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778	Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.	13,001,323	SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.	[ "Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions.", "Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical importance.", "Here, we show that mice lacking SIRT1 in steroidog...	CONTRADICT	[ 2, 3, 5 ]
779	Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.	13,001,323	SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.	[ "Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions.", "Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical importance.", "Here, we show that mice lacking SIRT1 in steroidog...	SUPPORT	[ 2, 3, 5 ]
780	Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.	8,246,922	the Development of Autoimmune Myocarditis in Mice by an	[ "BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses.", "This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma.", "Methods and Results- We examined the role of IL-12 receptor...	SUPPORT	[ 7, 11 ]
780	Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.	24,338,780	Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction.	[ "BACKGROUND Interferon-gamma (IFN-gamma) is an essential cytokine in the regulation of inflammatory responses in autoimmune diseases.", "Little is known about its role in inflammatory heart disease. \n", "METHODS AND RESULTS We showed that IFN-gamma receptor-deficient mice (IFN-gammaR(-/-)) on a BALB/c backgr...	SUPPORT	[ 2, 3, 6 ]
782	Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.	8,246,922	the Development of Autoimmune Myocarditis in Mice by an	[ "BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses.", "This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma.", "Methods and Results- We examined the role of IL-12 receptor...	SUPPORT	[ 7, 11 ]
787	Microcin J25 encourages nucleoside triphosphate (NTP) binding.	4,740,447	Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.	[ "The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP).", "Biochemical results indicate that inhibition of transcription occurs at the level of NTP uptake or NTP binding by RNAP.", "Genetic results indicate that inhibition of transcription requires an extensiv...	CONTRADICT	[ 1 ]
788	Microcin J25 inhibits nucleoside triphosphate (NTP) binding.	4,740,447	Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.	[ "The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP).", "Biochemical results indicate that inhibition of transcription occurs at the level of NTP uptake or NTP binding by RNAP.", "Genetic results indicate that inhibition of transcription requires an extensiv...	SUPPORT	[ 1 ]
789	Microglia are an innate immune cell type of the central nervous system.	15,493,354	Sublime Microglia: Expanding Roles for the Guardians of the CNS	[ "Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS).", "Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt the structure of the CNS, refine neuronal circuitry and netw...	SUPPORT	[ 2, 3 ]
790	Microglia are an innate immune cell type of the peripheral nervous system.	15,493,354	Sublime Microglia: Expanding Roles for the Guardians of the CNS	[ "Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS).", "Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt the structure of the CNS, refine neuronal circuitry and netw...	CONTRADICT	[ 2, 3 ]
791	Migraine with aura is associated with ischemic stroke.	15,984,735	Migraine and cardiovascular disease: systematic review and meta-analysis.	[ "OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. \n", "DESIGN Systematic review and meta-analysis. \n", "DATA SOURCES Electronic databases (PubMed, Embase, Cochrane Library) and reference lis...	SUPPORT	[ 11, 16 ]
792	Misunderstandings between doctors and patients can lead to non-adherence.	3,610,080	Misunderstandings in prescribing decisions in general practice: qualitative study.	[ "OBJECTIVES To identify and describe misunderstandings between patients and doctors associated with prescribing decisions in general practice. \n", "DESIGN Qualitative study. \n", "SETTING 20 general practices in the West Midlands and south east England. \n", "PARTICIPANTS 20 general practitioners and 3...	SUPPORT	[ 6, 7 ]
795	Mitochondria play a major role in apoptosis.	8,551,160	Mitochondria: Dynamic Organelles in Disease, Aging, and Development	[ "Mitochondria are the primary energy-generating system in most eukaryotic cells.", "Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis.", "Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predicta...	SUPPORT	[ 1 ]
797	Mitochondria play a major role in energy production.	8,551,160	Mitochondria: Dynamic Organelles in Disease, Aging, and Development	[ "Mitochondria are the primary energy-generating system in most eukaryotic cells.", "Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis.", "Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predicta...	SUPPORT	[ 0 ]
798	Mitochondria play a trivial role in calcium homeostasis.	8,551,160	Mitochondria: Dynamic Organelles in Disease, Aging, and Development	[ "Mitochondria are the primary energy-generating system in most eukaryotic cells.", "Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis.", "Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predicta...	CONTRADICT	[ 1 ]
799	Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).	5,293,024	Life is sweet: candy consumption and longevity.	[ "Our attitude towards candy—“if it tastes that good, it can't be healthy”—betrays society's puritanical stance towards pleasure.", "Candy has been blamed for various ills, including hyperactivity in children; however, clinical trials have not supported this.1 Candy—sugar confectionery and chocolate—is not a rece...	NEI	[]
801	Monoclonal antibody targeting of N-cadherin encourages castration resistance.	22,180,793	Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance	[ "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology.", "Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cadherin expression, which was also elevated in primary a...	CONTRADICT	[ 5 ]
802	Monoclonal antibody targeting of N-cadherin encourages metastasis.	22,180,793	Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance	[ "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology.", "Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cadherin expression, which was also elevated in primary a...	CONTRADICT	[ 4, 7 ]
803	Monoclonal antibody targeting of N-cadherin inhibits castration resistance.	22,180,793	Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance	[ "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology.", "Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cadherin expression, which was also elevated in primary a...	SUPPORT	[ 5 ]
804	Monoclonal antibody targeting of N-cadherin inhibits growth.	22,180,793	Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance	[ "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology.", "Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cadherin expression, which was also elevated in primary a...	SUPPORT	[ 3 ]
807	Most termination events in Okazaki fragments are dictated by initiation patterns.	36,606,083	Quantitative, genome-wide analysis of eukaryotic replication initiation and termination.	[ "Many fundamental aspects of DNA replication, such as the exact locations where DNA synthesis is initiated and terminated, how frequently origins are used, and how fork progression is influenced by transcription, are poorly understood.", "Via the deep sequencing of Okazaki fragments, we comprehensively document r...	SUPPORT	[ 4 ]
810	Mouse models can be generated using "artificial spermatids."	13,513,790	Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells	[ "Haploid cells are amenable for genetic analysis.", "Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells.", "However, successful generation of live animals from these haESCs, which is needed to extend the genetic an...	SUPPORT	[ 5 ]
812	Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.	19,799,455	Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival	[ "The only proven requirement for ascorbic acid (vitamin C) is in preventing scurvy, presumably because it is a cofactor for hydroxylases required for post-translational modifications that stabilize collagen.", "We have created mice deficient in the mouse ortholog (solute carrier family 23 member 1 or Slc23a1) of ...	SUPPORT	[ 4, 6, 8 ]
813	Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.	33,387,953	Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance	[ "Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined.", "Here we demonstrate that recurrent mutations in the Gβ proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G protein...	NEI	[]
815	Mutations in RIM1 decrease levels of IME1 RNA.	8,148,304	Molecular characterization of the yeast meiotic regulatory gene RIM1.	[ "In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis.", "rim1 mutations cause reduced expression of IME1, which is required for expression of many meiotic genes, and thus lead to a partial defect in meiosis and spore formation.", "We report t...	SUPPORT	[ 1, 13 ]
816	Mutations in RIM1 raise levels of IME1 RNA.	8,148,304	Molecular characterization of the yeast meiotic regulatory gene RIM1.	[ "In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis.", "rim1 mutations cause reduced expression of IME1, which is required for expression of many meiotic genes, and thus lead to a partial defect in meiosis and spore formation.", "We report t...	CONTRADICT	[ 1, 13 ]
817	Myelin sheaths are lipid-rich cellular structures.	17,814,815	Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy	[ "We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling.", "This method, based on spectral confocal reflectance microscopy (SCoRe), uses a conventional laser-scanning confocal system to gene...	NEI	[]
818	Myelin sheaths play a role in action potential propagation.	17,814,815	Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy	[ "We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling.", "This method, based on spectral confocal reflectance microscopy (SCoRe), uses a conventional laser-scanning confocal system to gene...	SUPPORT	[ 0, 2 ]
822	N348I mutations cause resistance to nevirapine.	15,319,019	N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance	[ "Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains.", "Almost all known RT inhibitor resistance mutations identified to date map to the polymerase domain of t...	SUPPORT	[ 13 ]
825	N348I mutations reduce resistance to nevirapine.	15,319,019	N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance	[ "Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains.", "Almost all known RT inhibitor resistance mutations identified to date map to the polymerase domain of t...	CONTRADICT	[ 13 ]
826	NAC destabilizes NO to increase the effect of contrast agents on renal functions.	4,678,846	Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.	[ "CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning.", "However, its role in coronary angiography is unclear. \n", "OBJECTIVE To determine whether oral acetylcysteine prevents acute deterioration in re...	NEI	[]
828	NAC inhibits the generation of angiotensin-converting enzyme.	4,678,846	Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.	[ "CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning.", "However, its role in coronary angiography is unclear. \n", "OBJECTIVE To determine whether oral acetylcysteine prevents acute deterioration in re...	NEI	[]
835	NR5A2 does not play a role in development of endometrial tissues.	15,928,989	Liver receptor homolog-1 is essential for pregnancy	[ "Successful pregnancy requires coordination of an array of signals and factors from multiple tissues.", "One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis.", "It is strongly expressed in granulosa cells of ovarian follicles and in t...	CONTRADICT	[ 5, 6, 7 ]
838	NR5A2 is important in reverse cholesterol transport in humans.	15,928,989	Liver receptor homolog-1 is essential for pregnancy	[ "Successful pregnancy requires coordination of an array of signals and factors from multiple tissues.", "One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis.", "It is strongly expressed in granulosa cells of ovarian follicles and in t...	NEI	[]
840	Natriuretic peptides increase susceptibility to diabetes.	15,663,829	Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies	[ "BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the prospective association of BNP with T2D is uncertain, and it is unclear whether the association is confounded. \n", "METHODS AND FI...	CONTRADICT	[ 4, 7 ]
841	Natriuretic peptides protect against diabetes.	15,663,829	Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies	[ "BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the prospective association of BNP with T2D is uncertain, and it is unclear whether the association is confounded. \n", "METHODS AND FI...	SUPPORT	[ 4, 7 ]
844	Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.	17,741,440	Netting neutrophils in autoimmune small-vessel vasculitis	[ "Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs).", "Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (...	SUPPORT	[ 1 ]
846	Neutrophils produce IL-1β in response to large particles.	22,696,649	Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size	[ "How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is unknown.", "Here, we have uncovered a role for reactive oxygen species (ROS) as sensors of microbe size.", "By sensing the differential localizatio...	SUPPORT	[ 4 ]
848	Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.	14,500,725	Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile	[ "BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern.", "Our objective was to determine current emigration trends of SSA physicians found in the physician workforce of the United States. \n", "METHODS AND FINDINGS We analyze...	NEI	[]
853	Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.	24,922,825	A chikungunya fever vaccine utilizing an insect-specific virus platform	[ "Traditionally, vaccine development involves tradeoffs between immunogenicity and safety.", "Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines.", "In contrast, the inability of inactivated vaccines to replicate enhances safety at th...	CONTRADICT	[ 7, 8 ]
854	Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.	12,206,390	Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study.	[ "CONTEXT The long-term risk for developing hypertension is best described by the lifetime risk statistic.", "The lifetime risk for hypertension and trends in this risk over time are unknown. \n", "OBJECTIVES To estimate the residual lifetime risk for hypertension in older US adults and to evaluate temporal tr...	SUPPORT	[ 5, 9 ]
855	Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.	8,190,282	Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial.	[ "CONTEXT Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure. \n", "OBJECTIVE To compare NIV with standard treatment using supplemental oxygen administration to avoid endotracheal intubation in recipients of soli...	CONTRADICT	[ 8, 9, 10, 12 ]
856	Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.	43,334,921	Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.	[ "IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. \n", "OBJECTIVE To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between ...	CONTRADICT	[ 6, 8, 10 ]
857	Nonsteroidal antinflammatory drugs show potential anticancer indications.	43,334,921	Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.	[ "IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. \n", "OBJECTIVE To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between ...	SUPPORT	[ 6, 8, 10 ]
858	Normal expression of RUNX1 causes tumorsupressing effects.	1,982,286	Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL	[ "The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL).", "Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3.", "This systems biology analysis ...	SUPPORT	[ 3 ]
860	Normal granulomas form in the absence of TNF in Zebrafish.	16,066,726	Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.	[ "Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells.", "Loss of TNF signaling causes progression of tuberculosis in humans, and the increased mortality of Mycobacte...	SUPPORT	[ 4, 5 ]
861	Normal granulomas form in the presence of TNF in Zebrafish.	16,066,726	Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.	[ "Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells.", "Loss of TNF signaling causes progression of tuberculosis in humans, and the increased mortality of Mycobacte...	CONTRADICT	[ 4, 5 ]
863	Notch signaling occurs between tumor cells and stromal cells.	20,568,364	Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.	[ "While significant progress has been made in understanding the induction of tumor vasculature by secreted angiogenic factors, little is known regarding contact-dependent signals that promote tumor angiogenesis.", "Here, we report that the Notch ligand Jagged1 induced by growth factors via mitogen-activating prote...	SUPPORT	[ 1, 4 ]
863	Notch signaling occurs between tumor cells and stromal cells.	16,361,581	Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.	[ "Notch receptors expressed on hematopoietic stem cells interact with their ligands on bone marrow stromal cells and thereby control cell fate decisions and survival.", "We recently demonstrated that Notch signaling is involved in proliferation and survival of B cell-derived tumor cells of classic Hodgkin disease ...	SUPPORT	[ 1 ]
866	Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.	37,822,406	Human somatic cell nuclear transfer using adult cells.	[ "Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts.", "However, successful SCNT with human cells has proved challenging to achieve, and thus far has only been reported with fetal or infant soma...	NEI	[]
867	Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.	14,340,571	The Molecular Basis for Oat Intolerance in Patients with Celiac Disease	[ "Background Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations.", "It is caused by an inappropriate immune response to dietary gluten and is treated with a gluten-free diet.", "Recent feeding studies have indica...	SUPPORT	[ 6 ]
871	Obesity decreases life quality.	195,689,316	Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.	[ "BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people.", "The Prospective Studies Collaboration aimed to investigate these associations by sharing data from many studies. \n", "MET...	NEI	[]
876	Obesity raises life quality.	195,689,316	Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.	[ "BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people.", "The Prospective Studies Collaboration aimed to investigate these associations by sharing data from many studies. \n", "MET...	NEI	[]
877	Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.	313,394	A Functional Neuroimaging Study of Sound Localization: Visual Cortex Activity Predicts Performance in Early-Blind Individuals	[ "Blind individuals often demonstrate enhanced nonvisual perceptual abilities.", "However, the neural substrate that underlies this improved performance remains to be fully understood.", "An earlier behavioral study demonstrated that some early-blind people localize sounds more accurately than sighted controls u...	NEI	[]
881	Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.	14,803,797	Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis	[ "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).", "We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat...	CONTRADICT	[ 2 ]
883	Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.	14,803,797	Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis	[ "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).", "We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat...	SUPPORT	[ 2 ]
884	Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.	14,803,797	Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis	[ "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).", "We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat...	SUPPORT	[ 2 ]
885	One in five surgical randomized controlled trials are discontinued early.	6,477,536	Discontinuation and non-publication of surgical randomised controlled trials: observational study	[ "OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. \n", "DESIGN Cross sectional observational study of registered and published trials. \n", "SETTING Randomised controlled trials of interventions in patients un...	SUPPORT	[ 10, 17 ]
886	One in two surgical randomized controlled trials are discontinued early.	6,477,536	Discontinuation and non-publication of surgical randomised controlled trials: observational study	[ "OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. \n", "DESIGN Cross sectional observational study of registered and published trials. \n", "SETTING Randomised controlled trials of interventions in patients un...	CONTRADICT	[ 10, 17 ]
890	Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.	2,097,256	Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis	[ "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas.", "We analysed the interaction between human population density and lack of tap water as a cause of dengue feve...	NEI	[]
891	Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.	2,097,256	Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis	[ "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas.", "We analysed the interaction between human population density and lack of tap water as a cause of dengue feve...	NEI	[]
893	Osteocytes have an essential role in G-CSF induced HSPC mobilization.	13,509,809	Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells.	[ "The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the circulation.", "Here, we demonstrate that osteocytes, the major cellular component of mature bone, are regulators of HSPC egress.", "Granulocyte colony-stimul...	SUPPORT	[ 2, 4 ]
894	Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.	14,724,693	Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial.	[ "CONTEXT Chronic low back pain (LBP) with degenerative lumbar osteoarthritis (OA) is widespread in the adult population.", "Although glucosamine is increasingly used by patients with chronic LBP, little is known about its effect in this setting. \n", "OBJECTIVE To investigate the effect of glucosamine in pati...	NEI	[]
895	Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.	18,750,453	Assessment of Volume Depletion in Children with Malaria	[ "Background The degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy.", "To assist management of severely ill children, and to test the hypothesis that volume changes in fluid compartments reflect disease severity, we measured body co...	NEI	[]
896	Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.	14,338,915	Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin	[ "The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood.", "Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human.", "Fission yeast sim1 mutants that alleviate kinetochore domain silencing are d...	NEI	[]
897	Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.	14,338,915	Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin	[ "The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood.", "Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human.", "Fission yeast sim1 mutants that alleviate kinetochore domain silencing are d...	NEI	[]
898	Oxidative DNA damage activates STING signalling.	13,106,686	Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.	[ "Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE).", "Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA.", "The oxidized base 8-hydroxyguanosine (8-OHG), a...	NEI	[]
898	Oxidative DNA damage activates STING signalling.	5,572,127	Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.	[ "The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases is unclear.", "We have previously shown that high levels of systemic DNA damage are induced by intestinal inflammation in wild-type mice.", "To determine the ef...	NEI	[]
899	Oxidative DNA damage inhibits STING signalling.	13,106,686	Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.	[ "Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE).", "Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA.", "The oxidized base 8-hydroxyguanosine (8-OHG), a...	NEI	[]
899	Oxidative DNA damage inhibits STING signalling.	5,572,127	Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.	[ "The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases is unclear.", "We have previously shown that high levels of systemic DNA damage are induced by intestinal inflammation in wild-type mice.", "To determine the ef...	NEI	[]
900	Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.	18,678,095	Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport	[ "Fast axonal transport (FAT) requires consistent energy over long distances to fuel the molecular motors that transport vesicles.", "We demonstrate that glycolysis provides ATP for the FAT of vesicles.", "Although inhibiting ATP production from mitochondria did not affect vesicles motility, pharmacological or g...	NEI	[]
901	PCSK9 inhibitors decrease plasma Lp(a) levels.	6,540,064	Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans	[ "BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB).", "Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCS...	SUPPORT	[ 3, 16 ]
902	PD-1 triggering on monocytes enhances IL-10 production by monocytes.	10,648,422	Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection	[ "Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection.", "Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection.", "Blocki...	SUPPORT	[ 4, 5 ]
908	PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.	6,923,961	Prostaglandin E2 promotes intestinal tumor growth via DNA methylation	[ "Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear.", "Here we show that prostaglandin E(2) (PGE(2)) silences ...	NEI	[]
909	PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.	11,254,556	Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity	[ "Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.", "Previous studies have functionally implicated the NMDA receptor-NO pathway and the downs...	CONTRADICT	[ 3, 9 ]
910	PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.	11,254,556	Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity	[ "Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.", "Previous studies have functionally implicated the NMDA receptor-NO pathway and the downs...	CONTRADICT	[ 5 ]
912	PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.	11,254,556	Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity	[ "Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.", "Previous studies have functionally implicated the NMDA receptor-NO pathway and the downs...	SUPPORT	[ 5 ]
916	PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.	18,037,805	Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro	[ "The transcriptional status of a gene can be maintained through multiple rounds of cell division during development.", "This epigenetic effect is believed to reflect heritable changes in chromatin folding and histone modifications or variants at target genes, but little is known about how these chromatin features...	NEI	[]
917	PTEN is a regulator for the transcriptional activity of SRF	34,071,621	Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation	[ "Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype and function.", "SMC contractile gene expression and, thus differentiation, is under direct transcriptional control by the transcription factor, serum response factor (SRF); however, the mechanisms dynam...	SUPPORT	[ 2, 3, 4 ]
919	Participants who quit smoking reduce lung cancer risk by approximately 50%.	16,422,880	Effect of smoking reduction on lung cancer risk.	[ "CONTEXT Many smokers are unable or unwilling to completely quit smoking.", "A proposed means of harm reduction is to reduce the number of cigarettes smoked per day.", "However, it is not clear whether this strategy decreases the risk for tobacco-related diseases. \n", "OBJECTIVE To assess the effects of sm...	SUPPORT	[ 11 ]
923	Patients in stable partnerships have a slower progression from HIV to AIDS.	17,077,004	Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.	[ "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). \n", "DESIGN Prospective cohort study of adults with HIV (Swiss HIV cohort study). \n", "SETTING Seven outpatient clinics throughout Switz...	SUPPORT	[ 7, 9 ]
925	Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.	17,077,004	Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.	[ "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). \n", "DESIGN Prospective cohort study of adults with HIV (Swiss HIV cohort study). \n", "SETTING Seven outpatient clinics throughout Switz...	CONTRADICT	[ 7, 9 ]
926	Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.	16,390,264	Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics	[ "OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by socioeconomic circumstances, age, sex, and year of admission for colorectal, breast, and lung cancer. \n", "DESIGN Repeated cross sectional study with data from individual ...	SUPPORT	[ 6, 7, 10 ]
927	Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.	16,390,264	Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics	[ "OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by socioeconomic circumstances, age, sex, and year of admission for colorectal, breast, and lung cancer. \n", "DESIGN Repeated cross sectional study with data from individual ...	CONTRADICT	[ 6, 7, 10 ]
928	Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.	18,174,210	Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia	[ "BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb).", "Individuals homozygous for alpha(+)-thalassaemia have microcytosis and an increased erythrocyte count.", "Alpha(+)-thalassaemia homozygo...	CONTRADICT	[ 2, 9, 10 ]
929	Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.	18,174,210	Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia	[ "BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb).", "Individuals homozygous for alpha(+)-thalassaemia have microcytosis and an increased erythrocyte count.", "Alpha(+)-thalassaemia homozygo...	SUPPORT	[ 2, 9, 10 ]
930	Patients with panic anxiety show decreased CSF levels of hypocretin.	16,056,514	A KEY ROLE FOR OREXIN IN PANIC ANXIETY	[ "Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks.", "In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic...	CONTRADICT	[ 5 ]
933	Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.	14,711,483	Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.	[ "CONTEXT Vaso-occlusion is central to the painful crises and acute and chronic organ damage in sickle cell disease.", "Abnormal nitric oxide-dependent regulation of vascular tone, adhesion, platelet activation, and inflammation contributes to the pathophysiology of vaso-occlusion.", "Nitric oxide may have promi...	SUPPORT	[ 12 ]
934	Perigenital skin is not the primary site of HIV acquisition.	8,563,659	Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition	[ "To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV-2 lesions from patients on and off antiviral therapy.", "CD4(+) and CD8(+) T cells and a mixed population of plasmacyt...	NEI	[]
935	Peroxynitrite is required for induction of T cell tolerance.	5,483,793	Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer	[ "Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape.", "Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibility complex (pMHC) dimers to CD8-expressing T cells th...	SUPPORT	[ 3, 5 ]
938	Persister cells provide relapse resistance in cancer patients.	26,231,129	A framework for understanding and targeting residual disease in oncogene-driven solid cancers	[ "Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer.", "However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers.", "Even the most effective targeted therapies generally do not induce a complete tumor...	NEI	[]
939	Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.	26,231,129	A framework for understanding and targeting residual disease in oncogene-driven solid cancers	[ "Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer.", "However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers.", "Even the most effective targeted therapies generally do not induce a complete tumor...	NEI	[]
940	Pharmacist attendance at ward rounds increases adverse events in wards.	12,258,338	Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.	[ "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs.", "However, whether pharmacist participation in the ICU at the time of drug prescribing reduces adverse events has not been studied. \n", "OBJE...	CONTRADICT	[ 11, 14 ]
941	Pharmacist attendance at ward rounds reduces adverse events in wards.	12,258,338	Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.	[ "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs.", "However, whether pharmacist participation in the ICU at the time of drug prescribing reduces adverse events has not been studied. \n", "OBJE...	SUPPORT	[ 11, 14 ]
942	Phase information is useful for predicting donor-recipient matches in organ transplantation.	11,527,199	MHC Haplotype Matching for Unrelated Hematopoietic Cell Transplantation	[ "Background Current criteria for the selection of unrelated donors for hematopoietic cell transplantation (HCT) include matching for the alleles of each human leukocyte antigen (HLA) locus within the major histocompatibility complex (MHC).", "Graft-versus-host disease (GVHD), however, remains a significant and p...	SUPPORT	[ 3 ]
944	Physical activity does not improve cognitive function in individuals with Alzheimers.	1,642,727	Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.	[ "CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. \n", "OBJECTIVE To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. \n", "DESIGN AND SETTING ...	CONTRADICT	[ 9, 13 ]
945	Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.	8,428,935	Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.	[ "CONTEXT Physical inactivity contributes to weight gain in adults, but whether this relationship is true for children of different ethnic groups is not well established. \n", "OBJECTIVE To assess participation in vigorous activity and television watching habits and their relationship to body weight and fatness ...	NEI	[]
945	Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.	26,112,696	Maximal aerobic capacity in African-American and Caucasian prepubertal children.	[ "The purpose of this study was to examine differences in resting, submaximal, and maximal (VO2max) oxygen consumption (VO2) in African-American (n = 44) and Caucasian (n = 31) prepubertal children aged 5-10 yr.", "Resting VO2 was measured via indirect calorimetry in the fasted state.", "Submaximal VO2 and VO2ma...	NEI	[]
945	Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.	4,463,588	Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents.	[ "BACKGROUND Little is known about how the intensity of exercise influences cardiovascular fitness and body composition, especially in obese adolescents. \n", "OBJECTIVE Our goal was to determine the effects of physical training intensity on the cardiovascular fitness, percentage of body fat (%BF), and visceral ...	NEI	[]
945	Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.	13,083,189	Determinants of adolescent physical activity and inactivity patterns.	[ "OBJECTIVES Despite recognition of the important influence of environmental determinants on physical activity patterns, minimal empirical research has been done to assess the impact of environmental/contextual determinants of physical activity.", "This article aims to investigate environmental and sociodemographi...	NEI	[]
946	Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.	8,428,935	Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.	[ "CONTEXT Physical inactivity contributes to weight gain in adults, but whether this relationship is true for children of different ethnic groups is not well established. \n", "OBJECTIVE To assess participation in vigorous activity and television watching habits and their relationship to body weight and fatness ...	NEI	[]

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