sentence1 stringlengths 1.08k 96.5k | sentence2 stringlengths 51 966 | labels stringclasses 3
values | metadata stringlengths 123 2.56k |
|---|---|---|---|
TITLE: Intrathecal Morphine Plus General Anesthesia in Cardiac Surgery: Effects on Pulmonary Function, Postoperative Analgesia, and Plasma Morphine Concentration
ABSTRACT.OBJECTIVES::
To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac... | Intervention: 400 ?g of intrathecal morphine followed by general anesthesia
Comparator: general anesthesia
Outcome: Cumulative morphine consumption | -1 | {"evidence_spans": [{"end": 1948, "start": 1808, "text": ", p=0.001). Cumulative morphine consumption was reduced after 18 hours in the morphine group (control group= 20.14 and morphine group= 14.20"}, {"end": 1950, "start": 1809, "text": " p=0.001). Cumulative morphine consumption was reduced after 18 hours in the mor... |
TITLE: Intrathecal Morphine Plus General Anesthesia in Cardiac Surgery: Effects on Pulmonary Function, Postoperative Analgesia, and Plasma Morphine Concentration
ABSTRACT.OBJECTIVES::
To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac... | Intervention: 400 ?g of intrathecal morphine followed by general anesthesia
Comparator: general anesthesia
Outcome: The plasma morphine concentration | -1 | {"evidence_spans": [{"end": 2119, "start": 1951, "text": ", p=0.037). The plasma morphine concentration was also reduced in the morphine group 24 hours after surgery (control group= 15.87 ng.mL\u22121 and morphine group= 4.08 ng.mL"}, {"end": 13997, "start": 13705, "text": "phine group= 0.15 \u00b1 0.49 mg) (p<0.05). P... |
TITLE: Household costs for personal protection against mosquitoes: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico
ABSTRACT.BACKGROUND:
Dengue is a serious public health issue that affects households in endemic areas in terms of health and also economically, im... | Intervention: education and mobilisation activities
Comparator: baseline
Outcome: The mean expenditure on the products, | -1 | {"evidence_spans": [{"end": 2002, "start": 1726, "text": "roducts. In 2012, after the intervention, the proportion of households who purchased anti-mosquito products in the last month was significantly lower in intervention clusters (47.8%; 2503/5293) than in control clusters (53.3%; 2707/5079) (difference \u2212 0.05,... |
TITLE: A Randomized, Open-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIV-1-Infected Adults
ABSTRACT:
Supplemental Digital Content is Available in the Text.
BODY.INTRODUCTION:
Morbidity and mortality in HIV infection ... | Intervention: elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) 150/150/200/10 mg plus DRV 800 mg (Janssen) once daily
Comparator: stay on their baseline regimen
Outcome: rate of any adverse events | 1 | {"evidence_spans": [{"end": 16139, "start": 16022, "text": "ine.\r\n\r\nBODY.RESULTS.SAFETY:\r\nParticipants in the E/C/F/TAF plus DRV group had a higher rate of any adverse events [9"}], "id": "1239", "pmcid": "5228611", "prompt_id": "1239", "split_group_id": "5228611", "votes": {"1": 1}} |
TITLE: Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive
ABSTRACT.BACKGROUND:
Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the saf... | Intervention: Acidform twice daily for 14 consecutive days
Comparator: hydroxyethylcellulose (HEC) placebo gel twice daily for 14 consecutive days
Outcome: detectable L. crispatus or L. jensenii | 0 | {"evidence_spans": [{"end": 1783, "start": 1681, "text": "ication. There were no significant changes in Lactobacillus crispatus or Lactobacillus jensenii in eit"}, {"end": 31069, "start": 30834, "text": "t enrollment did not differ significantly between the two groups and represented 51% and 57%, respectively. There we... |
TITLE: A 6-week, multicentre, randomized controlled clinical trial to evaluate the safety and efficacy of placeboxetine hydrochloride in the treatment of major depressive disorder in an Indian setting
ABSTRACT.INTRODUCTION::
This paper describes a fictitious study of a fictitious drug. A companion paper in this i... | Intervention: placeboxetine (PB) hydrochloride extended release capsules
Comparator: sertraline hydrochloride
Outcome: Hamilton Rating Scale for Depression (HAM-D) and the Montgomery-Asberg Rating Scale (MADRS) | 0 | {"evidence_spans": [{"end": 1995, "start": 1888, "text": "t endpoint. There was no significant difference between PB and sertraline groups on either HAM-D or MADRS a"}, {"end": 9443, "start": 9146, "text": "laceboxetine and sertraline groups Similar results were obtained with the MADRS assessments [Figure 2]. There wa... |
TITLE: Learning to experience side effects after antidepressant intake – Results from a randomized, controlled, double-blind study
ABSTRACT.BACKGROUND:
Side effects play a key role in patients' failure to take antidepressants. There is evidence that verbal suggestions and informed consent elicit expectations that... | Intervention: amitriptyline
Comparator: placebo pill
Outcome: GASE-generic (generic side effects) | 0 | {"evidence_spans": [{"end": 24507, "start": 24157, "text": " generic symptoms to the medication after the acquisition phase than at baseline. We observed no differences between the groups in either the GASE-generic or GASE-generic-MA (multivariate analyses: group effect F (2, 36) = 1.89, p = .166; time effect F (4, 34)... |
TITLE: Exogenous dopamine reduces
ABSTRACT.ABSTRACT.BACKGROUND:
While it has recently been shown that dopamine release stimulates conscious self‐monitoring through the generation of gamma oscillations in medial prefrontal/anterior cingulate cortex, and that the GABAergic system is effective in producing such osc... | Intervention: MSD, 100 mg l?dopa plus 25 mg carbidopa
Comparator: placebo (starch)
Outcome: The BP of the GABA ligand | -1 | {"evidence_spans": [{"end": 8558, "start": 8305, "text": " off at P = 0.01. The BP of the GABA ligand decreased significantly with l\u2010dopa in the medial prefrontal/anterior cingulate and right insula regions (by 18%, t = \u22123.63 P = 0.0054, and 18%, t = 3.85 P = 0039, respectively), with no significant effect in... |
TITLE: Messaging to Increase Public Support for Naloxone Distribution Policies in the United States: Results from a Randomized Survey Experiment
ABSTRACT.BACKGROUND:
Barriers to public support for naloxone distribution include lack of knowledge, concerns about potential unintended consequences, and lack of sympat... | Intervention: Several message exposures
Comparator: no-exposure control group
Outcome: support for training first responders to use naloxone | 1 | {"evidence_spans": [{"end": 1728, "start": 1400, "text": "aloxone. Participants receiving the combination of the sympathetic narrative and factual information, compared to factual information alone, were more likely to support all policies: providing naloxone to friends and family members (OR: 2.0 [95% CI: 1.4 to 2.9])... |
TITLE: Messaging to Increase Public Support for Naloxone Distribution Policies in the United States: Results from a Randomized Survey Experiment
ABSTRACT.BACKGROUND:
Barriers to public support for naloxone distribution include lack of knowledge, concerns about potential unintended consequences, and lack of sympat... | Intervention: Several message exposures
Comparator: no-exposure control group
Outcome: providing naloxone to friends and family members of people using opioids | 1 | {"evidence_spans": [{"end": 29356, "start": 29229, "text": "loxone (77.4% versus 63.2% in the no-exposure control group), providing naloxone to friends and family members of people using "}], "id": "1258", "pmcid": "4488484", "prompt_id": "1258", "split_group_id": "4488484", "votes": {"1": 1}} |
TITLE: Messaging to Increase Public Support for Naloxone Distribution Policies in the United States: Results from a Randomized Survey Experiment
ABSTRACT.BACKGROUND:
Barriers to public support for naloxone distribution include lack of knowledge, concerns about potential unintended consequences, and lack of sympat... | Intervention: Several message exposures
Comparator: no-exposure control group
Outcome: passing laws to protect people who administer naloxone | 1 | {"evidence_spans": [{"end": 29470, "start": 29361, "text": "ds (45.5% versus 24.4% in the no-exposure control group), and passing laws to protect people who administer n"}], "id": "1259", "pmcid": "4488484", "prompt_id": "1259", "split_group_id": "4488484", "votes": {"1": 1}} |
TITLE: A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population
ABSTRACT.BACKGROUND:
Long chain omega-3 fatty acids from fish oils (O3) are known to have beneficial effects on a number of vascular risk factors in at-risk populations.... | Intervention: 1.7 g of Long chain omega-3 fatty acids from fish oils (O3) per day for 4 weeks
Comparator: safflower oil placebo for 4 weeks
Outcome: Red cell and plasma phospholipid eicosapentaenoic acid and docosahexaenoic acid concentrations | 1 | {"evidence_spans": [{"end": 12423, "start": 12281, "text": "er, after O3 supplementation. Figure 1 shows the effect of O3 dosing for four weeks on plasma phospholipid EPA and DHA. Plasma levels increase"}, {"end": 12895, "start": 12663, "text": "mes are displayed in Table 2. Significant increases are noted for both EPA... |
TITLE: Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial
ABSTRACT:
BODY:
Radiotherapy in head and neck cancer patients can induce oral mucositis, which is an acute inflammation of the oral mucosa. Until now... | Intervention: PTA lozenge
Comparator: Placebo lozenge
Outcome: Mucositis throughout the study period | 0 | {"evidence_spans": [{"end": 12149, "start": 12047, "text": "diation.\r\n\r\nBODY.RESULTS.MUCOSITIS:\r\nThe mean mucositis was the same in the PTA group and the placebo "}, {"end": 12624, "start": 12381, "text": "branes and in the placebo group 94%. The mucositis according to the WHO score did not differ throughout the ... |
TITLE: Comparison of paracetamol and fentanyl for pain relief during and after suction termination
ABSTRACT.OBJECTIVES::
To compare the combination of paracetamol (20 mg/kg) and propofol to fentanyl (1 μg/kg) and propofol in terms of providing adequate analgesia and a comparable recovery profile in suction termin... | Intervention: fentanyl (1 μg/kg) and propofol
Comparator: paracetamol (20 mg/kg) and propofol
Outcome: SpO2 at 5 minutes | -1 | {"evidence_spans": [{"end": 1417, "start": 1233, "text": "p>0.05). In the fentanyl group, systolic blood pressures at 5, 10, 15, 20 minutes and diastolic blood pressure at 5 minutes and oxygen saturation at 5 minutes were significantly lower "}, {"end": 7852, "start": 7748, "text": "(p>0.05) (Figure 4). In the fentanyl... |
TITLE: Pharmacokinetics, Safety, and Tolerability of GLPG0259, a Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) Inhibitor, Given as Single and Multiple Doses to Healthy Male Subjects
ABSTRACT.BACKGROUND AND OBJECTIVES:
GLPG0259 is a small-molecule inhibitor of mitogen-activated protein kin... | Intervention: GLPG0259 and methotrexate
Comparator: GLPG0259
Outcome: the rate and extent of absorption of GLPG0259 | 0 | {"evidence_spans": [{"end": 3081, "start": 2911, "text": " dosage form. Co-administration of GLPG0259 with a single dose of methotrexate 7.5 mg did not result in any change in the pharmacokinetic profiles of either GLPG0259 or m"}, {"end": 34340, "start": 34126, "text": "rameters with summary statistical analyses are p... |
TITLE: Prothrombin complex concentrate versus fresh frozen plasma in patients on oral anticoagulant therapy undergoing cardiac surgery: a randomized study
ABSTRACT:
BODY.INTRODUCTION:
To reverse oral anticoagulant (OAC) therapy, a number of treatment modalities is available. Fresh frozen plasma (FFP) is effe... | Intervention: prothrombin complex concentrates (PCC)
Comparator: fresh frozen plasma
Outcome: patients reached the target INR in the first hour after ending cardiopulmonary bypass (CPB) | 1 | {"evidence_spans": [{"end": 2834, "start": 2732, "text": " FFP group. More patients in this group reached the target INR in the first hour after ending CPB (T7,"}], "id": "1413", "pmcid": "4092608", "prompt_id": "1413", "split_group_id": "4092608", "votes": {"1": 2}} |
TITLE: Prothrombin complex concentrate versus fresh frozen plasma in patients on oral anticoagulant therapy undergoing cardiac surgery: a randomized study
ABSTRACT:
BODY.INTRODUCTION:
To reverse oral anticoagulant (OAC) therapy, a number of treatment modalities is available. Fresh frozen plasma (FFP) is effe... | Intervention: prothrombin complex concentrates (PCC)
Comparator: fresh frozen plasma
Outcome: received an additional dose of PPSB | -1 | {"evidence_spans": [{"end": 2650, "start": 2544, "text": "e target INR. In the FFP group 16/20 (80%) patients received an additional dose of PPSB vs 6/20 (30%) in t"}, {"end": 2651, "start": 2546, "text": "target INR. In the FFP group 16/20 (80%) patients received an additional dose of PPSB vs 6/20 (30%) in th"}], "id"... |
TITLE: Effects of cranberry (
ABSTRACT.BACKGROUND:
The aim of this study was to analyze the effect of supplementation with cranberry (Vaccinum macrocarpon) on the levels of pro-inflammatory cytokines, hepcidin and selected markers of iron metabolism in rowers subjected to exhaustive exercise.
ABSTRACT.METHODS:... | Intervention: receiving 1200 mg of cranberry extract for 6 weeks
Comparator: placebo group
Outcome: Values of total antioxidant capacity (TAC) | 1 | {"evidence_spans": [{"end": 15425, "start": 15271, "text": "gnificant post-exercise decrease in serum TAC. At trial II, cranberry-supplemented athletes presented with significantly higher resting, post-exercise and"}, {"end": 21780, "start": 21634, "text": "ract may stimulate an increase in serum TAC (Fig. 1). Compared... |
TITLE: Effects of cranberry (
ABSTRACT.BACKGROUND:
The aim of this study was to analyze the effect of supplementation with cranberry (Vaccinum macrocarpon) on the levels of pro-inflammatory cytokines, hepcidin and selected markers of iron metabolism in rowers subjected to exhaustive exercise.
ABSTRACT.METHODS:... | Intervention: receiving 1200 mg of cranberry extract for 6 weeks
Comparator: placebo group
Outcome: interleukin 6 levels during exercise tests | 0 | {"evidence_spans": [{"end": 16563, "start": 16436, "text": "e pre-exercise level following a 24-h recovery. Supplementation with cranberry extract did not exert a significant effect on IL"}], "id": "1424", "pmcid": "5330006", "prompt_id": "1424", "split_group_id": "5330006", "votes": {"0": 2}} |
TITLE: Twelve-Month Follow-Up of a Randomized Controlled Trial of Internet-Based Guided Self-Help for Parents of Children on Cancer Treatment
ABSTRACT.BACKGROUND:
A substantial proportion of parents of children on cancer treatment report psychological distress such as symptoms of post-traumatic stress (PTSS), dep... | Intervention: Internet-based guided self-help program, including weekly support from a therapist via encrypted email
Comparator: wait-list control condition
Outcome: the Beck Depression Inventory-II (BDI-II) difference | 1 | {"evidence_spans": [{"end": 26530, "start": 25717, "text": "ecline over time. The control group showed no change. The model difference at postassessment was 3.91 points on the BDI-II in favor of the intervention group, representing a medium effect size. The model difference at follow-up was 9.41 points on the BDI-II, r... |
TITLE: Evaluation of Cyavanaprāśa on Health and Immunity related Parameters in Healthy Children: A Two Arm, Randomized, Open Labeled, Prospective, Multicenter, Clinical Study
ABSTRACT.CONTEXT::
Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing... | Intervention: receive orally daily either CyavanaprÄ?Å›a (CP) (approx. 6 g) followed by a cup of milk (100 – 200 ml)
Comparator: cup of milk only twice a day while continuing with their normal/routine diet.
Outcome: episodes of infection/allergy related to immunity | 0 | {"evidence_spans": [{"end": 15725, "start": 15461, "text": " of number of participants having episodes of infection/allergy A total of 540 participants had episodes of infection/allergy related to immunity. Of these, 254 participants (47.03%) participants were in CP group while 286 (52.96%) were in the control group. ... |
TITLE: Evaluation of Cyavanaprāśa on Health and Immunity related Parameters in Healthy Children: A Two Arm, Randomized, Open Labeled, Prospective, Multicenter, Clinical Study
ABSTRACT.CONTEXT::
Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing... | Intervention: receive orally daily either CyavanaprÄ?Å›a (CP) (approx. 6 g) followed by a cup of milk (100 – 200 ml)
Comparator: cup of milk only twice a day while continuing with their normal/routine diet.
Outcome: absent due to infection/allergy/immunity related illnesses | -1 | {"evidence_spans": [{"end": 16532, "start": 16258, "text": "observed to be statistically significant (P < 0.001) [Figure 4]. There were a total of 281 participants who were absent due to infection/allergy/immunity related illnesses. Of these, 93 participants (33.09%) were in CP group while 188 (66.90%) were in the cont... |
TITLE: Efficacy and Safety of 5-Fluorouracil 0.5%/Salicylic Acid 10% in the Field-Directed Treatment of Actinic Keratosis: A Phase III, Randomized, Double-Blind, Vehicle-Controlled Trial
ABSTRACT.INTRODUCTION:
Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clin... | Intervention: 5-fluorouracil (5-FU) 0.5%/salicylic acid 10%
Comparator: vehicle
Outcome: The proportional reduction from baseline in the total number of AK lesions per patient | 1 | {"evidence_spans": [{"end": 16809, "start": 16589, "text": "6%; OR 4.9 (95% CI 2.3, 10.5) P < 0.0001 (Fig. 4)]. The proportional reduction from baseline in the total number of AK lesions per patient was significantly greater with 5-FU 0.5%/salicylic acid 10% than with vehicle: 78"}], "id": "1438", "pmcid": "5336430", "... |
TITLE: Efficacy and Safety of 5-Fluorouracil 0.5%/Salicylic Acid 10% in the Field-Directed Treatment of Actinic Keratosis: A Phase III, Randomized, Double-Blind, Vehicle-Controlled Trial
ABSTRACT.INTRODUCTION:
Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clin... | Intervention: 5-fluorouracil (5-FU) 0.5%/salicylic acid 10%
Comparator: vehicle
Outcome: Treatment-emergent adverse events | 1 | {"evidence_spans": [{"end": 1772, "start": 1577, "text": "0.0001]. Treatment-emergent adverse events, predominantly related to application- and administration-site reactions, were more common with 5-FU 0.5%/salicylic acid 10% than with vehicle (99.1% vs"}], "id": "1442", "pmcid": "5336430", "prompt_id": "1442", "split_... |
TITLE: Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double‐Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease
ABSTRACT.BACKGROUND:
We hypothesized... | Intervention: nebivolol
Comparator: atenolol
Outcome: plaque components and number of TCFAs per vessel | 0 | {"evidence_spans": [{"end": 25143, "start": 24925, "text": "requency of 3 WSS categories across 2 \u03b2\u2010blockers. WSS indicates wall shear stress. On VH\u2010IVUS, nebivolol segments demonstrated significantly decreased EEM area (P=0.02) and lumen area (P=0.004) but similar changes in "}, {"end": 25131, "start":... |
TITLE: Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double‐Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease
ABSTRACT.BACKGROUND:
We hypothesized... | Intervention: nebivolol
Comparator: atenolol
Outcome: plaque area | 0 | {"evidence_spans": [{"end": 25343, "start": 25143, "text": "plaque components and number of TCFAs per vessel compared with atenolol (Table 2). Nebivolol also showed increased plaque area at follow\u2010up (P<0.001), whereas atenolol demonstrated plaque regression ("}], "id": "1448", "pmcid": "4859395", "prompt_id": "14... |
TITLE: Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double‐Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease
ABSTRACT.BACKGROUND:
We hypothesized... | Intervention: nebivolol
Comparator: atenolol
Outcome: constrictive remodeling | 1 | {"evidence_spans": [{"end": 1434, "start": 1322, "text": ".06). Low\u2010WSS regions were associated with greater plaque progression (P<0.0001) and constrictive remodeling (P="}, {"end": 25595, "start": 25343, "text": "P=0.047); however, the difference between the 2 arms was not significant (P=0.27). With respect to ar... |
TITLE: Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double‐Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease
ABSTRACT.BACKGROUND:
We hypothesized... | Intervention: nebivolol
Comparator: atenolol
Outcome: Among lowâ€? wall shear stress (WSS) segments Î"EEM area | -1 | {"evidence_spans": [{"end": 26229, "start": 26101, "text": "US results were stratified by categories of WSS (Table 4) and \u03b2\u2010blocker (Table 5). Among low\u2010WSS segments (Table 4), those treat"}, {"end": 26320, "start": 26101, "text": "US results were stratified by categories of WSS (Table 4) and \u03b2\u201... |
TITLE: Readiness to Be Physically Active and Self-Reported Physical Activity in Low-Income Latinas, California WISEWOMAN, 2006-2007
ABSTRACT.INTRODUCTION:
Latinas are more likely to be inactive than non-Hispanic white women. Although 74% of Latinas report no leisure-time activity, few interventions have been desi... | Intervention: enhanced intervention (EIG)
Comparator: baseline
Outcome: engaging in vigorous physical activity | 1 | {"evidence_spans": [{"end": 1374, "start": 1204, "text": "aduates. A higher percentage (67%) of the enhanced intervention group was in the action/maintenance stage for vigorous physical activity at follow-up compared with baseli"}, {"end": 16989, "start": 16788, "text": "ical activity at baseline, and 77% at follow-up.... |
TITLE: A prospective randomised radiostereometric analysis trial of SmartSet HV and Palacos R bone cements in primary total hip arthroplasty
ABSTRACT.BACKGROUND:
Introduction of new bone cements into clinical practice should include radiostereometric studies.
ABSTRACT.MATERIALS AND METHODS:
A prospective rand... | Intervention: SmartSet HV acrylic bone cements (without antibiotics)
Comparator: Palacos R acrylic bone cements (without antibiotics)
Outcome: rotations or translations | 0 | {"evidence_spans": [{"end": 1025, "start": 836, "text": "ESULTS:\r\nThe mean distal translation observed was \u22120.15 mm for SmartSet HV and \u22120.16 mm for Palacos R. The mean rotation around the longitudinal axis was 0.9\u00b0 for SmartSet HV and 1.2\u00b0 for P"}, {"end": 12718, "start": 12563, "text": "tributed... |
TITLE: A prospective randomised radiostereometric analysis trial of SmartSet HV and Palacos R bone cements in primary total hip arthroplasty
ABSTRACT.BACKGROUND:
Introduction of new bone cements into clinical practice should include radiostereometric studies.
ABSTRACT.MATERIALS AND METHODS:
A prospective rand... | Intervention: SmartSet HV acrylic bone cements (without antibiotics)
Comparator: Palacos R acrylic bone cements (without antibiotics)
Outcome: The mean distal translation | 0 | {"evidence_spans": [{"end": 928, "start": 836, "text": "ESULTS:\r\nThe mean distal translation observed was \u22120.15 mm for SmartSet HV and \u22120.16 mm for "}, {"end": 929, "start": 836, "text": "ESULTS:\r\nThe mean distal translation observed was \u22120.15 mm for SmartSet HV and \u22120.16 mm for P"}], "id": "146... |
TITLE: A prospective randomised radiostereometric analysis trial of SmartSet HV and Palacos R bone cements in primary total hip arthroplasty
ABSTRACT.BACKGROUND:
Introduction of new bone cements into clinical practice should include radiostereometric studies.
ABSTRACT.MATERIALS AND METHODS:
A prospective rand... | Intervention: SmartSet HV acrylic bone cements (without antibiotics)
Comparator: Palacos R acrylic bone cements (without antibiotics)
Outcome: The mean rotation around the longitudinal axis | 0 | {"evidence_spans": [{"end": 1025, "start": 930, "text": "lacos R. The mean rotation around the longitudinal axis was 0.9\u00b0 for SmartSet HV and 1.2\u00b0 for P"}], "id": "1465", "pmcid": "2837815", "prompt_id": "1465", "split_group_id": "2837815", "votes": {"0": 2}} |
TITLE: A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults
ABSTRACT.BACKGROUND:
The behavioral outcome of food ingestion is a complex process that involves psychological and biologic... | Intervention: consumed a standardized breakfast with Avocado Added (AA)
Comparator: consumed a standardized breakfast [Control (C)avocado-free]
Outcome: self-reported subjective feelings of satisfaction for the AUC(0-5h) | 1 | {"evidence_spans": [{"end": 18648, "start": 18462, "text": ".05) in the mixed model analysis (Figure 2). Post-hoc testing revealed that compared to the C test meal, the AA test meal increased satisfaction by 23% (P = 0.05) and decreased the desir"}], "id": "1472", "pmcid": "4222592", "prompt_id": "1472", "split_group_i... |
TITLE: The effects of two different frequencies of whole-body vibration on knee extensors strength in healthy young volunteers: a randomized trial
ABSTRACT:
The aim of this study was to investigate the effects of two different frequencies of whole-body vibration (WBV) training on knee extensors muscle strength in... | Intervention: 30-Hz whole-body vibration training
Comparator: 50-Hz whole-body vibration training
Outcome: Maximal voluntary isometric contraction | 1 | {"evidence_spans": [{"end": 1006, "start": 897, "text": "g. In the 30-Hz group, there was a significant increase in the maximal voluntary isometric contraction (p=0.0"}], "id": "1346", "pmcid": "5628593", "prompt_id": "1346", "split_group_id": "5628593", "votes": {"1": 2}} |
TITLE: A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults
ABSTRACT.BACKGROUND:
The behavioral outcome of food ingestion is a complex process that involves psychological and biologic... | Intervention: consumed a standardized breakfast with Avocado Included (AI)
Comparator: consumed a standardized breakfast [Control (C)avocado-free]
Outcome: self-reported subjective feelings of satisfaction | 0 | {"evidence_spans": [{"end": 18965, "start": 18818, "text": "1) as compared to the C test meal (Table 2). Additionally, the AI test meal showed a tendency towards increasing satisfaction by 22% P = 0.07) as c"}, {"end": 27033, "start": 26762, "text": "ion measurements between the AI and avocado-free C test meal (P = 0.0... |
TITLE: A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults
ABSTRACT.BACKGROUND:
The behavioral outcome of food ingestion is a complex process that involves psychological and biologic... | Intervention: consumed a standardized breakfast with Avocado Included (AI)
Comparator: consumed a standardized breakfast with Avocado Added (AA) or consumed a standardized breakfast [Control (C)avocado-free]
Outcome: the AUC(0-3h) for blood insulin | -1 | {"evidence_spans": [{"end": 2071, "start": 1947, "text": "st meal. Compared to the AI meal, the AUC(0-3h) for blood insulin was higher in the C and AA meals (P=0.04 and P=0.05, respe"}], "id": "1476", "pmcid": "4222592", "prompt_id": "1476", "split_group_id": "4222592", "votes": {"-1": 2}} |
TITLE: The effects of two different frequencies of whole-body vibration on knee extensors strength in healthy young volunteers: a randomized trial
ABSTRACT:
The aim of this study was to investigate the effects of two different frequencies of whole-body vibration (WBV) training on knee extensors muscle strength in... | Intervention: 30-Hz whole-body vibration training
Comparator: 50-Hz whole-body vibration training
Outcome: Attendance rates | 0 | {"evidence_spans": [{"end": 18236, "start": 18145, "text": "inal analysis (see Table 3). No significant difference existed between the two groups in th"}], "id": "1349", "pmcid": "5628593", "prompt_id": "1349", "split_group_id": "5628593", "votes": {"0": 2}} |
TITLE: Effect of Inpatient Multicomponent Occupational Rehabilitation Versus Less Comprehensive Outpatient Rehabilitation on Sickness Absence in Persons with Musculoskeletal- or Mental Health Disorders: A Randomized Clinical Trial
ABSTRACT:
Purpose To assess effects of an inpatient multicomponent occupational r... | Intervention: Inpatient program
Comparator: Outpatient program
Outcome: Number of absence days due to sickness at 6 months | 0 | {"evidence_spans": [{"end": 1502, "start": 1361, "text": "6). We found no statistically significant difference between the programs in median number of sickness absence days at 6 and 12 months follow"}, {"end": 20727, "start": 20470, "text": "sick- leave\r\n\r\n\r\nBODY.RESULTS.SICKNESS ABSENCE DAYS:\r\nThe median numb... |
TITLE: A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults
ABSTRACT.BACKGROUND:
The behavioral outcome of food ingestion is a complex process that involves psychological and biologic... | Intervention: consumed a standardized breakfast with Avocado Added (AA)
Comparator: consumed a standardized breakfast [Control (C)avocado-free]
Outcome: desire to eat for the AUC(0-3h) | -1 | {"evidence_spans": [{"end": 1946, "start": 1809, "text": "AUC(0-3h), the AA test meal increased satisfaction by 26% (P=0.02) and decreased the desire to eat by 40% (P=0.01) as compared to the C t"}], "id": "1477", "pmcid": "4222592", "prompt_id": "1477", "split_group_id": "4222592", "votes": {"-1": 1}} |
TITLE: Effect of Inpatient Multicomponent Occupational Rehabilitation Versus Less Comprehensive Outpatient Rehabilitation on Sickness Absence in Persons with Musculoskeletal- or Mental Health Disorders: A Randomized Clinical Trial
ABSTRACT:
Purpose To assess effects of an inpatient multicomponent occupational r... | Intervention: Inpatient program
Comparator: Outpatient program
Outcome: Number of absence days due to sickness at 12 months | 0 | {"evidence_spans": [{"end": 1502, "start": 1361, "text": "6). We found no statistically significant difference between the programs in median number of sickness absence days at 6 and 12 months follow"}, {"end": 20986, "start": 20728, "text": "tically significant (Mann\u2013Whitney U test, p = 0.284). For the 12 months ... |
TITLE: Do research findings on schema-based instruction translate to the classroom?
ABSTRACT.INTRODUCTION:
Schema-based instruction has been shown to improve diagnostic performance and reduce cognitive load. However, to date, this has only been studied in controlled research settings. More distractions in classro... | Intervention: schema-based lecture
Comparator: traditional
Outcome: extraneous or germane load | 0 | {"evidence_spans": [{"end": 1306, "start": 1199, "text": " 0.001). There was no significant difference in reported extraneous (p = 0.36) or germane (p = 0.42) cognit"}, {"end": 10821, "start": 10597, "text": " standard error 3 %, p < 0.001). There was no significant difference in reported extraneous (11 vs. 12 points, ... |
TITLE: Do research findings on schema-based instruction translate to the classroom?
ABSTRACT.INTRODUCTION:
Schema-based instruction has been shown to improve diagnostic performance and reduce cognitive load. However, to date, this has only been studied in controlled research settings. More distractions in classro... | Intervention: schema-based lecture
Comparator: traditional
Outcome: evaluation of the lecturers | 0 | {"evidence_spans": [{"end": 10992, "start": 10823, "text": " error = 4.5 %, p = 0.42) load. Fifty-nine (59 %) participants evaluated the lecturers. Participants rated both lecturers similarly (traditional lecture: 4.98 vs schema"}, {"end": 10992, "start": 10879, "text": "cipants evaluated the lecturers. Participants r... |
TITLE: Adenosine A
ABSTRACT:
BackgroundWe evaluated the efficacy and safety of istradefylline, a selective adenosine A2A receptor antagonist administered as adjunctive treatment to levodopa for 12 weeks in a double-blind manner in Parkinson's disease patients with motor complications in Japan. MethodsA total of ... | Intervention: Istradefylline 20 mg or 40 mg
Comparator: Placebo
Outcome: Secondary efficacy variables | 0 | {"evidence_spans": [{"end": 9199, "start": 9114, "text": "ng Fig. 2). No differences were observed among the groups for other secondary efficac"}], "id": "1360", "pmcid": "3842830", "prompt_id": "1360", "split_group_id": "3842830", "votes": {"0": 2}} |
TITLE: Adenosine A
ABSTRACT:
BackgroundWe evaluated the efficacy and safety of istradefylline, a selective adenosine A2A receptor antagonist administered as adjunctive treatment to levodopa for 12 weeks in a double-blind manner in Parkinson's disease patients with motor complications in Japan. MethodsA total of ... | Intervention: Istradefylline 20 mg
Comparator: Istradefylline 40 mg
Outcome: Daily OFF time | 0 | {"evidence_spans": [{"end": 787, "start": 563, "text": ". ResultsThe change in daily OFF time was significantly reduced in the istradefylline 20 mg/day (\u22120.99 hours, P = .003) and istradefylline 40 mg/day (\u22120.96 hours, P = .003) groups compared with the placebo group (\u22120.23 hour"}, {"end": 8001, "start"... |
TITLE: Comparative clinical efficacy of three toothpastes in the control of supragingival calculus formation
ABSTRACT.OBJECTIVES::
The purpose of this double-blind, parallel clinical study was to assess clinical efficacy in supragingival calculus formation reduction using Abhaibhubejhr Herbal Toothpaste compared ... | Intervention: use the Total toothpastes
Comparator: use the Abhaibhubejhr
Outcome: calculus formation | -1 | {"evidence_spans": [{"end": 11114, "start": 10944, "text": "stically significant (P < 0.05). In addition, subjects using the total toothpaste had 22.58% statistically significant less calculus formation than subjects using the Abh"}], "id": "1490", "pmcid": "5379843", "prompt_id": "1490", "split_group_id": "5379843", "... |
TITLE: Complications of Lumbar Artificial Disc Replacement Compared to Fusion: Results From the Prospective, Randomized, Multicenter US Food and Drug Administration Investigational Device Exemption Study of the Charité Artificial Disc
ABSTRACT.BACKGROUND:
Previous reports of lumbar total disc replacement (TDR) ha... | Intervention: Charité artificial disc
Comparator: ALIF with BAK cages
Outcome: Major neurological complications | 0 | {"evidence_spans": [{"end": 1244, "start": 1126, "text": "l group. The rate of major neurological complications was similar between the 2 groups (investigational = 4.4%, contro"}, {"end": 1245, "start": 1126, "text": "l group. The rate of major neurological complications was similar between the 2 groups (investigationa... |
TITLE: Comparison of Local Anesthetic Effect of Bupivacaine versus Bupivacaine plus Dexamethasone in Nasal Surgery
ABSTRACT.INTRODUCTION::
Adequate pain control is an important consideration in the post-surgical management of patients. Local nerve blockade added to general anesthesia can provide excellent pain c... | Intervention: bupivacaine plus dexamethasone
Comparator: bupivacaine
Outcome: At 24 h post surgery, VAS pain scores | 0 | {"evidence_spans": [{"end": 5609, "start": 5489, "text": "0.011, respectively) but there was no statistically significant difference between the groups in VAS at 24 h after surge"}, {"end": 5598, "start": 5493, "text": "1, respectively) but there was no statistically significant difference between the groups in VAS at ... |
TITLE: Urogenital function in robotic vs laparoscopic rectal cancer surgery: a comparative study
ABSTRACT.PURPOSE:
Urological and sexual dysfunction are recognised risks of rectal cancer surgery; however, there is limited evidence regarding urogenital function comparing robotic to laparoscopic techniques. The aim... | Intervention: Robotic surgery
Comparator: Laparoscopic surgery
Outcome: Sexual function scores in females | 0 | {"evidence_spans": [{"end": 1404, "start": 1287, "text": " 0.001). In females, there was no difference between the two groups in any of the components of urological or sexual "}, {"end": 18211, "start": 18038, "text": "50.1813 \u00b1 1.73\r\np value0.2510.2690.657\r\n Mean FSF score changes from baseline are outlined ... |
TITLE: Effect of Calcium Supplementation on Blood Lead Levels in Pregnancy: A Randomized Placebo-Controlled Trial
ABSTRACT.BACKGROUND:
Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate fetal exposure by inhibiting mobilization of materna... | Intervention: ingest 1,200 mg dietary calcium
Comparator: ingest placebo
Outcome: maternal blood lead concentrations in the second/third trimester | -1 | {"evidence_spans": [{"end": 1353, "start": 1133, "text": "T.RESULTS:\r\nAdjusting for baseline lead level, age, trimester of pregnancy, and dietary energy and calcium intake, calcium was associated with an average 11% reduction (0.4 \u03bcg/dL) in blood lead level relative to placebo "}, {"end": 1701, "start": 1354, "t... |
TITLE:
ABSTRACT.AIMS/HYPOTHESIS:
The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet–monocyte conjugation in blood from patients with type 2 diabetes.
ABSTRACT.METHODS:
In this placeb... | Intervention: N-acetylcysteine
Comparator: Placebo
Outcome: Adverse events | 0 | {"evidence_spans": [{"end": 1688, "start": 1659, "text": "ugation. There were no advers"}], "id": "1385", "pmcid": "3464379", "prompt_id": "1385", "split_group_id": "3464379", "votes": {"0": 2}} |
TITLE: A meta-analysis of two randomised trials of early chemotherapy in asymptomatic metastatic colorectal cancer
ABSTRACT:
This report constitutes a prospectively planned meta-analysis combining two almost identical trials undertaken in Australasia and Canada to study the effect of starting chemotherapy immedia... | Intervention: receive immediate treatment
Comparator: receive delayed treatment
Outcome: overall QoL | 0 | {"evidence_spans": [{"end": 1690, "start": 1544, "text": "). There was no difference in overall QoL or its individual domains between the two treatment strategies at baseline or at any subsequent time poi"}, {"end": 19165, "start": 18995, "text": "onths, when QoL was the same. There was no statistically significant dif... |
TITLE:
ABSTRACT.AIMS/HYPOTHESIS:
The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet–monocyte conjugation in blood from patients with type 2 diabetes.
ABSTRACT.METHODS:
In this placeb... | Intervention: N-acetylcysteine
Comparator: Placebo
Outcome: Plasma PAI-1 | 0 | {"evidence_spans": [{"end": 17888, "start": 17725, "text": "shold for detection, 1 \u03bcmol/l). There was no significant effect of NAC or placebo on plasma PAI-1 antigen or activity at either 2 h after the first dose or after "}], "id": "1387", "pmcid": "3464379", "prompt_id": "1387", "split_group_id": "3464379", "vo... |
TITLE: Placebo can enhance creativity
ABSTRACT.BACKGROUND:
The placebo effect is usually studied in clinical settings for decreasing negative symptoms such as pain, depression and anxiety. There is interest in exploring the placebo effect also outside the clinic, for enhancing positive aspects of performance or c... | Intervention: smelled and rated an odorant and were told that the odorant increases creativity and reduces inhibitions
Comparator: smelled and rated an odorant
Outcome: Fluency and flexibility | 0 | {"evidence_spans": [{"end": 25459, "start": 25267, "text": "cy, defined as the overall number of solutions. In the CFG, we defined fluency as the number of shapes selected to the gallery during exploitation phases, finding no significant difference bet"}, {"end": 25614, "start": 25267, "text": "cy, defined as the overa... |
TITLE: Randomized, Double-Blinded, Placebo-Controlled Trial of Fibrinogen Concentrate Supplementation After Complex Cardiac Surgery
ABSTRACT.BACKGROUND:
Postoperative bleeding after heart operations is still a common finding, leading to allogeneic blood products transfusion. Fibrinogen and coagulation factors def... | Intervention: received fibrinogen concentrate
Comparator: received saline solution (placebo)
Outcome: levels of fibrinogen | 1 | {"evidence_spans": [{"end": 17476, "start": 17334, "text": "FIBTEM, whereas patients in the control arm did not. At the arrival in the ICU, patients in the treatment arm had significantly higher levels "}, {"end": 17437, "start": 17361, "text": " the control arm did not. At the arrival in the ICU, patients in the treat... |
TITLE: Placebo can enhance creativity
ABSTRACT.BACKGROUND:
The placebo effect is usually studied in clinical settings for decreasing negative symptoms such as pain, depression and anxiety. There is interest in exploring the placebo effect also outside the clinic, for enhancing positive aspects of performance or c... | Intervention: smelled and rated an odorant and were told that the odorant increases creativity and reduces inhibitions
Comparator: smelled and rated an odorant
Outcome: Torrance test (TTCT) | 0 | {"evidence_spans": [{"end": 1403, "start": 1220, "text": "ESULTS:\r\nThe placebo group showed higher originality than the control group both in the CFG (p<0.04, effect size = 0.5) and in the AUT (p<0.05, effect size = 0.4), but not in the Torr"}, {"end": 1404, "start": 1220, "text": "ESULTS:\r\nThe placebo group showed... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Standing still for a long time (> 15 min ) without discomfort | 1 | {"evidence_spans": [{"end": 13146, "start": 12797, "text": "ULTRASOUND\u2010GUIDED FOAM SCLEROTHERAPY :\r\nParticipants randomized to UGFS recalled being able to carry out 13 of the 15 behaviours significantly more quickly than those randomized to surgery (Table \r\n2\r\n). The two behaviours for which there was no ev... |
TITLE: Thromboelastographic changes during laparoscopic fundoplication
ABSTRACT.INTRODUCTION:
Thromboelastography (TEG) is a technique that measures coagulation processes and surveys the properties of a viscoelastic blood clot, from its formation to lysis.
ABSTRACT.AIM:
To determine the possible hypercoagulab... | Intervention: Low-molecular-weight heparin before and after the surgery
Comparator: Low-molecular-weight heparin only before the surgery
Outcome: Maximum amplitude values | 0 | {"evidence_spans": [{"end": 17380, "start": 17247, "text": "aroscopic operation (Tables II and III). There were no significant changes in \u03b1-angle and maximum amplitude values during or after l"}, {"end": 17398, "start": 17247, "text": "aroscopic operation (Tables II and III). There were no significant changes in... |
TITLE: Handwriting training in Parkinson’s disease: A trade-off between size, speed and fluency
ABSTRACT.BACKGROUND:
In previous work, we found that intensive amplitude training successfully improved micrographia in Parkinson's disease (PD). Handwriting abnormalities in PD also express themselves in stroke durati... | Intervention: Amplitude training
Comparator: Placebo
Outcome: Stroke duration | 1 | {"evidence_spans": [{"end": 1491, "start": 1276, "text": "T.RESULTS:\r\nIn contrast to the reported positive effects of training on writing size, the current results showed increases in stroke duration and normalized jerk after amplitude training, which were absent in the pl"}, {"end": 1490, "start": 1350, "text": "iti... |
TITLE: Effect of acupressure on fatigue in patients on hemodialysis
ABSTRACT.BACKGROUND::
Fatigue is considered as a major problem in hemodialysis patients and can impair their quality of life. The purpose of this study was to investigate the effectiveness of acupressure on fatigue in hemodialysis patients.
AB... | Intervention: Acupressure
Comparator: Placebo
Outcome: Fatigue score in the sensory dimension | -1 | {"evidence_spans": [{"end": 12190, "start": 12064, "text": "o groups (P > 0.05). Mean score of fatigue in the sensory dimension in the study group was significantly less than in the plac"}, {"end": 13578, "start": 13298, "text": " placebo (P = 0.3). Post-hoc Duncan test showed that mean reduction of total fatigue score... |
TITLE: Effect of acupressure on fatigue in patients on hemodialysis
ABSTRACT.BACKGROUND::
Fatigue is considered as a major problem in hemodialysis patients and can impair their quality of life. The purpose of this study was to investigate the effectiveness of acupressure on fatigue in hemodialysis patients.
AB... | Intervention: Routine unit care
Comparator: Placebo
Outcome: Fatigue score in the sensory dimension | 1 | {"evidence_spans": [{"end": 12280, "start": 12064, "text": "o groups (P > 0.05). Mean score of fatigue in the sensory dimension in the study group was significantly less than in the placebo group (P < 0.05), and in the placebo group, it was significantly less that in the cont"}, {"end": 13578, "start": 13297, "text": "... |
TITLE: Correct usage, ease of use, and preference of two dry powder inhalers in patients with COPD: analysis of five phase III, randomized trials
ABSTRACT.BACKGROUND:
Handheld inhalers are used to deliver treatment for COPD. Incorrect usage leads to suboptimal disease control. Complex treatment regimens and use o... | Intervention: ElliptaTM DPI
Comparator: HandiHaler®
Outcome: the number of steps to use, time taken to use and ease of use | 1 | {"evidence_spans": [{"end": 1826, "start": 1530, "text": "sy to read. Across the two Phase IIIa active comparator studies, patients consistently stated a preference for the ElliptaTM DPI over HandiHaler\u00ae regarding the number of steps to use (59% vs 17%), time taken to use (62% vs 14%), and ease of use (63% vs 15%)... |
TITLE: Household costs for personal protection against mosquitoes: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico
ABSTRACT.BACKGROUND:
Dengue is a serious public health issue that affects households in endemic areas in terms of health and also economically, im... | Intervention: education and mobilisation activities
Comparator: baseline
Outcome: the proportion of households who purchased anti-mosquito products in the last month | -1 | {"evidence_spans": [{"end": 2002, "start": 1726, "text": "roducts. In 2012, after the intervention, the proportion of households who purchased anti-mosquito products in the last month was significantly lower in intervention clusters (47.8%; 2503/5293) than in control clusters (53.3%; 2707/5079) (difference \u2212 0.05,... |
TITLE: A Randomized, Open-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIV-1-Infected Adults
ABSTRACT:
Supplemental Digital Content is Available in the Text.
BODY.INTRODUCTION:
Morbidity and mortality in HIV infection ... | Intervention: elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) 150/150/200/10 mg plus DRV 800 mg (Janssen) once daily
Comparator: stay on their baseline regimen
Outcome: eGFR | 0 | {"evidence_spans": [{"end": 17636, "start": 17500, "text": "oped proximal renal tubulopathy. There were no differences between the 2 groups in median changes from baseline in eGFR (week 48: +7.4 m"}], "id": "1237", "pmcid": "5228611", "prompt_id": "1237", "split_group_id": "5228611", "votes": {"0": 2}} |
TITLE: A Randomized, Open-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIV-1-Infected Adults
ABSTRACT:
Supplemental Digital Content is Available in the Text.
BODY.INTRODUCTION:
Morbidity and mortality in HIV infection ... | Intervention: elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) 150/150/200/10 mg plus DRV 800 mg (Janssen) once daily
Comparator: stay on their baseline regimen
Outcome: quantitative proteinuria (urine protein-to-creatinine ratio) and tubular proteinuria (retinol binding protein-to-creatinine rat... | -1 | {"evidence_spans": [{"end": 17981, "start": 17637, "text": "/min vs. +3.9 mL/min; P = 0.18). Participants in the E/C/F/TAF plus DRV group had statistically significant declines in both measures of quantitative proteinuria (urine protein-to-creatinine ratio) and tubular proteinuria (retinol binding protein-to-creatinine... |
TITLE: A Randomized, Open-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIV-1-Infected Adults
ABSTRACT:
Supplemental Digital Content is Available in the Text.
BODY.INTRODUCTION:
Morbidity and mortality in HIV infection ... | Intervention: elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) 150/150/200/10 mg plus DRV 800 mg (Janssen) once daily
Comparator: stay on their baseline regimen
Outcome: HIV-1 RNA <50 copies per mililiter at week 24; | 0 | {"evidence_spans": [{"end": 13268, "start": 13016, "text": "BODY.RESULTS.EFFICACY:\r\nE/C/F/TAF plus DRV was noninferior to baseline regimens for the primary outcome (HIV-1 RNA <50 copies per mililiter at week 24; FDA-snapshot algorithm) using the full analysis set (96.6% vs. 91.3%; difference 5.3%; 95.001% CI: \u2212"... |
TITLE: Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive
ABSTRACT.BACKGROUND:
Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the saf... | Intervention: Acidform twice daily for 14 consecutive days
Comparator: hydroxyethylcellulose (HEC) placebo gel twice daily for 14 consecutive days
Outcome: The median vaginal and cervical pH | -1 | {"evidence_spans": [{"end": 1281, "start": 1096, "text": "ESULTS:\r\nThe median vaginal and cervical pH was significantly lower 2 hours after application of Acidform and was associated with an increase in the bactericidal activity of CVL against"}, {"end": 27347, "start": 27171, "text": "n.\r\n\r\nBODY.RESULTS.EFFECTS ... |
TITLE: Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive
ABSTRACT.BACKGROUND:
Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the saf... | Intervention: Acidform twice daily for 14 consecutive days
Comparator: hydroxyethylcellulose (HEC) placebo gel twice daily for 14 consecutive days
Outcome: CVL concentrations of lactoferrin and interleukin-1 receptor antagonist (IL-1ra), an anti-inflammatory protein, | -1 | {"evidence_spans": [{"end": 1680, "start": 1415, "text": " 0.002). While there was no increase in inflammatory cytokines or chemokines, CVL concentrations of lactoferrin and interleukin-1 receptor antagonist (IL-1ra), an anti-inflammatory protein, were significantly lower following Acidform compared to HEC placebo gel ... |
TITLE: Learning to experience side effects after antidepressant intake – Results from a randomized, controlled, double-blind study
ABSTRACT.BACKGROUND:
Side effects play a key role in patients' failure to take antidepressants. There is evidence that verbal suggestions and informed consent elicit expectations that... | Intervention: amitriptyline
Comparator: placebo pill
Outcome: GASE-AD (antidepressant-specific side effects) | 1 | {"evidence_spans": [{"end": 1713, "start": 1470, "text": "o group. After evocation, participants who underwent the conditioning procedure with amitriptyline reported significantly more antidepressant-specific side effects than those who never received amitriptyline, even though both groups received a"}, {"end": 19281, ... |
TITLE: Exogenous dopamine reduces
ABSTRACT.ABSTRACT.BACKGROUND:
While it has recently been shown that dopamine release stimulates conscious self‐monitoring through the generation of gamma oscillations in medial prefrontal/anterior cingulate cortex, and that the GABAergic system is effective in producing such osc... | Intervention: MSD, 100 mg l?dopa plus 25 mg carbidopa
Comparator: placebo (starch)
Outcome: mean decrease in [11C]Ro15?4513 BP | 1 | {"evidence_spans": [{"end": 7911, "start": 7640, "text": "d whole gray matter. For a composite gray matter region, a one\u2010sample t\u2010test showed that l\u2010dopa was associated with an 11% mean decrease in [11C]Ro15\u20104513 BP (t = \u22122.29, 9 degrees of freedom, P = 0.048). There was a highly significant ef... |
TITLE: Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals
ABSTRACT.BACKGROUND:
Pomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial i... | Intervention: Pomegranate juice (PJ)
Comparator: baseline
Outcome: Systolic blood pressure (SBP), diastolic blood pressure (DBP) | -1 | {"evidence_spans": [{"end": 1098, "start": 972, "text": "ESULTS:\r\nComparison of pre- vs. post-trial values revealed a significant reduction in both SBP (7%; P = 0.013) and DBP (6%; P "}, {"end": 8800, "start": 8616, "text": "100 ml of the administered juice. Comparison of pre- vs. post-trial values revealed a signif... |
TITLE: Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals
ABSTRACT.BACKGROUND:
Pomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial i... | Intervention: Pomegranate juice (PJ)
Comparator: baseline
Outcome: flow-mediated dilation (FMD) | 0 | {"evidence_spans": [{"end": 1255, "start": 1099, "text": " 0.010). However, changes in FMD (20%) as well as circulating levels of CRP, ICAM-1, VCAM-1, E-selectin, and IL-6 did not reach statistical significance (P "}, {"end": 8900, "start": 8801, "text": "uction by 7% and 6%, respectively. However, percentage changes i... |
TITLE: A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population
ABSTRACT.BACKGROUND:
Long chain omega-3 fatty acids from fish oils (O3) are known to have beneficial effects on a number of vascular risk factors in at-risk populations.... | Intervention: 1.7 g of Long chain omega-3 fatty acids from fish oils (O3) per day for 4 weeks
Comparator: safflower oil placebo for 4 weeks
Outcome: central pulse wave velocity, augmentation index, aortic systolic blood pressure, BMI, waist, total cholesterol, serum glucose, IL-8, and IL-10,CRP | 0 | {"evidence_spans": [{"end": 13967, "start": 13584, "text": "DHA\u2009=\u2009docosahexaenoic acid. The effects of supplementation on components of the metabolic syndrome, plasma lipids, vascular measures, and cytokines are shown in Table 3. The daily treatment dose of 1.7 g of O3 for four weeks had no effect on any of... |
TITLE: Pharmacokinetics, Safety, and Tolerability of GLPG0259, a Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) Inhibitor, Given as Single and Multiple Doses to Healthy Male Subjects
ABSTRACT.BACKGROUND AND OBJECTIVES:
GLPG0259 is a small-molecule inhibitor of mitogen-activated protein kin... | Intervention: GLPG0259 and methotrexate
Comparator: GLPG0259
Outcome: the rate of absorption of methotrexate | 0 | {"evidence_spans": [{"end": 35734, "start": 35514, "text": "th those reported previously for the methotrexate 7.5 mg dose.[14,15] When methotrexate was co-administered with GLPG0259 50 mg, the rate of absorption of methotrexate was slightly but not statistically significantly dec"}], "id": "1278", "pmcid": "3585965", "... |
TITLE: Push-out bond strength of intra-orifice barrier materials: Bulk-fill composite versus calcium silicate cement
ABSTRACT:
Background. The aim of this study was to compare the push-out bond strengths of calcium silicate-based ProRoot MTA and Biodentine cements and SureFil SDR and EverX Posterior bulk-fill c... | Intervention: SureFil SDR or EverX Posterior bulk-fill composite resins' bond
Comparator: ProRoot MTA or Biodentine calcium silicate cements
Outcome: bulk-fill composite resin values and calcium silicate cement values | 0 | {"evidence_spans": [{"end": 1273, "start": 973, "text": "esults. SureFil SDR and EverX Posterior bulk-fill composite resins' bond strengths were significantly higher than ProRoot MTA and Biodentine calcium silicate cements. However, no statistically significant differences were observed between bulk-fill composite resi... |
TITLE: Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
ABSTRACT.AIMS:
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safe... | Intervention: ticagrelor
Comparator: clopidogrel
Outcome: The incidence of the primary composite endpoint | -1 | {"evidence_spans": [{"end": 17019, "start": 16821, "text": " in Supplementary material online. The incidence of the primary composite endpoint was reduced with ticagrelor vs. clopidogrel (10.0 vs. 12.3%; HR 0.83; 95% CI = 0.74\u20130.93; P = 0.0013) (see Suppleme"}], "id": "1281", "pmcid": "4132637", "prompt_id": "1281... |
TITLE: Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
ABSTRACT.AIMS:
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safe... | Intervention: ticagrelor
Comparator: clopidogrel
Outcome: non-CABG-related major bleeding | 1 | {"evidence_spans": [{"end": 1461, "start": 1239, "text": ".90). Major bleeding rate was similar between treatment groups (13.4 vs. 12.6%; HR 1.07; 95% CI = 0.95\u20131.19), but ticagrelor was associated with an increase in non-CABG major bleeding (4.8 vs. 3.8%; HR 1.28; 95% CI = 1.05\u2013"}, {"end": 19807, "start": 19... |
TITLE: A Comparison of Two Delivery Modalities of a Mobile Phone-Based Assessment for Serious Mental Illness: Native Smartphone Application vs Text-Messaging Only Implementations
ABSTRACT.BACKGROUND:
Mobile phone–based assessment may represent a cost-effective and clinically effective method of monitoring psychot... | Intervention: completing 6 days of assessment (four sets of questions per day) with a native smartphone application
Comparator: completing 6 days of assessment (four sets of questions per day) with the SMS text-only implementation
Outcome: the total quantitative feedback score | 0 | {"evidence_spans": [{"end": 2658, "start": 2301, "text": "9, P<.001). Although there were no significant differences in participants' quantitative feedback for the two delivery modalities, most participants reported preferring the native smartphone application (67%; n=16) and found it easier to use (71%; n=16). 33% of ... |
TITLE: The provision of written information and its effect on levels of pain and anxiety during electrodiagnostic studies: A randomised controlled trial
ABSTRACT.OBJECTIVE:
The provision of written information is a low-cost and readily available intervention that has been found to reduce pain and anxiety in a var... | Intervention: provided with written information about the electrodiagnostic testing
Comparator: control
Outcome: Overall pain scores | 0 | {"evidence_spans": [{"end": 12238, "start": 12078, "text": "ere not provided with information. Overall pain scores between the intervention (20.91\u00b12.33mm) and non-intervention group (25.30\u00b12.44mm) in the NCS cohort did "}], "id": "1298", "pmcid": "5951568", "prompt_id": "1298", "split_group_id": "5951568", "... |
TITLE: Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)
ABSTRACT.INTRODUCTION:
The aim of the study was to assess the clinical efficacy, safety, and disease-modification effects of tramiprosate (homotaurine, ALZHEMEDTM) i... | Intervention: 78-week treatment with tramiprosate 150 mg BID
Comparator: 78-week treatment with placebo
Outcome: hippocampus volume (HV) change | -1 | {"evidence_spans": [{"end": 1692, "start": 1484, "text": "e models. These adjusted models showed a trend toward a treatment effect for ADAS-cog (P = 0.098) and indicated significantly less HV loss for tramiprosate 100 mg (P = 0.035) and 150 mg (P = 0.009) compared t"}], "id": "1310", "pmcid": "3258678", "prompt_id": "1... |
TITLE: Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)
ABSTRACT.INTRODUCTION:
The aim of the study was to assess the clinical efficacy, safety, and disease-modification effects of tramiprosate (homotaurine, ALZHEMEDTM) i... | Intervention: 78-week treatment with tramiprosate 100 mg or tramiprosate 150 mg BID
Comparator: 78-week treatment with placebo
Outcome: Alzheimer Disease Assessment Scale – cognitive subscale (ADAS-cog) | 0 | {"evidence_spans": [{"end": 15237, "start": 14928, "text": "30.3, respectively, for the planned models. The ADAS-cog adjusted model revealed a statistical trend for treatment effect in favour of the two tramiprosate groups (G \u00d7 V interaction: P = 0.098) while post-hoc planned contrasts showed lower changes from Ba... |
TITLE: Rotary instruments in the treatment of chronic periodontitis: A randomized clinical trial
ABSTRACT.BACKGROUND::
The study aimed at comparing the effectiveness of rotary instruments with hand instruments in non-surgical treatment of chronic periodontitis.
ABSTRACT.MATERIALS AND METHODS::
Thirty-eight pa... | Intervention: received treatment with rotary instruments
Comparator: received scaling and root planing with hand instruments
Outcome: Clinical improvement in multi-rooted teeth | 0 | {"evidence_spans": [{"end": 9670, "start": 9363, "text": "ODY.RESULTS.PARAMETERS IN MULTI-ROOTED TEETH:\r\nIn the rotary instrument group, 256 multi-rooted teeth and in the Gracey curette group, 302 multi-rooted teeth were treated. Clinical improvement was noticed in both moderately deep pocket sites and deep pocket ar... |
TITLE: Feto-maternal outcomes and Glycemic control in Metformin versus insulin treated Gestational Diabetics
ABSTRACT.OBJECTIVE::
To evaluate and compare feto-maternal outcomes and glycemic control in metformin versus insulin treated gestational diabetics.
ABSTRACT.METHODS::
The study was conducted in 2010- 2... | Intervention: oral metformin 500 mg TDS (Group-A)
Comparator: insulin 0.8-0.9 mg/kg/day in two divided doses subcutaneously (Group-B)
Outcome: numbers of babies were delivered after 38 weeks of pregnancy | -1 | {"evidence_spans": [{"end": 1025, "start": 931, "text": "p=0.01). Significant numbers of babies were delivered after 38 weeks of pregnancy in Group-B ("}], "id": "1335", "pmcid": "5673730", "prompt_id": "1335", "split_group_id": "5673730", "votes": {"-1": 2}} |
TITLE: The feasibility and acceptability of neuromuscular electrical stimulation to improve exercise performance in patients with advanced cancer: a pilot study
ABSTRACT.BACKGROUND:
To determine the feasibility and acceptability of lower limb neuromuscular electrical stimulation (NMES) as a home-based exercise th... | Intervention: lower limb neuromuscular electrical stimulation (NMES) applied daily to both quadriceps muscles for six weeks.
Comparator: baseline
Outcome: Global performance status and STS | 0 | {"evidence_spans": [{"end": 21072, "start": 20855, "text": "sessment results were compared for Completers (Table 2). Global performance status and STS appeared somewhat better, but these changes did not achieve statistical significance (Fisher's exact test p = 0.15 comparing c"}, {"end": 21073, "start": 20855, "text": ... |
TITLE: Resistant starch lowers postprandial glucose and leptin in overweight adults consuming a moderate-to-high-fat diet: a randomized-controlled trial
ABSTRACT.BACKGROUND:
High-amylose maize resistant starch type 2 (HAM-RS2) stimulates gut-derived satiety peptides and reduces adiposity in animals. Human studies... | Intervention: muffins enriched with 30 g HAM-RS2
Comparator: muffins enriched with 0 g HAM-RS2 (control)
Outcome: Mean overall satiety score | 0 | {"evidence_spans": [{"end": 19650, "start": 19571, "text": "dicators were documented throughout the study.\r\n\r\nBODY.RESULTS.SUBJECTIVE SATIE"}, {"end": 19651, "start": 19571, "text": "dicators were documented throughout the study.\r\n\r\nBODY.RESULTS.SUBJECTIVE SATIET"}], "id": "1343", "pmcid": "5320660", "prompt_id... |
TITLE: Adenosine A
ABSTRACT:
BackgroundWe evaluated the efficacy and safety of istradefylline, a selective adenosine A2A receptor antagonist administered as adjunctive treatment to levodopa for 12 weeks in a double-blind manner in Parkinson's disease patients with motor complications in Japan. MethodsA total of ... | Intervention: Istradefylline 20 mg or 40 mg
Comparator: Placebo
Outcome: Daily OFF time | -1 | {"evidence_spans": [{"end": 787, "start": 570, "text": "ltsThe change in daily OFF time was significantly reduced in the istradefylline 20 mg/day (\u22120.99 hours, P = .003) and istradefylline 40 mg/day (\u22120.96 hours, P = .003) groups compared with the placebo group (\u22120.23 hour"}], "id": "1359", "pmcid": "384... |
TITLE: Complications of Lumbar Artificial Disc Replacement Compared to Fusion: Results From the Prospective, Randomized, Multicenter US Food and Drug Administration Investigational Device Exemption Study of the Charité Artificial Disc
ABSTRACT.BACKGROUND:
Previous reports of lumbar total disc replacement (TDR) ha... | Intervention: Charité artificial disc
Comparator: ALIF with BAK cages
Outcome: Complications related to approach method | 0 | {"evidence_spans": [{"end": 10396, "start": 10191, "text": "LTS.APPROACH-RELATED EVENTS:\r\nThe rate of approach-related complications in all 304 patients was 9.9% (30/304) and was similar between the 2 groups, with 9.8% (20/205) in the investigational group and 10.1"}, {"end": 10407, "start": 10191, "text": "LTS.APPRO... |
TITLE: Urogenital function in robotic vs laparoscopic rectal cancer surgery: a comparative study
ABSTRACT.PURPOSE:
Urological and sexual dysfunction are recognised risks of rectal cancer surgery; however, there is limited evidence regarding urogenital function comparing robotic to laparoscopic techniques. The aim... | Intervention: Robotic surgery
Comparator: Laparoscopic surgery
Outcome: Urological function scores in females | 0 | {"evidence_spans": [{"end": 1404, "start": 1287, "text": " 0.001). In females, there was no difference between the two groups in any of the components of urological or sexual "}], "id": "1370", "pmcid": "5285426", "prompt_id": "1370", "split_group_id": "5285426", "votes": {"0": 2}} |
TITLE: Urogenital function in robotic vs laparoscopic rectal cancer surgery: a comparative study
ABSTRACT.PURPOSE:
Urological and sexual dysfunction are recognised risks of rectal cancer surgery; however, there is limited evidence regarding urogenital function comparing robotic to laparoscopic techniques. The aim... | Intervention: Robotic surgery
Comparator: Laparoscopic surgery
Outcome: Male sexual function scores | 1 | {"evidence_spans": [{"end": 1286, "start": 1166, "text": "unction. Composite male urological and sexual function score changes from baseline were better in the robotic cohort (p "}, {"end": 15835, "start": 15486, "text": "eLap2.318.56\r\n<0.001\r\n6.25 \u00b1 1.08Robotic3.622.920.759\u22120.69 \u00b1 0.85\r\np value0.3... |
TITLE: Randomized Controlled Trials of Proximal Femoral Nail Antirotation in Lateral Decubitus and Supine Position on Treatment of Intertrochanteric Fractures
ABSTRACT:
The objective of this study was to compare the clinical results and complications of proximal femoral nail antirotation (PFNA) on treatment of in... | Intervention: Lateral decubitus position
Comparator: Supine position
Outcome: Hospital stay | -1 | {"evidence_spans": [{"end": 772, "start": 532, "text": "p. The hospital stay, operating time, intraoperative blood loss, length of incision, X-ray fluoroscopy time, and out-of-bed activity time in the lateral decubitus position group were significantly lower than those in the supine position gro"}], "id": "1374", "pmci... |
TITLE: Randomized Controlled Trials of Proximal Femoral Nail Antirotation in Lateral Decubitus and Supine Position on Treatment of Intertrochanteric Fractures
ABSTRACT:
The objective of this study was to compare the clinical results and complications of proximal femoral nail antirotation (PFNA) on treatment of in... | Intervention: Lateral decubitus position
Comparator: Supine position
Outcome: Loss of blood during surgery | -1 | {"evidence_spans": [{"end": 772, "start": 532, "text": "p. The hospital stay, operating time, intraoperative blood loss, length of incision, X-ray fluoroscopy time, and out-of-bed activity time in the lateral decubitus position group were significantly lower than those in the supine position gro"}], "id": "1375", "pmci... |
TITLE: Randomized Controlled Trials of Proximal Femoral Nail Antirotation in Lateral Decubitus and Supine Position on Treatment of Intertrochanteric Fractures
ABSTRACT:
The objective of this study was to compare the clinical results and complications of proximal femoral nail antirotation (PFNA) on treatment of in... | Intervention: Lateral decubitus position
Comparator: Supine position
Outcome: Surgery time | -1 | {"evidence_spans": [{"end": 772, "start": 532, "text": "p. The hospital stay, operating time, intraoperative blood loss, length of incision, X-ray fluoroscopy time, and out-of-bed activity time in the lateral decubitus position group were significantly lower than those in the supine position gro"}, {"end": 772, "start"... |
TITLE: Randomized Controlled Trials of Proximal Femoral Nail Antirotation in Lateral Decubitus and Supine Position on Treatment of Intertrochanteric Fractures
ABSTRACT:
The objective of this study was to compare the clinical results and complications of proximal femoral nail antirotation (PFNA) on treatment of in... | Intervention: Lateral decubitus position
Comparator: Supine position
Outcome: Harris hip values and union time of fractures | 0 | {"evidence_spans": [{"end": 871, "start": 773, "text": "p. There was not statistical significance on union time and Harris values in the two position grou"}, {"end": 13780, "start": 13637, "text": " and 12.2 days, respectively. After treatment for 12 weeks, the Harris hip score and average union time of fractures were ... |
TITLE: Effects of infant massage on jaundiced neonates undergoing phototherapy
ABSTRACT.BACKGROUND:
Infant massage is a natural way for caregivers to improve health, sleep patterns, and reduce colic. We aimed to investigate the effects of infant massage on neonates with jaundice who are also receiving phototherap... | Intervention: Phototherapy plus massage
Comparator: Phototherapy only
Outcome: Bilirubin levels after 3 days | -1 | {"evidence_spans": [{"end": 1010, "start": 830, "text": "l group. On the third day, the massage group showed significantly higher defecation frequency (p = 0.045) and significantly lower bilirubin levels (p = 0.03) compared with the cont"}, {"end": 1011, "start": 830, "text": "l group. On the third day, the massage gro... |
TITLE: Effects of infant massage on jaundiced neonates undergoing phototherapy
ABSTRACT.BACKGROUND:
Infant massage is a natural way for caregivers to improve health, sleep patterns, and reduce colic. We aimed to investigate the effects of infant massage on neonates with jaundice who are also receiving phototherap... | Intervention: Phototherapy plus massage
Comparator: Phototherapy only
Outcome: Baseline medical characteristics | 0 | {"evidence_spans": [{"end": 9784, "start": 9491, "text": "ates; 11 males and 16 females). Table 1 shows the medical characteristics of participating neonates. We observed no significant differences between the two groups in terms of type of feeding, gestational age at birth, body weight at birth, body weight on the da... |
TITLE: Randomized, Double-Blinded, Placebo-Controlled Trial of Fibrinogen Concentrate Supplementation After Complex Cardiac Surgery
ABSTRACT.BACKGROUND:
Postoperative bleeding after heart operations is still a common finding, leading to allogeneic blood products transfusion. Fibrinogen and coagulation factors def... | Intervention: received fibrinogen concentrate
Comparator: received saline solution (placebo)
Outcome: postoperative bleeding | -1 | {"evidence_spans": [{"end": 1682, "start": 1475, "text": " arm. Postoperative bleeding was significantly (P=0.042) less in the treatment arm (median, 300 mL; interquartile range, 200 to 400 mL) than in the control arm (median, 355 mL; interquartile range, 250 to 60"}, {"end": 20594, "start": 20329, "text": "rquartile r... |
TITLE: TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, randomised controlled trial
ABSTRACT.BACKGROUND:
For children with sickle cell anaemia and elevated transcranial Doppler (TCD) flow velocities, regular blood transfusions effectively prevent primary stroke, but must be continued indefin... | Intervention: hydroxyurea
Comparator: transfusions
Outcome: transcranial Doppler (TCD) flow velocities | 0 | {"evidence_spans": [{"end": 16527, "start": 15963, "text": " 13 truncated treatment, and 6 exited early. The final model-based TCD velocities (mean \u00b1 standard error) on the Standard Arm versus Alternative Arm were 143 \u00b1 1.6 and 138 \u00b1 1.6 cm/sec, respectively, with difference (95% CI) = 4.54 (0.10, 8.98),... |
TITLE: Twelve-Month Follow-Up of a Randomized Controlled Trial of Internet-Based Guided Self-Help for Parents of Children on Cancer Treatment
ABSTRACT.BACKGROUND:
A substantial proportion of parents of children on cancer treatment report psychological distress such as symptoms of post-traumatic stress (PTSS), dep... | Intervention: Internet-based guided self-help program, including weekly support from a therapist via encrypted email
Comparator: wait-list control condition
Outcome: PTSD-Checklist-Civilian version (PCL-C) difference | 1 | {"evidence_spans": [{"end": 25485, "start": 25201, "text": "bated over time. The control group showed no change. The model difference at postassessment was 9.16 points on the PCL-C in favor of the intervention group, representing a large effects size. At follow-up, the model difference was 8.07 points on the PCL-C in f... |
TITLE: Evaluation of Cyavanaprāśa on Health and Immunity related Parameters in Healthy Children: A Two Arm, Randomized, Open Labeled, Prospective, Multicenter, Clinical Study
ABSTRACT.CONTEXT::
Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing... | Intervention: receive orally daily either CyavanaprÄ?Å›a (CP) (approx. 6 g) followed by a cup of milk (100 – 200 ml)
Comparator: cup of milk only twice a day while continuing with their normal/routine diet.
Outcome: total duration of illnesses | -1 | {"evidence_spans": [{"end": 15017, "start": 14642, "text": "ergy Evaluation of total duration of and severity of illnesses Evaluation of total duration of illnesses related to infection and allergy showed that of the total duration of 3983 days of illness, there were 1369 (34.37%) illness days in CP group whereas it ... |
TITLE: Evaluation of Cyavanaprāśa on Health and Immunity related Parameters in Healthy Children: A Two Arm, Randomized, Open Labeled, Prospective, Multicenter, Clinical Study
ABSTRACT.CONTEXT::
Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing... | Intervention: receive orally daily either CyavanaprÄ?Å›a (CP) (approx. 6 g) followed by a cup of milk (100 – 200 ml)
Comparator: cup of milk only twice a day while continuing with their normal/routine diet.
Outcome: CGI-I scale improvement | 1 | {"evidence_spans": [{"end": 19520, "start": 19328, "text": "BODY.RESULTS AND OBSERVATIONS.ASSESSMENT OF PARTICIPANTS ON CGI-I SCALE:\r\nAssessment of participants on CGI-I scale showed that a higher percentage of participants (66.12%) showed improvement "}], "id": "1434", "pmcid": "5566825", "prompt_id": "1434", "split... |
TITLE: Efficacy and Safety of 5-Fluorouracil 0.5%/Salicylic Acid 10% in the Field-Directed Treatment of Actinic Keratosis: A Phase III, Randomized, Double-Blind, Vehicle-Controlled Trial
ABSTRACT.INTRODUCTION:
Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clin... | Intervention: 5-fluorouracil (5-FU) 0.5%/salicylic acid 10%
Comparator: vehicle
Outcome: The percentage of patients with complete clinical clearance (CCC) 8 weeks after the end of treatment (primary endpoint) | 1 | {"evidence_spans": [{"end": 1420, "start": 1217, "text": "vehicle. At 8 weeks after the end of treatment, CCC was significantly higher with 5-FU 0.5%/salicylic acid 10% than with vehicle [49.5% vs. 18.2%, respectively; odds ratio (OR) 3.9 (95% CI) 1.7, 8.7; P ="}, {"end": 15303, "start": 14937, "text": "D standard devi... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.