from the ureter and/or kidney. After completing this procedure the Foley catheter is insert... | Intervention: With catheter (group II)
Comparator: Without catheter (group I)
Outcome: Fever | 0 | {"evidence_spans": [{"end": 1699, "start": 1386, "text": "roup II. Catheterisation does not influence: the number of additional doses of ketoprofen and pethidine administered during the 1st day after the operation, the duration of hospitalization, the occurrence of fever, significant bacteriuria, the postoperative acut... |
TITLE: Effect of adding insulin degludec to treatment in patients with type 2 diabetes inadequately controlled with metformin and liraglutide: a double‐blind randomized controlled trial (
ABSTRACT.AIM:
To evaluate the efficacy and safety of adding insulin degludec (IDeg) to treatment in patients with type 2 diabe... | Intervention: Liraglutide and metformin plus insulin degludec (IDeg)
Comparator: Liraglutide and metformin plus placebo
Outcome: Change in levels of glycated haemoglobin after 26 weeks | 1 | {"evidence_spans": [], "id": "1578", "pmcid": "5074260", "prompt_id": "1578", "split_group_id": "5074260", "votes": {"1": 1}} |
TITLE: Effect of adding insulin degludec to treatment in patients with type 2 diabetes inadequately controlled with metformin and liraglutide: a double‐blind randomized controlled trial (
ABSTRACT.AIM:
To evaluate the efficacy and safety of adding insulin degludec (IDeg) to treatment in patients with type 2 diabe... | Intervention: Liraglutide and metformin plus insulin degludec (IDeg)
Comparator: Liraglutide and metformin plus placebo
Outcome: Overall confirmed hypoglycaemia | 1 | {"evidence_spans": [{"end": 1727, "start": 1564, "text": "lutide). Confirmed hypoglycaemia rates were low in both groups, although higher with IDeg than with placebo (0.57 vs. 0.12 episodes/patient\u2010years of exposure; p = "}, {"end": 16871, "start": 16695, "text": "k 26.\r\n\r\nBODY.RESULTS.SAFETY ENDPOINTS.\r\n:\r... |
TITLE: The effect of school meals with fatty fish on adolescents’ self-reported symptoms for mental health: FINS-TEENS - a randomized controlled intervention trial
ABSTRACT.ABSTRACT:
There is a growing body of evidence linking fish consumption and n-3 LCPUFAs to mental health. Still, the results from randomized t... | Intervention: Lunch meals with fatty fish (fish group)
Comparator: Lunch meals with meat (meat group) or lunch meals with n-3 LCPUFAs supplements (supplements group)
Outcome: Baseline characteristics | 0 | {"evidence_spans": [{"end": 18148, "start": 18057, "text": "CTERISTICS OF THE STUDY POPULATION:\r\nNo differences in baseline characteristics were found "}, {"end": 18159, "start": 18057, "text": "CTERISTICS OF THE STUDY POPULATION:\r\nNo differences in baseline characteristics were found between the"}], "id": "1583", ... |
TITLE: The effect of school meals with fatty fish on adolescents’ self-reported symptoms for mental health: FINS-TEENS - a randomized controlled intervention trial
ABSTRACT.ABSTRACT:
There is a growing body of evidence linking fish consumption and n-3 LCPUFAs to mental health. Still, the results from randomized t... | Intervention: Lunch meals with fatty fish (fish group)
Comparator: Lunch meals with meat (meat group) or lunch meals with n-3 LCPUFAs supplements (supplements group)
Outcome: SDQ change scores | 0 | {"evidence_spans": [{"end": 20256, "start": 20019, "text": " ADOLESCENTS\u2019 SELF-REPORTED SDQ SCORES:\r\nThere were no differences in any of the SDQ change scores from pre to post between the fish and meat or fish and supplement group, neither before nor after adjusting for the participants' baseline"}, {"end": 2027... |
TITLE: Essential Amino Acid Enriched High-Protein Enteral Nutrition Modulates Insulin-Like Growth Factor-1 System Function in a Rat Model of Trauma-Hemorrhagic Shock
ABSTRACT.BACKGROUND:
Nutrition support for critically ill patients supplemented with additional modular protein may promote skeletal muscle protein ... | Intervention: T-HS/Ctr
Comparator: T-HS/SE, T-HS/EAA
Outcome: Free IGF-1 concentrations at day 4 and day 6 | -1 | {"evidence_spans": [{"end": 19276, "start": 19021, "text": "ficantly decreased by day 2 (\r\np<0.01, \r\nFigure 5A\r\n\r\n). Following this time point, free IGF-1 concentrations increased gradually, but most slowly in the T-HS/Ctr group, which remained statistically lower than the other EN-treated groups (vs T-HS/SE at... |
TITLE: The Effect of Anchoring Sutures on Medicinal Leech Mortality
ABSTRACT:
Objective: The implementation of leech therapy for surgical flaps is not always logistically easy or comfortable for patients or healthcare providers. We examine different methods of placing sutures in the medicinal leech, Hirudo medici... | Intervention: Suture groups
Comparator: Control groups
Outcome: Survival time | 0 | {"evidence_spans": [{"end": 742, "start": 670, "text": "s: No difference in survival time was observed across the different grou"}], "id": "1591", "pmcid": "2714198", "prompt_id": "1591", "split_group_id": "2714198", "votes": {"0": 2}} |
TITLE: Performance of Surgical Stress Index during Sevoflurane-Fentanyl and Isoflurane-Fentanyl Anesthesia
ABSTRACT:
The performance of recently introduced Surgical Stress Index (SSI), based on heart rate and photoplethysmography, was estimated during sevoflurane-fentanyl and isoflurane-fentanyl anesthesia during... | Intervention: Sevoflurane-fentanyl anesthesia
Comparator: Isoflurane-fentanyl anesthesia
Outcome: HR, MAC and SE values after fentanyl boluses | 0 | {"evidence_spans": [{"end": 7431, "start": 7330, "text": "ly (Figure 2). After fentanyl boluses, SE and HR changes were similar and MAC values remained stable "}], "id": "1596", "pmcid": "2911596", "prompt_id": "1596", "split_group_id": "2911596", "votes": {"0": 1}} |
TITLE: Text Message Feedback to Support Mindfulness Practice in People With Depressive Symptoms: A Pilot Randomized Controlled Trial
ABSTRACT.BACKGROUND:
It has been shown that mindfulness practice can be helpful in preventing relapse from depression. However, practicing mindfulness regularly at home is often a c... | Intervention: Patients receiving text message–based feedback
Comparator: Patients not receiving text message assistance during follow-up
Outcome: Number of practiced exercises | 0 | {"evidence_spans": [{"end": 28476, "start": 28219, "text": ". \r\n\r\nBODY.RESULTS.FEASIBILITY OF THE OUTCOME MEASURES:\r\nThe effects of the post-hoc assessment of mindfulness home practice (number and duration of exercises practiced) and the four selected outcome questionnaires (PHQ-9, PTQ, FFA, and SCS-D) yielded ne... |
TITLE: Text Message Feedback to Support Mindfulness Practice in People With Depressive Symptoms: A Pilot Randomized Controlled Trial
ABSTRACT.BACKGROUND:
It has been shown that mindfulness practice can be helpful in preventing relapse from depression. However, practicing mindfulness regularly at home is often a c... | Intervention: Patients receiving text message–based feedback
Comparator: Patients not receiving text message assistance during follow-up
Outcome: PTQ (perseverative thinking) scores | 0 | {"evidence_spans": [{"end": 28476, "start": 28219, "text": ". \r\n\r\nBODY.RESULTS.FEASIBILITY OF THE OUTCOME MEASURES:\r\nThe effects of the post-hoc assessment of mindfulness home practice (number and duration of exercises practiced) and the four selected outcome questionnaires (PHQ-9, PTQ, FFA, and SCS-D) yielded ne... |
TITLE: Text Message Feedback to Support Mindfulness Practice in People With Depressive Symptoms: A Pilot Randomized Controlled Trial
ABSTRACT.BACKGROUND:
It has been shown that mindfulness practice can be helpful in preventing relapse from depression. However, practicing mindfulness regularly at home is often a c... | Intervention: Patients receiving text message–based feedback
Comparator: Patients not receiving text message assistance during follow-up
Outcome: SCS-D (self-compassion) scores | 0 | {"evidence_spans": [{"end": 28476, "start": 28219, "text": ". \r\n\r\nBODY.RESULTS.FEASIBILITY OF THE OUTCOME MEASURES:\r\nThe effects of the post-hoc assessment of mindfulness home practice (number and duration of exercises practiced) and the four selected outcome questionnaires (PHQ-9, PTQ, FFA, and SCS-D) yielded ne... |
TITLE: Use of Remifentanil and Alfentanil in Endotracheal Intubation: A Comparative Study
ABSTRACT.BACKGROUND::
Opioids, such as alfentanil, are used to facilitate endotracheal intubation without the use of neuromuscular blocking agents in patients undergoing elective surgery.
ABSTRACT.OBJECTIVES::
The goal o... | Intervention: Alfentanil
Comparator: Remifentanil
Outcome: Vocal cords patency | -1 | {"evidence_spans": [{"end": 1660, "start": 1425, "text": ", and sex). Further, laryngoscopy, jaw relaxation, and limb movement scores were similar in the R and A groups and there were no significant differences, but vocal cords were significantly more patent in group R than those in group A ("}, {"end": 1659, "start": ... |
TITLE: Use of Remifentanil and Alfentanil in Endotracheal Intubation: A Comparative Study
ABSTRACT.BACKGROUND::
Opioids, such as alfentanil, are used to facilitate endotracheal intubation without the use of neuromuscular blocking agents in patients undergoing elective surgery.
ABSTRACT.OBJECTIVES::
The goal o... | Intervention: Alfentanil
Comparator: Remifentanil
Outcome: Scores for ease of laryngoscopy | 0 | {"evidence_spans": [{"end": 1565, "start": 1425, "text": ", and sex). Further, laryngoscopy, jaw relaxation, and limb movement scores were similar in the R and A groups and there were no significant"}, {"end": 7382, "start": 7097, "text": " in this regard (P = 0. 230). As shown in Table 3, the scores for ease of laryng... |
TITLE: Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
ABSTRACT:
Aim of the study: Pilot study to analyse the efficacy and embryo morphology using a new human embryo culture medium (GM501) versus the conventional used medium (ISM1). Methods: Over a four-month... | Intervention: New universal medium (GM501)
Comparator: Standard sequential culture medium ISM1
Outcome: Fertilization | 0 | {"evidence_spans": [{"end": 940, "start": 756, "text": "s: We did not observe any differences between the ISM1 control group and GM501 study group with regard to fertilization, pregnancy, implantation rates, ongoing pregnancy, and babies bo"}], "id": "1608", "pmcid": "4086013", "prompt_id": "1608", "split_group_id": "4... |
TITLE: Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
ABSTRACT:
Aim of the study: Pilot study to analyse the efficacy and embryo morphology using a new human embryo culture medium (GM501) versus the conventional used medium (ISM1). Methods: Over a four-month... | Intervention: New universal medium (GM501)
Comparator: Standard sequential culture medium ISM1
Outcome: Pregnancy | 0 | {"evidence_spans": [{"end": 940, "start": 756, "text": "s: We did not observe any differences between the ISM1 control group and GM501 study group with regard to fertilization, pregnancy, implantation rates, ongoing pregnancy, and babies bo"}], "id": "1609", "pmcid": "4086013", "prompt_id": "1609", "split_group_id": "4... |
TITLE: Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
ABSTRACT:
Aim of the study: Pilot study to analyse the efficacy and embryo morphology using a new human embryo culture medium (GM501) versus the conventional used medium (ISM1). Methods: Over a four-month... | Intervention: New universal medium (GM501)
Comparator: Standard sequential culture medium ISM1
Outcome: Live birth rate | 0 | {"evidence_spans": [{"end": 940, "start": 756, "text": "s: We did not observe any differences between the ISM1 control group and GM501 study group with regard to fertilization, pregnancy, implantation rates, ongoing pregnancy, and babies bo"}], "id": "1611", "pmcid": "4086013", "prompt_id": "1611", "split_group_id": "4... |
TITLE: A comparison between subpleural patient-controlled analgesia by bupivacaine and intermittent analgesia in post-operative thoracotomy: A double-blind randomized clinical trial
ABSTRACT.BACKGROUND::
The efficacy of subpleural analgesia to reduce postoperative pain intensity in patients after lateral thoracot... | Intervention: subpleural patient-controlled analgesia (SPCA) (0.02 cc/kg/h of 0.5% bupivacaine)
Comparator: subpleural intermittent analgesia (SIA) (0.1cc/kg/6h of 0.5% bupivacaine)
Outcome: PHS criteria and bupivacaine consumption | -1 | {"evidence_spans": [{"end": 10755, "start": 10511, "text": "duced to SIA group. Supplemental opioid demand, PHS criteria and bupivacaine consumption were statistically significant, as, rate of IV opioid consumption, PHS criteria and bupivacaine consumption in SPCA group was significantly lower than in "}, {"end": 1075... |
TITLE: Promoting sexual abstinence intention among female university students: A quasi-experimental study
ABSTRACT.BACKGROUND::
The effectiveness of a theory-based educational intervention on intension for sexual abstinence among female university students was evaluated.
ABSTRACT.MATERIALS AND METHODS::
Femal... | Intervention: received educational intervention plus routine education
Comparator: received just routine education
Outcome: the variables, knowledge | 1 | {"evidence_spans": [{"end": 1022, "start": 636, "text": "e study. Despite the similarity of two groups of intervention (n = 53) and control (n = 59) at baseline, there were significant differences between the two groups in mean scores of the variables, knowledge (4.62 \u00b1 1.38 vs. 3.53 \u00b1 1.61), perceived suscep... |
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